Robert J. Vassar Department of Neurology Northwestern University Feinberg School of Medicine Biography Publications Institution JoVE Articles Robert J. Vassar has not added a biography. If you are Robert J. Vassar and would like to personalize this page please email our Author Liaison for assistance. Publications The Case for Low-level BACE1 Inhibition for the Prevention of Alzheimer Disease Nature Reviews. Neurology. 11, 2021 | Pubmed ID: 34548654 A Promising New γ-secretase Modulator for Alzheimer's Disease The Journal of Experimental Medicine. 04, 2021 | Pubmed ID: 33683299 Early Detection and Personalized Medicine: Future Strategies Against Alzheimer's Disease Progress in Molecular Biology and Translational Science. 2021 | Pubmed ID: 33453940 Aβ-accelerated Neurodegeneration Caused by Alzheimer's-associated Variant R1279Q is Rescued by Angiotensin System Inhibition in Mice Science Translational Medicine. 09, 2020 | Pubmed ID: 32998969 Death by Microglia The Journal of Experimental Medicine. 11, 2019 | Pubmed ID: 31645368 Editorial: Implications for BACE1 Inhibitor Clinical Trials: Adult Conditional BACE1 Knockout Mice Exhibit Axonal Organization Defects in the Hippocampus The Journal of Prevention of Alzheimer's Disease. 2019 | Pubmed ID: 30756113 A Promising, Novel, and Unique BACE1 Inhibitor Emerges in the Quest to Prevent Alzheimer's Disease EMBO Molecular Medicine. 11, 2018 | Pubmed ID: 30322841 ER Stress is Not Elevated in the 5XFAD Mouse Model of Alzheimer's Disease The Journal of Biological Chemistry. 11, 2018 | Pubmed ID: 30315100 Axonal Organization Defects in the Hippocampus of Adult Conditional BACE1 Knockout Mice Science Translational Medicine. 09, 2018 | Pubmed ID: 30232227 Seeds of Destruction: New Mechanistic Insights into the Role of Apolipoprotein E4 in Alzheimer's Disease Neuron. 12, 2017 | Pubmed ID: 29216455 Inhibiting BACE1 to Reverse Synaptic Dysfunctions in Alzheimer's Disease Neuroscience and Biobehavioral Reviews. Jun, 2016 | Pubmed ID: 27044452 Presynaptic Dystrophic Neurites Surrounding Amyloid Plaques Are Sites of Microtubule Disruption, BACE1 Elevation, and Increased Aβ Generation in Alzheimer's Disease Acta Neuropathologica. 08, 2016 | Pubmed ID: 26993139 Aβ Reduction in BACE1 Heterozygous Null 5XFAD Mice is Associated with Transgenic APP Level Molecular Neurodegeneration. Jan, 2015 | Pubmed ID: 25567526 Molecular Neurodegeneration: Basic Biology and Disease Pathways Molecular Neurodegeneration. Sep, 2014 | Pubmed ID: 25248568 The Normal and Pathologic Roles of the Alzheimer's β-secretase, BACE1 Current Alzheimer Research. 2014 | Pubmed ID: 24893886 Increased MtDNA Mutations with Aging Promotes Amyloid Accumulation and Brain Atrophy in the APP/Ld Transgenic Mouse Model of Alzheimer's Disease Molecular Neurodegeneration. May, 2014 | Pubmed ID: 24885175 Targeting the β Secretase BACE1 for Alzheimer's Disease Therapy The Lancet. Neurology. Mar, 2014 | Pubmed ID: 24556009 ADAM10 Prodomain Mutations Cause Late-onset Alzheimer's Disease: Not Just the Latest FAD Neuron. Oct, 2013 | Pubmed ID: 24139026 Elevated Aβ42 in Aged, Non-demented Individuals with Cerebral Atherosclerosis Current Alzheimer Research. Oct, 2013 | Pubmed ID: 23919773 The β-secretase Enzyme BACE1 As a Therapeutic Target for Alzheimer's Disease Alzheimer's Research & Therapy. May, 2011 | Pubmed ID: 21639952 BACE1-/- Mice Exhibit Seizure Activity That Does Not Correlate with Sodium Channel Level or Axonal Localization Molecular Neurodegeneration. Aug, 2010 | Pubmed ID: 20731874 The Beta-secretase Enzyme BACE in Health and Alzheimer's Disease: Regulation, Cell Biology, Function, and Therapeutic Potential The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Oct, 2009 | Pubmed ID: 19828790 뇌에서 아밀로이드 피브릴 코어의 생화학 적 정제 및 프로테오믹 특성화 Arun Upadhyay1, Robert J. Vassar1, Jeffrey N. Savas1 1Department of Neurology, Northwestern University Feinberg School of Medicine JoVE 63816 Neuroscience
뇌에서 아밀로이드 피브릴 코어의 생화학 적 정제 및 프로테오믹 특성화 Arun Upadhyay1, Robert J. Vassar1, Jeffrey N. Savas1 1Department of Neurology, Northwestern University Feinberg School of Medicine JoVE 63816 Neuroscience