René Hen

Publications

• Protocol for In vivo Imaging and Analysis of Brainstem Neuronal Activity in the Dorsal Raphe Nucleus of Freely Behaving Mice
  STAR Protocols. Jan, 2023  |   Pubmed ID: 36853724
• Enduring Effects of Early-life Adversity on Reward Processes: A Systematic Review and Meta-analysis of Animal Studies
  Neuroscience and Biobehavioral Reviews. Nov, 2022  |   Pubmed ID: 36116576
• Integrative Multi-omics Landscape of Fluoxetine Action Across 27 Brain Regions Reveals Global Increase in Energy Metabolism and Region-specific Chromatin Remodelling
  Molecular Psychiatry. Nov, 2022  |   Pubmed ID: 36056172
• Contribution of the Opioid System to the Antidepressant Effects of Fluoxetine
  Biological Psychiatry. Dec, 2022  |   Pubmed ID: 35977861
• Delineating a Serotonin 1B Receptor Circuit for Appetite Suppression in Mice
  The Journal of Experimental Medicine. Aug, 2022  |   Pubmed ID: 35796804
• Single-cell Activity and Network Properties of Dorsal Raphe Nucleus Serotonin Neurons During Emotionally Salient Behaviors
  Neuron. Aug, 2022  |   Pubmed ID: 35700737
• Dysregulation of Adult Hippocampal Neuroplasticity in Major Depression: Pathogenesis and Therapeutic Implications
  Molecular Psychiatry. Jun, 2022  |   Pubmed ID: 35354926
• Parallel Processing of Sensory Cue and Spatial Information in the Dentate Gyrus
  Cell Reports. Jan, 2022  |   Pubmed ID: 35045280
• Mu Opioid Receptors on Hippocampal GABAergic Interneurons Are Critical for the Antidepressant Effects of Tianeptine
  Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. Jun, 2022  |   Pubmed ID: 34593976
• Increasing Adult Hippocampal Neurogenesis Promotes Resilience in a Mouse Model of Depression
  Cells. Apr, 2021  |   Pubmed ID: 33919292
• Adult Neurogenesis and Antidepressant Treatment: The Surprise Finding by Ron Duman and the Field 20 Years Later
  Biological Psychiatry. Jul, 2021  |   Pubmed ID: 33771348
• Adult Neurogenesis Augmentation Attenuates Anhedonia and HPA Axis Dysregulation in a Mouse Model of Chronic Stress and Depression
  Psychoneuroendocrinology. Feb, 2021  |   Pubmed ID: 33302237
• Contextual Fear Memory Retrieval by Correlated Ensembles of Ventral CA1 Neurons
  Nature Communications. Jul, 2020  |   Pubmed ID: 32661319
• A Distributed Neural Code in the Dentate Gyrus and in CA1
  Neuron. Aug, 2020  |   Pubmed ID: 32521223
• Rapid Anxiolytic Effects of RS67333, a Serotonin Type 4 Receptor Agonist, and Diazepam, a Benzodiazepine, Are Mediated by Projections From the Prefrontal Cortex to the Dorsal Raphe Nucleus
  Biological Psychiatry. Mar, 2020  |   Pubmed ID: 31623825
• Contributions of Adult Neurogenesis to Dentate Gyrus Network Activity and Computations
  Behavioural Brain Research. Nov, 2019  |   Pubmed ID: 31377252
• Adult-born Hippocampal Neurons Bidirectionally Modulate Entorhinal Inputs into the Dentate Gyrus
  Science (New York, N.Y.). May, 2019  |   Pubmed ID: 31073064
• Resilience Is Associated With Larger Dentate Gyrus, While Suicide Decedents With Major Depressive Disorder Have Fewer Granule Neurons
  Biological Psychiatry. May, 2019  |   Pubmed ID: 30819514
• Functional Interrogation of a Depression-Related Serotonergic Single Nucleotide Polymorphism, Rs6295, Using a Humanized Mouse Model
  ACS Chemical Neuroscience. Jul, 2019  |   Pubmed ID: 30694044
• Loss of Adult 5-HT1A Autoreceptors Results in a Paradoxical Anxiogenic Response to Antidepressant Treatment
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Feb, 2019  |   Pubmed ID: 30552180
• Hippocampal Neurogenesis Confers Stress Resilience by Inhibiting the Ventral Dentate Gyrus
  Nature. Jul, 2018  |   Pubmed ID: 29950730
• Targeting Kruppel-like Factor 9 in Excitatory Neurons Protects Against Chronic Stress-Induced Impairments in Dendritic Spines and Fear Responses
  Cell Reports. Jun, 2018  |   Pubmed ID: 29898391
• Optimization of Immunolabeling and Clearing Techniques for Indelibly Labeled Memory Traces
  Hippocampus. Jul, 2018  |   Pubmed ID: 29663578
• Loss of MeCP2 in Adult 5-HT Neurons Induces 5-HT1A Autoreceptors, with Opposite Sex-dependent Anxiety and Depression Phenotypes
  Scientific Reports. Apr, 2018  |   Pubmed ID: 29636529
• Efficient and Accurate Extraction of in Vivo Calcium Signals from Microendoscopic Video Data
  ELife. Feb, 2018  |   Pubmed ID: 29469809
• Anxiety Cells in a Hippocampal-Hypothalamic Circuit
  Neuron. Feb, 2018  |   Pubmed ID: 29397273
• Optogenetic Activation of Granule Cells in the Dorsal Dentate Gyrus Enhances Dopaminergic Neurotransmission in the Nucleus Accumbens
  Neuroscience Research. Sep, 2018  |   Pubmed ID: 29246683
• A Novel Method for Chronic Social Defeat Stress in Female Mice
  Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. May, 2018  |   Pubmed ID: 29090682
• Treatment Resistant Depression: A Multi-scale, Systems Biology Approach
  Neuroscience and Biobehavioral Reviews. Jan, 2018  |   Pubmed ID: 28859997
• Abrogated Freud-1/Cc2d1a Repression of 5-HT1A Autoreceptors Induces Fluoxetine-Resistant Anxiety/Depression-Like Behavior
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Dec, 2017  |   Pubmed ID: 29101244
• Increasing Adult Hippocampal Neurogenesis in Mice After Exposure to Unpredictable Chronic Mild Stress May Counteract Some of the Effects of Stress
  Neuropharmacology. Nov, 2017  |   Pubmed ID: 28890366
• Gambling Disorder: an Integrative Review of Animal and Human Studies
  Annals of the New York Academy of Sciences. Apr, 2017  |   Pubmed ID: 28486792
• Adult Hippocampal Neurogenesis and Cognitive Flexibility - Linking Memory and Mood
  Nature Reviews. Neuroscience. Jun, 2017  |   Pubmed ID: 28469276
• The Behavioral Effects of the Antidepressant Tianeptine Require the Mu-Opioid Receptor
  Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. Sep, 2017  |   Pubmed ID: 28303899
• Serotonin Receptors in Depression: from A to B
  F1000Research. 2017  |   Pubmed ID: 28232871
• S 38093, a Histamine H Antagonist/inverse Agonist, Promotes Hippocampal Neurogenesis and Improves Context Discrimination Task in Aged Mice
  Scientific Reports. Feb, 2017  |   Pubmed ID: 28218311
• Genetic and Modeling Approaches Reveal Distinct Components of Impulsive Behavior
  Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. May, 2017  |   Pubmed ID: 27976680
• Retinal Neuroprotective Effects of Flibanserin, an FDA-Approved Dual Serotonin Receptor Agonist-Antagonist
  PloS One. 2016  |   Pubmed ID: 27447833
• A Lack of Serotonin 1B Autoreceptors Results in Decreased Anxiety and Depression-Related Behaviors
  Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. Nov, 2016  |   Pubmed ID: 27353308
• Distinct Contribution of Adult-Born Hippocampal Granule Cells to Context Encoding
  Neuron. Apr, 2016  |   Pubmed ID: 26971949
• Activation of Local Inhibitory Circuits in the Dentate Gyrus by Adult-born Neurons
  Hippocampus. Jun, 2016  |   Pubmed ID: 26662922
• Concentration-Dependent Dual Mode of Zn Action at Serotonin 5-HT1A Receptors: In Vitro and In Vivo Studies
  Molecular Neurobiology. Dec, 2016  |   Pubmed ID: 26660328
• Neuroanatomic Differences Associated With Stress Susceptibility and Resilience
  Biological Psychiatry. May, 2016  |   Pubmed ID: 26422005
• Ketamine As a Prophylactic Against Stress-Induced Depressive-like Behavior
  Biological Psychiatry. May, 2016  |   Pubmed ID: 26037911
• Serotonin 1A and Serotonin 4 Receptors: Essential Mediators of the Neurogenic and Behavioral Actions of Antidepressants
  The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry. Feb, 2016  |   Pubmed ID: 25488850
• Regulation of Hippocampal Memory Traces by Neurogenesis
  Neurogenesis (Austin, Tex.). 2015  |   Pubmed ID: 27604158
• Genetic Pharmacotherapy As an Early CNS Drug Development Strategy: Testing Glutaminase Inhibition for Schizophrenia Treatment in Adult Mice
  Frontiers in Systems Neuroscience. 2015  |   Pubmed ID: 26778975
• 5-HT1A Receptors on Mature Dentate Gyrus Granule Cells Are Critical for the Antidepressant Response
  Nature Neuroscience. Nov, 2015  |   Pubmed ID: 26389840
• Loss of Striatonigral GABAergic Presynaptic Inhibition Enables Motor Sensitization in Parkinsonian Mice
  Neuron. Sep, 2015  |   Pubmed ID: 26335644
• Running Rescues a Fear-based Contextual Discrimination Deficit in Aged Mice
  Frontiers in Systems Neuroscience. 2015  |   Pubmed ID: 26321926
• Functional Differentiation of Adult-born Neurons Along the Septotemporal Axis of the Dentate Gyrus
  Cold Spring Harbor Perspectives in Biology. Aug, 2015  |   Pubmed ID: 26238355
• Distinct Circuits Underlie the Effects of 5-HT1B Receptors on Aggression and Impulsivity
  Neuron. May, 2015  |   Pubmed ID: 25892302
• Increasing Adult Hippocampal Neurogenesis is Sufficient to Reduce Anxiety and Depression-Like Behaviors
  Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. Sep, 2015  |   Pubmed ID: 25833129
• Hippocampal Subfields and Major Depressive Disorder
  Biological Psychiatry. Feb, 2015  |   Pubmed ID: 25542516
• Suppression of Adult Neurogenesis Increases the Acute Effects of Kainic Acid
  Experimental Neurology. Feb, 2015  |   Pubmed ID: 25476494
• The Current State of the Neurogenic Theory of Depression and Anxiety
  Current Opinion in Neurobiology. Feb, 2015  |   Pubmed ID: 25240202
• From Psychiatric Disorders to Animal Models: a Bidirectional and Dimensional Approach
  Biological Psychiatry. Jan, 2015  |   Pubmed ID: 24650688
• Serotonin/dopamine Interactions in a Hyperactive Mouse: Reduced Serotonin Receptor 1B Activity Reverses Effects of Dopamine Transporter Knockout
  PloS One. 2014  |   Pubmed ID: 25514162
• The Participation of Cortical Amygdala in Innate, Odour-driven Behaviour
  Nature. Nov, 2014  |   Pubmed ID: 25383519
• Hippocampal Memory Traces Are Differentially Modulated by Experience, Time, and Adult Neurogenesis
  Neuron. Jul, 2014  |   Pubmed ID: 24991962
• Benzodiazepines and the Potential Trophic Effect of Antidepressants on Dentate Gyrus Cells in Mood Disorders
  The International Journal of Neuropsychopharmacology. Dec, 2014  |   Pubmed ID: 24969726
• Dendritic Inhibition in the Hippocampus Supports Fear Learning
  Science (New York, N.Y.). Feb, 2014  |   Pubmed ID: 24558155
• Functional Dissociation of Adult-born Neurons Along the Dorsoventral Axis of the Dentate Gyrus
  Hippocampus. Jul, 2014  |   Pubmed ID: 24550158
• Impact of Social Status and Antidepressant Treatment on Neurogenesis in the Baboon Hippocampus
  Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. Jul, 2014  |   Pubmed ID: 24518288
• Rapid Anxiolytic Effects of a 5-HT₄ Receptor Agonist Are Mediated by a Neurogenesis-independent Mechanism
  Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. May, 2014  |   Pubmed ID: 24287720
• Developmental Effects of Serotonin 1A Autoreceptors on Anxiety and Social Behavior
  Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. Jan, 2014  |   Pubmed ID: 23907404
• Adult Neurogenesis in the Mammalian Hippocampus: Why the Dentate Gyrus?
  Learning & Memory (Cold Spring Harbor, N.Y.). Nov, 2013  |   Pubmed ID: 24255101
• (Radio)active Neurogenesis in the Human Hippocampus
  Cell. Jun, 2013  |   Pubmed ID: 23746833
• Repeated Cortico-striatal Stimulation Generates Persistent OCD-like Behavior
  Science (New York, N.Y.). Jun, 2013  |   Pubmed ID: 23744948
• Differential Control of Learning and Anxiety Along the Dorsoventral Axis of the Dentate Gyrus
  Neuron. Mar, 2013  |   Pubmed ID: 23473324
• The Young and the Restless: Regulation of Adult Neurogenesis by Wnt Signaling
  Cell Stem Cell. Feb, 2013  |   Pubmed ID: 23395437
• Genetic Approaches for Understanding the Role of Serotonin Receptors in Mood and Behavior
  Current Opinion in Neurobiology. Jun, 2013  |   Pubmed ID: 23385115
• Hippocampal Granule Neuron Number and Dentate Gyrus Volume in Antidepressant-treated and Untreated Major Depression
  Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. May, 2013  |   Pubmed ID: 23303074
• Neurogenesis and Generalization: a New Approach to Stratify and Treat Anxiety Disorders
  Nature Neuroscience. Dec, 2012  |   Pubmed ID: 23187693
• NR2B-dependent Plasticity of Adult-born Granule Cells is Necessary for Context Discrimination
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jun, 2012  |   Pubmed ID: 22723709
• Hippocampal Angiogenesis and Progenitor Cell Proliferation Are Increased with Antidepressant Use in Major Depression
  Biological Psychiatry. Oct, 2012  |   Pubmed ID: 22652019
• Adult-born Hippocampal Neurons Promote Cognitive Flexibility in Mice
  Hippocampus. Sep, 2012  |   Pubmed ID: 22431384
• 4- to 6-week-old Adult-born Hippocampal Neurons Influence Novelty-evoked Exploration and Contextual Fear Conditioning
  Hippocampus. May, 2012  |   Pubmed ID: 21739523
• Effects of Adult-generated Granule Cells on Coordinated Network Activity in the Dentate Gyrus
  Hippocampus. Jan, 2012  |   Pubmed ID: 20882540
• Experience Dictates Stem Cell Fate in the Adult Hippocampus
  Neuron. Jun, 2011  |   Pubmed ID: 21658584
• Pattern Separation: a Common Function for New Neurons in Hippocampus and Olfactory Bulb
  Neuron. May, 2011  |   Pubmed ID: 21609817
• Necessity of Hippocampal Neurogenesis for the Therapeutic Action of Antidepressants in Adult Nonhuman Primates
  PloS One. Apr, 2011  |   Pubmed ID: 21525974
• Serotonin-1A Autoreceptors Are Necessary and Sufficient for the Normal Formation of Circuits Underlying Innate Anxiety
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Apr, 2011  |   Pubmed ID: 21508226
• Increasing Adult Hippocampal Neurogenesis is Sufficient to Improve Pattern Separation
  Nature. Apr, 2011  |   Pubmed ID: 21460835
• Modeling Treatment-resistant Depression
  Neuropharmacology. Sep, 2011  |   Pubmed ID: 21356220
• Functional Connectome of the Striatal Medium Spiny Neuron
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jan, 2011  |   Pubmed ID: 21273403
• Dorsal Vs Ventral Hippocampal Neurogenesis: Implications for Cognition and Mood
  Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. Jan, 2011  |   Pubmed ID: 21116266
• Krüppel-like Factor 9 is Necessary for Late-phase Neuronal Maturation in the Developing Dentate Gyrus and During Adult Hippocampal Neurogenesis
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Aug, 2009  |   Pubmed ID: 19657039
• Antidepressants Increase Neural Progenitor Cells in the Human Hippocampus
  Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. Oct, 2009  |   Pubmed ID: 19606083
• Glutaminase-deficient Mice Display Hippocampal Hypoactivity, Insensitivity to Pro-psychotic Drugs and Potentiated Latent Inhibition: Relevance to Schizophrenia
  Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. Sep, 2009  |   Pubmed ID: 19516252
• Antidepressant-induced Neurogenesis in the Hippocampus of Adult Nonhuman Primates
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. May, 2007  |   Pubmed ID: 17475797
• Neurodevelopmental Origins of Depressive Disorders
  Current Opinion in Pharmacology. Feb, 2007  |   Pubmed ID: 17188022
• Cortical 5-HT2A Receptor Signaling Modulates Anxiety-like Behaviors in Mice
  Science (New York, N.Y.). Jul, 2006  |   Pubmed ID: 16873667
• Hippocampal Neurogenesis: Regulation by Stress and Antidepressants
  Biological Psychiatry. Jun, 2006  |   Pubmed ID: 16797263
• Genetic Approaches to the Study of Anxiety
  Annual Review of Neuroscience. 2004  |   Pubmed ID: 15217331
• The Serotonergic System and Anxiety
  Neuromolecular Medicine. 2004  |   Pubmed ID: 15001810
• Resistance of Alpha -synuclein Null Mice to the Parkinsonian Neurotoxin MPTP
  Proceedings of the National Academy of Sciences of the United States of America. Oct, 2002  |   Pubmed ID: 12376616
• Serotonin Receptor 1A Knockout: an Animal Model of Anxiety-related Disorder
  Proceedings of the National Academy of Sciences of the United States of America. Nov, 1998  |   Pubmed ID: 9826725