Petra Knaus Institute for Chemistry and Biochemistry Freie Universität Berlin Biography Publications Institution JoVE Articles Petra Knaus has not added a biography. If you are Petra Knaus and would like to personalize this page please email our Author Liaison for assistance. Publications Optimized Expression and Purification of a Soluble BMP2 Variant Based on In-silico Design Protein Expression and Purification. Oct, 2021 | Pubmed ID: 34044133 ActivinA Induced SMAD1/5 Signaling in an IPSC Derived EC Model of Fibrodysplasia Ossificans Progressiva (FOP) Can Be Rescued by the Drug Candidate Saracatinib Stem Cell Reviews and Reports. Jun, 2021 | Pubmed ID: 33410098 Antagonistic Activities of Vegfr3/Flt4 and Notch1b Fine-tune Mechanosensitive Signaling During Zebrafish Cardiac Valvulogenesis Cell Reports. 07, 2020 | Pubmed ID: 32668254 BMP Signalling in a Mechanical Context - Implications for Bone Biology Bone. 08, 2020 | Pubmed ID: 32422297 Biomechanical Stress Provides a Second Hit in the Establishment of BMP/TGFβ-related Vascular Disorders Cell Stress. Jan, 2020 | Pubmed ID: 32043077 AMOT130 Drives BMP-SMAD Signaling at the Apical Membrane in Polarized Cells Molecular Biology of the Cell. 01, 2020 | Pubmed ID: 31800378 BMPR2 Acts As A gatekeeper to Protect Endothelial Cells from Increased TGFβ responses and Altered Cell Mechanics PLoS Biology. 12, 2019 | Pubmed ID: 31826007 Sex-specific Metabolic and Functional Differences in Human Umbilical Vein Endothelial Cells from Twin Pairs Atherosclerosis. 12, 2019 | Pubmed ID: 31706078 Lessons from LIMK1 Enzymology and Their Impact on Inhibitor Design The Biochemical Journal. 11, 2019 | Pubmed ID: 31652302 Is NO the Answer? The Nitric Oxide Pathway Can Support Bone Morphogenetic Protein 2 Mediated Signaling Cells. 10, 2019 | Pubmed ID: 31635347 Load-induced Osteogenic Differentiation of Mesenchymal Stromal Cells is Caused by Mechano-regulated Autocrine Signaling Journal of Tissue Engineering and Regenerative Medicine. 11, 2019 | Pubmed ID: 31359634 Cofilin-1 Phosphorylation Catalyzed by ERK1/2 Alters Cardiac Actin Dynamics in Dilated Cardiomyopathy Caused by Lamin A/C Gene Mutation Human Molecular Genetics. 09, 2018 | Pubmed ID: 29878125 Impaired Proteoglycan Glycosylation, Elevated TGF-β Signaling, and Abnormal Osteoblast Differentiation As the Basis for Bone Fragility in a Mouse Model for Gerodermia Osteodysplastica PLoS Genetics. 03, 2018 | Pubmed ID: 29561836 Cell-specific Responses to the Cytokine TGFβ Are Determined by Variability in Protein Levels Molecular Systems Biology. 01, 2018 | Pubmed ID: 29371237 Enhanced Biological Activity of BMP-2 Bound to Surface-Grafted Heparan Sulfate Advanced Biosystems. Apr, 2017 | Pubmed ID: 32646162 Correction for Bagarova Et Al., "Constitutively Active ALK2 Receptor Mutants Require Type II Receptor Cooperation" Molecular and Cellular Biology. 10, 2017 | Pubmed ID: 28899999 IRS4, a Novel Modulator of BMP/Smad and Akt Signalling During Early Muscle Differentiation Scientific Reports. 08, 2017 | Pubmed ID: 28821740 Role of Bone Morphogenetic Proteins in Sprouting Angiogenesis: Differential BMP Receptor-dependent Signaling Pathways Balance Stalk Tip Cell Competence FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. 11, 2017 | Pubmed ID: 28733457 The Role of Titanium Surface Nanostructuring on Preosteoblast Morphology, Adhesion, and Migration Advanced Healthcare Materials. Aug, 2017 | Pubmed ID: 28371540 Dynamin-dependent Endocytosis of Bone Morphogenetic Protein2 (BMP2) and Its Receptors is Dispensable for the Initiation of Smad Signaling The International Journal of Biochemistry & Cell Biology. 07, 2016 | Pubmed ID: 27113717 YAP-Mediated Mechanotransduction in Skeletal Muscle Frontiers in Physiology. 2016 | Pubmed ID: 26909043 Emerging Regulators of BMP Bioavailability Bone. Dec, 2016 | Pubmed ID: 26825814 Actions from Head to Toe: An Update on Bone/Body Morphogenetic Proteins in Health and Disease Cytokine & Growth Factor Reviews. Feb, 2016 | Pubmed ID: 26803465 VE-cadherin Facilitates BMP-induced Endothelial Cell Permeability and Signaling Journal of Cell Science. Jan, 2016 | Pubmed ID: 26598555 Bone Morphogenetic Protein Signaling in Bone Homeostasis Bone. Nov, 2015 | Pubmed ID: 26051467 Small Molecules Dorsomorphin and LDN-193189 Inhibit Myostatin/GDF8 Signaling and Promote Functional Myoblast Differentiation The Journal of Biological Chemistry. Feb, 2015 | Pubmed ID: 25368322 BMP10 As a Potent Inducer of Trophoblast Differentiation in Human Embryonic and Induced Pluripotent Stem Cells Biomaterials. Dec, 2013 | Pubmed ID: 24070570 Growth and Differentiation Factor 3 Induces Expression of Genes Related to Differentiation in a Model of Cancer Stem Cells and Protects Them from Retinoic Acid-induced Apoptosis PloS One. 2013 | Pubmed ID: 23950971 Constitutively Active ALK2 Receptor Mutants Require Type II Receptor Cooperation Molecular and Cellular Biology. Jun, 2013 | Pubmed ID: 23572558 Structure of the Bone Morphogenetic Protein Receptor ALK2 and Implications for Fibrodysplasia Ossificans Progressiva The Journal of Biological Chemistry. Oct, 2012 | Pubmed ID: 22977237 SMAD Versus Non-SMAD Signaling is Determined by Lateral Mobility of Bone Morphogenetic Protein (BMP) Receptors The Journal of Biological Chemistry. Nov, 2012 | Pubmed ID: 22961979 BMPs Are Mediators in Tissue Crosstalk of the Regenerating Musculoskeletal System Cell and Tissue Research. Mar, 2012 | Pubmed ID: 22327483 A Portrait of Transforming Growth Factor β Superfamily Signalling: Background Matters The International Journal of Biochemistry & Cell Biology. Mar, 2012 | Pubmed ID: 22226817 Comprehensive Analysis of TGF-β and BMP Receptor Interactomes European Journal of Cell Biology. Apr, 2012 | Pubmed ID: 21715044 MicroRNAs Differentially Expressed in Postnatal Aortic Development Downregulate Elastin Via 3' UTR and Coding-sequence Binding Sites PloS One. Jan, 2011 | Pubmed ID: 21305018 Noggin The International Journal of Biochemistry & Cell Biology. Apr, 2011 | Pubmed ID: 21256973 Quantitative Analysis of TGFBR2 Mutations in Marfan-syndrome-related Disorders Suggests a Correlation Between Phenotypic Severity and Smad Signaling Activity Journal of Cell Science. Dec, 2010 | Pubmed ID: 21098638 Recent Advances in BMP Receptor Signaling Cytokine & Growth Factor Reviews. Oct-Dec, 2009 | Pubmed ID: 19897402 Monomeric and Dimeric GDF-5 Show Equal Type I Receptor Binding and Oligomerization Capability and Have the Same Biological Activity Biological Chemistry. Apr, 2006 | Pubmed ID: 16606344 Activating and Deactivating Mutations in the Receptor Interaction Site of GDF5 Cause Symphalangism or Brachydactyly Type A2 The Journal of Clinical Investigation. Sep, 2005 | Pubmed ID: 16127465 Visualization and Quantification of TGFβ/BMP/SMAD Signaling under Different Fluid Shear Stress Conditions using Proximity-Ligation-Assay Paul-Lennard Mendez1,2, Leon Obendorf1, Petra Knaus1 1Institute for Chemistry and Biochemistry, Freie Universität Berlin, 2International Max-Planck Research School for Biology and Computation JoVE 62608 Biochemistry
Visualization and Quantification of TGFβ/BMP/SMAD Signaling under Different Fluid Shear Stress Conditions using Proximity-Ligation-Assay Paul-Lennard Mendez1,2, Leon Obendorf1, Petra Knaus1 1Institute for Chemistry and Biochemistry, Freie Universität Berlin, 2International Max-Planck Research School for Biology and Computation JoVE 62608 Biochemistry
