Panayampalli Subbian Satheshkumar Lead, Immunodiagnostics and Proteomics Team, Poxvirus and Rabies Branch Centers for Disease Control and Prevention Biography Publications Institution JoVE Articles Panayampalli Subbian Satheshkumar Panayampalli Subbian Satheshkumar is the lead for Immunodiagnostics and Proteomics Team at the Poxvirus and Rabies Branch, Centers for Disease Control and Prevention, Atlanta, GA, USA. He studies Masters of Science in Integrated Biology at Madurai Kamaraj University, Madurai, India. He obtained his Ph.D. at Department of Biochemistry, Indian Institute of Science, Bangalore, India in 2005 with a thesis on “Mechanism of polyprotein processing and capsid assembly in Sesbania mosaic virus”. He completed his post-doctoral fellowship at the Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health with Dr. Bernard Moss and moved to Centers for Disease Control and Prevention.He focuses his scientific research on poxvirus and rabies virus ranging from diagnostics, proteomics, virus-host interactions and identification and characterization of novel anti-virals against these viruses. He has received several awards including the Presidential Early Career Award for Scientists and Engineers (PECASE) in 2019 from the United States Government. Publications IMVAMUNE® and ACAM2000® Provide Different Protection against Disease When Administered Postexposure in an Intranasal Monkeypox Challenge Prairie Dog ModelVaccines (Basel). Jul, 2020 | Pubmed ID: 32698399 Bat and Lyssavirus Exposure among Humans in Area that Celebrates Bat Festival, Nigeria, 2010 and 2013Emerg Infect Dis. Jul, 2020 | Pubmed ID: 32568051 Conserved Oligomeric Golgi (COG) Complex Proteins Facilitate Orthopoxvirus Entry, Fusion and SpreadViruses. Jun, 2020 | Pubmed ID: 32629851 Abortive vampire bat rabies infections in Peruvian peridomestic livestockPLoS Negl Trop Dis. Jun, 2020 | Pubmed ID: 32598388 Magnitude and diversity of immune response to vaccinia virus is dependent on route of administrationVirology. May, 2020 | Pubmed ID: 3217451 Discovery of Retro-1 Analogs Exhibiting Enhanced Anti-vaccinia Virus ActivityFront Microbiol. , 2020 | Pubmed ID: 32390964 Clinical Presentation and Serologic Response during a Rabies Epizootic in Captive Common Vampire Bats (Desmodus rotundus)Trop Med Infect Dis. Mar, 2020 | Pubmed ID: 32121499 Progressive Vaccinia Acquired through Zoonotic Transmission in a Patient with HIV/AIDS, ColombiaEmerg Infect Dis. Mar, 2020 | Pubmed ID: 32091366 The Serological Prevalence of Rabies Virus-Neutralizing Antibodies in the Bat Population on the Caribbean Island of TrinidadViruses. Feb, 2020 | Pubmed ID: 32033370 Using the LN34 Pan-Lyssavirus Real-Time RT-PCR Assay for Rabies Diagnosis and Rapid Genetic Typing from Formalin-Fixed Human Brain TissueViruses. Jan, 2020 | Pubmed ID: 31963651 Asymptomatic Orthopoxvirus Circulation in Humans in the Wake of a Monkeypox Outbreak among Chimpanzees in CameroonAm J Trop Med Hyg. Jan, 2020 | Pubmed ID: 31769389 Rabies Outbreak in Captive Big Brown Bats (Eptesicus fuscus) Used in a White-Nose Syndrome Vaccine TrialJ Wildl Dis. Jan, 2020 | Pubmed ID: 3129508 Seroprevalence and Risk Factors Possibly Associated with Emerging Zoonotic Vaccinia Virus in a Farming Community, ColombiaEmerg Infect Dis. Dec, 2019 | Pubmed ID: 31743085 Novel Treatment of a Vaccinia Virus Infection from an Occupational Needlestick - San Diego, California, 2019MMWR Morb Mortal Wkly Rep. Oct, 2019 | Pubmed ID: 31647789 Characterization of Monkeypox virus dissemination in the black-tailed prairie dog (Cynomys ludovicianus) through in vivo bioluminescent imagingPLoS One. , 2019 | Pubmed ID: 31557167 Outbreak of human monkeypox in Nigeria in 2017-18: a clinical and epidemiological reportLancet Infect Dis. Aug, 2019 | Pubmed ID: 3128514 Identification of CP77 as the Third Orthopoxvirus SAMD9 and SAMD9L Inhibitor with Unique Specificity for a Rodent SAMD9LJ Virol. Jun, 2019 | Pubmed ID: 30918078 Human Monkeypox in Sierra Leone after 44-Year Absence of Reported CasesEmerg Infect Dis. May, 2019 | Pubmed ID: 30753125 Epidemiologic and Ecologic Investigations of Monkeypox, Likouala Department, Republic of the Congo, 2017Emerg Infect Dis. Feb, 2019 | Pubmed ID: 30666937 A high throughput neutralization test based on GFP expression by recombinant rabies virusPLoS Negl Trop Dis. Dec, 2018 | Pubmed ID: 30550592 Novel mass spectrometry based detection and identification of variants of rabies virus nucleoprotein in infected brain tissuesPLoS Negl Trop Dis. Dec, 2018 | Pubmed ID: 30550539 Human Exposure to Novel Bartonella Species from Contact with Fruit BatsEmerg Infect Dis. Dec, 2018 | Pubmed ID: 30457529 An ELISA-based method for detection of rabies virus nucleoprotein-specific antibodies in human antemortem samplesPLoS One. , 2018 | Pubmed ID: 30403742 Potential Confounding of Diagnosis of Rabies in Patients with Recent Receipt of Intravenous Immune GlobulinMMWR Morb Mortal Wkly Rep. Feb, 2018 | Pubmed ID: 29420464 Retrospective Proteomic Analysis of Serum After Akhmeta Virus Infection: New Suspect Case Identification and Insights Into Poxvirus Humoral ImmunityJ Infect Dis. Dec, 2017 | Pubmed ID: 2902925 Isolation and identification of compounds from Kalanchoe pinnata having human alphaherpesvirus and vaccinia virus antiviral activityPharm Biol. Dec, 2017 | Pubmed ID: 28395583 Suppression of Poxvirus Replication by ResveratrolFront Microbiol. , 2017 | Pubmed ID: 29204136 Protection of bats (Eptesicus fuscus) against rabies following topical or oronasal exposure to a recombinant raccoon poxvirus vaccinePLoS Negl Trop Dis. Oct, 2017 | Pubmed ID: 28976983 Novel Orthopoxvirus Infection in an Alaska ResidentClin Infect Dis. Jun, 2017 | Pubmed ID: 28329402 Monkeypox Virus Host Factor Screen Using Haploid Cells Identifies Essential Role of GARP Complex in Extracellular Virus FormationJ Virol. Jun, 2017 | Pubmed ID: 28331092 A rapid Orthopoxvirus purification protocol suitable for high-containment laboratoriesJ Virol Methods. May, 2017 | Pubmed ID: 2813186 Detection and Molecular Characterization of Zoonotic Poxviruses Circulating in the Amazon Region of Colombia, 2014Emerg Infect Dis. Apr, 2017 | Pubmed ID: 28322708 Cross-Neutralizing and Protective Human Antibody Specificities to Poxvirus InfectionsCell. Oct, 2016 | Pubmed ID: 27768891 Human infection with a zoonotic orthopoxvirus in the country of GeorgiaN Engl J Med. Mar, 2015 | Pubmed ID: 25806914 Interactions of the vaccinia virus A19 proteinJ Virol. Oct, 2013 | Pubmed ID: 23885084 Vaccinia virus A19 protein participates in the transformation of spherical immature particles to barrel-shaped infectious virionsJ Virol. Oct, 2013 | Pubmed ID: 23885081 Role of the vaccinia virus O3 protein in cell entry can be fulfilled by its Sequence flexible transmembrane domainVirology. Sep, 2013 | Pubmed ID: 23816434 Orthopoxvirus species and strain differences in cell entryVirology. Nov, 2012 | Pubmed ID: 22999097 Sequence-divergent chordopoxvirus homologs of the o3 protein maintain functional interactions with components of the vaccinia virus entry-fusion complexJ Virol. Feb, 2012 | Pubmed ID: 22114343 Drosophila S2 cells are non-permissive for vaccinia virus DNA replication following entry via low pH-dependent endocytosis and early transcriptionPLoS One. Feb, 2011 | Pubmed ID: 21347205 Characterization of a newly identified 35-amino-acid component of the vaccinia virus entry/fusion complex conserved in all chordopoxvirusesJ Virol. Dec, 2009 | Pubmed ID: 19812151 A single point mutation disrupts the capsid assembly in Sesbania Mosaic Virus resulting in a stable isolated dimerVirology. Sep, 2009 | Pubmed ID: 1964345 Vaccinia virus H7 protein contributes to the formation of crescent membrane precursors of immature virionsJ Virol. Sep, 2009 | Pubmed ID: 19553304 Inhibition of the ubiquitin-proteasome system prevents vaccinia virus DNA replication and expression of intermediate and late genesJ Virol. Mar, 2009 | Pubmed ID: 19129442 Poxvirus transcriptome analysisProc Natl Acad Sci U S A. Oct, 2008 | Pubmed ID: 18832142 Structure of recombinant capsids formed by the beta-annulus deletion mutant -- rCP (Delta48-59) of Sesbania mosaic virusVirology. May, 2008 | Pubmed ID: 1829529 Crystal structure of the serine protease domain of Sesbania mosaic virus polyprotein and mutational analysis of residues forming the S1-binding pocketVirology. Mar, 2006 | Pubmed ID: 16356524 The role of arginine-rich motif and beta-annulus in the assembly and stability of Sesbania mosaic virus capsidsJ Mol Biol. Oct, 2005 | Pubmed ID: 1616900 Structure of a mutant T=1 capsid of Sesbania mosaic virus: role of water molecules in capsid architecture and integrityActa Crystallogr D Biol Crystallogr. Oct, 2005 | Pubmed ID: 1620489 Structural studies on recombinant T = 3 capsids of Sesbania mosaic virus coat protein mutantsActa Crystallogr D Biol Crystallogr. Oct, 2005 | Pubmed ID: 1620489 Natively unfolded VPg is essential for Sesbania mosaic virus serine protease activityJ Biol Chem. Aug, 2005 | Pubmed ID: 1594415 Virus-like particles: models for assembly studies and foreign epitope carriersProg Nucleic Acid Res Mol Biol. , 2005 | Pubmed ID: 16164974 Role of metal ion-mediated interactions in the assembly and stability of Sesbania mosaic virus T=3 and T=1 capsidsJ Mol Biol. Sep, 2004 | Pubmed ID: 1534225 T=1 capsid structures of Sesbania mosaic virus coat protein mutants: determinants of T=3 and T=1 capsid assemblyJ Mol Biol. Sep, 2004 | Pubmed ID: 1534225 Polyprotein processing: cis and trans proteolytic activities of Sesbania mosaic virus serine proteaseVirology. Jan, 2004 | Pubmed ID: 1497256 Crystal structure of Salmonella typhimurium 2-methylisocitrate lyase (PrpB) and its complex with pyruvate and Mg(2+)Biochem Biophys Res Commun. Nov, 2003 | Pubmed ID: 1457571 Cloning, expression, purification and preliminary X-ray crystallographic studies of 2-methylisocitrate lyase from Salmonella typhimuriumActa Crystallogr D Biol Crystallogr. Dec, 2002 | Pubmed ID: 1245448 A molecular switch in the capsid protein controls the particle polymorphism in an icosahedral virusVirology. Jan, 2002 | Pubmed ID: 1187892 Determination of the structure of the recombinant T=1 capsid of Sesbania mosaic virusCurrent Science . , 2002 | Pubmed ID: Complete nucleotide sequence of Sesbania mosaic virus: a new virus species of the genus SobemovirusArch Virol. , 2001 | Pubmed ID: 1131563 בדיקת אימונוהיסטוכימיה לגילוי אנטיגן ליסוירוס מרקמות קבועות פורמלין Michael Niezgoda1, Panayampalli Subbian Satheshkumar1 1Poxvirus and Rabies Branch, Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention JoVE 60138 Immunology and Infection
בדיקת אימונוהיסטוכימיה לגילוי אנטיגן ליסוירוס מרקמות קבועות פורמלין Michael Niezgoda1, Panayampalli Subbian Satheshkumar1 1Poxvirus and Rabies Branch, Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention JoVE 60138 Immunology and Infection
