Nicolas Servant

Publications

• Genomics to Select Treatment for Patients with Metastatic Breast Cancer
  Nature. Oct, 2022  |   Pubmed ID: 36071165
• Compartment-specific and ELAVL1-coordinated Regulation of Intronic Polyadenylation Isoforms by Doxorubicin
  Genome Research. Jul, 2022  |   Pubmed ID: 35858751
• Bioinformatics Methods for ChIP-seq Histone Analysis
  Methods in Molecular Biology (Clifton, N.J.). 2022  |   Pubmed ID: 35733020
• Inversion of a Topological Domain Leads to Restricted Changes in Its Gene Expression and Affects Interdomain Communication
  Development (Cambridge, England). 05, 2022  |   Pubmed ID: 35502750
• Human Papilloma Virus Integration Sites and Genomic Signatures in Head and Neck Squamous Cell Carcinoma
  Molecular Oncology. 08, 2022  |   Pubmed ID: 35398964
• A Computational Method for Prioritizing Targeted Therapies in Precision Oncology: Performance Analysis in the SHIVA01 Trial
  NPJ Precision Oncology. Jun, 2021  |   Pubmed ID: 34162980
• SMARCA4-deficient Rhabdoid Tumours Show Intermediate Molecular Features Between SMARCB1-deficient Rhabdoid Tumours and Small Cell Carcinomas of the Ovary, Hypercalcaemic Type
  The Journal of Pathology. 09, 2021  |   Pubmed ID: 33999421
• Human Papilloma Virus (HPV) Integration Signature in Cervical Cancer: Identification of MACROD2 Gene As HPV Hot Spot Integration Site
  British Journal of Cancer. 02, 2021  |   Pubmed ID: 33191407
• Bioinformatic Analysis of Single-Cell Hi-C Data from Early Mouse Embryo
  Methods in Molecular Biology (Clifton, N.J.). 2021  |   Pubmed ID: 32944918
• Interactive Analysis of Single-cell Epigenomic Landscapes with ChromSCape
  Nature Communications. 11, 2020  |   Pubmed ID: 33177523
• CD44 Regulates Epigenetic Plasticity by Mediating Iron Endocytosis
  Nature Chemistry. 10, 2020  |   Pubmed ID: 32747755
• Corrigendum to 'clinical and Genetic Landscape of Treatment Naive Cervical Cancer: Alterations in PIK3CA and in Epigenetic Modulators Associated with Sub-optimal Outcome'
  EBioMedicine. 07, 2020  |   Pubmed ID: 32650273
• Parental-to-embryo Switch of Chromosome Organization in Early Embryogenesis
  Nature. 04, 2020  |   Pubmed ID: 32238933
• A Conserved Noncoding Locus Regulates Random Monoallelic Xist Expression Across a Topological Boundary
  Molecular Cell. 01, 2020  |   Pubmed ID: 31759823
• Mechanistic Signatures of Human Papillomavirus Insertions in Anal Squamous Cell Carcinomas
  Cancers. Nov, 2019  |   Pubmed ID: 31766658
• Clonally Expanded T Cells Reveal Immunogenicity of Rhabdoid Tumors
  Cancer Cell. 12, 2019  |   Pubmed ID: 31708437
• Improving Breast Cancer Sensitivity to Paclitaxel by Increasing Aneuploidy
  Proceedings of the National Academy of Sciences of the United States of America. 11, 2019  |   Pubmed ID: 31685623
• Efficacy of Molecularly Targeted Agents Given in the Randomised Trial SHIVA01 According to the ESMO Scale for Clinical Actionability of Molecular Targets
  European Journal of Cancer (Oxford, England : 1990). 11, 2019  |   Pubmed ID: 31593830
• EZHIP Constrains Polycomb Repressive Complex 2 Activity in Germ Cells
  Nature Communications. 08, 2019  |   Pubmed ID: 31451685
• The Bipartite TAD Organization of the X-inactivation Center Ensures Opposing Developmental Regulation of Tsix and Xist
  Nature Genetics. 06, 2019  |   Pubmed ID: 31133748
• Clinical and Genetic Landscape of Treatment Naive Cervical Cancer: Alterations in PIK3CA and in Epigenetic Modulators Associated with Sub-optimal Outcome
  EBioMedicine. May, 2019  |   Pubmed ID: 30952619
• EZH1/2 Function Mostly Within Canonical PRC2 and Exhibit Proliferation-dependent Redundancy That Shapes Mutational Signatures in Cancer
  Proceedings of the National Academy of Sciences of the United States of America. 03, 2019  |   Pubmed ID: 30867289
• Lineage Tracing of Notch1-expressing Cells in Intestinal Tumours Reveals a Distinct Population of Cancer Stem Cells
  Scientific Reports. 01, 2019  |   Pubmed ID: 30696875
• BAP1 Complex Promotes Transcription by Opposing PRC1-mediated H2A Ubiquitylation
  Nature Communications. 01, 2019  |   Pubmed ID: 30664650
• Familial Breast Cancer and DNA Repair Genes: Insights into Known and Novel Susceptibility Genes from the GENESIS Study, and Implications for Multigene Panel Testing
  International Journal of Cancer. 04, 2019  |   Pubmed ID: 30303537
• Effective Normalization for Copy Number Variation in Hi-C Data
  BMC Bioinformatics. Sep, 2018  |   Pubmed ID: 30189838
• Transcriptome Profiling of Single Mouse Oocytes
  Methods in Molecular Biology (Clifton, N.J.). 2018  |   Pubmed ID: 29961255
• Revisited Analysis of a SHIVA01 Trial Cohort Using Functional Mutational Analyses Successfully Predicted Treatment Outcome
  Molecular Oncology. 05, 2018  |   Pubmed ID: 29464843
• Exome Sequencing Reveals Aberrant Signalling Pathways As Hallmark of Treatment-naive Anal Squamous Cell Carcinoma
  Oncotarget. Jan, 2018  |   Pubmed ID: 29416628
• Contribution of Epigenetic Landscapes and Transcription Factors to X-chromosome Reactivation in the Inner Cell Mass
  Nature Communications. 11, 2017  |   Pubmed ID: 29101321
• Genetic and Epigenetic Features Direct Differential Efficiency of Xist-mediated Silencing at X-chromosomal and Autosomal Locations
  Nature Communications. 09, 2017  |   Pubmed ID: 28947736
• Adrenal GIPR Expression and Chromosome 19q13 Microduplications in GIP-dependent Cushing's Syndrome
  JCI Insight. 09, 2017  |   Pubmed ID: 28931750
• PRC2 is Dispensable for -mediated Transcriptional Repression
  The EMBO Journal. 04, 2017  |   Pubmed ID: 28167697
• Xist-dependent Imprinted X Inactivation and the Early Developmental Consequences of Its Failure
  Nature Structural & Molecular Biology. 03, 2017  |   Pubmed ID: 28134930
• Maternal LSD1/KDM1A is an Essential Regulator of Chromatin and Transcription Landscapes During Zygotic Genome Activation
  ELife. 2016  |   Pubmed ID: 26836306
• Treatment Algorithms Based on Tumor Molecular Profiling: The Essence of Precision Medicine Trials
  Journal of the National Cancer Institute. Apr, 2016  |   Pubmed ID: 26598514
• Impaired PRC2 Activity Promotes Transcriptional Instability and Favors Breast Tumorigenesis
  Genes & Development. Dec, 2015  |   Pubmed ID: 26637281
• HiC-Pro: an Optimized and Flexible Pipeline for Hi-C Data Processing
  Genome Biology. 2015  |   Pubmed ID: 26619908
• Integration of a Radiosensitivity Molecular Signature Into the Assessment of Local Recurrence Risk in Breast Cancer
  International Journal of Radiation Oncology, Biology, Physics. Nov, 2015  |   Pubmed ID: 26461005
• Design and Statistical Principles of the SHIVA Trial
  Chinese Clinical Oncology. Sep, 2015  |   Pubmed ID: 26408299
• Molecularly Targeted Therapy Based on Tumour Molecular Profiling Versus Conventional Therapy for Advanced Cancer (SHIVA): a Multicentre, Open-label, Proof-of-concept, Randomised, Controlled Phase 2 Trial
  The Lancet. Oncology. Oct, 2015  |   Pubmed ID: 26342236
• DNA Methylation Restrains Transposons from Adopting a Chromatin Signature Permissive for Meiotic Recombination
  Genes & Development. Jun, 2015  |   Pubmed ID: 26109049
• Mechanical Induction of the Tumorigenic β-catenin Pathway by Tumour Growth Pressure
  Nature. Jul, 2015  |   Pubmed ID: 25970250
• Combinatorial Code Governing Cellular Responses to Complex Stimuli
  Nature Communications. Apr, 2015  |   Pubmed ID: 25896517
• Jarid2 Methylation Via the PRC2 Complex Regulates H3K27me3 Deposition During Cell Differentiation
  Molecular Cell. Mar, 2015  |   Pubmed ID: 25620564
• Challenges for the Implementation of High-throughput Testing and Liquid Biopsies in Personalized Medicine Cancer Trials
  Personalized Medicine. Jul, 2014  |   Pubmed ID: 29758779
• The Spectrum of Clinical Trials Aiming at Personalizing Medicine
  Chinese Clinical Oncology. Jun, 2014  |   Pubmed ID: 25841410
• Epigenomic Alterations in Breast Carcinoma from Primary Tumor to Locoregional Recurrences
  PloS One. 2014  |   Pubmed ID: 25098247
• Multi-factor Data Normalization Enables the Detection of Copy Number Aberrations in Amplicon Sequencing Data
  Bioinformatics (Oxford, England). Dec, 2014  |   Pubmed ID: 25016581
• [Biological Network Modelling and Precision Medicine in Oncology]
  Bulletin Du Cancer. Jun, 2014  |   Pubmed ID: 24966078
• Bioinformatics for Precision Medicine in Oncology: Principles and Application to the SHIVA Clinical Trial
  Frontiers in Genetics. 2014  |   Pubmed ID: 24910641
• Combinatorial Flexibility of Cytokine Function During Human T Helper Cell Differentiation
  Nature Communications. May, 2014  |   Pubmed ID: 24865484
• Developmental Dynamics and Disease Potential of Random Monoallelic Gene Expression
  Developmental Cell. Feb, 2014  |   Pubmed ID: 24576422
• Changes in the Organization of the Genome During the Mammalian Cell Cycle
  Genome Biology. 2013  |   Pubmed ID: 24368000
• RNAi-dependent and Independent Control of LINE1 Accumulation and Mobility in Mouse Embryonic Stem Cells
  PLoS Genetics. Nov, 2013  |   Pubmed ID: 24244175
• Telomere Crisis in Kidney Epithelial Cells Promotes the Acquisition of a MicroRNA Signature Retrieved in Aggressive Renal Cell Carcinomas
  Carcinogenesis. May, 2013  |   Pubmed ID: 23358853
• Designs and Challenges for Personalized Medicine Studies in Oncology: Focus on the SHIVA Trial
  Targeted Oncology. Dec, 2012  |   Pubmed ID: 23161020
• NcPRO-seq: a Tool for Annotation and Profiling of NcRNAs in SRNA-seq Data
  Bioinformatics (Oxford, England). Dec, 2012  |   Pubmed ID: 23044543
• HiTC: Exploration of High-throughput 'C' Experiments
  Bioinformatics (Oxford, England). Nov, 2012  |   Pubmed ID: 22923296
• Independent Transcriptional Reprogramming and Apoptosis Induction by Cisplatin
  Cell Cycle (Georgetown, Tex.). Sep, 2012  |   Pubmed ID: 22918244
• Spatial Partitioning of the Regulatory Landscape of the X-inactivation Centre
  Nature. May, 2012  |   Pubmed ID: 22495304
• Deep-sequencing Protocols Influence the Results Obtained in Small-RNA Sequencing
  PloS One. 2012  |   Pubmed ID: 22384282
• Search for a Gene Expression Signature of Breast Cancer Local Recurrence in Young Women
  Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Mar, 2012  |   Pubmed ID: 22271875
• Importance of Pre-analytical Steps for Transcriptome and RT-qPCR Analyses in the Context of the Phase II Randomised Multicentre Trial REMAGUS02 of Neoadjuvant Chemotherapy in Breast Cancer Patients
  BMC Cancer. Jun, 2011  |   Pubmed ID: 21631949
• EMA - A R Package for Easy Microarray Data Analysis
  BMC Research Notes. Nov, 2010  |   Pubmed ID: 21047405
• LINE-1 Activity in Facultative Heterochromatin Formation During X Chromosome Inactivation
  Cell. Jun, 2010  |   Pubmed ID: 20550932
• Highly Dynamic and Sex-specific Expression of MicroRNAs During Early ES Cell Differentiation
  PLoS Genetics. Aug, 2009  |   Pubmed ID: 19714213
• Multiparametric Analysis of Cytokine-driven Human Th17 Differentiation Reveals a Differential Regulation of IL-17 and IL-22 Production
  Blood. Oct, 2009  |   Pubmed ID: 19704117
• Tumor Aromatase Expression As a Prognostic Factor for Local Control in Young Breast Cancer Patients After Breast-conserving Treatment
  Breast Cancer Research : BCR. 2009  |   Pubmed ID: 19638208
• High-resolution Mapping of DNA Breakpoints to Define True Recurrences Among Ipsilateral Breast Cancers
  Journal of the National Cancer Institute. Jan, 2008  |   Pubmed ID: 18159071
• VAMP: Visualization and Analysis of Array-CGH, Transcriptome and Other Molecular Profiles
  Bioinformatics (Oxford, England). Sep, 2006  |   Pubmed ID: 16820431