Niels Fertig Nanion Technologies GmbH Biography Publications Institution JoVE Articles Niels Fertig has not added a biography. If you are Niels Fertig and would like to personalize this page please email our Author Liaison for assistance. Publications A Modern Automated Patch-clamp Approach for High Throughput Electrophysiology Recordings in Native Cardiomyocytes Communications Biology. 09, 2022 | Pubmed ID: 36109584 There is No F in APC: Using Physiological Fluoride-free Solutions for High Throughput Automated Patch Clamp Experiments Frontiers in Molecular Neuroscience. 2022 | Pubmed ID: 36072300 SSM-based Electrophysiology, a Label-free Real-time Method Reveals Sugar Binding & Transport Events in SGLT1 Biosensors & Bioelectronics. Feb, 2022 | Pubmed ID: 34768066 The Suitability of High Throughput Automated Patch Clamp for Physiological Applications The Journal of Physiology. 01, 2022 | Pubmed ID: 34555195 Reliable Identification of Cardiac Conduction Abnormalities in Drug Discovery Using Automated Patch Clamp II: Best Practices for Nav1.5 Peak Current in a High Throughput Screening Environment Journal of Pharmacological and Toxicological Methods. Nov-Dec, 2021 | Pubmed ID: 34500078 A Scalable Approach Reveals Functional Responses of IPSC Cardiomyocyte 3D Spheroids SLAS Discovery : Advancing Life Sciences R & D. 03, 2021 | Pubmed ID: 33283596 Electrophysiology on Channel-Forming Proteins in Artificial Lipid Bilayers: Next-Generation Instrumentation for Multiple Recordings in Parallel Methods in Molecular Biology (Clifton, N.J.). 2021 | Pubmed ID: 33119847 Integration of Mechanical Conditioning into a High Throughput Contractility Assay for Cardiac Safety Assessment Journal of Pharmacological and Toxicological Methods. Sep, 2020 | Pubmed ID: 32629160 Reliable Identification of Cardiac Liability in Drug Discovery Using Automated Patch Clamp: Benchmarking Best Practices and Calibration Standards for Improved Proarrhythmic Assessment Journal of Pharmacological and Toxicological Methods. Sep, 2020 | Pubmed ID: 32565325 Automated Dynamic Clamp for Simulation of I in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes in Real Time Using Patchliner Dynamite Current Protocols in Pharmacology. 03, 2020 | Pubmed ID: 31868992 Real-time Monitoring β-lactam/β-lactamase Inhibitor (BL/BLI) Mixture Towards the Bacteria Porin Pathway at Single Molecule Level Analytical and Bioanalytical Chemistry. Mar, 2019 | Pubmed ID: 30824965 A Novel Gain-of-function Mutation of Piezo1 is Functionally Affirmed in Red Blood Cells by High-throughput Patch Clamp Haematologica. 05, 2019 | Pubmed ID: 30237269 An Update on the Advancing High-throughput Screening Techniques for Patch Clamp-based Ion Channel Screens: Implications for Drug Discovery Expert Opinion on Drug Discovery. 03, 2018 | Pubmed ID: 29343120 Identification of Drug-Drug Interactions In Vitro: A Case Study Evaluating the Effects of Sofosbuvir and Amiodarone on HiPSC-Derived Cardiomyocytes Toxicological Sciences : an Official Journal of the Society of Toxicology. 11, 2016 | Pubmed ID: 27503387 Safety Pharmacology Studies Using EFP and Impedance Journal of Pharmacological and Toxicological Methods. Sep-Oct, 2016 | Pubmed ID: 27084108 A Biomimetic DNA-based Channel for the Ligand-controlled Transport of Charged Molecular Cargo Across a Biological Membrane Nature Nanotechnology. Feb, 2016 | Pubmed ID: 26751170 Automated Patch Clamp Meets High-Throughput Screening: 384 Cells Recorded in Parallel on a Planar Patch Clamp Module Journal of Laboratory Automation. Dec, 2016 | Pubmed ID: 26702021 Novel Screening Techniques for Ion Channel Targeting Drugs Channels (Austin, Tex.). 2015 | Pubmed ID: 26556400 Antibiotic Translocation Through Porins Studied in Planar Lipid Bilayers Using Parallel Platforms The Analyst. Jul, 2015 | Pubmed ID: 25834843 New Easy-to-use Hybrid System for Extracellular Potential and Impedance Recordings Journal of Laboratory Automation. Apr, 2015 | Pubmed ID: 25532527 Bilayer-spanning DNA Nanopores with Voltage-switching Between Open and Closed State ACS Nano. Feb, 2015 | Pubmed ID: 25338165 Temperature-sensitive Gating of HCx26: High-resolution Raman Spectroscopy Sheds Light on Conformational Changes Biomedical Optics Express. Jul, 2014 | Pubmed ID: 25071948 Membrane Assembly of the Functional KcsA Potassium Channel in a Vesicle-based Eukaryotic Cell-free Translation System Biosensors & Bioelectronics. Sep, 2014 | Pubmed ID: 24727603 Minimized Cell Usage for Stem Cell-derived and Primary Cells on an Automated Patch Clamp System Journal of Pharmacological and Toxicological Methods. Jul-Aug, 2013 | Pubmed ID: 23567076 Characterizing Human Ion Channels in Induced Pluripotent Stem Cell-derived Neurons Journal of Biomolecular Screening. Oct, 2012 | Pubmed ID: 22923790 Green Fluorescent Protein Changes the Conductance of Connexin 43 (Cx43) Hemichannels Reconstituted in Planar Lipid Bilayers The Journal of Biological Chemistry. Jan, 2012 | Pubmed ID: 22139870 State-of-the-Art Automated Patch Clamp Devices: Heat Activation, Action Potentials, and High Throughput in Ion Channel Screening Frontiers in Pharmacology. 2011 | Pubmed ID: 22131976 Automated Patch Clamp on MESC-derived Cardiomyocytes for Cardiotoxicity Prediction Journal of Biomolecular Screening. Sep, 2011 | Pubmed ID: 21775699 The M34A Mutant of Connexin26 Reveals Active Conductance States in Pore-suspending Membranes Journal of Structural Biology. Oct, 2009 | Pubmed ID: 19236918 Port-a-patch and Patchliner: High Fidelity Electrophysiology for Secondary Screening and Safety Pharmacology Combinatorial Chemistry & High Throughput Screening. Jan, 2009 | Pubmed ID: 19149489 Planar Patch Clamp: Advances in Electrophysiology Methods in Molecular Biology (Clifton, N.J.). 2008 | Pubmed ID: 18998092 Rapid Screening of Membrane Protein Activity: Electrophysiological Analysis of OmpF Reconstituted in Proteoliposomes Lab on a Chip. Apr, 2008 | Pubmed ID: 18369514 Automated Ion Channel Screening: Patch Clamping Made Easy Expert Opinion on Therapeutic Targets. Apr, 2007 | Pubmed ID: 17373884 Microchip Technology for Automated and Parallel Patch-clamp Recording Small (Weinheim an Der Bergstrasse, Germany). Jul, 2006 | Pubmed ID: 17193131 Microstructured Apertures in Planar Glass Substrates for Ion Channel Research Receptors & Channels. 2003 | Pubmed ID: 12825296 Sistema de análisis de células híbridas para evaluar cambios estructurales y contráctiles de cardiomiocitos humanos derivados de iPSC para la evaluación preclínica del riesgo cardíaco Bettina Lickiss1, Matthias Gossmann1, Peter Linder1, Ulrich Thomas2, Elena Dragicevic2, Marta Lemme2, Michael George2, Niels Fertig2, Sonja Stölzle-Feix2 1innoVitro GmbH, 2Nanion Technologies GmbH JoVE 64283 Bioengineering
Sistema de análisis de células híbridas para evaluar cambios estructurales y contráctiles de cardiomiocitos humanos derivados de iPSC para la evaluación preclínica del riesgo cardíaco Bettina Lickiss1, Matthias Gossmann1, Peter Linder1, Ulrich Thomas2, Elena Dragicevic2, Marta Lemme2, Michael George2, Niels Fertig2, Sonja Stölzle-Feix2 1innoVitro GmbH, 2Nanion Technologies GmbH JoVE 64283 Bioengineering