Robert F. Margolskee Monell Chemical Senses Center Biography Publications Institution JoVE Articles Robert F. Margolskee has not added a biography. If you are Robert F. Margolskee and would like to personalize this page please email our Author Liaison for assistance. Publications Activation of Intestinal Tuft Cell-expressed Sucnr1 Triggers Type 2 Immunity in the Mouse Small Intestine Proceedings of the National Academy of Sciences of the United States of America. 05, 2018 | Pubmed ID: 29735652 Aggravated Gut Inflammation in Mice Lacking the Taste Signaling Protein α-gustducin Brain, Behavior, and Immunity. Jul, 2018 | Pubmed ID: 29678794 Gli3 is a Negative Regulator of Tas1r3-expressing Taste Cells PLoS Genetics. 02, 2018 | Pubmed ID: 29415007 Bitter Taste Responses of Gustducin-positive Taste Cells in Mouse Fungiform and Circumvallate Papillae Neuroscience. Jan, 2018 | Pubmed ID: 29113930 Bacterial D-amino Acids Suppress Sinonasal Innate Immunity Through Sweet Taste Receptors in Solitary Chemosensory Cells Science Signaling. Sep, 2017 | Pubmed ID: 28874606 Whole Transcriptome Profiling of Taste Bud Cells Scientific Reports. Aug, 2017 | Pubmed ID: 28790351 Transcriptome Analyses of Taste Organoids Reveal Multiple Pathways Involved in Taste Cell Generation Scientific Reports. Jun, 2017 | Pubmed ID: 28638111 Taste Cell-expressed α-glucosidase Enzymes Contribute to Gustatory Responses to Disaccharides Proceedings of the National Academy of Sciences of the United States of America. May, 2016 | Pubmed ID: 27162343 Amiloride-Insensitive Salt Taste Is Mediated by Two Populations of Type III Taste Cells with Distinct Transduction Mechanisms The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Feb, 2016 | Pubmed ID: 26865617 Tuft Cells, Taste-chemosensory Cells, Orchestrate Parasite Type 2 Immunity in the Gut Science (New York, N.Y.). Mar, 2016 | Pubmed ID: 26847546 Functional Analyses of Bitter Taste Receptors in Domestic Cats (Felis Catus) PloS One. 2015 | Pubmed ID: 26488302 Characterization of the Binding Site of Aspartame in the Human Sweet Taste Receptor Chemical Senses. Oct, 2015 | Pubmed ID: 26377607 Sugar-induced Cephalic-phase Insulin Release is Mediated by a T1r2+T1r3-independent Taste Transduction Pathway in Mice American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. Sep, 2015 | Pubmed ID: 26157055 Leptin Suppresses Mouse Taste Cell Responses to Sweet Compounds Diabetes. Nov, 2015 | Pubmed ID: 26116698 Glucagon-like Peptide-1 is Specifically Involved in Sweet Taste Transmission FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Jun, 2015 | Pubmed ID: 25678625 Single Lgr5- or Lgr6-expressing Taste Stem/progenitor Cells Generate Taste Bud Cells Ex Vivo Proceedings of the National Academy of Sciences of the United States of America. Nov, 2014 | Pubmed ID: 25368147 Differential Contribution of TRPM4 and TRPM5 Nonselective Cation Channels to the Slow Afterdepolarization in Mouse Prefrontal Cortex Neurons Frontiers in Cellular Neuroscience. 2014 | Pubmed ID: 25237295 Expression and Nuclear Translocation of Glucocorticoid Receptors in Type 2 Taste Receptor Cells Neuroscience Letters. Jun, 2014 | Pubmed ID: 24814581 The Bamboo-eating Giant Panda (Ailuropoda Melanoleuca) Has a Sweet Tooth: Behavioral and Molecular Responses to Compounds That Taste Sweet to Humans PloS One. 2014 | Pubmed ID: 24671207 Effects of Roux-en-Y Gastric Bypass on Energy and Glucose Homeostasis Are Preserved in Two Mouse Models of Functional Glucagon-like Peptide-1 Deficiency Molecular Metabolism. Apr, 2014 | Pubmed ID: 24634822 Bitter and Sweet Taste Receptors Regulate Human Upper Respiratory Innate Immunity The Journal of Clinical Investigation. Mar, 2014 | Pubmed ID: 24531552 Endocrine Taste Cells The British Journal of Nutrition. Jun, 2014 | Pubmed ID: 24382120 Mouse Nasal Epithelial Innate Immune Responses to Pseudomonas Aeruginosa Quorum-sensing Molecules Require Taste Signaling Components Innate Immunity. Aug, 2014 | Pubmed ID: 24045336 Genetic Loss or Pharmacological Blockade of Testes-expressed Taste Genes Causes Male Sterility Proceedings of the National Academy of Sciences of the United States of America. Jul, 2013 | Pubmed ID: 23818598 Lgr5-EGFP Marks Taste Bud Stem/progenitor Cells in Posterior Tongue Stem Cells (Dayton, Ohio). May, 2013 | Pubmed ID: 23377989 Gustducin Couples Fatty Acid Receptors to GLP-1 Release in Colon American Journal of Physiology. Endocrinology and Metabolism. Mar, 2013 | Pubmed ID: 23341498 The Role of T1r3 and Trpm5 in Carbohydrate-induced Obesity in Mice Physiology & Behavior. Aug, 2012 | Pubmed ID: 22683548 Targeted Taste Cell-specific Overexpression of Brain-derived Neurotrophic Factor in Adult Taste Buds Elevates Phosphorylated TrkB Protein Levels in Taste Cells, Increases Taste Bud Size, and Promotes Gustatory Innervation The Journal of Biological Chemistry. May, 2012 | Pubmed ID: 22442142 Major Taste Loss in Carnivorous Mammals Proceedings of the National Academy of Sciences of the United States of America. Mar, 2012 | Pubmed ID: 22411809 A Conditioned Aversion Study of Sucrose and SC45647 Taste in TRPM5 Knockout Mice Chemical Senses. Jun, 2012 | Pubmed ID: 21987728 Glucose Transporters and ATP-gated K+ (KATP) Metabolic Sensors Are Present in Type 1 Taste Receptor 3 (T1r3)-expressing Taste Cells Proceedings of the National Academy of Sciences of the United States of America. Mar, 2011 | Pubmed ID: 21383163 REEP2 Enhances Sweet Receptor Function by Recruitment to Lipid Rafts The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Oct, 2010 | Pubmed ID: 20943918 Gut T1R3 Sweet Taste Receptors Do Not Mediate Sucrose-conditioned Flavor Preferences in Mice American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. Dec, 2010 | Pubmed ID: 20926763 Gustation Genetics: Sweet Gustducin! Chemical Senses. Sep, 2010 | Pubmed ID: 20660058 Action Potential-enhanced ATP Release from Taste Cells Through Hemichannels Journal of Neurophysiology. Aug, 2010 | Pubmed ID: 20519578 Phenoxy Herbicides and Fibrates Potently Inhibit the Human Chemosensory Receptor Subunit T1R3 Journal of Medicinal Chemistry. Nov, 2009 | Pubmed ID: 19817384 Role of Olfaction in the Conditioned Sucrose Preference of Sweet-ageusic T1R3 Knockout Mice Chemical Senses. Oct, 2009 | Pubmed ID: 19736224 Expression of the Voltage-gated Potassium Channel KCNQ1 in Mammalian Taste Bud Cells and the Effect of Its Null-mutation on Taste Preferences The Journal of Comparative Neurology. Jan, 2009 | Pubmed ID: 19006182 Involvement of T1R3 in Calcium-magnesium Taste Physiological Genomics. Aug, 2008 | Pubmed ID: 18593862 Efeitos de gosto sinalização Abolishment de proteína na inflamação do intestino em um modelo de Mouse de doença inflamatória intestinal Ya-Wen Du*1, Qun Liu*1, Xiao-Cui Luo1, Dong-Xiao Zhao1, Jian-Bo Xue1, Pu Feng2, Robert F. Margolskee2, Hong Wang2, Liquan Huang1,2 1College of Life Sciences, Zhejiang University, 2Monell Chemical Senses Center JoVE 58668 Immunology and Infection
Efeitos de gosto sinalização Abolishment de proteína na inflamação do intestino em um modelo de Mouse de doença inflamatória intestinal Ya-Wen Du*1, Qun Liu*1, Xiao-Cui Luo1, Dong-Xiao Zhao1, Jian-Bo Xue1, Pu Feng2, Robert F. Margolskee2, Hong Wang2, Liquan Huang1,2 1College of Life Sciences, Zhejiang University, 2Monell Chemical Senses Center JoVE 58668 Immunology and Infection