Rick L. Tarleton

Publications

• High Variation in Immune Responses and Parasite Phenotypes in Naturally Acquired Trypanosoma Cruzi Infection in a Captive Non-human Primate Breeding Colony in Texas, USA
  PLoS Neglected Tropical Diseases. 03, 2021  |   Pubmed ID: 33788859
• Reduced Trypanosoma Cruzi-specific Humoral Response and Enhanced T Cell Immunity After Treatment Interruption with Benznidazole in Chronic Chagas Disease
  The Journal of Antimicrobial Chemotherapy. 05, 2021  |   Pubmed ID: 33693664
• A Flexible, Pan-species, Multi-antigen Platform for the Detection and Monitoring of SARS-CoV-2-specific Antibody Responses
  MedRxiv : the Preprint Server for Health Sciences. Jan, 2021  |   Pubmed ID: 33532799
• Strain-specific Genome Evolution in Trypanosoma Cruzi, the Agent of Chagas Disease
  PLoS Pathogens. 01, 2021  |   Pubmed ID: 33508020
• A Modified Drug Regimen Clears Active and Dormant Trypanosomes in Mouse Models of Chagas Disease
  Science Translational Medicine. 10, 2020  |   Pubmed ID: 33115952
• Cutting Edge: Augmenting Muscle MHC Expression Enhances Systemic Pathogen Control at the Expense of T Cell Exhaustion
  Journal of Immunology (Baltimore, Md. : 1950). 08, 2020  |   Pubmed ID: 32591392
• New Scheme of Intermittent Benznidazole Administration in Patients Chronically Infected with Trypanosoma Cruzi: Clinical, Parasitological, and Serological Assessment After Three Years of Follow-Up
  Antimicrobial Agents and Chemotherapy. 08, 2020  |   Pubmed ID: 32571827
• Chagas Disease Drug Discovery: Multiparametric Lead Optimization Against in Acylaminobenzothiazole Series
  Journal of Medicinal Chemistry. 11, 2019  |   Pubmed ID: 31657555
• Protozoan Persister-like Cells and Drug Treatment Failure
  Nature Reviews. Microbiology. 10, 2019  |   Pubmed ID: 31444481
• Drug Discovery for Kinetoplastid Diseases: Future Directions
  ACS Infectious Diseases. 02, 2019  |   Pubmed ID: 30543391
• Highly Competent, Non-exhausted CD8+ T Cells Continue to Tightly Control Pathogen Load Throughout Chronic Trypanosoma Cruzi Infection
  PLoS Pathogens. 11, 2018  |   Pubmed ID: 30419010
• Spontaneous Dormancy Protects During Extended Drug Exposure
  ELife. 03, 2018  |   Pubmed ID: 29578409
• Rapid, Selection-Free, High-Efficiency Genome Editing in Protozoan Parasites Using CRISPR-Cas9 Ribonucleoproteins
  MBio. 11, 2017  |   Pubmed ID: 29114029
• The Significance of Discordant Serology in Chagas Disease: Enhanced T-Cell Immunity to in Serodiscordant Subjects
  Frontiers in Immunology. 2017  |   Pubmed ID: 28966620
• Recombination-driven Generation of the Largest Pathogen Repository of Antigen Variants in the Protozoan Trypanosoma Cruzi
  BMC Genomics. 09, 2016  |   Pubmed ID: 27619017
• Chagas Disease: A Solvable Problem, Ignored
  Trends in Molecular Medicine. Oct, 2016  |   Pubmed ID: 27523778
• Long-Term Immunity to Trypanosoma Cruzi in the Absence of Immunodominant Trans-Sialidase-Specific CD8+ T Cells
  Infection and Immunity. 09, 2016  |   Pubmed ID: 27354447
• A Framework for Ontology-based Question Answering with Application to Parasite Immunology
  Journal of Biomedical Semantics. 2015  |   Pubmed ID: 26185615
• CD8+ T Cells in Trypanosoma Cruzi Infection
  Seminars in Immunopathology. May, 2015  |   Pubmed ID: 25921214
• Chemokine Receptor 7 (CCR7)-expression and IFNγ Production Define Vaccine-specific Canine T-cell Subsets
  Veterinary Immunology and Immunopathology. Apr, 2015  |   Pubmed ID: 25758065
• CRISPR-Cas9-mediated Single-gene and Gene Family Disruption in Trypanosoma Cruzi
  MBio. Dec, 2014  |   Pubmed ID: 25550322
• Chagas Disease and the London Declaration on Neglected Tropical Diseases
  PLoS Neglected Tropical Diseases. Oct, 2014  |   Pubmed ID: 25299701
• The Trypanosoma Cruzi Flagellum is Discarded Via Asymmetric Cell Division Following Invasion and Provides Early Targets for Protective CD8⁺ T Cells
  Cell Host & Microbe. Oct, 2014  |   Pubmed ID: 25299330
• Frequency of IFNγ-producing T Cells Correlates with Seroreactivity and Activated T Cells During Canine Trypanosoma Cruzi Infection
  Veterinary Research. Jan, 2014  |   Pubmed ID: 24456537
• New, Combined, and Reduced Dosing Treatment Protocols Cure Trypanosoma Cruzi Infection in Mice
  The Journal of Infectious Diseases. Jan, 2014  |   Pubmed ID: 23945371
• Perpetual Expression of PAMPs Necessary for Optimal Immune Control and Clearance of a Persistent Pathogen
  Nature Communications. 2013  |   Pubmed ID: 24149620
• Evidence for the Role of Vacuolar Soluble Pyrophosphatase and Inorganic Polyphosphate in Trypanosoma Cruzi Persistence
  Molecular Microbiology. Nov, 2013  |   Pubmed ID: 24033456
• A Systematic Review of High Quality Diagnostic Tests for Chagas Disease
  PLoS Neglected Tropical Diseases. 2012  |   Pubmed ID: 23145201
• Is Chagas Disease Really the "new HIV/AIDS of the Americas"?
  PLoS Neglected Tropical Diseases. 2012  |   Pubmed ID: 23145193
• Inhibitory Receptors Are Expressed by Trypanosoma Cruzi-specific Effector T Cells and in Hearts of Subjects with Chronic Chagas Disease
  PloS One. 2012  |   Pubmed ID: 22574131
• Transgenic Parasites Accelerate Drug Discovery
  Trends in Parasitology. Mar, 2012  |   Pubmed ID: 22277131
• Report of the 2nd Chagas Drug Discovery Consortium Meeting, Held on 3 November 2010; Atlanta GA, USA
  Expert Opinion on Drug Discovery. 09, 2011  |   Pubmed ID: 22646217
• Knockout of the Dhfr-ts Gene in Trypanosoma Cruzi Generates Attenuated Parasites Able to Confer Protection Against a Virulent Challenge
  PLoS Neglected Tropical Diseases. Dec, 2011  |   Pubmed ID: 22180798
• Methodological Advances in Drug Discovery for Chagas Disease
  Expert Opinion on Drug Discovery. Jun, 2011  |   Pubmed ID: 21712965
• Oral Exposure to Trypanosoma Cruzi Elicits a Systemic CD8⁺ T Cell Response and Protection Against Heterotopic Challenge
  Infection and Immunity. Aug, 2011  |   Pubmed ID: 21628516
• Widespread, Focal Copy Number Variations (CNV) and Whole Chromosome Aneuploidies in Trypanosoma Cruzi Strains Revealed by Array Comparative Genomic Hybridization
  BMC Genomics. 2011  |   Pubmed ID: 21385342
• In Vitro and in Vivo High-throughput Assays for the Testing of Anti-Trypanosoma Cruzi Compounds
  PLoS Neglected Tropical Diseases. Jul, 2010  |   Pubmed ID: 20644616
• CD8+ T Cells Specific for Immunodominant Trans-sialidase Epitopes Contribute to Control of Trypanosoma Cruzi Infection but Are Not Required for Resistance
  Journal of Immunology (Baltimore, Md. : 1950). Jul, 2010  |   Pubmed ID: 20530265
• Generation of Trypanosoma Cruzi-specific CD8+ T-cell Immunity is Unaffected by the Absence of Type I Interferon Signaling
  Infection and Immunity. Jul, 2010  |   Pubmed ID: 20457790
• Trypanosoma Cruzi-specific Immune Responses in Subjects from Endemic Areas of Chagas Disease of Argentina
  Microbes and Infection. May, 2010  |   Pubmed ID: 20123034
• Changes in Trypanosoma Cruzi-specific Immune Responses After Treatment: Surrogate Markers of Treatment Efficacy
  Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America. Dec, 2009  |   Pubmed ID: 19877967
• Chronic Human Infection with Trypanosoma Cruzi Drives CD4+ T Cells to Immune Senescence
  Journal of Immunology (Baltimore, Md. : 1950). Sep, 2009  |   Pubmed ID: 19692645
• The Steady-state Transcriptome of the Four Major Life-cycle Stages of Trypanosoma Cruzi
  BMC Genomics. 2009  |   Pubmed ID: 19664227
• CD8+ T Cells in Trypanosoma Cruzi Infection
  Current Opinion in Immunology. Aug, 2009  |   Pubmed ID: 19646853
• Insufficient TLR Activation Contributes to the Slow Development of CD8+ T Cell Responses in Trypanosoma Cruzi Infection
  Journal of Immunology (Baltimore, Md. : 1950). Jul, 2009  |   Pubmed ID: 19553540
• Chromosome Level Assembly of the Hybrid Trypanosoma Cruzi Genome
  BMC Genomics. 2009  |   Pubmed ID: 19486522
• Evaluation of High Efficiency Gene Knockout Strategies for Trypanosoma Cruzi
  BMC Microbiology. May, 2009  |   Pubmed ID: 19432966
• Eliminating Chagas Disease: Challenges and a Roadmap
  BMJ (Clinical Research Ed.). Apr, 2009  |   Pubmed ID: 19366739
• HLA Class I-T Cell Epitopes from Trans-sialidase Proteins Reveal Functionally Distinct Subsets of CD8+ T Cells in Chronic Chagas Disease
  PLoS Neglected Tropical Diseases. 2008  |   Pubmed ID: 18846233
• High Throughput Selection of Effective Serodiagnostics for Trypanosoma Cruzi Infection
  PLoS Neglected Tropical Diseases. 2008  |   Pubmed ID: 18841200
• Stable CD8+ T Cell Memory During Persistent Trypanosoma Cruzi Infection
  Journal of Immunology (Baltimore, Md. : 1950). Aug, 2008  |   Pubmed ID: 18684955
• Drug-induced Cure Drives Conversion to a Stable and Protective CD8+ T Central Memory Response in Chronic Chagas Disease
  Nature Medicine. May, 2008  |   Pubmed ID: 18425131
• The Challenges of Chagas Disease-- Grim Outlook or Glimmer of Hope
  PLoS Medicine. Dec, 2007  |   Pubmed ID: 18162039
• TGF-beta Regulates Pathology but Not Tissue CD8+ T Cell Dysfunction During Experimental Trypanosoma Cruzi Infection
  European Journal of Immunology. Oct, 2007  |   Pubmed ID: 17823982
• Immune System Recognition of Trypanosoma Cruzi
  Current Opinion in Immunology. Aug, 2007  |   Pubmed ID: 17651955
• A Semi-quantitative GeLC-MS Analysis of Temporal Proteome Expression in the Emerging Nosocomial Pathogen Ochrobactrum Anthropi
  Genome Biology. 2007  |   Pubmed ID: 17567905
• CD8+ T-Cell Responses to Trypanosoma Cruzi Are Highly Focused on Strain-variant Trans-sialidase Epitopes
  PLoS Pathogens. Aug, 2006  |   Pubmed ID: 16879036
• New Approaches in Vaccine Development for Parasitic Infections
  Cellular Microbiology. Oct, 2005  |   Pubmed ID: 16153238
• A Heuristic Method for Assigning a False-discovery Rate for Protein Identifications from Mascot Database Search Results
  Molecular & Cellular Proteomics : MCP. Jun, 2005  |   Pubmed ID: 15703444
• Antigen-specific T Cells Maintain an Effector Memory Phenotype During Persistent Trypanosoma Cruzi Infection
  Journal of Immunology (Baltimore, Md. : 1950). Feb, 2005  |   Pubmed ID: 15661921
• Inducible Nitric Oxide Synthase is Not Essential for Control of Trypanosoma Cruzi Infection in Mice
  Infection and Immunity. Jul, 2004  |   Pubmed ID: 15213153
• TcruziDB: an Integrated Trypanosoma Cruzi Genome Resource
  Nucleic Acids Research. Jan, 2004  |   Pubmed ID: 14681430
• Chagas Disease: a Role for Autoimmunity?
  Trends in Parasitology. Oct, 2003  |   Pubmed ID: 14519582
• Microarray Profiling of Gene Expression During Trypomastigote to Amastigote Transition in Trypanosoma Cruzi
  Molecular and Biochemical Parasitology. Sep, 2003  |   Pubmed ID: 12967712
• Genetic Immunization with LYT1 or a Pool of Trans-sialidase Genes Protects Mice from Lethal Trypanosoma Cruzi Infection
  Vaccine. Jun, 2003  |   Pubmed ID: 12798651
• Rapid Quantitation of Trypanosoma Cruzi in Host Tissue by Real-time PCR
  Molecular and Biochemical Parasitology. Jun, 2003  |   Pubmed ID: 12798506
• Cutting Edge: Dysfunctional CD8+ T Cells Reside in Nonlymphoid Tissues During Chronic Trypanosoma Cruzi Infection
  Journal of Immunology (Baltimore, Md. : 1950). Mar, 2003  |   Pubmed ID: 12594245
• Genetic Immunization Elicits Antigen-specific Protective Immune Responses and Decreases Disease Severity in Trypanosoma Cruzi Infection
  Infection and Immunity. Oct, 2002  |   Pubmed ID: 12228281
• Vaccination with Trypomastigote Surface Antigen 1-encoding Plasmid DNA Confers Protection Against Lethal Trypanosoma Cruzi Infection
  Infection and Immunity. Nov, 1998  |   Pubmed ID: 9784506