In JoVE (1)
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Articles by Nicola Fusco in JoVE
Building Up a High-throughput Screening Platform to Assess the Heterogeneity of HER2 Gene Amplification in Breast Cancers Giulia Ercoli1, Gianluca Lopez1,2, Camilla Ciapponi1,3, Chiara Corti1,2, Luca Despini4, Donatella Gambini5, Letterio Runza1, Concetta Blundo4, Amedeo Sciarra1, Nicola Fusco1,6 1 Heterogeneous distribution of HER2-positive cells can be observed in a subset of breast cancers and generates clinical dilemmas. Here, we introduce a reliable and cost-effective protocol to define, quantify, and compare HER2 intra-tumor genetic heterogeneity in a large series of heterogeneously processed breast cancers.