Peter ten Dijke Dept. Cell Chemical Biology Leiden University Medical Center Biography Publications Institution JoVE Articles Peter ten Dijke has not added a biography. If you are Peter ten Dijke and would like to personalize this page please email our Author Liaison for assistance. Publications A Comprehensive Enhancer Screen Identifies TRAM2 As a Key and Novel Mediator of YAP Oncogenesis Genome Biology. Jan, 2021 | Pubmed ID: 33514403 E3 Ubiquitin Ligases: Key Regulators of TGFβ Signaling in Cancer Progression International Journal of Molecular Sciences. Jan, 2021 | Pubmed ID: 33418880 Targeting TGFβ Signal Transduction for Cancer Therapy Signal Transduction and Targeted Therapy. Jan, 2021 | Pubmed ID: 33414388 Therapeutic Targeting of TGF-β in Cancer: Hacking a Master Switch of Immune Suppression Clinical Science (London, England : 1979). Jan, 2021 | Pubmed ID: 33399850 Uncovering the Deubiquitinase Activity Landscape of Breast Cancer Oncoscience. Nov, 2020 | Pubmed ID: 33457450 TGF-β Signaling in Liver Metastasis Clinical and Translational Medicine. Nov, 2020 | Pubmed ID: 33252863 Designed Nanomolar Small-molecule Inhibitors of Ena/VASP EVH1 Interaction Impair Invasion and Extravasation of Breast Cancer Cells Proceedings of the National Academy of Sciences of the United States of America. 11, 2020 | Pubmed ID: 33184177 Current Perspectives on Inhibitory SMAD7 in Health and Disease Critical Reviews in Biochemistry and Molecular Biology. Oct, 2020 | Pubmed ID: 33081543 Small-Molecule Activity-Based Probe for Monitoring Ubiquitin C-Terminal Hydrolase L1 (UCHL1) Activity in Live Cells and Zebrafish Embryos Journal of the American Chemical Society. Sep, 2020 | Pubmed ID: 32886496 Mechanotransduction is a Context-dependent Activator of TGF-β Signaling in Mesenchymal Stem Cells Biomaterials. Nov, 2020 | Pubmed ID: 32836056 Cercosporamide Inhibits Bone Morphogenetic Protein Receptor Type I Kinase Activity in Zebrafish Disease Models & Mechanisms. Sep, 2020 | Pubmed ID: 32820031 Reactivation of BMP Signaling by Suboptimal Concentrations of MEK Inhibitor and FK506 Reduces Organ-specific Breast Cancer Metastasis Cancer Letters. Nov, 2020 | Pubmed ID: 32768522 On-Target Anti-TGF-β Therapies Are Not Succeeding in Clinical Cancer Treatments: What Are Remaining Challenges? Frontiers in Cell and Developmental Biology. 2020 | Pubmed ID: 32733895 Role of Glycosylation in TGF-β Signaling and Epithelial-to-mesenchymal Transition in Cancer Protein & Cell. Jun, 2020 | Pubmed ID: 32583064 Differential - and Glycosphingolipid Glycosylation in Human Pancreatic Adenocarcinoma Cells With Opposite Morphology and Metastatic Behavior Frontiers in Oncology. 2020 | Pubmed ID: 32582529 MnTBAP Reverses Pulmonary Vascular Remodeling and Improves Cardiac Function in Experimentally Induced Pulmonary Arterial Hypertension International Journal of Molecular Sciences. Jun, 2020 | Pubmed ID: 32531895 Bone Morphogenetic Protein Receptors: Structure, Function and Targeting by Selective Small Molecule Kinase Inhibitors Bone. Sep, 2020 | Pubmed ID: 32522605 Secreted BMP Antagonists and Their Role in Cancer and Bone Metastases Bone. Aug, 2020 | Pubmed ID: 32473315 TGF-β-Induced Endothelial to Mesenchymal Transition in Disease and Tissue Engineering Frontiers in Cell and Developmental Biology. 2020 | Pubmed ID: 32373613 TGFβ and EGF Signaling Orchestrates the AP-1- and P63 Transcriptional Regulation of Breast Cancer Invasiveness Oncogene. May, 2020 | Pubmed ID: 32350443 Development of a 96-well Plate Sample Preparation Method for Integrated N- and O-glycomics Using Porous Graphitized Carbon Liquid Chromatography-mass Spectrometry Molecular Omics. 08, 2020 | Pubmed ID: 32281997 Immunotherapeutic Potential of TGF-β Inhibition and Oncolytic Viruses Trends in Immunology. 05, 2020 | Pubmed ID: 32223932 A Signaling Crosstalk Between BMP9 and HGF/c-Met Regulates Mouse Adult Liver Progenitor Cell Survival Cells. 03, 2020 | Pubmed ID: 32204446 Controlling Smad4 Signaling with a Wip EMBO Reports. 05, 2020 | Pubmed ID: 32189449 Mutant ACVR1 Arrests Glial Cell Differentiation to Drive Tumorigenesis in Pediatric Gliomas Cancer Cell. 03, 2020 | Pubmed ID: 32142668 THG-1 Suppresses SALL4 Degradation to Induce Stemness Genes and Tumorsphere Formation Through Antagonizing NRBP1 in Squamous Cell Carcinoma Cells Biochemical and Biophysical Research Communications. 03, 2020 | Pubmed ID: 31864704 TGFβ-induced Metabolic Reprogramming During Epithelial-to-mesenchymal Transition in Cancer Cellular and Molecular Life Sciences : CMLS. Jun, 2020 | Pubmed ID: 31822964 Tacrolimus-Induced BMP/SMAD Signaling Associates With Metabolic Stress-Activated FOXO1 to Trigger β-Cell Failure Diabetes. 02, 2020 | Pubmed ID: 31732500 VprBP Mitigates TGF-β and Activin Signaling by Promoting Smurf1-mediated Type I Receptor Degradation Journal of Molecular Cell Biology. 02, 2020 | Pubmed ID: 31291647 Development of Macrocycle Kinase Inhibitors for ALK2 Using Fibrodysplasia Ossificans Progressiva-Derived Endothelial Cells JBMR Plus. Nov, 2019 | Pubmed ID: 31768489 JNK-Dependent CJun Phosphorylation Mitigates TGFβ- and EGF-Induced Pre-Malignant Breast Cancer Cell Invasion by Suppressing AP-1-Mediated Transcriptional Responses Cells. 11, 2019 | Pubmed ID: 31766464 A Perspective on the Development of TGF-β Inhibitors for Cancer Treatment Biomolecules. 11, 2019 | Pubmed ID: 31744193 Author Correction: C-Met Activation Leads to the Establishment of a TGFβ-receptor Regulatory Network in Bladder Cancer Progression Nature Communications. Nov, 2019 | Pubmed ID: 31704935 GREM1 is Associated with Metastasis and Predicts Poor Prognosis in ER-negative Breast Cancer Patients Cell Communication and Signaling : CCS. 11, 2019 | Pubmed ID: 31694641 C-Met Activation Leads to the Establishment of a TGFβ-receptor Regulatory Network in Bladder Cancer Progression Nature Communications. 09, 2019 | Pubmed ID: 31554791 Cancer-associated Fibroblast-derived Gremlin 1 Promotes Breast Cancer Progression Breast Cancer Research : BCR. 09, 2019 | Pubmed ID: 31533776 In Vivo Imaging of TGFβ Signalling Components Using Positron Emission Tomography Drug Discovery Today. 12, 2019 | Pubmed ID: 31494189 Role of Soluble Endoglin in BMP9 Signaling Proceedings of the National Academy of Sciences of the United States of America. 09, 2019 | Pubmed ID: 31431534 Prevention of Progression of Pulmonary Hypertension by the Nur77 Agonist 6-mercaptopurine: Role of BMP Signalling The European Respiratory Journal. 09, 2019 | Pubmed ID: 31273046 Autophagy Contributes to BMP Type 2 Receptor Degradation And development of Pulmonary Arterial Hypertension The Journal of Pathology. 11, 2019 | Pubmed ID: 31257577 Generation of Non-standard Macrocyclic Peptides Specifically Binding TSC-22 Homologous Gene-1 Biochemical and Biophysical Research Communications. 08, 2019 | Pubmed ID: 31227214 TGF-β-Mediated Epithelial-Mesenchymal Transition and Cancer Metastasis International Journal of Molecular Sciences. Jun, 2019 | Pubmed ID: 31195692 Epigenetic Reprogramming of TGF-β Signaling in Breast Cancer Cancers. May, 2019 | Pubmed ID: 31137748 Combined Inhibition of TGF-β Signaling and the PD-L1 Immune Checkpoint Is Differentially Effective in Tumor Models Cells. 04, 2019 | Pubmed ID: 30959852 TGF-β Family Signaling Pathways in Cellular Dormancy Trends in Cancer. 01, 2019 | Pubmed ID: 30616757 Inflammation Induces Endothelial-to-mesenchymal Transition and Promotes Vascular Calcification Through Downregulation of BMPR2 The Journal of Pathology. 03, 2019 | Pubmed ID: 30430573 Bone Morphogenetic Protein Receptor Signal Transduction in Human Disease The Journal of Pathology. 01, 2019 | Pubmed ID: 30246251 The Therapeutic Potential of Targeting the Endothelial-to-mesenchymal Transition Angiogenesis. 02, 2019 | Pubmed ID: 30076548 Epithelial-mesenchymal-transition-inducing Transcription Factors: New Targets for Tackling Chemoresistance in Cancer? Oncogene. 11, 2018 | Pubmed ID: 30002444 Endoglin Expression on Cancer-Associated Fibroblasts Regulates Invasion and Stimulates Colorectal Cancer Metastasis Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. 12, 2018 | Pubmed ID: 29945992 Bone Morphogenetic Protein 9 As a Key Regulator of Liver Progenitor Cells in DDC-induced Cholestatic Liver Injury Liver International : Official Journal of the International Association for the Study of the Liver. 09, 2018 | Pubmed ID: 29751359 TGF-β Family Co-receptor Function and Signaling Acta Biochimica Et Biophysica Sinica. Jan, 2018 | Pubmed ID: 29293886 JUNB Governs a Feed-forward Network of TGFβ Signaling That Aggravates Breast Cancer Invasion Nucleic Acids Research. 02, 2018 | Pubmed ID: 29186616 Endothelial-to-mesenchymal Transition in Cardiovascular Diseases: Developmental Signaling Pathways Gone Awry Developmental Dynamics : an Official Publication of the American Association of Anatomists. 03, 2018 | Pubmed ID: 28891150 Breast Cancer Metastasis Suppressor OTUD1 Deubiquitinates SMAD7 Nature Communications. 12, 2017 | Pubmed ID: 29235476 TGF-β-Induced Endothelial-Mesenchymal Transition in Fibrotic Diseases International Journal of Molecular Sciences. Oct, 2017 | Pubmed ID: 29039786 Disparate Phospho-Smad2 Levels in Advanced Type 2 Diabetes Patients with Diabetic Nephropathy and Early Experimental Db/db Mouse Model Renal Failure. Nov, 2017 | Pubmed ID: 28805484 Bone Morphogenetic Protein 9 Protects Against Neonatal Hyperoxia-Induced Impairment of Alveolarization and Pulmonary Inflammation Frontiers in Physiology. 2017 | Pubmed ID: 28751863 Targeting TGF-β Signaling in Cancer Trends in Cancer. 01, 2017 | Pubmed ID: 28718426 SUMO-triggered Ubiquitination of NR4A1 Controls Macrophage Cell Death Cell Death and Differentiation. 09, 2017 | Pubmed ID: 28622293 TGFβ1-induced SMAD2/3 and SMAD1/5 Phosphorylation Are Both ALK5-kinase-dependent in Primary Chondrocytes and Mediated by TAK1 Kinase Activity Arthritis Research & Therapy. May, 2017 | Pubmed ID: 28569204 Erratum To: BMP Type II Receptor As a Therapeutic Target in Pulmonary Arterial Hypertension Cellular and Molecular Life Sciences : CMLS. 08, 2017 | Pubmed ID: 28536788 USP4 Inhibits SMAD4 Monoubiquitination and Promotes Activin and BMP Signaling The EMBO Journal. 06, 2017 | Pubmed ID: 28468752 BMP Type II Receptor As a Therapeutic Target in Pulmonary Arterial Hypertension Cellular and Molecular Life Sciences : CMLS. 08, 2017 | Pubmed ID: 28447104 FAF1 Phosphorylation by AKT Accumulates TGF-β Type II Receptor and Drives Breast Cancer Metastasis Nature Communications. 04, 2017 | Pubmed ID: 28443643 Bone Morphogenetic Proteins in Vascular Homeostasis and Disease Cold Spring Harbor Perspectives in Biology. Mar, 2017 | Pubmed ID: 28348038 TGF-β Signaling in Control of Cardiovascular Function Cold Spring Harbor Perspectives in Biology. Mar, 2017 | Pubmed ID: 28348036 BMP-9 Interferes with Liver Regeneration and Promotes Liver Fibrosis Gut. May, 2017 | Pubmed ID: 28336518 Fluid Shear Stress-induced TGF-β/ALK5 Signaling in Renal Epithelial Cells is Modulated by MEK1/2 Cellular and Molecular Life Sciences : CMLS. Feb, 2017 | Pubmed ID: 28168444 TMED10 Protein Interferes with Transforming Growth Factor (TGF)-β Signaling by Disrupting TGF-β Receptor Complex Formation The Journal of Biological Chemistry. Mar, 2017 | Pubmed ID: 28115518 Smad2 Phosphorylation in Diabetic Kidney Tubule Epithelial Cells Is Associated with Modulation of Several Transforming Growth Factor-β Family Members Nephron. 2017 | Pubmed ID: 28064277 New Function of the Myostatin/activin Type I Receptor (ALK4) As a Mediator of Muscle Atrophy and Muscle Regeneration FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Jan, 2017 | Pubmed ID: 27733450 Fish Tales: The Use of Zebrafish Xenograft Human Cancer Cell Models Histology and Histopathology. Dec, 2016 | Pubmed ID: 27933602 Immunoregulation by Members of the TGFβ Superfamily Nature Reviews. Immunology. 11, 2016 | Pubmed ID: 27885276 Towards a Cure for Fibrodysplasia Ossificans Progressiva Annals of Translational Medicine. Oct, 2016 | Pubmed ID: 27867996 Mutational Activation of BRAF Confers Sensitivity to Transforming Growth Factor Beta Inhibitors in Human Cancer Cells Oncotarget. Dec, 2016 | Pubmed ID: 27835901 Targeting Tumour Vasculature by Inhibiting Activin Receptor-like Kinase (ALK)1 Function Biochemical Society Transactions. Aug, 2016 | Pubmed ID: 27528762 A Current Perspective on Applications of Macrocyclic-peptide-based High-affinity Ligands Biopolymers. Nov, 2016 | Pubmed ID: 27352774 C-Myb Enhances Breast Cancer Invasion and Metastasis Through the Wnt/β-Catenin/Axin2 Pathway Cancer Research. Jun, 2016 | Pubmed ID: 27197202 Delta-Like Ligand 4 Modulates Liver Damage by Down-Regulating Chemokine Expression The American Journal of Pathology. Jul, 2016 | Pubmed ID: 27171900 Regulation of the TGF-β Pathway by Deubiquitinases in Cancer The International Journal of Biochemistry & Cell Biology. Jul, 2016 | Pubmed ID: 27155333 Smad6 Determines BMP-regulated Invasive Behaviour of Breast Cancer Cells in a Zebrafish Xenograft Model Scientific Reports. Apr, 2016 | Pubmed ID: 27113436 Inhibition of Activin Signaling Slows Progression of Polycystic Kidney Disease Journal of the American Society of Nephrology : JASN. Dec, 2016 | Pubmed ID: 27020852 Emerging Regulators of BMP Bioavailability Bone. Dec, 2016 | Pubmed ID: 26825814 The Rationale for Targeting TGF-β in Chronic Liver Diseases European Journal of Clinical Investigation. Apr, 2016 | Pubmed ID: 26823073 TGF-β Signalling and Liver Disease The FEBS Journal. Jun, 2016 | Pubmed ID: 26807763 Interrogating TGF-β Function and Regulation in Endothelial Cells Methods in Molecular Biology (Clifton, N.J.). 2016 | Pubmed ID: 26520125 Determining TGF-β Receptor Levels in the Cell Membrane Methods in Molecular Biology (Clifton, N.J.). 2016 | Pubmed ID: 26520116 In Brief: Endothelial-to-mesenchymal Transition The Journal of Pathology. Feb, 2016 | Pubmed ID: 26446982 Regulatory RNAs Controlling Vascular (dys)function by Affecting TGF-ß Family Signalling EXCLI Journal. 2015 | Pubmed ID: 26862319 Signal Transduction: Gain of Activin Turns Muscle into Bone Current Biology : CB. Dec, 2015 | Pubmed ID: 26654374 Induced Pluripotent Stem Cells to Model Human Fibrodysplasia Ossificans Progressiva Stem Cell Reports. Dec, 2015 | Pubmed ID: 26626181 Targeting BMP Signalling in Cardiovascular Disease and Anaemia Nature Reviews. Cardiology. Oct, 2015 | Pubmed ID: 26461965 Bone Morphogenetic Protein 6 and Oxidized Low-density Lipoprotein Synergistically Recruit Osteogenic Differentiation in Endothelial Cells Cardiovascular Research. Nov, 2015 | Pubmed ID: 26410368 Heterozygous Disruption of Activin Receptor-like Kinase 1 is Associated with Increased Arterial Pressure in Mice Disease Models & Mechanisms. Nov, 2015 | Pubmed ID: 26398936 Activin Receptor-like Kinase 1 Ligand Trap Reduces Microvascular Density and Improves Chemotherapy Efficiency to Various Solid Tumors Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Sep, 2015 | Pubmed ID: 26373572 Bone Morphogenetic Protein Signaling in Bone Homeostasis Bone. Nov, 2015 | Pubmed ID: 26051467 A Kinome-Wide Small Interfering RNA Screen Identifies Proviral and Antiviral Host Factors in Severe Acute Respiratory Syndrome Coronavirus Replication, Including Double-Stranded RNA-Activated Protein Kinase and Early Secretory Pathway Proteins Journal of Virology. Aug, 2015 | Pubmed ID: 26041291 Genetic Depletion and Pharmacological Targeting of αv Integrin in Breast Cancer Cells Impairs Metastasis in Zebrafish and Mouse Xenograft Models Breast Cancer Research : BCR. Feb, 2015 | Pubmed ID: 25849225 Transforming Growth Factor β Signaling in Colorectal Cancer Cells With Microsatellite Instability Despite Biallelic Mutations in TGFBR2 Gastroenterology. Jun, 2015 | Pubmed ID: 25736321 14-3-3ζ Turns TGF-β to the Dark Side Cancer Cell. Feb, 2015 | Pubmed ID: 25670073 SLUG is Expressed in Endothelial Cells Lacking Primary Cilia to Promote Cellular Calcification Arteriosclerosis, Thrombosis, and Vascular Biology. Mar, 2015 | Pubmed ID: 25633317 Clinical Utility Gene Card For: Fibrodysplasia Ossificans Progressiva European Journal of Human Genetics : EJHG. Oct, 2015 | Pubmed ID: 25604857 Inhibition of TGFβ Type I Receptor Activity Facilitates Liver Regeneration Upon Acute CCl4 Intoxication in Mice Archives of Toxicology. Jan, 2015 | Pubmed ID: 25566828 Ter94/VCP is a Novel Component Involved in BMP Signaling PloS One. 2014 | Pubmed ID: 25469707 Wild-type P53 Inhibits Pro-invasive Properties of TGF-β3 in Breast Cancer, in Part Through Regulation of EPHB2, a New TGF-β Target Gene Breast Cancer Research and Treatment. Nov, 2014 | Pubmed ID: 25257729 Assessment of Functional Competence of Endothelial Cells from Human Pluripotent Stem Cells in Zebrafish Embryos Methods in Molecular Biology (Clifton, N.J.). 2014 | Pubmed ID: 25173378 Time-resolved Dissection of Early Phosphoproteome and Ensuing Proteome Changes in Response to TGF-β Science Signaling. Jul, 2014 | Pubmed ID: 25056879 Generation, Expansion and Functional Analysis of Endothelial Cells and Pericytes Derived from Human Pluripotent Stem Cells Nature Protocols. 2014 | Pubmed ID: 24874816 Loss of SMAD4 Alters BMP Signaling to Promote Colorectal Cancer Cell Metastasis Via Activation of Rho and ROCK Gastroenterology. Jul, 2014 | Pubmed ID: 24704720 Targeting TGF-β Signaling by Antisense Oligonucleotide-mediated Knockdown of TGF-β Type I Receptor Molecular Therapy. Nucleic Acids. Apr, 2014 | Pubmed ID: 24691207 Nuclear Receptor NR4A1 Promotes Breast Cancer Invasion and Metastasis by Activating TGF-β Signalling Nature Communications. 2014 | Pubmed ID: 24584437 ENDOGLIN is Dispensable for Vasculogenesis, but Required for Vascular Endothelial Growth Factor-induced Angiogenesis PloS One. 2014 | Pubmed ID: 24489709 Novel Ex Vivo Culture Method for the Study of Dupuytren's Disease: Effects of TGFβ Type 1 Receptor Modulation by Antisense Oligonucleotides Molecular Therapy. Nucleic Acids. 2014 | Pubmed ID: 24448195 Functionality of Endothelial Cells and Pericytes from Human Pluripotent Stem Cells Demonstrated in Cultured Vascular Plexus and Zebrafish Xenografts Arteriosclerosis, Thrombosis, and Vascular Biology. Jan, 2014 | Pubmed ID: 24158517 Mutational Analysis of Sclerostin Shows Importance of the Flexible Loop and the Cystine-knot for Wnt-signaling Inhibition PloS One. 2013 | Pubmed ID: 24312339 Signaling Interplay Between Transforming Growth Factor-β Receptor and PI3K/AKT Pathways in Cancer Trends in Biochemical Sciences. Dec, 2013 | Pubmed ID: 24239264 Transforming Growth Factor-β Signalling Controls Human Breast Cancer Metastasis in a Zebrafish Xenograft Model Breast Cancer Research : BCR. Nov, 2013 | Pubmed ID: 24196484 Activin Receptor-like Kinase 1 As a Target for Anti-angiogenesis Therapy Expert Opinion on Investigational Drugs. Nov, 2013 | Pubmed ID: 24053899 Transforming Growth Factor-β (TGF-β)-mediated Connective Tissue Growth Factor (CTGF) Expression in Hepatic Stellate Cells Requires Stat3 Signaling Activation The Journal of Biological Chemistry. Oct, 2013 | Pubmed ID: 24005672 TRAF4 Promotes TGF-β Receptor Signaling and Drives Breast Cancer Metastasis Molecular Cell. Sep, 2013 | Pubmed ID: 23973329 FK506 Activates BMPR2, Rescues Endothelial Dysfunction, and Reverses Pulmonary Hypertension The Journal of Clinical Investigation. Aug, 2013 | Pubmed ID: 23867624 Antisense-oligonucleotide Mediated Exon Skipping in Activin-receptor-like Kinase 2: Inhibiting the Receptor That is Overactive in Fibrodysplasia Ossificans Progressiva PloS One. 2013 | Pubmed ID: 23861958 Three-dimensional Co-cultures of Human Endothelial Cells and Embryonic Stem Cell-derived Pericytes Inside a Microfluidic Device Lab on a Chip. Sep, 2013 | Pubmed ID: 23702711 Anti-Sclerostin Antibody Inhibits Internalization of Sclerostin and Sclerostin-mediated Antagonism of Wnt/LRP6 Signaling PloS One. 2013 | Pubmed ID: 23638027 Snail and Slug, Key Regulators of TGF-β-induced EMT, Are Sufficient for the Induction of Single-cell Invasion Biochemical and Biophysical Research Communications. May, 2013 | Pubmed ID: 23618854 Preventive and Therapeutic Effects of Smad7 on Radiation-induced Oral Mucositis Nature Medicine. Apr, 2013 | Pubmed ID: 23475202 Fine-tuning BMP7 Signalling in Adipogenesis by UBE2O/E2-230K-mediated Monoubiquitination of SMAD6 The EMBO Journal. Apr, 2013 | Pubmed ID: 23455153 Deficiency for Endoglin in Tumor Vasculature Weakens the Endothelial Barrier to Metastatic Dissemination The Journal of Experimental Medicine. Mar, 2013 | Pubmed ID: 23401487 UBE2O Negatively Regulates TRAF6-mediated NF-κB Activation by Inhibiting TRAF6 Polyubiquitination Cell Research. Mar, 2013 | Pubmed ID: 23381138 Endoglin for Tumor Imaging and Targeted Cancer Therapy Expert Opinion on Therapeutic Targets. Apr, 2013 | Pubmed ID: 23327677 Overactive Bone Morphogenetic Protein Signaling in Heterotopic Ossification and Duchenne Muscular Dystrophy Cellular and Molecular Life Sciences : CMLS. Feb, 2013 | Pubmed ID: 22752156 Soluble Fms-like Tyrosine Kinase 1 and Soluble Endoglin Are Elevated Circulating Anti-angiogenic Factors in Pre-eclampsia Pregnancy Hypertension. Oct, 2012 | Pubmed ID: 26105603 MicroRNA-155 Functions As a Negative Regulator of RhoA Signaling in TGF-β-induced Endothelial to Mesenchymal Transition MicroRNA (Shariqah, United Arab Emirates). 2012 | Pubmed ID: 25048084 Animal Models of Chronic Liver Diseases American Journal of Physiology. Gastrointestinal and Liver Physiology. Dec, 2012 | Pubmed ID: 23275613 MED12 Controls the Response to Multiple Cancer Drugs Through Regulation of TGF-β Receptor Signaling Cell. Nov, 2012 | Pubmed ID: 23178117 The Activities of Smad and Gli Mediated Signalling Pathways in High-grade Conventional Osteosarcoma European Journal of Cancer (Oxford, England : 1990). Dec, 2012 | Pubmed ID: 22868198 Fas-associated Factor 1 is a Scaffold Protein That Promotes β-transducin Repeat-containing Protein (β-TrCP)-mediated β-catenin Ubiquitination and Degradation The Journal of Biological Chemistry. Aug, 2012 | Pubmed ID: 22730322 TGF-β Signalling and Its Role in Cancer Progression and Metastasis Cancer Metastasis Reviews. Dec, 2012 | Pubmed ID: 22714591 BMP Signaling in Vascular Diseases FEBS Letters. Jul, 2012 | Pubmed ID: 22710160 USP4 is Regulated by AKT Phosphorylation and Directly Deubiquitylates TGF-β Type I Receptor Nature Cell Biology. Jun, 2012 | Pubmed ID: 22706160 TGFβ Signaling in Liver Regeneration Current Pharmaceutical Design. 2012 | Pubmed ID: 22630085 Deregulated Bone Morphogenetic Protein Receptor Signaling Underlies Fibrodysplasia Ossificans Progressiva Current Pharmaceutical Design. 2012 | Pubmed ID: 22630080 Role of Endoglin in Fibrosis and Scleroderma International Review of Cell and Molecular Biology. 2012 | Pubmed ID: 22608563 LRP8 Mediates Wnt/β-catenin Signaling and Controls Osteoblast Differentiation Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research. Oct, 2012 | Pubmed ID: 22589174 RNF12 Controls Embryonic Stem Cell Fate and Morphogenesis in Zebrafish Embryos by Targeting Smad7 for Degradation Molecular Cell. Jun, 2012 | Pubmed ID: 22560923 Anti-human Activin Receptor-like Kinase 1 (ALK1) Antibody Attenuates Bone Morphogenetic Protein 9 (BMP9)-induced ALK1 Signaling and Interferes with Endothelial Cell Sprouting The Journal of Biological Chemistry. May, 2012 | Pubmed ID: 22493445 Shear Induced Collateral Artery Growth Modulated by Endoglin but Not by ALK1 Journal of Cellular and Molecular Medicine. Oct, 2012 | Pubmed ID: 22436015 Vanilloid Receptor-1 Regulates Neurogenic Inflammation in Colon and Protects Mice from Colon Cancer Cancer Research. Apr, 2012 | Pubmed ID: 22396497 TGF-β Signaling in Endothelial-to-mesenchymal Transition: the Role of Shear Stress and Primary Cilia Science Signaling. Feb, 2012 | Pubmed ID: 22355187 Key Role for Ubiquitin Protein Modification in TGFβ Signal Transduction Upsala Journal of Medical Sciences. Feb, 2012 | Pubmed ID: 22335355 Wnt/β-catenin Signaling Changes C2C12 Myoblast Proliferation and Differentiation by Inducing Id3 Expression Biochemical and Biophysical Research Communications. Feb, 2012 | Pubmed ID: 22326917 Key Signaling Nodes in Mammary Gland Development and Cancer: Smad Signal Integration in Epithelial Cell Plasticity Breast Cancer Research : BCR. Feb, 2012 | Pubmed ID: 22315972 A Covalently Dimerized Recombinant Human Bone Morphogenetic Protein-15 Variant Identifies Bone Morphogenetic Protein Receptor Type 1B As a Key Cell Surface Receptor on Ovarian Granulosa Cells Endocrinology. Jan, 2012 | Pubmed ID: 22294741 Non-synonymous Variants in the SMAD6 Gene Predispose to Congenital Cardiovascular Malformation Human Mutation. Jan, 2012 | Pubmed ID: 22275001 Ubiquitin-specific Protease 4 Mitigates Toll-like/interleukin-1 Receptor Signaling and Regulates Innate Immune Activation The Journal of Biological Chemistry. Jan, 2012 | Pubmed ID: 22262844 TGFβ Signaling and Cardiovascular Diseases International Journal of Biological Sciences. 2012 | Pubmed ID: 22253564 TGF-β in Progression of Liver Disease Cell and Tissue Research. Jan, 2012 | Pubmed ID: 22006249 BMP-7 Inhibits TGF-β-induced Invasion of Breast Cancer Cells Through Inhibition of Integrin β(3) Expression Cellular Oncology (Dordrecht). Feb, 2012 | Pubmed ID: 21935711 Regulation of Endothelial Cell Plasticity by TGF-β Cell and Tissue Research. Jan, 2012 | Pubmed ID: 21866313 Age-dependent Alteration of TGF-β Signalling in Osteoarthritis Cell and Tissue Research. Jan, 2012 | Pubmed ID: 21638205 Regulation of Endothelial Barrier Function by TGF-β Type I Receptor ALK5: Potential Role of Contractile Mechanisms and Heat Shock Protein 90 Journal of Cellular Physiology. Feb, 2012 | Pubmed ID: 21465483 Cell-type Specific Regulation of Myostatin Signaling The FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Dec, 2011 | Pubmed ID: 22202673 Temporal Smad7 Transgene Induction in Mouse Epidermis Accelerates Skin Wound Healing The American Journal of Pathology. Oct, 2011 | Pubmed ID: 21944279 GSK3β Inactivation Induces Apoptosis of Leukemia Cells by Repressing the Function of C-Myb Molecular Biology of the Cell. Sep, 2011 | Pubmed ID: 21795403 Controlling Angiogenesis by Two Unique TGF-β Type I Receptor Signaling Pathways Histology and Histopathology. Sep, 2011 | Pubmed ID: 21751154 Exploring Anti-TGF-β Therapies in Cancer and Fibrosis Growth Factors (Chur, Switzerland). Aug, 2011 | Pubmed ID: 21718111 Elevated Transforming Growth Factor β and Mitogen-activated Protein Kinase Pathways Mediate Fibrotic Traits of Dupuytren's Disease Fibroblasts Fibrogenesis & Tissue Repair. 2011 | Pubmed ID: 21711521 TGF-β Receptor Signaling Pathways in Angiogenesis; Emerging Targets for Anti-Angiogenesis Therapy Current Pharmaceutical Biotechnology. May, 2011 | Pubmed ID: 21619534 Biphasic Effects of Transforming Growth Factor β on Bone Morphogenetic Protein-induced Osteoblast Differentiation Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research. Jun, 2011 | Pubmed ID: 21611961 Tgfβ/Alk5 Signaling is Required for Shear Stress Induced Klf2 Expression in Embryonic Endothelial Cells Developmental Dynamics : an Official Publication of the American Association of Anatomists. Jul, 2011 | Pubmed ID: 21604321 Dual Exon Skipping in Myostatin and Dystrophin for Duchenne Muscular Dystrophy BMC Medical Genomics. 2011 | Pubmed ID: 21507246 TGF-β Signaling in Breast Cancer Cell Invasion and Bone Metastasis Journal of Mammary Gland Biology and Neoplasia. Jun, 2011 | Pubmed ID: 21494783 TGF-β1/ALK5-induced Monocyte Migration Involves PI3K and P38 Pathways and is Not Negatively Affected by Diabetes Mellitus Cardiovascular Research. Aug, 2011 | Pubmed ID: 21478266 Fas-associated Factor 1 Antagonizes Wnt Signaling by Promoting β-catenin Degradation Molecular Biology of the Cell. May, 2011 | Pubmed ID: 21411632 Lack of Primary Cilia Primes Shear-induced Endothelial-to-mesenchymal Transition Circulation Research. Apr, 2011 | Pubmed ID: 21393577 Endoglin Promotes TGF-β/Smad1 Signaling in Scleroderma Fibroblasts Journal of Cellular Physiology. Dec, 2011 | Pubmed ID: 21344387 ALK2 Mutation in a Patient with Down's Syndrome and a Congenital Heart Defect European Journal of Human Genetics : EJHG. Apr, 2011 | Pubmed ID: 21248739 TGFbeta Activates Mitogen- and Stress-activated Protein Kinase-1 (MSK1) to Attenuate Cell Death The Journal of Biological Chemistry. Feb, 2011 | Pubmed ID: 21106525 The Dynamic Roles of TGF-β in Cancer The Journal of Pathology. Jan, 2011 | Pubmed ID: 20957627 Activin A Induces a Non-fibrotic Phenotype in Smooth Muscle Cells in Contrast to TGF-β Experimental Cell Research. Jan, 2011 | Pubmed ID: 20955695 BMP Antagonists Enhance Myogenic Differentiation and Ameliorate the Dystrophic Phenotype in a DMD Mouse Model Neurobiology of Disease. Feb, 2011 | Pubmed ID: 20940052 The TGF-β/Smad Pathway Induces Breast Cancer Cell Invasion Through the Up-regulation of Matrix Metalloproteinase 2 and 9 in a Spheroid Invasion Model System Breast Cancer Research and Treatment. Aug, 2011 | Pubmed ID: 20821046 Biphasic Effects of Transforming Growth Factor-β on Bone Morphogenetic Protein-induced Osteoblast Differentiation Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research. Dec, 2010 | Pubmed ID: 21162084 Measurement of Constitutive Activity of BMP Type I Receptors Methods in Enzymology. 2010 | Pubmed ID: 21036238 Distinct Modes of Inhibition by Sclerostin on Bone Morphogenetic Protein and Wnt Signaling Pathways The Journal of Biological Chemistry. Dec, 2010 | Pubmed ID: 20952383 Signaling by Members of the TGF-beta Family in Vascular Morphogenesis and Disease Trends in Cell Biology. Sep, 2010 | Pubmed ID: 20656490 Integration of Transcriptional Signals at the Tumor Cell Invasive Front Cell Cycle (Georgetown, Tex.). Jul, 2010 | Pubmed ID: 20647778 Elevated TGFbeta-Smad Signalling in Experimental Pkd1 Models and Human Patients with Polycystic Kidney Disease The Journal of Pathology. Sep, 2010 | Pubmed ID: 20549648 In Situ Proximity Ligation Detection of C-Jun/AP-1 Dimers Reveals Increased Levels of C-Jun/Fra1 Complexes in Aggressive Breast Cancer Cell Lines in Vitro and in Vivo Molecular & Cellular Proteomics : MCP. Sep, 2010 | Pubmed ID: 20511396 Matrix Metalloproteinase-14 (MT1-MMP)-mediated Endoglin Shedding Inhibits Tumor Angiogenesis Cancer Research. May, 2010 | Pubmed ID: 20424116 Annexin A1 Regulates TGF-beta Signaling and Promotes Metastasis Formation of Basal-like Breast Cancer Cells Proceedings of the National Academy of Sciences of the United States of America. Apr, 2010 | Pubmed ID: 20308542 TMEPAI, a Transmembrane TGF-beta-inducible Protein, Sequesters Smad Proteins from Active Participation in TGF-beta Signaling Molecular Cell. Jan, 2010 | Pubmed ID: 20129061 Genetic and Pharmacological Targeting of Activin Receptor-like Kinase 1 Impairs Tumor Growth and Angiogenesis The Journal of Experimental Medicine. Jan, 2010 | Pubmed ID: 20065063 Identification of a Key Residue Mediating Bone Morphogenetic Protein (BMP)-6 Resistance to Noggin Inhibition Allows for Engineered BMPs with Superior Agonist Activity The Journal of Biological Chemistry. Apr, 2010 | Pubmed ID: 20048150 ALK2 R206H Mutation Linked to Fibrodysplasia Ossificans Progressiva Confers Constitutive Activity to the BMP Type I Receptor and Sensitizes Mesenchymal Cells to BMP-induced Osteoblast Differentiation and Bone Formation Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research. Jun, 2010 | Pubmed ID: 19929436 5-Aminosalicylic Acid Inhibits TGF-beta1 Signalling in Colorectal Cancer Cells Cancer Letters. Jan, 2010 | Pubmed ID: 19541409 Autocrine Bone Morphogenetic Protein-9 Signals Through Activin Receptor-like Kinase-2/Smad1/Smad4 to Promote Ovarian Cancer Cell Proliferation Cancer Research. Dec, 2009 | Pubmed ID: 19996292 VEGF and Inhibitors of TGFbeta Type-I Receptor Kinase Synergistically Promote Blood-vessel Formation by Inducing Alpha5-integrin Expression Journal of Cell Science. Sep, 2009 | Pubmed ID: 19706683 Smad3 is a Key Nonredundant Mediator of Transforming Growth Factor Beta Signaling in Nme Mouse Mammary Epithelial Cells Molecular Cancer Research : MCR. Aug, 2009 | Pubmed ID: 19671686 Endoglin Haploinsufficiency Reduces Radiation-induced Fibrosis and Telangiectasia Formation in Mouse Kidneys Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology. Sep, 2009 | Pubmed ID: 19576647 Dominant-negative ALK2 Allele Associates with Congenital Heart Defects Circulation. Jun, 2009 | Pubmed ID: 19506109 Transforming Growth Factor-beta Signaling and Tumor Angiogenesis Frontiers in Bioscience : a Journal and Virtual Library. 2009 | Pubmed ID: 19482591 Poor Vessel Formation in Embryos from Knock-in Mice Expressing ALK5 with L45 Loop Mutation Defective in Smad Activation Laboratory Investigation; a Journal of Technical Methods and Pathology. Jul, 2009 | Pubmed ID: 19398960 Ionizing Radiation Shifts the PAI-1/ID-1 Balance and Activates Notch Signaling in Endothelial Cells International Journal of Radiation Oncology, Biology, Physics. Feb, 2009 | Pubmed ID: 19147015 TGF-beta Signaling in Vascular Biology and Dysfunction Cell Research. Jan, 2009 | Pubmed ID: 19114994 Ski Co-repressor Complexes Maintain the Basal Repressed State of the TGF-beta Target Gene, SMAD7, Via HDAC3 and PRMT5 Genes to Cells : Devoted to Molecular & Cellular Mechanisms. Jan, 2009 | Pubmed ID: 19032343 Transforming Growth Factor Beta-induced Endothelial-to-mesenchymal Transition: a Switch to Cardiac Fibrosis? Trends in Cardiovascular Medicine. Nov, 2008 | Pubmed ID: 19345316 Smad1 Pathway is Activated in Systemic Sclerosis Fibroblasts and is Targeted by Imatinib Mesylate Arthritis and Rheumatism. Aug, 2008 | Pubmed ID: 18668566 The Bone Morphogenetic Protein Pathway is Inactivated in the Majority of Sporadic Colorectal Cancers Gastroenterology. May, 2008 | Pubmed ID: 18471510 VE-cadherin is a Critical Endothelial Regulator of TGF-beta Signalling The EMBO Journal. Apr, 2008 | Pubmed ID: 18337748 ALK1 Opposes ALK5/Smad3 Signaling and Expression of Extracellular Matrix Components in Human Chondrocytes Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research. Jun, 2008 | Pubmed ID: 18333754 L- and S-endoglin Differentially Modulate TGFbeta1 Signaling Mediated by ALK1 and ALK5 in L6E9 Myoblasts Journal of Cell Science. Mar, 2008 | Pubmed ID: 18303046 Osteocyte-derived Sclerostin Inhibits Bone Formation: Its Role in Bone Morphogenetic Protein and Wnt Signaling The Journal of Bone and Joint Surgery. American Volume. Feb, 2008 | Pubmed ID: 18292354 Endoglin in Angiogenesis and Vascular Diseases Angiogenesis. 2008 | Pubmed ID: 18283546 Two Novel Type II Receptors Mediate BMP Signalling and Are Required to Establish Left-right Asymmetry in Zebrafish Developmental Biology. Mar, 2008 | Pubmed ID: 18222420 Transforming Growth Factor Beta and Wound Healing in Human Cholesteatoma The Laryngoscope. Jan, 2008 | Pubmed ID: 17989584 Compensatory Signalling Induced in the Yolk Sac Vasculature by Deletion of TGFbeta Receptors in Mice Journal of Cell Science. Dec, 2007 | Pubmed ID: 18029401 TGF-beta and BMP7 Interactions in Tumour Progression and Bone Metastasis Clinical & Experimental Metastasis. 2007 | Pubmed ID: 18008174 Extracellular Control of TGFbeta Signalling in Vascular Development and Disease Nature Reviews. Molecular Cell Biology. Nov, 2007 | Pubmed ID: 17895899 A Rapid and Sensitive Bioassay to Measure Bone Morphogenetic Protein Activity BMC Cell Biology. 2007 | Pubmed ID: 17880711 Bone Morphogenetic Protein 7 in the Development and Treatment of Bone Metastases from Breast Cancer Cancer Research. Sep, 2007 | Pubmed ID: 17875715 BMP7, a Putative Regulator of Epithelial Homeostasis in the Human Prostate, is a Potent Inhibitor of Prostate Cancer Bone Metastasis in Vivo The American Journal of Pathology. Sep, 2007 | Pubmed ID: 17724140 Induction of Sonic Hedgehog Mediators by Transforming Growth Factor-beta: Smad3-dependent Activation of Gli2 and Gli1 Expression in Vitro and in Vivo Cancer Research. Jul, 2007 | Pubmed ID: 17638910 Signaling by ALK5 Mediates TGF-beta-induced ET-1 Expression in Endothelial Cells: a Role for Migration and Proliferation Journal of Cell Science. Apr, 2007 | Pubmed ID: 17376964 Transforming Growth Factor-beta Receptor Type I-dependent Fibrogenic Gene Program is Mediated Via Activation of Smad1 and ERK1/2 Pathways The Journal of Biological Chemistry. Apr, 2007 | Pubmed ID: 17317656 Negative Regulation of TGF-beta Receptor/Smad Signal Transduction Current Opinion in Cell Biology. Apr, 2007 | Pubmed ID: 17317136 Aberrant Bmp Signaling and Notochord Delamination in the Pathogenesis of Esophageal Atresia Developmental Dynamics : an Official Publication of the American Association of Anatomists. Mar, 2007 | Pubmed ID: 17260385 SOST Expression is Restricted to the Great Arteries During Embryonic and Neonatal Cardiovascular Development Developmental Dynamics : an Official Publication of the American Association of Anatomists. Feb, 2007 | Pubmed ID: 17195180 KLF2 Suppresses TGF-beta Signaling in Endothelium Through Induction of Smad7 and Inhibition of AP-1 Arteriosclerosis, Thrombosis, and Vascular Biology. Mar, 2007 | Pubmed ID: 17194892 Wnt but Not BMP Signaling is Involved in the Inhibitory Action of Sclerostin on BMP-stimulated Bone Formation Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research. Jan, 2007 | Pubmed ID: 17032150 Methylation of Smad6 by Protein Arginine N-methyltransferase 1 FEBS Letters. Dec, 2006 | Pubmed ID: 17118358 Endoglin Has a Crucial Role in Blood Cell-mediated Vascular Repair Circulation. Nov, 2006 | Pubmed ID: 17088457 A Rate Equation Approach to Elucidate the Kinetics and Robustness of the TGF-beta Pathway Biophysical Journal. Dec, 2006 | Pubmed ID: 17012329 Smad7-induced Beta-catenin Degradation Alters Epidermal Appendage Development Developmental Cell. Sep, 2006 | Pubmed ID: 16950122 Id1 is a Critical Mediator in TGF-beta-induced Transdifferentiation of Rat Hepatic Stellate Cells Hepatology (Baltimore, Md.). May, 2006 | Pubmed ID: 16628634 Smad7 and Protein Phosphatase 1alpha Are Critical Determinants in the Duration of TGF-beta/ALK1 Signaling in Endothelial Cells BMC Cell Biology. 2006 | Pubmed ID: 16571110 The Tumor Suppressor Smad4 is Required for Transforming Growth Factor Beta-induced Epithelial to Mesenchymal Transition and Bone Metastasis of Breast Cancer Cells Cancer Research. Feb, 2006 | Pubmed ID: 16489022 Transforming Growth Factor-beta Signal Transduction in Angiogenesis and Vascular Disorders Chest. Dec, 2005 | Pubmed ID: 16373850 The Deubiquitinating Enzyme UCH37 Interacts with Smads and Regulates TGF-beta Signalling Oncogene. Dec, 2005 | Pubmed ID: 16027725 Global Analysis of Smad2/3-dependent TGF-beta Signaling in Living Mice Reveals Prominent Tissue-specific Responses to Injury Journal of Immunology (Baltimore, Md. : 1950). Jul, 2005 | Pubmed ID: 15972691 Transforming Growth Factor-beta1 to the Bone Endocrine Reviews. Oct, 2005 | Pubmed ID: 15901668 SOST/sclerostin, an Osteocyte-derived Negative Regulator of Bone Formation Cytokine & Growth Factor Reviews. Jun, 2005 | Pubmed ID: 15869900 New Mechanisms of Skin Innate Immunity: ASK1-mediated Keratinocyte Differentiation Regulates the Expression of Beta-defensins, LL37, and TLR2 European Journal of Immunology. Jun, 2005 | Pubmed ID: 15864780 TGF-beta Receptor Function in the Endothelium Cardiovascular Research. Feb, 2005 | Pubmed ID: 15664386 Defective Paracrine Signalling by TGFbeta in Yolk Sac Vasculature of Endoglin Mutant Mice: a Paradigm for Hereditary Haemorrhagic Telangiectasia Development (Cambridge, England). Dec, 2004 | Pubmed ID: 15548578 Endoglin Promotes Endothelial Cell Proliferation and TGF-beta/ALK1 Signal Transduction The EMBO Journal. Oct, 2004 | Pubmed ID: 15385967 Connective Tissue Growth Factor Expression and Smad Signaling During Mouse Heart Development and Myocardial Infarction Developmental Dynamics : an Official Publication of the American Association of Anatomists. Nov, 2004 | Pubmed ID: 15376321 Spatio-temporal Activation of Smad1 and Smad5 in Vivo: Monitoring Transcriptional Activity of Smad Proteins Journal of Cell Science. Sep, 2004 | Pubmed ID: 15331632 RLP, a Novel Ras-like Protein, is an Immediate-early Transforming Growth Factor-beta (TGF-beta) Target Gene That Negatively Regulates Transcriptional Activity Induced by TGF-beta The Biochemical Journal. Oct, 2004 | Pubmed ID: 15239668 New Insights into TGF-beta-Smad Signalling Trends in Biochemical Sciences. May, 2004 | Pubmed ID: 15130563 Sclerostin is an Osteocyte-expressed Negative Regulator of Bone Formation, but Not a Classical BMP Antagonist The Journal of Experimental Medicine. Mar, 2004 | Pubmed ID: 15024046 Nerve Growth Factor Mediates Activation of the Smad Pathway in PC12 Cells European Journal of Biochemistry / FEBS. Mar, 2004 | Pubmed ID: 15009204 Controlling Cell Fate by Bone Morphogenetic Protein Receptors Molecular and Cellular Endocrinology. Dec, 2003 | Pubmed ID: 14656483 Activin Receptor-like Kinase (ALK)1 is an Antagonistic Mediator of Lateral TGFbeta/ALK5 Signaling Molecular Cell. Oct, 2003 | Pubmed ID: 14580334 Controlling Mesenchymal Stem Cell Differentiation by TGFBeta Family Members Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association. 2003 | Pubmed ID: 14557946 Signal Transduction of Bone Morphogenetic Proteins in Osteoblast Differentiation The Journal of Bone and Joint Surgery. American Volume. 2003 | Pubmed ID: 12925607 Gene Array Analysis of Bone Morphogenetic Protein Type I Receptor-induced Osteoblast Differentiation Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research. Jul, 2003 | Pubmed ID: 12854827 Smad7 Prevents Activation of Hepatic Stellate Cells and Liver Fibrosis in Rats Gastroenterology. Jul, 2003 | Pubmed ID: 12851882 Nuclear Factor YY1 Inhibits Transforming Growth Factor Beta- and Bone Morphogenetic Protein-induced Cell Differentiation Molecular and Cellular Biology. Jul, 2003 | Pubmed ID: 12808092 Distribution of Phosphorylated Smad2 Identifies Target Tissues of TGF Beta Ligands in Mouse Development Gene Expression Patterns : GEP. Jun, 2003 | Pubmed ID: 12799085 DSmurf Selectively Degrades Decapentaplegic-activated MAD, and Its Overexpression Disrupts Imaginal Disc Development The Journal of Biological Chemistry. Jul, 2003 | Pubmed ID: 12754252 Smad Protein and TGF-beta Signaling in Vascular Smooth Muscle Cells International Journal of Molecular Medicine. May, 2003 | Pubmed ID: 12684705 Synthetic Triterpenoids Enhance Transforming Growth Factor Beta/Smad Signaling Cancer Research. Mar, 2003 | Pubmed ID: 12649201 Transforming Growth Factor-beta1 (TGF-beta)-induced Apoptosis of Prostate Cancer Cells Involves Smad7-dependent Activation of P38 by TGF-beta-activated Kinase 1 and Mitogen-activated Protein Kinase Kinase 3 Molecular Biology of the Cell. Feb, 2003 | Pubmed ID: 12589052 Growth Differentiation Factor-9 Induces Smad2 Activation and Inhibin B Production in Cultured Human Granulosa-luteal Cells The Journal of Clinical Endocrinology and Metabolism. Feb, 2003 | Pubmed ID: 12574210 Transforming Growth Factor-beta 1 Mutations in Camurati-Engelmann Disease Lead to Increased Signaling by Altering Either Activation or Secretion of the Mutant Protein The Journal of Biological Chemistry. Feb, 2003 | Pubmed ID: 12493741 Elucidation of Smad Requirement in Transforming Growth Factor-beta Type I Receptor-induced Responses The Journal of Biological Chemistry. Feb, 2003 | Pubmed ID: 12446693 BMP Pathways Are Involved in Otic Capsule Formation and Epithelial-mesenchymal Signaling in the Developing Chicken Inner Ear Developmental Biology. Nov, 2002 | Pubmed ID: 12435365 Stimulation of Id1 Expression by Bone Morphogenetic Protein is Sufficient and Necessary for Bone Morphogenetic Protein-induced Activation of Endothelial Cells Circulation. Oct, 2002 | Pubmed ID: 12390958 Immunohistochemical Localization of Osteogenetic Protein (OP-1) and Its Receptors in Rabbit Articular Cartilage The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. Oct, 2002 | Pubmed ID: 12364567 Engagement of Activin and Bone Morphogenetic Protein Signaling Pathway Smad Proteins in the Induction of Inhibin B Production in Ovarian Granulosa Cells Molecular and Cellular Endocrinology. Sep, 2002 | Pubmed ID: 12354674 Activation of Bone Morphogenetic Protein/Smad Signaling in Bronchial Epithelial Cells During Airway Inflammation American Journal of Respiratory Cell and Molecular Biology. Aug, 2002 | Pubmed ID: 12151307 Overexpression of Smad7 Results in Severe Pathological Alterations in Multiple Epithelial Tissues The EMBO Journal. Jun, 2002 | Pubmed ID: 12032071 Transforming Growth Factor Beta Signal Transduction Journal of Leukocyte Biology. May, 2002 | Pubmed ID: 11994497 Balancing the Activation State of the Endothelium Via Two Distinct TGF-beta Type I Receptors The EMBO Journal. Apr, 2002 | Pubmed ID: 11927558 Regulation of Cell Proliferation by Smad Proteins Journal of Cellular Physiology. Apr, 2002 | Pubmed ID: 11920677 Deficient Smad7 Expression: a Putative Molecular Defect in Scleroderma Proceedings of the National Academy of Sciences of the United States of America. Mar, 2002 | Pubmed ID: 11904440 Action Range of BMP is Defined by Its N-terminal Basic Amino Acid Core Current Biology : CB. Feb, 2002 | Pubmed ID: 11839272 Physical and Functional Interaction Between GATA-3 and Smad3 Allows TGF-beta Regulation of GATA Target Genes Current Biology : CB. Jan, 2002 | Pubmed ID: 11790301 Transient Disruption of Autocrine TGF-beta Signaling Leads to Enhanced Survival and Proliferation Potential in Single Primitive Human Hemopoietic Progenitor Cells Journal of Immunology (Baltimore, Md. : 1950). Jan, 2002 | Pubmed ID: 11777969 Identification and Functional Characterization of Distinct Critically Important Bone Morphogenetic Protein-specific Response Elements in the Id1 Promoter The Journal of Biological Chemistry. Feb, 2002 | Pubmed ID: 11729207 Deubiquitinase Activity Profiling Identifies UCHL1 As a Candidate Oncoprotein That Promotes TGFβ-Induced Breast Cancer Metastasis Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. | Pubmed ID: 31857432 टीजीएफ-β-मध्यस्थता एंडोथेलियल से मेसेंचिमल ट्रांजिशन (एंडएमटी) और CRISPR/Cas9 जीन संपादन का उपयोग करके एंडएमटी प्रभावकर्ताओं का कार्यात्मक मूल्यांकन Jin Ma1,2, Gerard van der Zon1,2, Gonzalo Sanchez-Duffhues1, Peter ten Dijke1,2 1Dept. Cell Chemical Biology, Leiden University Medical Center, 2Oncode Institute, Leiden University Medical Center JoVE 62198 Biology स्तन कैंसर और सामान्य कोशिकाओं में टीजीएफ-β सिग्नलिंग और टीजीएफ-β-प्रेरित एपिथेलियल-टू-मेसेन्चिमल संक्रमण का अध्ययन Jing Zhang1, Midory Thorikay1, Gerard van der Zon1, Maarten van Dinther1, Peter ten Dijke1 1Oncode Institute and Department of Cell Chemical Biology, Leiden University Medical Center JoVE 61830 Cancer Research भ्रूणीय Zebrafish में मानव स्तन कैंसर की कोशिकाओं के आक्रामक व्यवहार Jiang Ren*1, Sijia Liu*1, Chao Cui1, Peter ten Dijke1 1Department of Molecular Cell Biology, Cancer Genomics Centre Netherlands, Leiden University Medical Center JoVE 55459 Cancer Research उपगोल TGF-β प्रेरित आक्रमण उपाय परख Hildegonda P.H. Naber1, Eliza Wiercinska1, Peter ten Dijke1, Theo van Laar1 1Department of Molecular Cell Biology and Centre for Biomedial Genetics, Leiden University Medical Centre JoVE 3337 Medicine
टीजीएफ-β-मध्यस्थता एंडोथेलियल से मेसेंचिमल ट्रांजिशन (एंडएमटी) और CRISPR/Cas9 जीन संपादन का उपयोग करके एंडएमटी प्रभावकर्ताओं का कार्यात्मक मूल्यांकन Jin Ma1,2, Gerard van der Zon1,2, Gonzalo Sanchez-Duffhues1, Peter ten Dijke1,2 1Dept. Cell Chemical Biology, Leiden University Medical Center, 2Oncode Institute, Leiden University Medical Center JoVE 62198 Biology
स्तन कैंसर और सामान्य कोशिकाओं में टीजीएफ-β सिग्नलिंग और टीजीएफ-β-प्रेरित एपिथेलियल-टू-मेसेन्चिमल संक्रमण का अध्ययन Jing Zhang1, Midory Thorikay1, Gerard van der Zon1, Maarten van Dinther1, Peter ten Dijke1 1Oncode Institute and Department of Cell Chemical Biology, Leiden University Medical Center JoVE 61830 Cancer Research
भ्रूणीय Zebrafish में मानव स्तन कैंसर की कोशिकाओं के आक्रामक व्यवहार Jiang Ren*1, Sijia Liu*1, Chao Cui1, Peter ten Dijke1 1Department of Molecular Cell Biology, Cancer Genomics Centre Netherlands, Leiden University Medical Center JoVE 55459 Cancer Research
उपगोल TGF-β प्रेरित आक्रमण उपाय परख Hildegonda P.H. Naber1, Eliza Wiercinska1, Peter ten Dijke1, Theo van Laar1 1Department of Molecular Cell Biology and Centre for Biomedial Genetics, Leiden University Medical Centre JoVE 3337 Medicine
