Robert P. Mecham

Publications

• Loss of Angiotensin II Type 2 Receptor Improves Blood Pressure in Elastin Insufficiency
  Frontiers in Cardiovascular Medicine. 2021  |   Pubmed ID: 34790711
• Deletion of Type VIII Collagen Reduces Blood Pressure, Increases Carotid Artery Functional Distensibility and Promotes Elastin Deposition
  Matrix Biology Plus. Dec, 2021  |   Pubmed ID: 34693248
• Vascular Smooth Muscle Cell Subpopulations and Neointimal Formation in Mouse Models of Elastin Insufficiency
  Arteriosclerosis, Thrombosis, and Vascular Biology. 12, 2021  |   Pubmed ID: 34587758
• Tissue-specific Smooth Muscle Cell Subtypes Identified by Transcriptional Profiling
  The International Journal of Biochemistry & Cell Biology. 10, 2021  |   Pubmed ID: 34411694
• JNK2 Gene Silencing for Elastic Matrix Regenerative Repair
  Tissue Engineering. Part A. Aug, 2021  |   Pubmed ID: 34409851
• Inhibition of NOX1 Mitigates Blood Pressure Increases in Elastin Insufficiency
  Function (Oxford, England). 2021  |   Pubmed ID: 34223172
• SVEP1 is a Human Coronary Artery Disease Locus That Promotes Atherosclerosis
  Science Translational Medicine. 03, 2021  |   Pubmed ID: 33762433
• Complex Consequences of Cantu Syndrome SUR2 Variant R1154Q in Genetically Modified Mice
  JCI Insight. 03, 2021  |   Pubmed ID: 33529173
• RNA Vaccines for COVID-19: 5 Things Every Cardiologist Should Know
  JACC. Basic to Translational Science. Dec, 2020  |   Pubmed ID: 33251385
• A Matricellular Protein Fibulin-4 is Essential for the Activation of Lysyl Oxidase
  Science Advances. Nov, 2020  |   Pubmed ID: 33239290
• Whole Exome Sequencing in Patients with Williams-Beuren Syndrome Followed by Disease Modeling in Mice Points to Four Novel Pathways That May Modify Stenosis Risk
  Human Molecular Genetics. May, 2020  |   Pubmed ID: 32412588
• Identification of the Growth Factor-binding Sequence in the Extracellular Matrix Protein MAGP-1
  The Journal of Biological Chemistry. 02, 2020  |   Pubmed ID: 31988245
• Elastic Fiber Ultrastructure and Assembly
  Matrix Biology : Journal of the International Society for Matrix Biology. 11, 2019  |   Pubmed ID: 31669522
• Sodium-activated Potassium Channels Moderate Excitability in Vascular Smooth Muscle
  The Journal of Physiology. 10, 2019  |   Pubmed ID: 31444905
• Intracellular Retention of Mutant Lysyl Oxidase Leads to Aortic Dilation in Response to Increased Hemodynamic Stress
  JCI Insight. 06, 2019  |   Pubmed ID: 31211696
• Decreased Lysyl Oxidase Level Protects Against Development of Retinal Vascular Lesions in Diabetic Retinopathy
  Experimental Eye Research. 07, 2019  |   Pubmed ID: 31022398
• Cardiovascular Consequences of KATP Overactivity in Cantu Syndrome
  JCI Insight. 08, 2018  |   Pubmed ID: 30089727
• Extracellular Determinants of Arterial Morphogenesis, Growth, and Homeostasis
  Current Topics in Developmental Biology. 2018  |   Pubmed ID: 29853177
• Spatial and Temporal Changes in Extracellular Elastin and Laminin Distribution During Lung Alveolar Development
  Scientific Reports. 05, 2018  |   Pubmed ID: 29844468
• Requisite Endothelial Reactivation and Effective SiRNA Nanoparticle Targeting of Etv2/Er71 in Tumor Angiogenesis
  JCI Insight. 04, 2018  |   Pubmed ID: 29669933
• Microfibril-associated Glycoproteins MAGP-1 and MAGP-2 in Disease
  Matrix Biology : Journal of the International Society for Matrix Biology. 10, 2018  |   Pubmed ID: 29524629
• Contribution of Metabolic Disease to Bone Fragility in MAGP1-deficient Mice
  Matrix Biology : Journal of the International Society for Matrix Biology. 04, 2018  |   Pubmed ID: 29519758
• Elastin in Lung Development and Disease Pathogenesis
  Matrix Biology : Journal of the International Society for Matrix Biology. 11, 2018  |   Pubmed ID: 29331337
• Elastin Purification and Solubilization
  Methods in Cell Biology. 2018  |   Pubmed ID: 29310779
• Measurement of Elastin, Collagen, and Total Protein Levels in Tissues
  Methods in Cell Biology. 2018  |   Pubmed ID: 29310774
• FGF Receptors Control Alveolar Elastogenesis
  Development (Cambridge, England). 12, 2017  |   Pubmed ID: 29122839
• Downregulation of Lysyl Oxidase Protects Retinal Endothelial Cells From High Glucose-Induced Apoptosis
  Investigative Ophthalmology & Visual Science. 05, 2017  |   Pubmed ID: 28538980
• Fibulin-4 is Essential for Maintaining Arterial Wall Integrity in Conduit but Not Muscular Arteries
  Science Advances. May, 2017  |   Pubmed ID: 28508064
• Inhibition of MAPK-Erk Pathway In vivo Attenuates Aortic Valve Disease Processes in Emilin1-deficient Mouse Model
  Physiological Reports. Mar, 2017  |   Pubmed ID: 28270590
• Deficient Circumferential Growth Is the Primary Determinant of Aortic Obstruction Attributable to Partial Elastin Deficiency
  Arteriosclerosis, Thrombosis, and Vascular Biology. 05, 2017  |   Pubmed ID: 28254817
• Marrow Adipose Tissue Expansion Coincides with Insulin Resistance in MAGP1-Deficient Mice
  Frontiers in Endocrinology. 2016  |   Pubmed ID: 27445989
• Loss of Function Mutation in LOX Causes Thoracic Aortic Aneurysm and Dissection in Humans
  Proceedings of the National Academy of Sciences of the United States of America. 08, 2016  |   Pubmed ID: 27432961
• Albumin Contributes to Kidney Disease Progression in Alport Syndrome
  American Journal of Physiology. Renal Physiology. 07, 2016  |   Pubmed ID: 27147675
• Characterization of Metabolic Health in Mouse Models of Fibrillin-1 Perturbation
  Matrix Biology : Journal of the International Society for Matrix Biology. 09, 2016  |   Pubmed ID: 26902431
• Chronic Antihypertensive Treatment Improves Pulse Pressure but Not Large Artery Mechanics in a Mouse Model of Congenital Vascular Stiffness
  American Journal of Physiology. Heart and Circulatory Physiology. Sep, 2015  |   Pubmed ID: 26232234
• Fibulin-4 E57K Knock-in Mice Recapitulate Cutaneous, Vascular and Skeletal Defects of Recessive Cutis Laxa 1B with Both Elastic Fiber and Collagen Fibril Abnormalities
  The Journal of Biological Chemistry. Aug, 2015  |   Pubmed ID: 26178373
• The Microfibril-associated Glycoproteins (MAGPs) and the Microfibrillar Niche
  Matrix Biology : Journal of the International Society for Matrix Biology. Sep, 2015  |   Pubmed ID: 25963142
• Adamtsl2 Deletion Results in Bronchial Fibrillin Microfibril Accumulation and Bronchial Epithelial Dysplasia--a Novel Mouse Model Providing Insights into Geleophysic Dysplasia
  Disease Models & Mechanisms. May, 2015  |   Pubmed ID: 25762570
• Fibroblast Growth Factor 2 is Required for Epithelial Recovery, but Not for Pulmonary Fibrosis, in Response to Bleomycin
  American Journal of Respiratory Cell and Molecular Biology. Jan, 2015  |   Pubmed ID: 24988442
• The Extracellular Matrix Protein MAGP1 Supports Thermogenesis and Protects Against Obesity and Diabetes Through Regulation of TGF-β
  Diabetes. Jun, 2014  |   Pubmed ID: 24458361
• Altered Reactivity of Resistance Vasculature Contributes to Hypertension in Elastin Insufficiency
  American Journal of Physiology. Heart and Circulatory Physiology. Mar, 2014  |   Pubmed ID: 24414067
• Nonselective Assembly of Fibrillin 1 and Fibrillin 2 in the Rodent Ocular Zonule and in Cultured Cells: Implications for Marfan Syndrome
  Investigative Ophthalmology & Visual Science. Dec, 2013  |   Pubmed ID: 24265020
• Ocular Phenotype of Fbn2-null Mice
  Investigative Ophthalmology & Visual Science. Nov, 2013  |   Pubmed ID: 24130178
• Hypotension Due to Kir6.1 Gain-of-function in Vascular Smooth Muscle
  Journal of the American Heart Association. Aug, 2013  |   Pubmed ID: 23974906
• Microfibril-associated Glycoprotein 2 (MAGP2) Loss of Function Has Pleiotropic Effects in Vivo
  The Journal of Biological Chemistry. Oct, 2013  |   Pubmed ID: 23963447
• Zap70 Inhibits Syk-mediated Osteoclast Function
  Journal of Cellular Biochemistry. Aug, 2013  |   Pubmed ID: 23494777
• Development, Composition, and Structural Arrangements of the Ciliary Zonule of the Mouse
  Investigative Ophthalmology & Visual Science. Apr, 2013  |   Pubmed ID: 23493297
• A Fiber-based Constitutive Model Predicts Changes in Amount and Organization of Matrix Proteins with Development and Disease in the Mouse Aorta
  Biomechanics and Modeling in Mechanobiology. Jun, 2013  |   Pubmed ID: 22790326
• Overview of Extracellular Matrix
  Current Protocols in Cell Biology. Dec, 2012  |   Pubmed ID: 23208544
• Paxillin Contracts the Osteoclast Cytoskeleton
  Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research. Dec, 2012  |   Pubmed ID: 22807029
• Alternative Splicing and Tissue-specific Elastin Misassembly Act As Biological Modifiers of Human Elastin Gene Frameshift Mutations Associated with Dominant Cutis Laxa
  The Journal of Biological Chemistry. Jun, 2012  |   Pubmed ID: 22573328
• Oophorectomy-induced Bone Loss is Attenuated in MAGP1-deficient Mice
  Journal of Cellular Biochemistry. Jan, 2012  |   Pubmed ID: 21898536
• Inhibition of MicroRNA-29 Enhances Elastin Levels in Cells Haploinsufficient for Elastin and in Bioengineered Vessels
  Arteriosclerosis, Thrombosis, and Vascular Biology. Nov, 2011  |   Pubmed ID: 22095981
• Genetic Modifiers of Cardiovascular Phenotype Caused by Elastin Haploinsufficiency Act by Extrinsic Noncomplementation
  The Journal of Biological Chemistry. Dec, 2011  |   Pubmed ID: 22049077
• Pathogenesis of Aortic Dilatation in Mucopolysaccharidosis VII Mice May Involve Complement Activation
  Molecular Genetics and Metabolism. Dec, 2011  |   Pubmed ID: 21944884
• Characterization of Erectile Function in Elastin Haploinsufficicent Mice
  The Journal of Sexual Medicine. Nov, 2011  |   Pubmed ID: 21883953
• Decreased Aortic Diameter and Compliance Precedes Blood Pressure Increases in Postnatal Development of Elastin-insufficient Mice
  American Journal of Physiology. Heart and Circulatory Physiology. Jul, 2011  |   Pubmed ID: 21536846
• Oxidative Modifications of the C-terminal Domain of Tropoelastin Prevent Cell Binding
  The Journal of Biological Chemistry. Apr, 2011  |   Pubmed ID: 21321118
• New Insights into the Pathogenesis of Autosomal-dominant Cutis Laxa with Report of Five ELN Mutations
  Human Mutation. Apr, 2011  |   Pubmed ID: 21309044
• Evidence for Heterozygous Abnormalities of the Elastin Gene (ELN) Affecting the Quantity of Vocal Fold Elastic Fibers: a Pilot Study
  Journal of Voice : Official Journal of the Voice Foundation. Mar, 2011  |   Pubmed ID: 20926252
• Oxidative and Nitrosative Modifications of Tropoelastin Prevent Elastic Fiber Assembly in Vitro
  The Journal of Biological Chemistry. Nov, 2010  |   Pubmed ID: 20847053
• The Matrix-binding Domain of Microfibril-associated Glycoprotein-1 Targets Active Connective Tissue Growth Factor to a Fibroblast-produced Extracellular Matrix
  Macromolecular Bioscience. Nov, 2010  |   Pubmed ID: 20799254
• Mechanisms of Emphysema in Autosomal Dominant Cutis Laxa
  Matrix Biology : Journal of the International Society for Matrix Biology. Sep, 2010  |   Pubmed ID: 20600892
• Microfibril-associated Glycoprotein-1, an Extracellular Matrix Regulator of Bone Remodeling
  The Journal of Biological Chemistry. Jul, 2010  |   Pubmed ID: 20501659
• Discrete Contributions of Elastic Fiber Components to Arterial Development and Mechanical Compliance
  Arteriosclerosis, Thrombosis, and Vascular Biology. Dec, 2009  |   Pubmed ID: 19850904
• Vascular Extracellular Matrix and Arterial Mechanics
  Physiological Reviews. Jul, 2009  |   Pubmed ID: 19584318
• Effects of Chronic Treatment with a Low Dose of Nicorandil on the Function of the Rat Aorta During Ageing
  Clinical and Experimental Pharmacology & Physiology. Oct, 2009  |   Pubmed ID: 19473347
• Reduced Vessel Elasticity Alters Cardiovascular Structure and Function in Newborn Mice
  Circulation Research. May, 2009  |   Pubmed ID: 19372465
• Fibrillins, Fibulins, and Matrix-associated Glycoprotein Modulate the Kinetics and Morphology of in Vitro Self-assembly of a Recombinant Elastin-like Polypeptide
  Biochemistry. Nov, 2008  |   Pubmed ID: 18973305
• Essential Role for Fibrillin-2 in Zebrafish Notochord and Vascular Morphogenesis
  Developmental Dynamics : an Official Publication of the American Association of Anatomists. Oct, 2008  |   Pubmed ID: 18816837
• Elastin Insufficiency Predisposes to Elevated Pulmonary Circulatory Pressures Through Changes in Elastic Artery Structure
  Journal of Applied Physiology (Bethesda, Md. : 1985). Nov, 2008  |   Pubmed ID: 18772328
• Deficiency in Microfibril-associated Glycoprotein-1 Leads to Complex Phenotypes in Multiple Organ Systems
  The Journal of Biological Chemistry. Sep, 2008  |   Pubmed ID: 18625713
• Modification and Functional Inactivation of the Tropoelastin Carboxy-terminal Domain in Cross-linked Elastin
  Matrix Biology : Journal of the International Society for Matrix Biology. Sep, 2008  |   Pubmed ID: 18602002
• Upregulation of Elastase Proteins Results in Aortic Dilatation in Mucopolysaccharidosis I Mice
  Molecular Genetics and Metabolism. Jul, 2008  |   Pubmed ID: 18479957
• Methods in Elastic Tissue Biology: Elastin Isolation and Purification
  Methods (San Diego, Calif.). May, 2008  |   Pubmed ID: 18442703
• Mice Lacking the Extracellular Matrix Protein MAGP1 Display Delayed Thrombotic Occlusion Following Vessel Injury
  Blood. Apr, 2008  |   Pubmed ID: 18281502
• Neutrophil Elastase Cleaves Laminin-332 (laminin-5) Generating Peptides That Are Chemotactic for Neutrophils
  The Journal of Biological Chemistry. Apr, 2008  |   Pubmed ID: 18178964
• Elastin Haploinsufficiency Induces Alternative Aging Processes in the Aorta
  Rejuvenation Research. Feb, 2008  |   Pubmed ID: 18173368
• Fibulin-2 is Dispensable for Mouse Development and Elastic Fiber Formation
  Molecular and Cellular Biology. Feb, 2008  |   Pubmed ID: 18070922
• New Insights into Elastic Fiber Assembly
  Birth Defects Research. Part C, Embryo Today : Reviews. Dec, 2007  |   Pubmed ID: 18228265
• The Intracellular Form of Human MAGP1 Elicits a Complex and Specific Transcriptional Response
  The International Journal of Biochemistry & Cell Biology. 2007  |   Pubmed ID: 17692555
• Functional Rescue of Elastin Insufficiency in Mice by the Human Elastin Gene: Implications for Mouse Models of Human Disease
  Circulation Research. Aug, 2007  |   Pubmed ID: 17626896
• Elastin-insufficient Mice Show Normal Cardiovascular Remodeling in 2K1C Hypertension Despite Higher Baseline Pressure and Unique Cardiovascular Architecture
  American Journal of Physiology. Heart and Circulatory Physiology. Jul, 2007  |   Pubmed ID: 17400710
• Elastin Protein Levels Are a Vital Modifier Affecting Normal Lung Development and Susceptibility to Emphysema
  American Journal of Physiology. Lung Cellular and Molecular Physiology. Mar, 2007  |   Pubmed ID: 17142349
• Domains 16 and 17 of Tropoelastin in Elastic Fibre Formation
  The Biochemical Journal. Feb, 2007  |   Pubmed ID: 17037986
• Fibulin-5 Mutations: Mechanisms of Impaired Elastic Fiber Formation in Recessive Cutis Laxa
  Human Molecular Genetics. Dec, 2006  |   Pubmed ID: 17035250
• The Stumbling Block in Lung Repair of Emphysema: Elastic Fiber Assembly
  Proceedings of the American Thoracic Society. Jul, 2006  |   Pubmed ID: 16799087
• Specific Sequence Motifs Direct the Oxygenation and Chlorination of Tryptophan by Myeloperoxidase
  Biochemistry. Mar, 2006  |   Pubmed ID: 16548523
• Elastin Fragments Drive Disease Progression in a Murine Model of Emphysema
  The Journal of Clinical Investigation. Mar, 2006  |   Pubmed ID: 16470245
• Elastic Fiber Formation: a Dynamic View of Extracellular Matrix Assembly Using Timer Reporters
  Journal of Cellular Physiology. Apr, 2006  |   Pubmed ID: 16261592
• Tropoelastin Interacts with Cell-surface Glycosaminoglycans Via Its COOH-terminal Domain
  The Journal of Biological Chemistry. Dec, 2005  |   Pubmed ID: 16192266
• A Functional Mutation in the Terminal Exon of Elastin in Severe, Early-onset Chronic Obstructive Pulmonary Disease
  American Journal of Respiratory Cell and Molecular Biology. Oct, 2005  |   Pubmed ID: 16081882
• Effects of Elastin Haploinsufficiency on the Mechanical Behavior of Mouse Arteries
  American Journal of Physiology. Heart and Circulatory Physiology. Sep, 2005  |   Pubmed ID: 15863465
• Altered Vascular Remodeling in Fibulin-5-deficient Mice Reveals a Role of Fibulin-5 in Smooth Muscle Cell Proliferation and Migration
  Proceedings of the National Academy of Sciences of the United States of America. Feb, 2005  |   Pubmed ID: 15710889
• TGF-beta-dependent Pathogenesis of Mitral Valve Prolapse in a Mouse Model of Marfan Syndrome
  The Journal of Clinical Investigation. Dec, 2004  |   Pubmed ID: 15546004
• Vascular Extracellular Matrix and Aortic Development
  Current Topics in Developmental Biology. 2004  |   Pubmed ID: 15522742
• Deposition of Tropoelastin into the Extracellular Matrix Requires a Competent Elastic Fiber Scaffold but Not Live Cells
  Matrix Biology : Journal of the International Society for Matrix Biology. Apr, 2004  |   Pubmed ID: 15172035
• Neutrophil Serine Proteinases Inactivate Surfactant Protein D by Cleaving Within a Conserved Subregion of the Carbohydrate Recognition Domain
  The Journal of Biological Chemistry. Jun, 2004  |   Pubmed ID: 15078883
• Identification of a Major Microfibril-associated Glycoprotein-1-binding Domain in Fibrillin-2
  The Journal of Biological Chemistry. May, 2004  |   Pubmed ID: 15044481
• Developmental Adaptation of the Mouse Cardiovascular System to Elastin Haploinsufficiency
  The Journal of Clinical Investigation. Nov, 2003  |   Pubmed ID: 14597767
• Dexamethasone Induction of Hypertension and Diabetes is PPAR-alpha Dependent in LDL Receptor-null Mice
  Nature Medicine. Aug, 2003  |   Pubmed ID: 12847522
• Fibrillin-1 and -2 Contain Heparin-binding Sites Important for Matrix Deposition and That Support Cell Attachment
  The Biochemical Journal. Oct, 2003  |   Pubmed ID: 12837131
• A Site on Laminin Alpha 5, AQARSAASKVKVSMKF, Induces Inflammatory Cell Production of Matrix Metalloproteinase-9 and Chemotaxis
  Journal of Immunology (Baltimore, Md. : 1950). Jul, 2003  |   Pubmed ID: 12817023
• Domains in Tropoelastin That Mediate Elastin Deposition in Vitro and in Vivo
  The Journal of Biological Chemistry. May, 2003  |   Pubmed ID: 12626514
• Hypertension and Prolonged Vasoconstrictor Signaling in RGS2-deficient Mice
  The Journal of Clinical Investigation. Feb, 2003  |   Pubmed ID: 12588882
• Lysyl Oxidase is Required for Vascular and Diaphragmatic Development in Mice
  The Journal of Biological Chemistry. Apr, 2003  |   Pubmed ID: 12473682
• The Microfibrillar Proteins MAGP-1 and Fibrillin-1 Form a Ternary Complex with the Chondroitin Sulfate Proteoglycan Decorin
  Molecular Biology of the Cell. May, 2000  |   Pubmed ID: 10793130
• Characterization of an in Vitro Model of Elastic Fiber Assembly
  Molecular Biology of the Cell. Nov, 1999  |   Pubmed ID: 10564258
• Identification of Tropoelastin As a Ligand for the 65-kD FK506-binding Protein, FKBP65, in the Secretory Pathway
  The Journal of Cell Biology. Jan, 1998  |   Pubmed ID: 9442105
• Chlamydomonas Agglutinin is a Hydroxyproline-rich Glycoprotein
  Proceedings of the National Academy of Sciences of the United States of America. Oct, 1983  |   Pubmed ID: 16593377