Paul Gadue Center for Cellular and Molecular Therapeutics The Children's Hospital of Philadelphia Biography Publications Institution JoVE Articles Paul Gadue has not added a biography. If you are Paul Gadue and would like to personalize this page please email our Author Liaison for assistance. Publications Modeling Monogenic Diabetes Using Human ESCs Reveals Developmental and Metabolic Deficiencies Caused by Mutations in HNF1A Cell Stem Cell. Aug, 2019 | Pubmed ID: 31374199 Generation of Spinocerebellar Ataxia Type 2 Induced Pluripotent Stem Cell Lines, CHOPi002-A and CHOPi003-A, from Patients with Abnormal CAG Repeats in the Coding Region of the ATXN2 Gene Stem Cell Research. 01, 2019 | Pubmed ID: 30611021 Highly Efficient CRISPR-Cas9-Mediated Genome Editing in Human Pluripotent Stem Cells Current Protocols in Stem Cell Biology. 02, 2019 | Pubmed ID: 30358158 Generation of a Human Juvenile Myelomonocytic Leukemia IPSC Line, CHOPi001-A, with a Mutation in CBL Stem Cell Research. 08, 2018 | Pubmed ID: 30096712 GATA6 Suppression Enhances Lung Specification from Human Pluripotent Stem Cells The Journal of Clinical Investigation. 07, 2018 | Pubmed ID: 29889101 Exploring the Interaction Between EIF2α Dysregulation, Acute Endoplasmic Reticulum Stress and DYT1 Dystonia in the Mammalian Brain Neuroscience. 02, 2018 | Pubmed ID: 29289717 Induced Pluripotent Stem Cell-Derived Megakaryocytes and Platelets for Disease Modeling and Future Clinical Applications Arteriosclerosis, Thrombosis, and Vascular Biology. 11, 2017 | Pubmed ID: 28982668 GATA6 Plays an Important Role in the Induction of Human Definitive Endoderm, Development of the Pancreas, and Functionality of Pancreatic β Cells Stem Cell Reports. 03, 2017 | Pubmed ID: 28196690 Generation of Human Control IPS Cell Line CHOPWT10 from Healthy Adult Peripheral Blood Mononuclear Cells Stem Cell Research. Mar, 2016 | Pubmed ID: 27345999 Generation of Hermansky Pudlak Syndrome Type 2 (HPS2) Induced Pluripotent Stem Cells (iPSCs) Stem Cell Research. Mar, 2016 | Pubmed ID: 27345985 Generation of Hermansky-Pudlak Syndrome Type 1 (HPS1) Induced Pluripotent Stem Cells (iPSCs) Stem Cell Research. Mar, 2016 | Pubmed ID: 27345974 Generation of Human Control IPS Cell Line CHOPWT9 from Healthy Adult Peripheral Blood Mononuclear Cells Stem Cell Research. Jan, 2016 | Pubmed ID: 27345777 A Doxycycline-Inducible System for Genetic Correction of IPSC Disease Models Methods in Molecular Biology (Clifton, N.J.). 2016 | Pubmed ID: 25630922 Generation of Poikiloderma with Neutropenia (PN) Induced Pluripotent Stem Cells (iPSCs) Stem Cell Research. Nov, 2015 | Pubmed ID: 26987923 OCT4 Coordinates with WNT Signaling to Pre-pattern Chromatin at the SOX17 Locus During Human ES Cell Differentiation into Definitive Endoderm Stem Cell Reports. Oct, 2015 | Pubmed ID: 26411902 Inducible Gata1 Suppression Expands Megakaryocyte-erythroid Progenitors from Embryonic Stem Cells The Journal of Clinical Investigation. Jun, 2015 | Pubmed ID: 25961454 Comparative Analysis of Human Ex Vivo-generated Platelets Vs Megakaryocyte-generated Platelets in Mice: a Cautionary Tale Blood. Jun, 2015 | Pubmed ID: 25852052 Emergence of a Stage-dependent Human Liver Disease Signature with Directed Differentiation of Alpha-1 Antitrypsin-deficient IPS Cells Stem Cell Reports. May, 2015 | Pubmed ID: 25843048 Pluripotent Stem Cells Reveal Erythroid-specific Activities of the GATA1 N-terminus The Journal of Clinical Investigation. Mar, 2015 | Pubmed ID: 25621499 Hematopoietic Differentiation of Pluripotent Stem Cells in Culture Methods in Molecular Biology (Clifton, N.J.). 2014 | Pubmed ID: 25062629 Utilization of the AAVS1 Safe Harbor Locus for Hematopoietic Specific Transgene Expression and Gene Knockdown in Human ES Cells Stem Cell Research. May, 2014 | Pubmed ID: 24631742 The Negative Impact of Wnt Signaling on Megakaryocyte and Primitive Erythroid Progenitors Derived from Human Embryonic Stem Cells Stem Cell Research. Mar, 2014 | Pubmed ID: 24412757 High-level Transgene Expression in Induced Pluripotent Stem Cell-derived Megakaryocytes: Correction of Glanzmann Thrombasthenia Blood. Jan, 2014 | Pubmed ID: 24335497 Clonal Genetic and Hematopoietic Heterogeneity Among Human-induced Pluripotent Stem Cell Lines Blood. Sep, 2013 | Pubmed ID: 23940280 Ribosomal and Hematopoietic Defects in Induced Pluripotent Stem Cells Derived from Diamond Blackfan Anemia Patients Blood. Aug, 2013 | Pubmed ID: 23744582 AAV-mediated Gene Therapy for Choroideremia: Preclinical Studies in Personalized Models PloS One. 2013 | Pubmed ID: 23667438 Trisomy 21-associated Defects in Human Primitive Hematopoiesis Revealed Through Induced Pluripotent Stem Cells Proceedings of the National Academy of Sciences of the United States of America. Oct, 2012 | Pubmed ID: 23045704 Líneas De Progenitor Endodermal Renueva a Sí Misma Generadas a Partir De Células Madre Pluripotentes Humanas Cell Stem Cell. Apr, 2012 | Pubmed ID: 22482503 Ensayo De Cribado De Alto Rendimiento Para La Diferenciación De Cuerpo Embryoid De Células Madre Embrionarias Humanas Current Protocols in Stem Cell Biology. Mar, 2012 | Pubmed ID: 22415836 Un Nicho De Células Endoteliales Induce Especificación Hepática a Través De La Represión Dual De Wnt Y Muesca De Señalización Stem Cells (Dayton, Ohio). Feb, 2011 | Pubmed ID: 21732480 ES De Ratón Y Células IPS Pueden Formar Endodermo Definitivo Similar a Pesar De Las Diferencias En Los Genes Impresos The Journal of Clinical Investigation. Jun, 2011 | Pubmed ID: 21537085 Una Selección De Alto Rendimiento Para La Optimización De Multiplexado Ensayo Suero Libre De Protocolos De Diferenciación De Células Madre Embrionarias Humanas Stem Cell Research. Mar, 2011 | Pubmed ID: 21169079 Regeneración Hepática De Células Madre Pluripotentes Inducidas Molecular Therapy : the Journal of the American Society of Gene Therapy. Dec, 2010 | Pubmed ID: 21119691 Generación De Células Pluripotentes Inducidas Humanas De La Enfermedad-específica Pulmón Libre De Transgenes Usando Un Cassette De Célula Madre Lentivirales Los Stem Cells (Dayton, Ohio). Oct, 2010 | Pubmed ID: 20715179 Competencia Transcripcional Y La Marca Activa De Tejidos Específicos Enhancers De Factores De Transcripción Definida En Células Madre Pluripotentes Embrionarias E Inducidos Genes & Development. Dec, 2009 | Pubmed ID: 20008934 Las Células Madre Descifra La Hematopoyesis Del Saco Vitelino Blood. Aug, 2009 | Pubmed ID: 19696206 Generación De Anticuerpos Monoclonales Específicos Para Moléculas De Superficie Celular Expresado En El Endodermo Temprano De Ratón Stem Cells (Dayton, Ohio). Sep, 2009 | Pubmed ID: 19522011 Células Epidérmicas Acelerar Reprogramación Nature Biotechnology. Nov, 2008 | Pubmed ID: 18997762 Entumecido Interviene En La Interacción De Wnt Y Muesca Para Modular La Especificación Eritropoyética Primitivo De La Hemangioblasto99 Development (Cambridge, England). Oct, 2008 | Pubmed ID: 18799543 Wnt, Activina Y BMP Señalización Regulan Distintas Etapas En El Camino Del Desarrollo De Las Células Madre Embrionarias a Sangre Cell Stem Cell. Jan, 2008 | Pubmed ID: 18371422 Identificación Y Focalización Del Locus ROSA26 En Células Madre Embrionarias Humanas Nature Biotechnology. Dec, 2007 | Pubmed ID: 18037879 BMP-4 Se Requiere Para La Especificación Hepática De Embrionarias Derivadas De Células Madre Definitivo Endodermo De Ratón Nature Biotechnology. Nov, 2006 | Pubmed ID: 17086172 Se Requiere Para La Inducción De Un Modelo in Vitro De La Formación De La Línea Primitiva Utilizando Células Madre Embrionarias De Wnt Y Señalización De TGF-beta Proceedings of the National Academy of Sciences of the United States of America. Nov, 2006 | Pubmed ID: 17077151 Inducción De La Capa Germinal De Células Madre Embrionarias Experimental Hematology. Sep, 2005 | Pubmed ID: 16140142 Desarrollo De La Célula De T De Restauración De NK En Ratones Mutantes Fyn Por Un TCR Revela Un Requisito Para Fyn Durante La Ontogenia De La Célula NK T Temprano Journal of Immunology (Baltimore, Md. : 1950). May, 2004 | Pubmed ID: 15128794 La Mer Receptor Tirosina Quinasa: Expresión Y Función Sugieren Un Papel En La Inmunidad Innata European Journal of Immunology. Aug, 2003 | Pubmed ID: 12884290 Precursores De Células NK T Exhiben Regulación Diferencial Citocinas Y Requieren Itk Para Maduración Eficiente Journal of Immunology (Baltimore, Md. : 1950). Sep, 2002 | Pubmed ID: 12193707 Generación de modificaciones genómicas definidas utilizando CRISPR-CAS9 en células madre pluripotentes humanas Fabian L. Cardenas-Diaz*1, Jean Ann Maguire*1, Paul Gadue1,2,3, Deborah L. French1,2,3 1Center for Cellular and Molecular Therapeutics, The Children's Hospital of Philadelphia, 2Department of Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia, 3Department of Pathology and Laboratory Medicine, University of Pennsylvania JoVE 60085 Genetics Generación de las células madre pluripotentes inducidas a partir de sangre periférica mediante el STEMCCA vector lentiviral Andreia Gianotti Sommer1, Sarah S. Rozelle1, Spencer Sullivan2, Jason A. Mills3, Seon-Mi Park1, Brenden W. Smith1, Amulya M. Iyer1, Deborah L. French3, Darrell N. Kotton1, Paul Gadue3, George J. Murphy1, Gustavo Mostoslavsky1 1Center for Regenerative Medicine (CReM), Boston University School of Medicine, 2Department of Hematology, Children's Hospital of Philadelphia, 3Center for Cellular and Molecular Therapeutics, Children's Hospital of Philadelphia JoVE 4327 Biology
Generación de modificaciones genómicas definidas utilizando CRISPR-CAS9 en células madre pluripotentes humanas Fabian L. Cardenas-Diaz*1, Jean Ann Maguire*1, Paul Gadue1,2,3, Deborah L. French1,2,3 1Center for Cellular and Molecular Therapeutics, The Children's Hospital of Philadelphia, 2Department of Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia, 3Department of Pathology and Laboratory Medicine, University of Pennsylvania JoVE 60085 Genetics
Generación de las células madre pluripotentes inducidas a partir de sangre periférica mediante el STEMCCA vector lentiviral Andreia Gianotti Sommer1, Sarah S. Rozelle1, Spencer Sullivan2, Jason A. Mills3, Seon-Mi Park1, Brenden W. Smith1, Amulya M. Iyer1, Deborah L. French3, Darrell N. Kotton1, Paul Gadue3, George J. Murphy1, Gustavo Mostoslavsky1 1Center for Regenerative Medicine (CReM), Boston University School of Medicine, 2Department of Hematology, Children's Hospital of Philadelphia, 3Center for Cellular and Molecular Therapeutics, Children's Hospital of Philadelphia JoVE 4327 Biology