Ronald L. Klein Department of Pharmacology, Toxicology, and Neuroscience Louisiana State University Health Sciences Center Biography Publications Institution JoVE Articles Ronald L. Klein has not added a biography. If you are Ronald L. Klein and would like to personalize this page please email our Author Liaison for assistance. Publications Entorhinal Tau Pathology Disrupts Hippocampal-prefrontal Oscillatory Coupling During Associative Learning Neurobiology of Aging. Jul, 2017 | Pubmed ID: 28735144 P62 Pathology Model in the Rat Substantia Nigra with Filamentous Inclusions and Progressive Neurodegeneration PloS One. 2017 | Pubmed ID: 28076378 Corrigendum: Better Targeting, Better Efficiency for Wide-Scale Neuronal Transduction with the Synapsin Promoter and AAV-PHP.B Frontiers in Molecular Neuroscience. 2016 | Pubmed ID: 28008310 Better Targeting, Better Efficiency for Wide-Scale Neuronal Transduction with the Synapsin Promoter and AAV-PHP.B Frontiers in Molecular Neuroscience. 2016 | Pubmed ID: 27867348 Severe Respiratory Changes at End Stage in a FUS-induced Disease State in Adult Rats BMC Neuroscience. Oct, 2016 | Pubmed ID: 27793099 Gene Vector 'magic Bullet': Targeted Expression in the Central Nervous System After Peripheral Delivery Using the Synapsin Promoter Expert Opinion on Therapeutic Targets. Oct, 2016 | Pubmed ID: 27424738 Sequential Adeno-Associated Viral Vector Serotype 9-Green Fluorescent Protein Gene Transfer Causes Massive Inflammation and Intense Immune Response in Rat Striatum Human Gene Therapy. Jul, 2016 | Pubmed ID: 26847924 AAV9 Supports Wide-scale Transduction of the CNS and TDP-43 Disease Modeling in Adult Rats Molecular Therapy. Methods & Clinical Development. 2015 | Pubmed ID: 26445725 Initial Gene Vector Dosing for Studying Symptomatology of Amyotrophic Lateral Sclerosis in Non-human Primates Journal of Medical Primatology. Apr, 2015 | Pubmed ID: 25639184 Selective Forelimb Impairment in Rats Expressing a Pathological TDP-43 25 KDa C-terminal Fragment to Mimic Amyotrophic Lateral Sclerosis Molecular Therapy : the Journal of the American Society of Gene Therapy. Jul, 2013 | Pubmed ID: 28160795 Selective Forelimb Impairment in Rats Expressing a Pathological TDP-43 25 kDa C-terminal Fragment to Mimic Amyotrophic Lateral Sclerosis Molecular Therapy : the Journal of the American Society of Gene Therapy. Jul, 2013 | Pubmed ID: 23689600 Pre-immunization with an Intramuscular Injection of AAV9-Human Erythropoietin Vectors Reduces the Vector-Mediated Transduction Following Re-Administration in Rat Brain PloS One. 2013 | Pubmed ID: 23667683 Recombinant AAV9-TLK1B Administration Ameliorates Fractionated Radiation-induced Xerostomia Human Gene Therapy. Jun, 2013 | Pubmed ID: 23614651 Imaging the Response of the Retina to Electrical Stimulation with Genetically Encoded Calcium Indicators Journal of Neurophysiology. Apr, 2013 | Pubmed ID: 23343890 A Spirulina-enhanced Diet Provides Neuroprotection in an α-synuclein Model of Parkinson's Disease PloS One. 2012 | Pubmed ID: 23028885 Adult-onset Focal Expression of Mutated Human Tau in the Hippocampus Impairs Spatial Working Memory of Rats Behavioural Brain Research. Jul, 2012 | Pubmed ID: 22561128 Isocitrate Dehydrogenase 1 is Downregulated During Early Skin Tumorigenesis Which Can Be Inhibited by Overexpression of Manganese Superoxide Dismutase Cancer Science. Aug, 2012 | Pubmed ID: 22533343 The Advent of AAV9 Expands Applications for Brain and Spinal Cord Gene Delivery Expert Opinion on Biological Therapy. Jun, 2012 | Pubmed ID: 22519910 Frontotemporal Lobar Degeneration-related Proteins Induce Only Subtle Memory-related Deficits when Bilaterally Overexpressed in the Dorsal Hippocampus Experimental Neurology. Feb, 2012 | Pubmed ID: 22177996 Genetic Strategies to Study TDP-43 in Rodents and to Develop Preclinical Therapeutics for Amyotrophic Lateral Sclerosis The European Journal of Neuroscience. Oct, 2011 | Pubmed ID: 21777407 Focal Expression of Mutated Tau in Entorhinal Cortex Neurons of Rats Impairs Spatial Working Memory Behavioural Brain Research. Jan, 2011 | Pubmed ID: 20727915 Expansive Gene Transfer in the Rat CNS Rapidly Produces Amyotrophic Lateral Sclerosis Relevant Sequelae when TDP-43 is Overexpressed Molecular Therapy : the Journal of the American Society of Gene Therapy. Dec, 2010 | Pubmed ID: 20877346 Circulating Neprilysin Clears Brain Amyloid Molecular and Cellular Neurosciences. Oct, 2010 | Pubmed ID: 20558294 Transcriptome Analysis of a Tau Overexpression Model in Rats Implicates an Early Pro-inflammatory Response Experimental Neurology. Jul, 2010 | Pubmed ID: 20346943 Pronounced Microgliosis and Neurodegeneration in Aged Rats After Tau Gene Transfer Neurobiology of Aging. Dec, 2010 | Pubmed ID: 19155101 Versatile Somatic Gene Transfer for Modeling Neurodegenerative Diseases Neurotoxicity Research. Oct, 2009 | Pubmed ID: 19669852 쥐 Nigrostriatal 시스템에서 도파민과 GABA 조절 단백질에 일방적인 GDNF 관리의 양자 효과 Experimental Neurology. Sep, 2009 | Pubmed ID: 19460370 PET Imaging in Rats to Discern Temporal Onset Differences Between 6-hydroxydopamine and Tau Gene Vector Neurodegeneration Models Brain Research. Mar, 2009 | Pubmed ID: 19368808 Mimicking Aspects of Frontotemporal Lobar Degeneration and Lou Gehrig's Disease in Rats Via TDP-43 Overexpression Molecular Therapy : the Journal of the American Society of Gene Therapy. Apr, 2009 | Pubmed ID: 19223871 Effect of CNTF on Retinal Ganglion Cell Survival in Experimental Glaucoma Investigative Ophthalmology & Visual Science. May, 2009 | Pubmed ID: 19060281 다양 한 Adeno 제휴해 바이러스 벡터 Serotypes에서 타우 식 레벨 등급된 Neurodegenerative 질병 상태를 생성합니다 The European Journal of Neuroscience. Apr, 2008 | Pubmed ID: 18380664 AAV8, 9, Rh10, Rh43 Vector Gene Transfer in the Rat Brain: Effects of Serotype, Promoter and Purification Method Molecular Therapy : the Journal of the American Society of Gene Therapy. Jan, 2008 | Pubmed ID: 17955025 Memory-related Deficits Following Selective Hippocampal Expression of Swedish Mutation Amyloid Precursor Protein in the Rat Experimental Neurology. Aug, 2006 | Pubmed ID: 16780838 Parkin is Protective for Substantia Nigra Dopamine Neurons in a Tau Gene Transfer Neurodegeneration Model Neuroscience Letters. Jun, 2006 | Pubmed ID: 16554120 Efficient Neuronal Gene Transfer with AAV8 Leads to Neurotoxic Levels of Tau or Green Fluorescent Proteins Molecular Therapy : the Journal of the American Society of Gene Therapy. Mar, 2006 | Pubmed ID: 16325474 Tau Gene Transfer, but Not Alpha-synuclein, Induces Both Progressive Dopamine Neuron Degeneration and Rotational Behavior in the Rat Neurobiology of Disease. Oct, 2005 | Pubmed ID: 16137567 Adeno-associated Viruses Containing BFGF or BDNF Are Neuroprotective Against Excitotoxicity Current Eye Research. Dec, 2004 | Pubmed ID: 15764082 Recombinant Adeno-associated Virus Serotype 2 Effectively Transduces Primary Rat Brain Astrocytes and Microglia Brain Research. Brain Research Protocols. Nov, 2004 | Pubmed ID: 15519948 돌연변이 타우의 지역화 된 유전자 이동 후 빠른 Neurofibrillary 얽힌 형성 The American Journal of Pathology. Jan, 2004 | Pubmed ID: 14695347 Long-term Neuronal Effects and Disposition of Ectopic PreproNGF Gene Transfer into the Rat Septum Human Gene Therapy. Oct, 2003 | Pubmed ID: 14577926 Gene Therapy with Brain-derived Neurotrophic Factor As a Protection: Retinal Ganglion Cells in a Rat Glaucoma Model Investigative Ophthalmology & Visual Science. Oct, 2003 | Pubmed ID: 14507880 Adeno-associated Virus Vector Expressing Nerve Growth Factor Enhances Cholinergic Axonal Sprouting After Cortical Injury in Rats The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Apr, 2003 | Pubmed ID: 12684466 Suppression of Insult-induced Neurogenesis in Adult Rat Brain by Brain-derived Neurotrophic Factor Experimental Neurology. Sep, 2002 | Pubmed ID: 12429205 Particle Detection, Number Estimation, and Feature Measurement in Gene Transfer Studies: Optical Fractionator Stereology Integrated with Digital Image Processing and Analysis Methods (San Diego, Calif.). Oct, 2002 | Pubmed ID: 12413429 Measurements of Vector-derived Neurotrophic Factor and Green Fluorescent Protein Levels in the Brain Methods (San Diego, Calif.). Oct, 2002 | Pubmed ID: 12413428 Gene Delivery to the Eye Using Adeno-associated Viral Vectors Methods (San Diego, Calif.). Oct, 2002 | Pubmed ID: 12413426 Pre- and Post-synaptic Modification by Neurotrophins Neuroscience Research. Jul, 2002 | Pubmed ID: 12103437 Dose and Promoter Effects of Adeno-associated Viral Vector for Green Fluorescent Protein Expression in the Rat Brain Experimental Neurology. Jul, 2002 | Pubmed ID: 12093083 Dopaminergic Cell Loss Induced by Human A30P Alpha-synuclein Gene Transfer to the Rat Substantia Nigra Human Gene Therapy. Mar, 2002 | Pubmed ID: 11916484 Neuropathological and Behavioral Consequences of Adeno-associated Viral Vector-mediated Continuous Intrastriatal Neurotrophin Delivery in a Focal Ischemia Model in Rats Neurobiology of Disease. Mar, 2002 | Pubmed ID: 11895371 메서드 및 Adeno 관련 바이러스를 쥐의 정 맥 관리 및 중앙 신경 전달의 평가 대 한 팁 Mychal S. Grames1, Kasey L. Jackson1, Robert D. Dayton1, John A. Stanford2, Ronald L. Klein1 1Department of Pharmacology, Toxicology, and Neuroscience, Louisiana State University Health Sciences Center, 2Department of Molecular & Integrative Physiology, University of Kansas Medical Center JoVE 55994 Neuroscience
메서드 및 Adeno 관련 바이러스를 쥐의 정 맥 관리 및 중앙 신경 전달의 평가 대 한 팁 Mychal S. Grames1, Kasey L. Jackson1, Robert D. Dayton1, John A. Stanford2, Ronald L. Klein1 1Department of Pharmacology, Toxicology, and Neuroscience, Louisiana State University Health Sciences Center, 2Department of Molecular & Integrative Physiology, University of Kansas Medical Center JoVE 55994 Neuroscience