Ravindra Majeti

Publications

• Convergent Epigenetic Evolution Drives Relapse in Acute Myeloid Leukemia
  BioRxiv : the Preprint Server for Biology. Oct, 2023  |   Pubmed ID: 37873452
• Immune Surveillance of Acute Myeloid Leukemia Is Mediated by HLA-Presented Antigens on Leukemia Progenitor Cells
  Blood Cancer Discovery. Nov, 2023  |   Pubmed ID: 37847741
• RUNX1 Loss Renders Hematopoietic and Leukemic Cells Dependent on IL-3 and Sensitive to JAK Inhibition
  The Journal of Clinical Investigation. Oct, 2023  |   Pubmed ID: 37581927
• Patient-Derived IPSCs Faithfully Represent the Genetic Diversity and Cellular Architecture of Human Acute Myeloid Leukemia
  Blood Cancer Discovery. Jul, 2023  |   Pubmed ID: 37067914
• Current Landscape of Translational and Clinical Research in Myelodysplastic Syndromes/neoplasms (MDS): Proceedings from the 1 International Workshop on MDS (iwMDS) Of the International Consortium for MDS (icMDS)
  Blood Reviews. Mar, 2023  |   Pubmed ID: 36934059
• MYC-driven Synthesis of Siglec Ligands is a Glycoimmune Checkpoint
  Proceedings of the National Academy of Sciences of the United States of America. Mar, 2023  |   Pubmed ID: 36897988
• Reprogramming Cancer into Antigen Presenting Cells As a Novel Immunotherapy
  Cancer Discovery. Mar, 2023  |   Pubmed ID: 36856575
• Dysregulated Lipid Synthesis by Oncogenic IDH1 Mutation Is a Targetable Synthetic Lethal Vulnerability
  Cancer Discovery. Feb, 2023  |   Pubmed ID: 36355448
• Single-cell Genomics in AML: Extending the Frontiers of AML Research
  Blood. Jan, 2023  |   Pubmed ID: 35926108
• An Agenda to Advance Research in MDS: A TOP 10 Priority List from the First International Workshop in MDS (iwMDS)
  Blood Advances. Oct, 2022  |   Pubmed ID: 36260702
• Transition to a Mesenchymal State in Neuroblastoma Confers Resistance to Anti-GD2 Antibody Via Reduced Expression of ST8SIA1
  Nature Cancer. Aug, 2022  |   Pubmed ID: 35817829
• The Cell Type-Specific 5hmC Landscape and Dynamics of Healthy Human Hematopoiesis and TET2-Mutant Preleukemia
  Blood Cancer Discovery. Jul, 2022  |   Pubmed ID: 35532363
• CytofIn Enables Integrated Analysis of Public Mass Cytometry Datasets Using Generalized Anchors
  Nature Communications. Feb, 2022  |   Pubmed ID: 35177627
• Anti-GD2 Synergizes with CD47 Blockade to Mediate Tumor Eradication
  Nature Medicine. Feb, 2022  |   Pubmed ID: 35027753
• Clonal Architecture Predicts Clinical Outcomes and Drug Sensitivity in Acute Myeloid Leukemia
  Nature Communications. Dec, 2021  |   Pubmed ID: 34903734
• NOT-Gated CD93 CAR T Cells Effectively Target AML with Minimized Endothelial Cross-Reactivity
  Blood Cancer Discovery. Nov, 2021  |   Pubmed ID: 34778803
• Monocytic Differentiation and AHR Signaling As Primary Nodes of BET Inhibitor Response in Acute Myeloid Leukemia
  Blood Cancer Discovery. Sep, 2021  |   Pubmed ID: 34568834
• Clonal Hematopoiesis: From Mechanisms to Clinical Intervention
  Cancer Discovery. Dec, 2021  |   Pubmed ID: 34407958
• The TRACE-Seq Method Tracks Recombination Alleles and Identifies Clonal Reconstitution Dynamics of Gene Targeted Human Hematopoietic Stem Cells
  Nature Communications. Jan, 2021  |   Pubmed ID: 33473139
• Targeting LSCs: Peeling Back the Curtain on the Metabolic Complexities of AML
  Cell Stem Cell. Nov, 2020  |   Pubmed ID: 33157042
• CD34 Expression Does Not Correlate with Immunophenotypic Stem Cell or Progenitor Content in Human Cord Blood Products
  Blood Advances. Nov, 2020  |   Pubmed ID: 33136125
• Integrated Analysis of Patient Samples Identifies Biomarkers for Venetoclax Efficacy and Combination Strategies in Acute Myeloid Leukemia
  Nature Cancer. Aug, 2020  |   Pubmed ID: 33123685
• Targeting Macrophage Checkpoint Inhibitor SIRPα for Anticancer Therapy
  JCI Insight. Jun, 2020  |   Pubmed ID: 32427583
• IL-6 Blockade Reverses Bone Marrow Failure Induced by Human Acute Myeloid Leukemia
  Science Translational Medicine. Apr, 2020  |   Pubmed ID: 32269167
• A Dysregulated DNA Methylation Landscape Linked to Gene Expression in MLL-Rearranged AML
  Epigenetics. Aug, 2020  |   Pubmed ID: 32114880
• The Phosphatidylethanolamine Biosynthesis Pathway Provides a New Target for Cancer Chemotherapy
  Journal of Hepatology. Apr, 2020  |   Pubmed ID: 31760071
• Sufficiency for Inducible Caspase-9 Safety Switch in Human Pluripotent Stem Cells and Disease Cells
  Gene Therapy. Nov, 2019  |   Pubmed ID: 32704085
• Use of Polyvinyl Alcohol for Chimeric Antigen Receptor T-cell Expansion
  Experimental Hematology. Dec, 2019  |   Pubmed ID: 31874780
• Single-cell Multiomic Analysis Identifies Regulatory Programs in Mixed-phenotype Acute Leukemia
  Nature Biotechnology. Dec, 2019  |   Pubmed ID: 31792411
• Mebendazole for Differentiation Therapy of Acute Myeloid Leukemia Identified by a Lineage Maturation Index
  Scientific Reports. Nov, 2019  |   Pubmed ID: 31727951
• Single-cell Lineage Tracing by Endogenous Mutations Enriched in Transposase Accessible Mitochondrial DNA
  ELife. Apr, 2019  |   Pubmed ID: 30958261
• No Matter How You Splice It, RBM39 Inhibition Targets Spliceosome Mutant AML
  Cancer Cell. Mar, 2019  |   Pubmed ID: 30889374
• First-in-Human, First-in-Class Phase I Trial of the Anti-CD47 Antibody Hu5F9-G4 in Patients With Advanced Cancers
  Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Apr, 2019  |   Pubmed ID: 30811285
• Data Mining for Mutation-specific Targets in Acute Myeloid Leukemia
  Leukemia. Apr, 2019  |   Pubmed ID: 30728456
• Induced Pluripotent Stem Cell Modeling of Malignant Hematopoiesis
  Experimental Hematology. Mar, 2019  |   Pubmed ID: 30659850
• CAR T Cells Targeting B7-H3, a Pan-Cancer Antigen, Demonstrate Potent Preclinical Activity Against Pediatric Solid Tumors and Brain Tumors
  Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Apr, 2019  |   Pubmed ID: 30655315
• Targeting Cancer Stemness in the Clinic: From Hype to Hope
  Cell Stem Cell. 01, 2019  |   Pubmed ID: 30595497
• Integrated Single-Cell Analysis Maps the Continuous Regulatory Landscape of Human Hematopoietic Differentiation
  Cell. May, 2018  |   Pubmed ID: 29706549
• Proposed Terminology and Classification of Pre-Malignant Neoplastic Conditions: A Consensus Proposal
  EBioMedicine. Dec, 2017  |   Pubmed ID: 29203377
• Preleukemic Hematopoietic Stem Cells in Human Acute Myeloid Leukemia
  Frontiers in Oncology. 2017  |   Pubmed ID: 29164062
• Superenhancer Analysis Defines Novel Epigenomic Subtypes of Non-APL AML, Including an RARα Dependency Targetable by SY-1425, a Potent and Selective RARα Agonist
  Cancer Discovery. Oct, 2017  |   Pubmed ID: 28729405
• Systematic Discovery of Mutation-specific Synthetic Lethals by Mining Pan-cancer Human Primary Tumor Data
  Nature Communications. May, 2017  |   Pubmed ID: 28561042
• Optimizing Next-Generation AML Therapy: Activity of Mutant IDH2 Inhibitor AG-221 in Preclinical Models
  Cancer Discovery. May, 2017  |   Pubmed ID: 28461409
• Biology and Relevance of Human Acute Myeloid Leukemia Stem Cells
  Blood. Mar, 2017  |   Pubmed ID: 28159741
• The Role of Mutations in the Cohesin Complex in Acute Myeloid Leukemia
  International Journal of Hematology. Jan, 2017  |   Pubmed ID: 27796738
• Sticking It to the Niche: CD98 Mediates Critical Adhesive Signals in AML
  Cancer Cell. Nov, 2016  |   Pubmed ID: 27846387
• CRISPR/Cas9 β-globin Gene Targeting in Human Haematopoietic Stem Cells
  Nature. Nov, 2016  |   Pubmed ID: 27820943
• Autophagy Mediates Proteolysis of NPM1 and HEXIM1 and Sensitivity to BET Inhibition in AML Cells
  Oncotarget. Nov, 2016  |   Pubmed ID: 27732946
• Lineage-specific and Single-cell Chromatin Accessibility Charts Human Hematopoiesis and Leukemia Evolution
  Nature Genetics. Oct, 2016  |   Pubmed ID: 27526324
• Alkylator-Induced and Patient-Derived Xenograft Mouse Models of Therapy-Related Myeloid Neoplasms Model Clinical Disease and Suggest the Presence of Multiple Cell Subpopulations with Leukemia Stem Cell Activity
  PloS One. 2016  |   Pubmed ID: 27428079
• Burning Fat Fuels Leukemic Stem Cell Heterogeneity
  Cell Stem Cell. Jul, 2016  |   Pubmed ID: 27392217
• CD47-blocking Immunotherapies Stimulate Macrophage-mediated Destruction of Small-cell Lung Cancer
  The Journal of Clinical Investigation. Jul, 2016  |   Pubmed ID: 27294525
• A Humanized Bone Marrow Ossicle Xenotransplantation Model Enables Improved Engraftment of Healthy and Leukemic Human Hematopoietic Cells
  Nature Medicine. Jul, 2016  |   Pubmed ID: 27213817
• ASH1L Links Histone H3 Lysine 36 Dimethylation to MLL Leukemia
  Cancer Discovery. Jul, 2016  |   Pubmed ID: 27154821
• SIRPα-Antibody Fusion Proteins Selectively Bind and Eliminate Dual Antigen-Expressing Tumor Cells
  Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Oct, 2016  |   Pubmed ID: 27126995
• Leukemia-Associated Cohesin Mutants Dominantly Enforce Stem Cell Programs and Impair Human Hematopoietic Progenitor Differentiation
  Cell Stem Cell. Dec, 2015  |   Pubmed ID: 26607380
• Pre-Clinical Development of a Humanized Anti-CD47 Antibody with Anti-Cancer Therapeutic Potential
  PloS One. 2015  |   Pubmed ID: 26390038
• Biology and Clinical Relevance of Acute Myeloid Leukemia Stem Cells
  Seminars in Hematology. Jul, 2015  |   Pubmed ID: 26111462
• Reply to Fišer Et Al.: Myeloid Reprogramming of Ph+ B-ALL: A Potential Therapeutic Strategy
  Proceedings of the National Academy of Sciences of the United States of America. Jul, 2015  |   Pubmed ID: 26069209
• Reprogramming of Primary Human Philadelphia Chromosome-positive B Cell Acute Lymphoblastic Leukemia Cells into Nonleukemic Macrophages
  Proceedings of the National Academy of Sciences of the United States of America. Mar, 2015  |   Pubmed ID: 25775523
• Tuning Cytokine Receptor Signaling by Re-orienting Dimer Geometry with Surrogate Ligands
  Cell. Mar, 2015  |   Pubmed ID: 25728669
• Isocitrate Dehydrogenase 1 and 2 Mutations Induce BCL-2 Dependence in Acute Myeloid Leukemia
  Nature Medicine. Feb, 2015  |   Pubmed ID: 25599133
• Mutant WT1 is Associated with DNA Hypermethylation of PRC2 Targets in AML and Responds to EZH2 Inhibition
  Blood. Jan, 2015  |   Pubmed ID: 25398938
• Clonal Evolution of Pre-leukemic Hematopoietic Stem Cells Precedes Human Acute Myeloid Leukemia
  Best Practice & Research. Clinical Haematology. 2014  |   Pubmed ID: 25455271
• Pre-leukemic Evolution of Hematopoietic Stem Cells: the Importance of Early Mutations in Leukemogenesis
  Leukemia. Dec, 2014  |   Pubmed ID: 25005245
• Transient Expression of Bcl6 is Sufficient for Oncogenic Function and Induction of Mature B-cell Lymphoma
  Nature Communications. Jun, 2014  |   Pubmed ID: 24887457
• Interaction of TIF-90 and Filamin A in the Regulation of RRNA Synthesis in Leukemic Cells
  Blood. Jul, 2014  |   Pubmed ID: 24850755
• Centrosome-kinase Fusions Promote Oncogenic Signaling and Disrupt Centrosome Function in Myeloproliferative Neoplasms
  PloS One. 2014  |   Pubmed ID: 24658090
• Preleukemic Mutations in Human Acute Myeloid Leukemia Affect Epigenetic Regulators and Persist in Remission
  Proceedings of the National Academy of Sciences of the United States of America. Feb, 2014  |   Pubmed ID: 24550281
• Role of DNMT3A, TET2, and IDH1/2 Mutations in Pre-leukemic Stem Cells in Acute Myeloid Leukemia
  International Journal of Hematology. Dec, 2013  |   Pubmed ID: 23949914
• The Cancer Stem Cell Model: B Cell Acute Lymphoblastic Leukaemia Breaks the Mould
  EMBO Molecular Medicine. Jan, 2013  |   Pubmed ID: 23229878
• Clonal Evolution of Acute Leukemia Genomes
  Oncogene. Jan, 2013  |   Pubmed ID: 22349821
• Clonal Evolution of Preleukemic Hematopoietic Stem Cells Precedes Human Acute Myeloid Leukemia
  Science Translational Medicine. Aug, 2012  |   Pubmed ID: 22932223
• Antibody Therapy Targeting the CD47 Protein is Effective in a Model of Aggressive Metastatic Leiomyosarcoma
  Proceedings of the National Academy of Sciences of the United States of America. Apr, 2012  |   Pubmed ID: 22451919
• The CD47-SIRPα Pathway in Cancer Immune Evasion and Potential Therapeutic Implications
  Current Opinion in Immunology. Apr, 2012  |   Pubmed ID: 22310103
• Programmed Cell Removal: a New Obstacle in the Road to Developing Cancer
  Nature Reviews. Cancer. Jan, 2012  |   Pubmed ID: 22158022
• Treatment Advances Have Not Improved the Early Death Rate in Acute Promyelocytic Leukemia
  Haematologica. Jan, 2012  |   Pubmed ID: 21993679
• Surprise! HSC Are Aberrant in Chronic Lymphocytic Leukemia
  Cancer Cell. Aug, 2011  |   Pubmed ID: 21840478
• Prospective Separation of Normal and Leukemic Stem Cells Based on Differential Expression of TIM3, a Human Acute Myeloid Leukemia Stem Cell Marker
  Proceedings of the National Academy of Sciences of the United States of America. Mar, 2011  |   Pubmed ID: 21383193
• Single-cell Phospho-specific Flow Cytometric Analysis Demonstrates Biochemical and Functional Heterogeneity in Human Hematopoietic Stem and Progenitor Compartments
  Blood. Apr, 2011  |   Pubmed ID: 21357764
• Human Acute Myelogenous Leukemia Stem Cells Revisited: There's More Than Meets the Eye
  Cancer Cell. Jan, 2011  |   Pubmed ID: 21251611
• Monoclonal Antibody Therapy Directed Against Human Acute Myeloid Leukemia Stem Cells
  Oncogene. Mar, 2011  |   Pubmed ID: 21076471
• Association of a Leukemic Stem Cell Gene Expression Signature with Clinical Outcomes in Acute Myeloid Leukemia
  JAMA. Dec, 2010  |   Pubmed ID: 21177505
• Metastatic Cancer Stem Cells: an Opportunity for Improving Cancer Treatment?
  Cell Stem Cell. Jun, 2010  |   Pubmed ID: 20569685
• CD47 is an Adverse Prognostic Factor and Therapeutic Antibody Target on Human Acute Myeloid Leukemia Stem Cells
  Cell. Jul, 2009  |   Pubmed ID: 19632179
• CD47 is Upregulated on Circulating Hematopoietic Stem Cells and Leukemia Cells to Avoid Phagocytosis
  Cell. Jul, 2009  |   Pubmed ID: 19632178
• The Adhesion Molecule Esam1 is a Novel Hematopoietic Stem Cell Marker
  Stem Cells (Dayton, Ohio). Mar, 2009  |   Pubmed ID: 19074415