Niels Fertig

Publications

• A Modern Automated Patch-clamp Approach for High Throughput Electrophysiology Recordings in Native Cardiomyocytes
  Communications Biology. 09, 2022  |   Pubmed ID: 36109584
• There is No F in APC: Using Physiological Fluoride-free Solutions for High Throughput Automated Patch Clamp Experiments
  Frontiers in Molecular Neuroscience. 2022  |   Pubmed ID: 36072300
• SSM-based Electrophysiology, a Label-free Real-time Method Reveals Sugar Binding & Transport Events in SGLT1
  Biosensors & Bioelectronics. Feb, 2022  |   Pubmed ID: 34768066
• The Suitability of High Throughput Automated Patch Clamp for Physiological Applications
  The Journal of Physiology. 01, 2022  |   Pubmed ID: 34555195
• Reliable Identification of Cardiac Conduction Abnormalities in Drug Discovery Using Automated Patch Clamp II: Best Practices for Nav1.5 Peak Current in a High Throughput Screening Environment
  Journal of Pharmacological and Toxicological Methods. Nov-Dec, 2021  |   Pubmed ID: 34500078
• A Scalable Approach Reveals Functional Responses of IPSC Cardiomyocyte 3D Spheroids
  SLAS Discovery : Advancing Life Sciences R & D. 03, 2021  |   Pubmed ID: 33283596
• Electrophysiology on Channel-Forming Proteins in Artificial Lipid Bilayers: Next-Generation Instrumentation for Multiple Recordings in Parallel
  Methods in Molecular Biology (Clifton, N.J.). 2021  |   Pubmed ID: 33119847
• Integration of Mechanical Conditioning into a High Throughput Contractility Assay for Cardiac Safety Assessment
  Journal of Pharmacological and Toxicological Methods. Sep, 2020  |   Pubmed ID: 32629160
• Reliable Identification of Cardiac Liability in Drug Discovery Using Automated Patch Clamp: Benchmarking Best Practices and Calibration Standards for Improved Proarrhythmic Assessment
  Journal of Pharmacological and Toxicological Methods. Sep, 2020  |   Pubmed ID: 32565325
• Automated Dynamic Clamp for Simulation of I in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes in Real Time Using Patchliner Dynamite
  Current Protocols in Pharmacology. 03, 2020  |   Pubmed ID: 31868992
• Real-time Monitoring β-lactam/β-lactamase Inhibitor (BL/BLI) Mixture Towards the Bacteria Porin Pathway at Single Molecule Level
  Analytical and Bioanalytical Chemistry. Mar, 2019  |   Pubmed ID: 30824965
• A Novel Gain-of-function Mutation of Piezo1 is Functionally Affirmed in Red Blood Cells by High-throughput Patch Clamp
  Haematologica. 05, 2019  |   Pubmed ID: 30237269
• An Update on the Advancing High-throughput Screening Techniques for Patch Clamp-based Ion Channel Screens: Implications for Drug Discovery
  Expert Opinion on Drug Discovery. 03, 2018  |   Pubmed ID: 29343120
• Identification of Drug-Drug Interactions In Vitro: A Case Study Evaluating the Effects of Sofosbuvir and Amiodarone on HiPSC-Derived Cardiomyocytes
  Toxicological Sciences : an Official Journal of the Society of Toxicology. 11, 2016  |   Pubmed ID: 27503387
• Safety Pharmacology Studies Using EFP and Impedance
  Journal of Pharmacological and Toxicological Methods. Sep-Oct, 2016  |   Pubmed ID: 27084108
• A Biomimetic DNA-based Channel for the Ligand-controlled Transport of Charged Molecular Cargo Across a Biological Membrane
  Nature Nanotechnology. Feb, 2016  |   Pubmed ID: 26751170
• Automated Patch Clamp Meets High-Throughput Screening: 384 Cells Recorded in Parallel on a Planar Patch Clamp Module
  Journal of Laboratory Automation. Dec, 2016  |   Pubmed ID: 26702021
• Novel Screening Techniques for Ion Channel Targeting Drugs
  Channels (Austin, Tex.). 2015  |   Pubmed ID: 26556400
• Antibiotic Translocation Through Porins Studied in Planar Lipid Bilayers Using Parallel Platforms
  The Analyst. Jul, 2015  |   Pubmed ID: 25834843
• New Easy-to-use Hybrid System for Extracellular Potential and Impedance Recordings
  Journal of Laboratory Automation. Apr, 2015  |   Pubmed ID: 25532527
• Bilayer-spanning DNA Nanopores with Voltage-switching Between Open and Closed State
  ACS Nano. Feb, 2015  |   Pubmed ID: 25338165
• Temperature-sensitive Gating of HCx26: High-resolution Raman Spectroscopy Sheds Light on Conformational Changes
  Biomedical Optics Express. Jul, 2014  |   Pubmed ID: 25071948
• Membrane Assembly of the Functional KcsA Potassium Channel in a Vesicle-based Eukaryotic Cell-free Translation System
  Biosensors & Bioelectronics. Sep, 2014  |   Pubmed ID: 24727603
• Minimized Cell Usage for Stem Cell-derived and Primary Cells on an Automated Patch Clamp System
  Journal of Pharmacological and Toxicological Methods. Jul-Aug, 2013  |   Pubmed ID: 23567076
• Characterizing Human Ion Channels in Induced Pluripotent Stem Cell-derived Neurons
  Journal of Biomolecular Screening. Oct, 2012  |   Pubmed ID: 22923790
• Green Fluorescent Protein Changes the Conductance of Connexin 43 (Cx43) Hemichannels Reconstituted in Planar Lipid Bilayers
  The Journal of Biological Chemistry. Jan, 2012  |   Pubmed ID: 22139870
• State-of-the-Art Automated Patch Clamp Devices: Heat Activation, Action Potentials, and High Throughput in Ion Channel Screening
  Frontiers in Pharmacology. 2011  |   Pubmed ID: 22131976
• Automated Patch Clamp on MESC-derived Cardiomyocytes for Cardiotoxicity Prediction
  Journal of Biomolecular Screening. Sep, 2011  |   Pubmed ID: 21775699
• The M34A Mutant of Connexin26 Reveals Active Conductance States in Pore-suspending Membranes
  Journal of Structural Biology. Oct, 2009  |   Pubmed ID: 19236918
• Port-a-patch and Patchliner: High Fidelity Electrophysiology for Secondary Screening and Safety Pharmacology
  Combinatorial Chemistry & High Throughput Screening. Jan, 2009  |   Pubmed ID: 19149489
• Planar Patch Clamp: Advances in Electrophysiology
  Methods in Molecular Biology (Clifton, N.J.). 2008  |   Pubmed ID: 18998092
• Rapid Screening of Membrane Protein Activity: Electrophysiological Analysis of OmpF Reconstituted in Proteoliposomes
  Lab on a Chip. Apr, 2008  |   Pubmed ID: 18369514
• Automated Ion Channel Screening: Patch Clamping Made Easy
  Expert Opinion on Therapeutic Targets. Apr, 2007  |   Pubmed ID: 17373884
• Microchip Technology for Automated and Parallel Patch-clamp Recording
  Small (Weinheim an Der Bergstrasse, Germany). Jul, 2006  |   Pubmed ID: 17193131
• Microstructured Apertures in Planar Glass Substrates for Ion Channel Research
  Receptors & Channels. 2003  |   Pubmed ID: 12825296