Robert B. Clarke Breast Biology Group, Manchester Breast Centre, Division of Cancer Sciences, Faculty of Biology, Medicine and Health University of Manchester Biography Publications Institution JoVE Articles Robert B. Clarke has not added a biography. If you are Robert B. Clarke and would like to personalize this page please email our Author Liaison for assistance. Publications Increased Expression of Interleukin-1 Receptor Characterizes Anti-estrogen-Resistant ALDH Breast Cancer Stem Cells Stem Cell Reports. 08, 2020 | Pubmed ID: 32707076 Tailored Functionalized Magnetic Nanoparticles to Target Breast Cancer Cells Including Cancer Stem-Like Cells Cancers. May, 2020 | Pubmed ID: 32485849 Targeting STAT3 Signaling Using Stabilised Sulforaphane (SFX-01) Inhibits Endocrine Resistant Stem-like Cells in ER-positive Breast Cancer Oncogene. 06, 2020 | Pubmed ID: 32472077 Development of Clinically Relevant in Vivo Metastasis Models Using Human Bone Discs and Breast Cancer Patient-derived Xenografts Breast Cancer Research : BCR. 11, 2019 | Pubmed ID: 31783893 Microenvironmental IL1β Promotes Breast Cancer Metastatic Colonisation in the Bone Via Activation of Wnt Signalling Nature Communications. 11, 2019 | Pubmed ID: 31676788 The Notch Pathway Promotes Osteosarcoma Progression Through Activation of Ephrin Reverse Signaling Molecular Cancer Research : MCR. 12, 2019 | Pubmed ID: 31570655 The Milk Protein Alpha-Casein Suppresses Triple Negative Breast Cancer Stem Cell Activity Via STAT and HIF-1alpha Signalling Pathways in Breast Cancer Cells and Fibroblasts Journal of Mammary Gland Biology and Neoplasia. 09, 2019 | Pubmed ID: 31529195 PAK4 Regulates Stemness and Progression in Endocrine Resistant ER-positive Metastatic Breast Cancer Cancer Letters. 08, 2019 | Pubmed ID: 31121213 Targeting Endometrial Cancer Stem Cell Activity with Metformin Is Inhibited by Patient-Derived Adipocyte-Secreted Factors Cancers. May, 2019 | Pubmed ID: 31083574 FKBPL and Its Peptide Derivatives Inhibit Endocrine Therapy Resistant Cancer Stem Cells and Breast Cancer Metastasis by Downregulating DLL4 and Notch4 BMC Cancer. Apr, 2019 | Pubmed ID: 30975104 Estrogenicity of Essential Oils is Not Required to Relieve Symptoms of Urogenital Atrophy in Breast Cancer Survivors Therapeutic Advances in Medical Oncology. 2018 | Pubmed ID: 29636827 The Role of Steroid Hormones in Breast and Effects on Cancer Stem Cells Current Stem Cell Reports. 2018 | Pubmed ID: 29600163 Ethnicity Influences Breast Cancer Stem Cells' Drug Resistance The Breast Journal. 07, 2018 | Pubmed ID: 29498455 Acquired Resistance of ER-Positive Breast Cancer to Endocrine Treatment Confers an Adaptive Sensitivity to TRAIL Through Posttranslational Downregulation of C-FLIP Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. 05, 2018 | Pubmed ID: 29363524 G Protein-Coupled Receptors at the Crossroad Between Physiologic and Pathologic Angiogenesis: Old Paradigms and Emerging Concepts International Journal of Molecular Sciences. Dec, 2017 | Pubmed ID: 29240722 GPER Mediates the Angiocrine Actions Induced by IGF1 Through the HIF-1α/VEGF Pathway in the Breast Tumor Microenvironment Breast Cancer Research : BCR. Dec, 2017 | Pubmed ID: 29212519 Interrogating Open Issues in Cancer Precision Medicine with Patient-derived Xenografts Nature Reviews. Cancer. 01, 2017 | Pubmed ID: 28104906 Patient-derived Xenograft (PDX) Models in Basic and Translational Breast Cancer Research Cancer Metastasis Reviews. 12, 2016 | Pubmed ID: 28025748 Complexity Galore: 3D Cultures, Biomechanics and Systems Medicine at the Eighth ENBDC Workshop "Methods in Mammary Gland Development and Cancer" Breast Cancer Research : BCR. 11, 2016 | Pubmed ID: 27887657 Erratum To: Patient-Derived Mammosphere and Xenograft Tumour Initiation Correlates with Progression to Metastasis Journal of Mammary Gland Biology and Neoplasia. Dec, 2016 | Pubmed ID: 27815673 Patient-derived Mammosphere and Xenograft Tumour Initiation Correlates with Progression to Metastasis Journal of Mammary Gland Biology and Neoplasia. Dec, 2016 | Pubmed ID: 27680982 SPRY1 Regulates Mammary Epithelial Morphogenesis by Modulating EGFR-dependent Stromal Paracrine Signaling and ECM Remodeling Proceedings of the National Academy of Sciences of the United States of America. 09, 2016 | Pubmed ID: 27621461 Intermittent Energy Restriction Induces Changes in Breast Gene Expression and Systemic Metabolism Breast Cancer Research : BCR. 05, 2016 | Pubmed ID: 27233359 Cisplatin Selects for Stem-like Cells in Osteosarcoma by Activating Notch Signaling Oncotarget. May, 2016 | Pubmed ID: 27102300 A Role for Notch Signalling in Breast Cancer and Endocrine Resistance Stem Cells International. 2016 | Pubmed ID: 26880941 An Integrated Genomic Approach Identifies That the PI3K/AKT/FOXO Pathway is Involved in Breast Cancer Tumor Initiation Oncotarget. Jan, 2016 | Pubmed ID: 26595803 Anti-estrogen Resistance in Human Breast Tumors Is Driven by JAG1-NOTCH4-Dependent Cancer Stem Cell Activity Cell Reports. Sep, 2015 | Pubmed ID: 26387946 The Role of Steroid Hormones in Breast Cancer Stem Cells Endocrine-related Cancer. Dec, 2015 | Pubmed ID: 26381288 The Seventh ENBDC Workshop on Methods in Mammary Gland Development and Cancer Breast Cancer Research : BCR. Sep, 2015 | Pubmed ID: 26330220 Dissecting Tumor Metabolic Heterogeneity: Telomerase and Large Cell Size Metabolically Define a Sub-population of Stem-like, Mitochondrial-rich, Cancer Cells Oncotarget. Sep, 2015 | Pubmed ID: 26323205 Doxycycline Down-regulates DNA-PK and Radiosensitizes Tumor Initiating Cells: Implications for More Effective Radiation Therapy Oncotarget. Jun, 2015 | Pubmed ID: 26087309 Focal Adhesion Kinase and Wnt Signaling Regulate Human Ductal Carcinoma in Situ Stem Cell Activity and Response to Radiotherapy Stem Cells (Dayton, Ohio). Feb, 2015 | Pubmed ID: 25187396 Risk Determination and Prevention of Breast Cancer Breast Cancer Research : BCR. Sep, 2014 | Pubmed ID: 25467785 Co-ordination of Cell Cycle, Migration and Stem Cell-like Activity in Breast Cancer Oncotarget. Sep, 2014 | Pubmed ID: 25277201 Patient-derived Xenograft Models: an Emerging Platform for Translational Cancer Research Cancer Discovery. Sep, 2014 | Pubmed ID: 25185190 17β-estradiol Regulates Giant Vesicle Formation Via Estrogen Receptor-alpha in Human Breast Cancer Cells Oncotarget. May, 2014 | Pubmed ID: 24931391 A Differential Role for CXCR4 in the Regulation of Normal Versus Malignant Breast Stem Cell Activity Oncotarget. Feb, 2014 | Pubmed ID: 24583601 P-cadherin Signals Through the Laminin Receptor α6β4 Integrin to Induce Stem Cell and Invasive Properties in Basal-like Breast Cancer Cells Oncotarget. Feb, 2014 | Pubmed ID: 24553076 Lapatinib Inhibits Stem/progenitor Proliferation in Preclinical in Vitro Models of Ductal Carcinoma in Situ (DCIS) Cell Cycle (Georgetown, Tex.). 2014 | Pubmed ID: 24247151 Enrichment of Human Osteosarcoma Stem Cells Based on HTERT Transcriptional Activity Oncotarget. Dec, 2013 | Pubmed ID: 24334332 Critical Research Gaps and Translational Priorities for the Successful Prevention and Treatment of Breast Cancer Breast Cancer Research : BCR. 2013 | Pubmed ID: 24286369 ‘The Charmingest Place’: Non-coding RNA, Lineage Tracing, Tumor Heterogeneity, Metastasis and Metabolism--new Methods in Mammary Gland Development and Cancer: the Fifth ENBDC Workshop Breast Cancer Research : BCR. 2013 | Pubmed ID: 24103450 Recent Advances Reveal IL-8 Signaling As a Potential Key to Targeting Breast Cancer Stem Cells Breast Cancer Research : BCR. 2013 | Pubmed ID: 24041156 Targeting IL-8 Signalling to Inhibit Breast Cancer Stem Cell Activity Expert Opinion on Therapeutic Targets. Nov, 2013 | Pubmed ID: 24032691 Wnt Pathway Activity in Breast Cancer Sub-types and Stem-like Cells PloS One. 2013 | Pubmed ID: 23861811 Cell Cycle Regulators Cyclin D1 and CDK4/6 Have Estrogen Receptor-dependent Divergent Functions in Breast Cancer Migration and Stem Cell-like Activity Cell Cycle (Georgetown, Tex.). Aug, 2013 | Pubmed ID: 23839043 Oestrogen Increases the Activity of Oestrogen Receptor Negative Breast Cancer Stem Cells Through Paracrine EGFR and Notch Signalling Breast Cancer Research : BCR. Mar, 2013 | Pubmed ID: 23497505 Combined Inhibition of ErbB1/2 and Notch Receptors Effectively Targets Breast Ductal Carcinoma in Situ (DCIS) Stem/progenitor Cell Activity Regardless of ErbB2 Status PloS One. 2013 | Pubmed ID: 23457626 Combining Notch Inhibition with Current Therapies for Breast Cancer Treatment Therapeutic Advances in Medical Oncology. Jan, 2013 | Pubmed ID: 23323144 Contrasting Hypoxic Effects on Breast Cancer Stem Cell Hierarchy is Dependent on ER-α Status Cancer Research. Feb, 2013 | Pubmed ID: 23248117 Targeting CXCR1/2 Significantly Reduces Breast Cancer Stem Cell Activity and Increases the Efficacy of Inhibiting HER2 Via HER2-dependent and -independent Mechanisms Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Feb, 2013 | Pubmed ID: 23149820 A Detailed Mammosphere Assay Protocol for the Quantification of Breast Stem Cell Activity Journal of Mammary Gland Biology and Neoplasia. Jun, 2012 | Pubmed ID: 22665270 Stem Cells in Breast Tumours: Are They Ready for the Clinic? European Journal of Cancer (Oxford, England : 1990). Sep, 2012 | Pubmed ID: 22542086 Hormones and Cancer: Update from Tokyo 2010 Expert Review of Endocrinology & Metabolism. Jan, 2011 | Pubmed ID: 30764033 The Devil is in the Methods: Lineage Tracing, Functional Screens and Sequencing, Hormones, Tumour-stroma Interactions, and Expansion of Human Breast Tumours As Xenografts Breast Cancer Research : BCR. Oct, 2011 | Pubmed ID: 22017807 Dickkopf1 Regulates Fate Decision and Drives Breast Cancer Stem Cells to Differentiation: an Experimentally Supported Mathematical Model PloS One. 2011 | Pubmed ID: 21915302 Breast Cancer Stem Cells and Their Role in Resistance to Endocrine Therapy Hormones & Cancer. Apr, 2011 | Pubmed ID: 21761332 Breast Cancer Stem Cells: Something out of Notching? Cancer Research. Nov, 2010 | Pubmed ID: 21045140 The Embryonic Transcription Cofactor LBH is a Direct Target of the Wnt Signaling Pathway in Epithelial Development and in Aggressive Basal Subtype Breast Cancers Molecular and Cellular Biology. Sep, 2010 | Pubmed ID: 20606007 Disruption of a Quorum Sensing Mechanism Triggers Tumorigenesis: a Simple Discrete Model Corroborated by Experiments in Mammary Cancer Stem Cells Biology Direct. 2010 | Pubmed ID: 20406437 Regulation of Breast Cancer Stem Cell Activity by Signaling Through the Notch4 Receptor Cancer Research. Jan, 2010 | Pubmed ID: 20068161 It's All in the Details: Methods in Breast Development and Cancer Breast Cancer Research : BCR. 2009 | Pubmed ID: 19691817 Biomarkers of Dietary Energy Restriction in Women at Increased Risk of Breast Cancer Cancer Prevention Research (Philadelphia, Pa.). Aug, 2009 | Pubmed ID: 19656771 Targeting Inhibitor of Apoptosis Proteins in Combination with ErbB Antagonists in Breast Cancer Breast Cancer Research : BCR. 2009 | Pubmed ID: 19563669 Normal Breast Tissue Implanted into Athymic Nude Mice Identifies Biomarkers of the Effects of Human Pregnancy Levels of Estrogen Cancer Prevention Research (Philadelphia, Pa.). Mar, 2009 | Pubmed ID: 19258541 Resistance to Endocrine Therapy: Are Breast Cancer Stem Cells the Culprits? Journal of Mammary Gland Biology and Neoplasia. Mar, 2009 | Pubmed ID: 19252972 Are Stem-like Cells Responsible for Resistance to Therapy in Breast Cancer? Breast Disease. 2008 | Pubmed ID: 19029627 The Removal of Multiplicative, Systematic Bias Allows Integration of Breast Cancer Gene Expression Datasets - Improving Meta-analysis and Prediction of Prognosis BMC Medical Genomics. 2008 | Pubmed ID: 18803878 Prolactin Receptor Antagonism Reduces the Clonogenic Capacity of Breast Cancer Cells and Potentiates Doxorubicin and Paclitaxel Cytotoxicity Breast Cancer Research : BCR. 2008 | Pubmed ID: 18681966 The Origin of Estrogen Receptor Alpha-positive and Alpha-negative Breast Cancer Advances in Experimental Medicine and Biology. 2008 | Pubmed ID: 18497032 Mammary Stem Cells and Breast Cancer--role of Notch Signalling Stem Cell Reviews. Jun, 2007 | Pubmed ID: 17873349 Origins of Breast Cancer Subtypes and Therapeutic Implications Nature Clinical Practice. Oncology. Sep, 2007 | Pubmed ID: 17728710 Novel Cell Culture Technique for Primary Ductal Carcinoma in Situ: Role of Notch and Epidermal Growth Factor Receptor Signaling Pathways Journal of the National Cancer Institute. Apr, 2007 | Pubmed ID: 17440163 Estrogen Deprivation for Breast Cancer Prevention Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progrès Dans Les Recherches Sur Le Cancer. 2007 | Pubmed ID: 17302193 High-throughput Genomic Technology in Research and Clinical Management of Breast Cancer. Exploiting the Potential of Gene Expression Profiling: is It Ready for the Clinic? Breast Cancer Research : BCR. 2006 | Pubmed ID: 17076877 Ovarian Steroids and the Human Breast: Regulation of Stem Cells and Cell Proliferation Maturitas. Jul, 2006 | Pubmed ID: 16806749 Human Breast Epithelial Stem Cells and Their Regulation The Journal of Pathology. Jan, 2006 | Pubmed ID: 16294373 Mechanisms of Disease: Prediction and Prevention of Breast Cancer--cellular and Molecular Interactions Nature Clinical Practice. Oncology. Dec, 2005 | Pubmed ID: 16341119 Isolation and Characterization of Human Mammary Stem Cells Cell Proliferation. Dec, 2005 | Pubmed ID: 16300651 Stem Cells and Tissue Homeostasis in Mammary Glands Journal of Mammary Gland Biology and Neoplasia. Jan, 2005 | Pubmed ID: 15886881 Do Early Premalignant Changes in Normal Breast Epithelial Cells Predict Cancer Development? Breast Cancer Research : BCR. 2005 | Pubmed ID: 15642177 A Putative Human Breast Stem Cell Population is Enriched for Steroid Receptor-positive Cells Developmental Biology. Jan, 2005 | Pubmed ID: 15617686 Preparation of a User-Defined Peptide Gel for Controlled 3D Culture Models of Cancer and Disease Jennifer C. Ashworth1, Rebecca L. Morgan1, Kataryna Lis-Slimak1, Kate A. Meade1, Sal Jones1, Katherine Spence2, Charlotte E. Slater1, Jamie L. Thompson1, Anna M. Grabowska1, Robert B. Clarke2, Gilian Farnie3, Cathy L. R. Merry1 1Division of Cancer & Stem Cells, School of Medicine, Nottingham Biodiscovery Institute, University of Nottingham, 2Breast Biology Group, Manchester Breast Centre, Division of Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, 3SGC, Botnar Research Centre, NDORMS, University of Oxford JoVE 61710 Biology
Preparation of a User-Defined Peptide Gel for Controlled 3D Culture Models of Cancer and Disease Jennifer C. Ashworth1, Rebecca L. Morgan1, Kataryna Lis-Slimak1, Kate A. Meade1, Sal Jones1, Katherine Spence2, Charlotte E. Slater1, Jamie L. Thompson1, Anna M. Grabowska1, Robert B. Clarke2, Gilian Farnie3, Cathy L. R. Merry1 1Division of Cancer & Stem Cells, School of Medicine, Nottingham Biodiscovery Institute, University of Nottingham, 2Breast Biology Group, Manchester Breast Centre, Division of Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, 3SGC, Botnar Research Centre, NDORMS, University of Oxford JoVE 61710 Biology