Patrick A. Lewis School of Pharmacy University of Reading Biography Publications Institution JoVE Articles Patrick A. Lewis has not added a biography. If you are Patrick A. Lewis and would like to personalize this page please email our Author Liaison for assistance. Publications Analysis of Macroautophagy Related Proteins in G2019S LRRK2 Parkinson's Disease Brains with Lewy Body Pathology Brain Research. Jul, 2018 | Pubmed ID: 30055128 Stratification of Candidate Genes for Parkinson's Disease Using Weighted Protein-protein Interaction Network Analysis BMC Genomics. Jun, 2018 | Pubmed ID: 29898659 LRRK2 is a Negative Regulator of Phagosome Maturation in Macrophages The EMBO Journal. Jun, 2018 | Pubmed ID: 29789389 Mutations in LRRK2 Amplify Cell-to-cell Protein Aggregate Propagation: a Hypothesis Acta Neuropathologica. Jun, 2018 | Pubmed ID: 29600398 MTOR Independent Alteration in ULK1 Ser758 Phosphorylation Following Chronic LRRK2 Kinase Inhibition Bioscience Reports. Apr, 2018 | Pubmed ID: 29563162 Comparative Protein Interaction Network Analysis Identifies Shared and Distinct Functions for the Human ROCO Proteins Proteomics. May, 2018 | Pubmed ID: 29513927 The LRRK2 Signalling System Cell and Tissue Research. Jul, 2018 | Pubmed ID: 29308544 Genome, Transcriptome and Proteome: the Rise of Omics Data and Their Integration in Biomedical Sciences Briefings in Bioinformatics. Mar, 2018 | Pubmed ID: 27881428 PAK6 Phosphorylates 14-3-3γ to Regulate Steady State Phosphorylation of LRRK2 Frontiers in Molecular Neuroscience. 2017 | Pubmed ID: 29311810 Estimating the Causal Influence of Body Mass Index on Risk of Parkinson Disease: A Mendelian Randomisation Study PLoS Medicine. Jun, 2017 | Pubmed ID: 28609445 Leucine Rich Repeat Kinase 2: Beyond Parkinson's and Beyond Kinase Inhibitors Expert Opinion on Therapeutic Targets. 08, 2017 | Pubmed ID: 28609155 Increased Brain Expression of GPNMB is Associated with Genome Wide Significant Risk for Parkinson's Disease on Chromosome 7p15.3 Neurogenetics. Jul, 2017 | Pubmed ID: 28391543 LRRK2 and Autophagy Advances in Neurobiology. 2017 | Pubmed ID: 28353280 Weighted Protein Interaction Network Analysis of Frontotemporal Dementia Journal of Proteome Research. 02, 2017 | Pubmed ID: 28004582 Additional Rare Variant Analysis in Parkinson's Disease Cases with and Without Known Pathogenic Mutations: Evidence for Oligogenic Inheritance Human Molecular Genetics. Oct, 2016 | Pubmed ID: 27798102 MTOR Independent Regulation of Macroautophagy by Leucine Rich Repeat Kinase 2 Via Beclin-1 Scientific Reports. 10, 2016 | Pubmed ID: 27731364 Genetic and Phenotypic Characterization of Complex Hereditary Spastic Paraplegia Brain : a Journal of Neurology. 07, 2016 | Pubmed ID: 27217339 Parkinson's Disease: From Human Genetics to Clinical Trials Science Translational Medicine. Sep, 2015 | Pubmed ID: 26378242 Leucine-rich Repeat Kinase 2 Interacts with P21-activated Kinase 6 to Control Neurite Complexity in Mammalian Brain Journal of Neurochemistry. Sep, 2015 | Pubmed ID: 26375402 Distinct Clinical and Neuropathological Features of G51D SNCA Mutation Cases Compared with SNCA Duplication and H50Q Mutation Molecular Neurodegeneration. Aug, 2015 | Pubmed ID: 26306801 Computational Analysis of the LRRK2 Interactome PeerJ. 2015 | Pubmed ID: 25737818 Genetic, Structural, and Molecular Insights into the Function of Ras of Complex Proteins Domains Chemistry & Biology. Jul, 2014 | Pubmed ID: 24981771 Arsenite Stress Down-regulates Phosphorylation and 14-3-3 Binding of Leucine-rich Repeat Kinase 2 (LRRK2), Promoting Self-association and Cellular Redistribution The Journal of Biological Chemistry. Aug, 2014 | Pubmed ID: 24942733 Parkinson's Disease-linked Mutations in VPS35 Induce Dopaminergic Neurodegeneration Human Molecular Genetics. Sep, 2014 | Pubmed ID: 24740878 Rare Variants in LRRK1 and Parkinson's Disease Neurogenetics. Mar, 2014 | Pubmed ID: 24241507 Pathogenic Parkinson's Disease Mutations Across the Functional Domains of LRRK2 Alter the Autophagic/lysosomal Response to Starvation Biochemical and Biophysical Research Communications. Nov, 2013 | Pubmed ID: 24211199 Fine-mapping, Gene Expression and Splicing Analysis of the Disease Associated LRRK2 Locus PloS One. 2013 | Pubmed ID: 23967090 LRRK2: Cause, Risk, and Mechanism Journal of Parkinson's Disease. 2013 | Pubmed ID: 23938341 Inhibition of LRRK2 Kinase Activity Stimulates Macroautophagy Biochimica Et Biophysica Acta. Dec, 2013 | Pubmed ID: 23916833 Divergent α-synuclein Solubility and Aggregation Properties in G2019S LRRK2 Parkinson's Disease Brains with Lewy Body Pathology Compared to Idiopathic Cases Neurobiology of Disease. Oct, 2013 | Pubmed ID: 23747310 Dysfunction of the Autophagy/lysosomal Degradation Pathway is a Shared Feature of the Genetic Synucleinopathies FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Sep, 2013 | Pubmed ID: 23682122 α-Synuclein Mutations Cluster Around a Putative Protein Loop Neuroscience Letters. Jun, 2013 | Pubmed ID: 23669636 GTP Binding and Intramolecular Regulation by the ROC Domain of Death Associated Protein Kinase 1 Scientific Reports. 2012 | Pubmed ID: 23019516 訂正:病原LRRK2変異は、細胞モデル·システムまたはヒト脳組織における遺伝子発現を変更されることはありません PloS One. 2012 | Pubmed ID: 22303433 LRRK2とヒト疾患:複雑な問題や錯体の質問? Science Signaling. 2012 | Pubmed ID: 22253261 パーキンソン病脳における遺伝子発現 Brain Research Bulletin. Dec, 2011 | Pubmed ID: 22173063 α-シヌクレイン遺伝子座の三重とパーキンソン病の誘導多能性幹細胞 Nature Communications. 2011 | Pubmed ID: 21863007 病原性のLRRK2変異は、細胞モデル·システムまたはヒト脳組織における遺伝子発現を変更されることはありません PloS One. 2011 | Pubmed ID: 21799870 もつれたウェブ - タウおよび散発性パーキンソン病 Frontiers in Psychiatry / Frontiers Research Foundation. 2010 | Pubmed ID: 21423457 がんや神経変性:悪魔とディープブルーの海との間 PLoS Genetics. 2010 | Pubmed ID: 21203498 R1441C変異は、LRRK2のROCドメインの折りたたみプロパティを変更します。 Biochimica Et Biophysica Acta. Dec, 2009 | Pubmed ID: 19781641 健康と病気のROCOタンパク質の機能 Biology of the Cell / Under the Auspices of the European Cell Biology Organization. Mar, 2009 | Pubmed ID: 19152505 遺伝パーキンソン病の新たな道筋:もつれ、レビー小体とLRRK2 The FEBS Journal. Dec, 2008 | Pubmed ID: 19021752 遺伝パーキンソン病の新たな経路 The FEBS Journal. Dec, 2008 | Pubmed ID: 19021751 パーキンソン病の遺伝的神経 International Journal of Clinical and Experimental Pathology. 2008 | Pubmed ID: 18784814 Structure of the ROC Domain from the Parkinson's Disease-associated Leucine-rich Repeat Kinase 2 Reveals a Dimeric GTPase Proceedings of the National Academy of Sciences of the United States of America. Feb, 2008 | Pubmed ID: 18230735 メタロプロテアーゼインヒビターTIMP-3は、アミロイド前駆体蛋白質およびアポリポタンパク質E受容体のタンパク質分解を調節する The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Oct, 2007 | Pubmed ID: 17913923 LRRK2のR1441C変異はGTP加水分解を混乱させる Biochemical and Biophysical Research Communications. Jun, 2007 | Pubmed ID: 17442267 パーキンソン病に関連付けられているLRRK2/dardarinの変異は、相同キナーゼLRRK1で同等の変異よりも毒性が高い Journal of Neurochemistry. Jul, 2007 | Pubmed ID: 17394548 ヒトプリオン蛋白のコドン129多型は、アミロイド形成の動力学に影響を与える The Journal of General Virology. Aug, 2006 | Pubmed ID: 16847141 カテプシンDによるPRP(SC)からGPIアンカーの除去は、プリオン感染を減らすことはありません The Biochemical Journal. Apr, 2006 | Pubmed ID: 16441239 家族前頭側頭型認知症に伴うプレセニリン1の変異は、APPとNotchのγ-セクレターゼ切断を阻害 Neurobiology of Disease. Mar, 2002 | Pubmed ID: 11895378 教育実習でラクターゼ酵素活性の測定 Cattleya S. Leksmono1, Claudia Manzoni1,2, James E. Tomkins1, Walter Lucchesi1,3, Graeme Cottrell1, Patrick A. Lewis1 1School of Pharmacy, University of Reading, 2Department of Molecular Neuroscience, UCL Institute of Neurology, 3School of Biological Sciences, Royal Hollway, University of London JoVE 54377 Biology LRRK2のキナーゼ活性を測定する in vitroで Patrick A. Lewis1 1Department of Molecular Neuroscience, UCL Institute of Neurology JoVE 3495 Biology
教育実習でラクターゼ酵素活性の測定 Cattleya S. Leksmono1, Claudia Manzoni1,2, James E. Tomkins1, Walter Lucchesi1,3, Graeme Cottrell1, Patrick A. Lewis1 1School of Pharmacy, University of Reading, 2Department of Molecular Neuroscience, UCL Institute of Neurology, 3School of Biological Sciences, Royal Hollway, University of London JoVE 54377 Biology
LRRK2のキナーゼ活性を測定する in vitroで Patrick A. Lewis1 1Department of Molecular Neuroscience, UCL Institute of Neurology JoVE 3495 Biology