Articles by Nodir Saidov in JoVE
Cochlear Implantation in the Guinea Pig Clemens Honeder*1, Navid Ahmadi*1, Anne-Margarethe Kramer2, Chengjing Zhu1, Nodir Saidov1, Christoph Arnoldner1 1Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Vienna, 2Department of Biomedical Research, Medical University of Vienna The goal of this protocol is to provide an animal model of cochlear implantation, which can be used to address a multitude of research questions. Potential applications include the evaluation of pharmaceutical interventions or electrical stimulation for beneficial effects on hearing thresholds or electrode impedances.
Other articles by Nodir Saidov on PubMed
Effects of Sustained Release Dexamethasone Hydrogels in Hearing Preservation Cochlear Implantation Hearing Research. 11, 2016 | Pubmed ID: 27519654 It has been shown that glucocorticoids reduce the hearing threshold shifts associated with cochlear implantation. Previous studies evaluated the administration of glucocorticoids immediately before surgery or the repeated pre- or perioperative systemic application of glucocorticoids. The aim of this study was to evaluate the effects of a sustained release dexamethasone hydrogel in hearing preservation cochlear implantation. To address this issue, a guinea pig model of cochlear implantation was used. 30 normal hearing pigmented guinea pigs were randomized into a group receiving a single dose of a dexamethasone/poloxamer407 hydrogel one day prior to surgery, a second group receiving the hydrogel seven days prior to surgery and a control group. A silicone cochlear implant electrode designed for the use in guinea pigs was inserted to a depth of 5 mm through a cochleostomy. Compound action potentials of the auditory nerve (frequency range 0.5-32 kHz) were measured preoperatively, directly postoperatively and on postoperative days 3, 7, 14, 21 and 28. Following the last audiometry, temporal bones were harvested and histologically evaluated. Dexamethasone hydrogel application one day prior to surgery resulted in significantly reduced hearing threshold shifts at low, middle and high frequencies measured at postoperative day 28 (p