Robert M. Brosh Jr. Laboratory of Molecular Gerontology National Institute on Aging, NIH Biography Publications Institution JoVE Articles Robert M. Brosh Jr. has not added a biography. If you are Robert M. Brosh Jr. and would like to personalize this page please email our Author Liaison for assistance. Publications DNA Helicase and Helicase-nuclease Enzymes with a Conserved Iron-sulfur Cluster Nucleic Acids Research. Jan, 2012 | Pubmed ID: 22287629 Biochemical Characterization of Warsaw Breakage Syndrome Helicase The Journal of Biological Chemistry. Jan, 2012 | Pubmed ID: 22102414 Fanconi Anemia and Bloom's Syndrome Crosstalk Through FANCJ-BLM Helicase Interaction Trends in Genetics : TIG. Jan, 2012 | Pubmed ID: 22024395 Put on Your Thinking Cap: G-quadruplexes, Helicases, and Telomeres Aging. Apr, 2011 | Pubmed ID: 21732565 Interaction Between the Helicases Genetically Linked to Fanconi Anemia Group J and Bloom's Syndrome The EMBO Journal. Feb, 2011 | Pubmed ID: 21240188 Inhibition of Helicase Activity by a Small Molecule Impairs Werner Syndrome Helicase (WRN) Function in the Cellular Response to DNA Damage or Replication Stress Proceedings of the National Academy of Sciences of the United States of America. Jan, 2011 | Pubmed ID: 21220316 Helicase-inactivating Mutations As a Basis for Dominant Negative Phenotypes Cell Cycle (Georgetown, Tex.). Oct, 2010 | Pubmed ID: 20980836 Genetic Mutants Illuminate the Roles of RecQ Helicases in Recombinational Repair or Response to Replicational Stress Cell Cycle (Georgetown, Tex.). Aug, 2010 | Pubmed ID: 20703073 G-quadruplex Nucleic Acids and Human Disease The FEBS Journal. Sep, 2010 | Pubmed ID: 20670277 Fanconi Anemia Group J Mutation Abolishes Its DNA Repair Function by Uncoupling DNA Translocation from Helicase Activity or Disruption of Protein-DNA Complexes Blood. Nov, 2010 | Pubmed ID: 20639400 Special Methods Collection on DNA Helicases Methods (San Diego, Calif.). Jul, 2010 | Pubmed ID: 20610179 Mechanistic and Biological Aspects of Helicase Action on Damaged DNA Cell Cycle (Georgetown, Tex.). Jun, 2010 | Pubmed ID: 20574162 Delineation of WRN Helicase Function with EXO1 in the Replicational Stress Response DNA Repair. Jul, 2010 | Pubmed ID: 20447876 Impact Papers on Aging in 2009 Aging. Mar, 2010 | Pubmed ID: 20351400 Distinct Roles of RECQ1 in the Maintenance of Genomic Stability DNA Repair. Mar, 2010 | Pubmed ID: 20061189 Premature Aging Syndrome Gene WRN Genetically Interacts with a Topoisomerase Cell Cycle (Georgetown, Tex.). Jul, 2009 | Pubmed ID: 19587535 FANCJ Helicase Operates in the Fanconi Anemia DNA Repair Pathway and the Response to Replicational Stress Current Molecular Medicine. May, 2009 | Pubmed ID: 19519404 FANCJ Helicase Uniquely Senses Oxidative Base Damage in Either Strand of Duplex DNA and is Stimulated by Replication Protein A to Unwind the Damaged DNA Substrate in a Strand-specific Manner The Journal of Biological Chemistry. Jul, 2009 | Pubmed ID: 19419957 Hitting the Bull's Eye: Novel Directed Cancer Therapy Through Helicase-targeted Synthetic Lethality Journal of Cellular Biochemistry. Apr, 2009 | Pubmed ID: 19173305 FANCJ Uses Its Motor ATPase to Destabilize Protein-DNA Complexes, Unwind Triplexes, and Inhibit RAD51 Strand Exchange The Journal of Biological Chemistry. Mar, 2009 | Pubmed ID: 19150983 Molecular Biology: The Bloom's Complex Mousetrap Nature. Nov, 2008 | Pubmed ID: 19037304 RECQ1 Possesses DNA Branch Migration Activity The Journal of Biological Chemistry. Jul, 2008 | Pubmed ID: 18495662 BRCA-FA Pathway As a Target for Anti-tumor Drugs Anti-cancer Agents in Medicinal Chemistry. May, 2008 | Pubmed ID: 18473727 Helicases As Prospective Targets for Anti-cancer Therapy Anti-cancer Agents in Medicinal Chemistry. May, 2008 | Pubmed ID: 18473724 DNA Repair As a Target for Anti-cancer Therapy Anti-cancer Agents in Medicinal Chemistry. May, 2008 | Pubmed ID: 18473719 FANCJ Helicase Defective in Fanconia Anemia and Breast Cancer Unwinds G-quadruplex DNA to Defend Genomic Stability Molecular and Cellular Biology. Jun, 2008 | Pubmed ID: 18426915 Unique and Important Consequences of RECQ1 Deficiency in Mammalian Cells Cell Cycle (Georgetown, Tex.). Apr, 2008 | Pubmed ID: 18414032 Human Replication Protein A Melts a DNA Triple Helix Structure in a Potent and Specific Manner Biochemistry. May, 2008 | Pubmed ID: 18410127 Processing of DNA Replication and Repair Intermediates by the Concerted Action of RecQ Helicases and Rad2 Structure-specific Nucleases Protein and Peptide Letters. 2008 | Pubmed ID: 18221018 Human RECQ1 is a DNA Damage Responsive Protein Required for Genotoxic Stress Resistance and Suppression of Sister Chromatid Exchanges PloS One. 2007 | Pubmed ID: 18074021 Human Premature Aging, DNA Repair and RecQ Helicases Nucleic Acids Research. 2007 | Pubmed ID: 18006573 FANCJ (BACH1) Helicase Forms DNA Damage Inducible Foci with Replication Protein A and Interacts Physically and Functionally with the Single-stranded DNA-binding Protein Blood. Oct, 2007 | Pubmed ID: 17596542 The FANCJ/MutLalpha Interaction is Required for Correction of the Cross-link Response in FA-J Cells The EMBO Journal. Jul, 2007 | Pubmed ID: 17581638 DNA Repair Helicases As Targets for Anti-cancer Therapy Current Medicinal Chemistry. 2007 | Pubmed ID: 17346143 RECQL, a Member of the RecQ Family of DNA Helicases, Suppresses Chromosomal Instability Molecular and Cellular Biology. Mar, 2007 | Pubmed ID: 17158923 Tetraplex Binding Molecules As Anti-cancer Agents Recent Patents on Anti-cancer Drug Discovery. Jun, 2006 | Pubmed ID: 18221036 Inhibition of BACH1 (FANCJ) Helicase by Backbone Discontinuity is Overcome by Increased Motor ATPase or Length of Loading Strand Nucleic Acids Research. 2006 | Pubmed ID: 17145708 Mechanisms of RecQ Helicases in Pathways of DNA Metabolism and Maintenance of Genomic Stability The Biochemical Journal. Sep, 2006 | Pubmed ID: 16925525 Enzymatic Mechanism of the WRN Helicase/nuclease Methods in Enzymology. 2006 | Pubmed ID: 16793395 Biochemical Assays for the Characterization of DNA Helicases Methods in Molecular Biology (Clifton, N.J.). 2006 | Pubmed ID: 16673896 Cockayne Syndrome Group B Protein Has Novel Strand Annealing and Exchange Activities Nucleic Acids Research. 2006 | Pubmed ID: 16410611 Inhibition of Werner Syndrome Helicase Activity by Benzo[a]pyrene Diol Epoxide Adducts Can Be Overcome by Replication Protein A The Journal of Biological Chemistry. Mar, 2006 | Pubmed ID: 16380375 The Interaction Site of Flap Endonuclease-1 with WRN Helicase Suggests a Coordination of WRN and PCNA Nucleic Acids Research. 2005 | Pubmed ID: 16326861 Modulation of Werner Syndrome Protein Function by a Single Mutation in the Conserved RecQ Domain The Journal of Biological Chemistry. Nov, 2005 | Pubmed ID: 16150736 DNA Helicases As Targets for Anti-cancer Drugs Current Medicinal Chemistry. Anti-cancer Agents. May, 2005 | Pubmed ID: 15992349 Physical and Functional Mapping of the Replication Protein a Interaction Domain of the Werner and Bloom Syndrome Helicases The Journal of Biological Chemistry. Aug, 2005 | Pubmed ID: 15965237 Biochemical Analysis of the DNA Unwinding and Strand Annealing Activities Catalyzed by Human RECQ1 The Journal of Biological Chemistry. Jul, 2005 | Pubmed ID: 15899892 RECQ1 Helicase Interacts with Human Mismatch Repair Factors That Regulate Genetic Recombination The Journal of Biological Chemistry. Jul, 2005 | Pubmed ID: 15886194 Analysis of the DNA Substrate Specificity of the Human BACH1 Helicase Associated with Breast Cancer The Journal of Biological Chemistry. Jul, 2005 | Pubmed ID: 15878853 P53 Modulates RPA-dependent and RPA-independent WRN Helicase Activity Cancer Research. Feb, 2005 | Pubmed ID: 15735006 In Vivo Function of the Conserved Non-catalytic Domain of Werner Syndrome Helicase in DNA Replication Human Molecular Genetics. Oct, 2004 | Pubmed ID: 15282207 Biochemical and Kinetic Characterization of the DNA Helicase and Exonuclease Activities of Werner Syndrome Protein The Journal of Biological Chemistry. Aug, 2004 | Pubmed ID: 15187093 Analysis of the Unwinding Activity of the Dimeric RECQ1 Helicase in the Presence of Human Replication Protein A Nucleic Acids Research. 2004 | Pubmed ID: 15096578 Stimulation of Flap Endonuclease-1 by the Bloom's Syndrome Protein The Journal of Biological Chemistry. Mar, 2004 | Pubmed ID: 14688284 WRN Helicase and FEN-1 Form a Complex Upon Replication Arrest and Together Process Branchmigrating DNA Structures Associated with the Replication Fork Molecular Biology of the Cell. Feb, 2004 | Pubmed ID: 14657243 Inhibition of Werner Syndrome Helicase Activity by Benzo[c]phenanthrene Diol Epoxide DA Adducts in DNA is Both Strand-and Stereoisomer-dependent The Journal of Biological Chemistry. Oct, 2003 | Pubmed ID: 12881525 The Exonucleolytic and Endonucleolytic Cleavage Activities of Human Exonuclease 1 Are Stimulated by an Interaction with the Carboxyl-terminal Region of the Werner Syndrome Protein The Journal of Biological Chemistry. Jun, 2003 | Pubmed ID: 12704184 The Transcriptional Response After Oxidative Stress is Defective in Cockayne Syndrome Group B Cells Oncogene. Feb, 2003 | Pubmed ID: 12606941 Functional Consequences of Mutations in the Conserved SF2 Motifs and Post-translational Phosphorylation of the CSB Protein Nucleic Acids Research. Feb, 2003 | Pubmed ID: 12560492 Biochemical Characterization of the WRN-FEN-1 Functional Interaction Biochemistry. Oct, 2002 | Pubmed ID: 12356323 The Processing of Holliday Junctions by BLM and WRN Helicases is Regulated by P53 The Journal of Biological Chemistry. Aug, 2002 | Pubmed ID: 12080066 Global Genome Repair of 8-oxoG in Hamster Cells Requires a Functional CSB Gene Product Oncogene. May, 2002 | Pubmed ID: 12032859 Pathways Defective in the Human Premature Aging Disease Werner Syndrome Biogerontology. 2002 | Pubmed ID: 12014850 Biochemical Characterization of the DNA Substrate Specificity of Werner Syndrome Helicase The Journal of Biological Chemistry. Jun, 2002 | Pubmed ID: 11956187 Colocalization, Physical, and Functional Interaction Between Werner and Bloom Syndrome Proteins The Journal of Biological Chemistry. Jun, 2002 | Pubmed ID: 11919194 Werner Protein is a Target of DNA-dependent Protein Kinase in Vivo and in Vitro, and Its Catalytic Activities Are Regulated by Phosphorylation The Journal of Biological Chemistry. May, 2002 | Pubmed ID: 11889123 Phenotypic Consequences of Mutations in the Conserved Motifs of the Putative Helicase Domain of the Human Cockayne Syndrome Group B Gene Gene. Jan, 2002 | Pubmed ID: 11867210 Roles of the Werner Syndrome Protein in Pathways Required for Maintenance of Genome Stability Experimental Gerontology. Apr, 2002 | Pubmed ID: 11830352 Differential Requirement for the ATPase Domain of the Cockayne Syndrome Group B Gene in the Processing of UV-induced DNA Damage and 8-oxoguanine Lesions in Human Cells Nucleic Acids Research. Feb, 2002 | Pubmed ID: 11809892 Genetiska studier av människans proteiner DNA Repair använder jäst som modellsystem Monika Aggarwal1, Robert M. Brosh Jr.1 1Laboratory of Molecular Gerontology, National Institute on Aging, NIH JoVE 1639 Biology
Genetiska studier av människans proteiner DNA Repair använder jäst som modellsystem Monika Aggarwal1, Robert M. Brosh Jr.1 1Laboratory of Molecular Gerontology, National Institute on Aging, NIH JoVE 1639 Biology