Roberto Pili Genitourinary Section, Department of Medicine Roswell Park Cancer Institute Biography Publications Institution JoVE Articles Roberto Pili has not added a biography. If you are Roberto Pili and would like to personalize this page please email our Author Liaison for assistance. Publications Mechanism of Action and Clinical Activity of Tasquinimod in Castrate-resistant Prostate Cancer OncoTargets and Therapy. 2014 | Pubmed ID: 24600234 Kidney Cancer, Version 2.2014 Journal of the National Comprehensive Cancer Network : JNCCN. Feb, 2014 | Pubmed ID: 24586079 Active Smoking May Negatively Affect Response Rate, Progression-free Survival, and Overall Survival of Patients with Metastatic Renal Cell Carcinoma Treated with Sunitinib The Oncologist. Jan, 2014 | Pubmed ID: 24309979 Dietary Protein Restriction Inhibits Tumor Growth in Human Xenograft Models Oncotarget. Dec, 2013 | Pubmed ID: 24353195 Combinatorial Antitumor Effect of HDAC and the PI3K-Akt-mTOR Pathway Inhibition in a Pten Defecient Model of Prostate Cancer Oncotarget. Dec, 2013 | Pubmed ID: 24163230 Understanding Avoidance, Refusal, and Abandonment of Chemotherapy Before and After Cystectomy for Bladder Cancer Urology. Dec, 2013 | Pubmed ID: 24125689 Major Response to Cyclophosphamide and Prednisone in Recurrent Castration-resistant Prostate Cancer Journal of the National Comprehensive Cancer Network : JNCCN. Aug, 2013 | Pubmed ID: 23946170 Histone Modifications: Implications in Renal Cell Carcinoma Epigenomics. Aug, 2013 | Pubmed ID: 23895657 A Phase II Safety and Efficacy Study of the Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitor Pazopanib in Patients with Metastatic Urothelial Cancer Clinical Genitourinary Cancer. Dec, 2013 | Pubmed ID: 23891158 Histone Deacetylase Inhibitors and Epigenetic Modifications As a Novel Strategy in Renal Cell Carcinoma Cancer Journal (Sudbury, Mass.). Jul-Aug, 2013 | Pubmed ID: 23867515 Use of a Glycolipid Inhibitor to Ameliorate Renal Cancer in a Mouse Model PloS One. 2013 | Pubmed ID: 23671696 Tasquinimod: a Novel Angiogenesis Inhibitor-development in Prostate Cancer Current Oncology Reports. Apr, 2013 | Pubmed ID: 23334511 Class I Histone Deacetylase Inhibition is a Novel Mechanism to Target Regulatory T Cells in Immunotherapy Oncoimmunology. Sep, 2012 | Pubmed ID: 23162767 Pretreatment Neutrophil-to-lymphocyte Ratio in Metastatic Castration-resistant Prostate Cancer Patients Treated with Ketoconazole: Association with Outcome and Predictive Nomogram The Oncologist. 2012 | Pubmed ID: 22971522 Nanosponge-encapsulated Camptothecin Exerts Anti-tumor Activity in Human Prostate Cancer Cells European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences. Nov, 2012 | Pubmed ID: 22917641 苏尼替尼在体内转移的模型内的对比效果。 Angiogenesis. Dec, 2012 | Pubmed ID: 22843200 Prolyl Hydroxylase 2 Dependent and Von-Hippel-Lindau Independent Degradation of Hypoxia-inducible Factor 1 and 2 Alpha by Selenium in Clear Cell Renal Cell Carcinoma Leads to Tumor Growth Inhibition BMC Cancer. 2012 | Pubmed ID: 22804960 Mind the Gap: Potential for Rebounds During Antiangiogenic Treatment Breaks Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jul, 2012 | Pubmed ID: 22679177 Testicular Cancer Journal of the National Comprehensive Cancer Network : JNCCN. Apr, 2012 | Pubmed ID: 22491049 Bisphosphonates Combined with Sunitinib May Improve the Response Rate, Progression Free Survival and Overall Survival of Patients with Bone Metastases from Renal Cell Carcinoma European Journal of Cancer (Oxford, England : 1990). May, 2012 | Pubmed ID: 22409947 一类组蛋白去乙酰酶抑制剂 Entinostat 取消管制的 T 细胞和增强免疫治疗中肾和前列腺癌模型中的。 PloS One. 2012 | Pubmed ID: 22303460 Modulation of Chemotherapeutic Efficacy by Vascular Disrupting Agents: Optimizing the Sequence and Schedule Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Mar, 2012 | Pubmed ID: 22291088 Vascular Disruption in Combination with MTOR Inhibition in Renal Cell Carcinoma Molecular Cancer Therapeutics. Feb, 2012 | Pubmed ID: 22084164 The Association of Pre-treatment Neutrophil to Lymphocyte Ratio with Response Rate, Progression Free Survival and Overall Survival of Patients Treated with Sunitinib for Metastatic Renal Cell Carcinoma European Journal of Cancer (Oxford, England : 1990). Jan, 2012 | Pubmed ID: 22018713 Development of a Castrate Resistant Transplant Tumor Model of Prostate Cancer The Prostate. May, 2012 | Pubmed ID: 21796655 A Phase II Study of 2-methoxyestradiol Nanocrystal Colloidal Dispersion Alone and in Combination with Sunitinib Malate in Patients with Metastatic Renal Cell Carcinoma Progressing on Sunitinib Malate Investigational New Drugs. Apr, 2012 | Pubmed ID: 21174224 Resistance to Angiogenesis Inhibitors in Renal Cell Carcinoma Clinical Advances in Hematology & Oncology : H&O. Feb, 2011 | Pubmed ID: 22173604 Concurrent HDAC and MTORC1 Inhibition Attenuate Androgen Receptor and Hypoxia Signaling Associated with Alterations in MicroRNA Expression PloS One. 2011 | Pubmed ID: 22087262 Lysosomal Sequestration of Sunitinib: a Novel Mechanism of Drug Resistance Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Dec, 2011 | Pubmed ID: 21980135 Phase II Randomized, Double-blind, Placebo-controlled Study of Tasquinimod in Men with Minimally Symptomatic Metastatic Castrate-resistant Prostate Cancer Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Oct, 2011 | Pubmed ID: 21931019 Role of Immunotherapy for Renal Cell Cancer in 2011 Journal of the National Comprehensive Cancer Network : JNCCN. Sep, 2011 | Pubmed ID: 21917625 Kidney Cancer Journal of the National Comprehensive Cancer Network : JNCCN. Sep, 2011 | Pubmed ID: 21917622 Provenge: Combating Prostate Cancer with a Vengeance? Expert Review of Vaccines. Aug, 2011 | Pubmed ID: 21854304 Nuclear Factor Erythroid 2-related Factor-2 Activity Controls 4-hydroxynonenal Metabolism and Activity in Prostate Cancer Cells Free Radical Biology & Medicine. Oct, 2011 | Pubmed ID: 21816220 Impact of Cytoreductive Nephrectomy on Eligibility for Systemic Treatment and Effects on Survival: Are Surgical Complications or Disease Related Factors Responsible? Urology. Sep, 2011 | Pubmed ID: 21777963 Angiotensin System Inhibitors and Outcome of Sunitinib Treatment in Patients with Metastatic Renal Cell Carcinoma: a Retrospective Examination European Journal of Cancer (Oxford, England : 1990). Sep, 2011 | Pubmed ID: 21600760 NCCN Task Force Report: Optimizing Treatment of Advanced Renal Cell Carcinoma with Molecular Targeted Therapy Journal of the National Comprehensive Cancer Network : JNCCN. Feb, 2011 | Pubmed ID: 21335444 Induction of Cell Cycle Arrest and DNA Damage by the HDAC Inhibitor Panobinostat (LBH589) and the Lipid Peroxidation End Product 4-hydroxynonenal in Prostate Cancer Cells Free Radical Biology & Medicine. Jan, 2011 | Pubmed ID: 21078383 A Phase II Study of 2-methoxyestradiol (2ME2) NanoCrystal® Dispersion (NCD) in Patients with Taxane-refractory, Metastatic Castrate-resistant Prostate Cancer (CRPC) Investigational New Drugs. Dec, 2011 | Pubmed ID: 20499131 A Phase I Study of OSI-461 in Combination with Mitoxantrone in Patients with Advanced Solid Tumors Potentially Responsive to Mitoxantrone Cancer Chemotherapy and Pharmacology. Feb, 2011 | Pubmed ID: 20445979 Is This a True Renaissance for the Treatment of Prostate Cancer? Oncology (Williston Park, N.Y.). Dec, 2010 | Pubmed ID: 21294477 Histone Deacetylase Inhibitors: Advancing Therapeutic Strategies in Hematological and Solid Malignancies Pharmaceuticals (Basel, Switzerland). Aug, 2010 | Pubmed ID: 21151768 Lenalidomide in Nonmetastatic Biochemically Relapsed Prostate Cancer: Results of a Phase I/II Double-blinded, Randomized Study Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Nov, 2010 | Pubmed ID: 20978144 Reversible Epithelial to Mesenchymal Transition and Acquired Resistance to Sunitinib in Patients with Renal Cell Carcinoma: Evidence from a Xenograft Study Molecular Cancer Therapeutics. Jun, 2010 | Pubmed ID: 20501804 Phase II Study on the Addition of ASA404 (vadimezan; 5,6-dimethylxanthenone-4-acetic Acid) to Docetaxel in CRMPC Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. May, 2010 | Pubmed ID: 20460477 Needs Assessments Can Identify Scores on HRQOL Questionnaires That Represent Problems for Patients: an Illustration with the Supportive Care Needs Survey and the QLQ-C30 Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation. Aug, 2010 | Pubmed ID: 20340048 Pentastatin-1, a Collagen IV Derived 20-mer Peptide, Suppresses Tumor Growth in a Small Cell Lung Cancer Xenograft Model BMC Cancer. 2010 | Pubmed ID: 20122172 The Relationship of Vascular Endothelial Growth Factor and Coagulation Factor (fibrin and Fibrinogen) Expression in Clear Cell Renal Cell Carcinoma Urology. Mar, 2010 | Pubmed ID: 19683801 Pre-clinical Models of Renal Carcinoma and Their Utility in Drug Development Current Protocols in Pharmacology / Editorial Board, S.J. Enna (editor-in-chief) ... [et Al.]. Dec, 2009 | Pubmed ID: 22294393 Update on Novel Agents in Renal Cell Carcinoma Expert Review of Anticancer Therapy. Dec, 2009 | Pubmed ID: 19954293 Vorinostat in Advanced Prostate Cancer Patients Progressing on Prior Chemotherapy (National Cancer Institute Trial 6862): Trial Results and Interleukin-6 Analysis: a Study by the Department of Defense Prostate Cancer Clinical Trial Consortium and University of Chicago Phase 2 Consortium Cancer. Dec, 2009 | Pubmed ID: 19711464 Concordance of Cancer Patients' Function, Symptoms, and Supportive Care Needs Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation. Oct, 2009 | Pubmed ID: 19657724 NCCN Clinical Practice Guidelines in Oncology: Kidney Cancer Journal of the National Comprehensive Cancer Network : JNCCN. Jun, 2009 | Pubmed ID: 19555584 NCCN Clinical Practice Guidelines in Oncology: Testicular Cancer Journal of the National Comprehensive Cancer Network : JNCCN. Jun, 2009 | Pubmed ID: 19555582 Vinflunine in Platinum-pretreated Patients with Locally Advanced or Metastatic Urothelial Carcinoma: Results of a Large Phase 2 Study Cancer. Sep, 2009 | Pubmed ID: 19536904 Recent Investigations of Histone Deacetylase Inhibitors in Renal Cell Carcinoma Clinical Advances in Hematology & Oncology : H&O. Apr, 2009 | Pubmed ID: 19521328 Overall Survival and Updated Results for Sunitinib Compared with Interferon Alfa in Patients with Metastatic Renal Cell Carcinoma Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Aug, 2009 | Pubmed ID: 19487381 VEGF 新兵 Lactosylceramide 诱使血管内皮细胞粘附分子表达及血管生成体外和体内。 Glycoconjugate Journal. Jul, 2009 | Pubmed ID: 19219548 Targeting Tumor Angiogenesis with Histone Deacetylase Inhibitors Cancer Letters. Aug, 2009 | Pubmed ID: 19111391 A Phase II Trial of 17-allylamino-17-demethoxygeldanamycin in Patients with Hormone-refractory Metastatic Prostate Cancer Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Dec, 2008 | Pubmed ID: 19047126 Digoxin and Other Cardiac Glycosides Inhibit HIF-1alpha Synthesis and Block Tumor Growth Proceedings of the National Academy of Sciences of the United States of America. Dec, 2008 | Pubmed ID: 19020076 Reproducibility of Tumor Blood Flow Quantification with 15O-water PET Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. Oct, 2008 | Pubmed ID: 18832120 Phase II Trial of Docetaxel with Rapid Androgen Cycling for Progressive Noncastrate Prostate Cancer Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Jun, 2008 | Pubmed ID: 18565882 Combination Strategy Targeting the Hypoxia Inducible Factor-1 Alpha with Mammalian Target of Rapamycin and Histone Deacetylase Inhibitors Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jun, 2008 | Pubmed ID: 18519793 Symptoms, Supportive Care Needs, and Function in Cancer Patients: How Are They Related? Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation. Jun, 2008 | Pubmed ID: 18493865 Phase I Study of MGCD0103 Given As a Three-times-per-week Oral Dose in Patients with Advanced Solid Tumors Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Apr, 2008 | Pubmed ID: 18421048 Population Pharmacokinetic-pharmacodynamic Model of the Vascular-disrupting Agent 5,6-dimethylxanthenone-4-acetic Acid in Cancer Patients Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Apr, 2008 | Pubmed ID: 18381951 Posttranscription Regulation of Prostate Cancer Growth Cancer Journal (Sudbury, Mass.). Jan-Feb, 2008 | Pubmed ID: 18303483 Intravenous Bevacizumab Causes Regression of Choroidal Neovascularization Secondary to Diseases Other Than Age-related Macular Degeneration American Journal of Ophthalmology. Feb, 2008 | Pubmed ID: 18054887 Platelets Take Up the Monoclonal Antibody Bevacizumab Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Sep, 2007 | Pubmed ID: 17855648 The N-Myc Down Regulated Gene1 (NDRG1) Is a Rab4a Effector Involved in Vesicular Recycling of E-cadherin PloS One. 2007 | Pubmed ID: 17786215 Preclinical and Clinical Studies with the Multi-kinase Inhibitor CEP-701 As Treatment for Prostate Cancer Demonstrate the Inadequacy of PSA Response As a Primary Endpoint Cancer Biology & Therapy. Sep, 2007 | Pubmed ID: 17786033 Synergistic in Vivo Antitumor Effect of the Histone Deacetylase Inhibitor MS-275 in Combination with Interleukin 2 in a Murine Model of Renal Cell Carcinoma Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Aug, 2007 | Pubmed ID: 17671140 Vascular Endothelial Growth Factor Trap Blocks Tumor Growth, Metastasis Formation, and Vascular Leakage in an Orthotopic Murine Renal Cell Cancer Model Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jul, 2007 | Pubmed ID: 17634549 Antitumor Activity of the Histone Deacetylase Inhibitor MS-275 in Prostate Cancer Models The Prostate. Aug, 2007 | Pubmed ID: 17520666 Phase II Study of Imatinib Mesylate in Patients with Prostate Cancer with Evidence of Biochemical Relapse After Definitive Radical Retropubic Prostatectomy or Radiotherapy Urology. Mar, 2007 | Pubmed ID: 17382158 Sequence-dependent Antitumor Effects of Differentiation Agents in Combination with Cell Cycle-dependent Cytotoxic Drugs Cancer Chemotherapy and Pharmacology. Aug, 2007 | Pubmed ID: 17256134 Antitumor Effect of the Histone Deacetylase Inhibitor LAQ824 in Combination with 13-cis-retinoic Acid in Human Malignant Melanoma Molecular Cancer Therapeutics. Jan, 2007 | Pubmed ID: 17237267 A Liquid Chromatography/tandem Mass Spectrometry Assay to Quantitate MS-275 in Human Plasma Journal of Pharmaceutical and Biomedical Analysis. Jan, 2007 | Pubmed ID: 16971082 Identification of ABR-215050 As Lead Second Generation Quinoline-3-carboxamide Anti-angiogenic Agent for the Treatment of Prostate Cancer The Prostate. Dec, 2006 | Pubmed ID: 16955399 Class II Histone Deacetylases Are Associated with VHL-independent Regulation of Hypoxia-inducible Factor 1 Alpha Cancer Research. Sep, 2006 | Pubmed ID: 16951198 Phase I Dose Escalation and Pharmacokinetic Study of Enzastaurin, an Oral Protein Kinase C Beta Inhibitor, in Patients with Advanced Cancer Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Sep, 2006 | Pubmed ID: 16943527 Phase II Evaluation of Docetaxel Plus Exisulind in Patients with Androgen Independent Prostate Carcinoma American Journal of Clinical Oncology. Aug, 2006 | Pubmed ID: 16891869 1 型肌苷磷酸脱氢酶作为抗血管生成药物目标的标识。 Journal of Medicinal Chemistry. May, 2006 | Pubmed ID: 16640327 Targeting Tumor Angiogenesis with Histone Deacetylase Inhibitors: the Hydroxamic Acid Derivative LBH589 Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jan, 2006 | Pubmed ID: 16428510 Kidney Cancer. Clinical Practice Guidelines Journal of the National Comprehensive Cancer Network : JNCCN. Jan, 2005 | Pubmed ID: 19813325 A Phase II Trial of 17-allylamino-17- Demethoxygeldanamycin in Patients with Hormone-refractory Metastatic Prostate Cancer Clinical Prostate Cancer. Sep, 2005 | Pubmed ID: 16197617 Modeling the Cost of Management Options for Stage I Nonseminomatous Germ Cell Tumors: a Decision Tree Analysis Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Aug, 2005 | Pubmed ID: 16110033 Marimastat in the Treatment of Patients with Biochemically Relapsed Prostate Cancer: a Prospective Randomized, Double-blind, Phase I/II Trial Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jun, 2005 | Pubmed ID: 15958628 Epigenetic Modulation of Retinoic Acid Receptor Beta2 by the Histone Deacetylase Inhibitor MS-275 in Human Renal Cell Carcinoma Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. May, 2005 | Pubmed ID: 15867257 A New High Affinity Technetium-99m-bombesin Analogue with Low Abdominal Accumulation Bioconjugate Chemistry. Jan-Feb, 2005 | Pubmed ID: 15656574 In Vivo Imaging of Retinoic Acid Receptor Beta2 Transcriptional Activation by the Histone Deacetylase Inhibitor MS-275 in Retinoid-resistant Prostate Cancer Cells The Prostate. Jun, 2005 | Pubmed ID: 15651062 A New High Affinity Technetium Analogue of Bombesin Containing DTPA As a Pharmacokinetic Modifier Bioconjugate Chemistry. Nov-Dec, 2004 | Pubmed ID: 15546210 The Histone Deacetylase Inhibitor NVP-LAQ824 Inhibits Angiogenesis and Has a Greater Antitumor Effect in Combination with the Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitor PTK787/ZK222584 Cancer Research. Sep, 2004 | Pubmed ID: 15374977 Targeting Vascular Endothelial Growth Factor for Relapsed and Refractory Adult Acute Myelogenous Leukemias: Therapy with Sequential 1-beta-d-arabinofuranosylcytosine, Mitoxantrone, and Bevacizumab Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jun, 2004 | Pubmed ID: 15173063 A Phase II Trial of Temozolomide and IFN-alpha in Patients with Advanced Renal Cell Carcinoma Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research. Jan, 2004 | Pubmed ID: 14980083 CEP-7055: a Novel, Orally Active Pan Inhibitor of Vascular Endothelial Growth Factor Receptor Tyrosine Kinases with Potent Antiangiogenic Activity and Antitumor Efficacy in Preclinical Models Cancer Research. Sep, 2003 | Pubmed ID: 14522925 Is HIF-1 Alpha a Valid Therapeutic Target? Journal of the National Cancer Institute. Apr, 2003 | Pubmed ID: 12671009 Id1 Regulates Angiogenesis Through Transcriptional Repression of Thrombospondin-1 Cancer Cell. Dec, 2002 | Pubmed ID: 12498716 Endogenous Reactivation of the RARbeta2 Tumor Suppressor Gene Epigenetically Silenced in Breast Cancer Cancer Research. May, 2002 | Pubmed ID: 11980632 在小鼠模型自发转移性肾细胞癌(MRCC)肾切除 Amanda Tracz1, Michalis Mastri1, Christina R. Lee2, Roberto Pili1, John M. L. Ebos1 1Genitourinary Section, Department of Medicine, Roswell Park Cancer Institute, 2Biological Sciences Platform, Sunnybrook Research Institute JoVE 51485 Medicine
在小鼠模型自发转移性肾细胞癌(MRCC)肾切除 Amanda Tracz1, Michalis Mastri1, Christina R. Lee2, Roberto Pili1, John M. L. Ebos1 1Genitourinary Section, Department of Medicine, Roswell Park Cancer Institute, 2Biological Sciences Platform, Sunnybrook Research Institute JoVE 51485 Medicine