Roosmarijn E. Vandenbroucke VIB Center for Inflammation Research VIB Biography Publications Institution JoVE Articles Roosmarijn E. Vandenbroucke has not added a biography. If you are Roosmarijn E. Vandenbroucke and would like to personalize this page please email our Author Liaison for assistance. Publications Choroid Plexus-derived Extracellular Vesicles Exhibit Brain Targeting Characteristics Biomaterials. Nov, 2022 | Pubmed ID: 36302306 A Mouse Model of Hepatic Encephalopathy: Bile Duct Ligation Induces Brain Ammonia Overload, Glial Cell Activation and Neuroinflammation Scientific Reports. Oct, 2022 | Pubmed ID: 36266427 Differential Plasticity and Fate of Brain-resident and Recruited Macrophages During the Onset and Resolution of Neuroinflammation Immunity. Nov, 2022 | Pubmed ID: 36228615 Recent Insights into Viral Infections As a Trigger and Accelerator in Alzheimer's Disease Drug Discovery Today. Aug, 2022 | Pubmed ID: 35987492 Biomarker and Therapeutic Potential of Peripheral Extracellular Vesicles in Alzheimer's Disease Advanced Drug Delivery Reviews. Nov, 2022 | Pubmed ID: 35952829 Targeting Gliovascular Connexins Prevents Inflammatory Blood-brain Barrier Leakage and Astrogliosis JCI Insight. Aug, 2022 | Pubmed ID: 35881483 High-Precision Isotopic Analysis of Cu and Fe Multi-Collector Inductively Coupled Plasma-Mass Spectrometry Reveals Lipopolysaccharide-Induced Inflammatory Effects in Blood Plasma and Brain Tissues Frontiers in Chemistry. 2022 | Pubmed ID: 35783204 Astrocyte-targeted Gene Delivery of Interleukin 2 Specifically Increases Brain-resident Regulatory T Cell Numbers and Protects Against Pathological Neuroinflammation Nature Immunology. Jun, 2022 | Pubmed ID: 35618831 The Tremendous Biomedical Potential of Bacterial Extracellular Vesicles Trends in Biotechnology. Oct, 2022 | Pubmed ID: 35581020 Fighting Fire with Fire: The Immune System Might Be Key in Our Fight Against Alzheimer's Disease Drug Discovery Today. May, 2022 | Pubmed ID: 35032668 The Impact of Systemic Inflammation on Alzheimer's Disease Pathology Frontiers in Immunology. 2021 | Pubmed ID: 35069578 Anti-Inflammatory Mesenchymal Stromal Cell-Derived Extracellular Vesicles Improve Pathology in Niemann-Pick Type C Disease Biomedicines. Dec, 2021 | Pubmed ID: 34944681 Special DelEVery: Extracellular Vesicles As Promising Delivery Platform to the Brain Biomedicines. Nov, 2021 | Pubmed ID: 34829963 Gastric Infection Partially Protects Against Neurotoxicity in A 6-OHDA Parkinson's Disease Mouse Model International Journal of Molecular Sciences. Oct, 2021 | Pubmed ID: 34768765 Involvement of the Choroid Plexus in the Pathogenesis of Niemann-Pick Disease Type C Frontiers in Cellular Neuroscience. 2021 | Pubmed ID: 34720883 Low-grade Peripheral Inflammation Affects Brain Pathology in the Appmouse Model of Alzheimer's Disease Acta Neuropathologica Communications. Oct, 2021 | Pubmed ID: 34620254 Amelioration of Systemic Inflammation Via the Display of Two Different Decoy Protein Receptors on Extracellular Vesicles Nature Biomedical Engineering. Sep, 2021 | Pubmed ID: 34616047 The Neurogliovascular Unit in Hepatic Encephalopathy JHEP Reports : Innovation in Hepatology. Oct, 2021 | Pubmed ID: 34611619 Extracellular Vesicles: A Double-Edged Sword in Sepsis Pharmaceuticals (Basel, Switzerland). Aug, 2021 | Pubmed ID: 34451925 The Power of Imaging to Understand Extracellular Vesicle Biology in Vivo Nature Methods. Sep, 2021 | Pubmed ID: 34446922 Importance of Extracellular Vesicle Secretion at the Blood-cerebrospinal Fluid Interface in the Pathogenesis of Alzheimer's Disease Acta Neuropathologica Communications. Aug, 2021 | Pubmed ID: 34425919 Effect of Endotoxemia Induced by Intraperitoneal Injection of Lipopolysaccharide on the Mg Isotopic Composition of Biofluids and Tissues in Mice Frontiers in Medicine. 2021 | Pubmed ID: 34368182 Profiling of Extracellular Small RNAs Highlights a Strong Bias Towards Non-Vesicular Secretion Cells. Jun, 2021 | Pubmed ID: 34207405 Single-cell Profiling of Myeloid Cells in Glioblastoma Across Species and Disease Stage Reveals Macrophage Competition and Specialization Nature Neuroscience. Apr, 2021 | Pubmed ID: 33782623 and the Potential Role in Neurological Disorders: There Is More Than Frontiers in Immunology. 2020 | Pubmed ID: 33633723 Extracellular Vesicles in Alzheimer's and Parkinson's Disease: Small Entities with Large Consequences Cells. Nov, 2020 | Pubmed ID: 33203181 High-precision Isotopic Analysis of Mg and Ca in Biological Samples Using Multi-collector ICP-mass Spectrometry After Their Sequential Chromatographic Isolation - Application to the Characterization of the Body Distribution of Mg and Ca Isotopes in Mice Analytica Chimica Acta. Sep, 2020 | Pubmed ID: 32892933 Tightening the Retinal Glia Limitans Attenuates Neuroinflammation After Optic Nerve Injury Glia. Dec, 2020 | Pubmed ID: 32645232 Microglial Activation Arises After Aggregation of Phosphorylated-tau in a Neuron-specific P301S Tauopathy Mouse Model Neurobiology of Aging. May, 2020 | Pubmed ID: 32008854 A Study of Cecal Ligation and Puncture-Induced Sepsis in Tissue-Specific Tumor Necrosis Factor Receptor 1-Deficient Mice Frontiers in Immunology. 2019 | Pubmed ID: 31787972 Biological Membranes in EV Biogenesis, Stability, Uptake, and Cargo Transfer: an ISEV Position Paper Arising from the ISEV Membranes and EVs Workshop Journal of Extracellular Vesicles. 2019 | Pubmed ID: 31762963 Blocking Connexin43 Hemichannels Protects Mice Against Tumour Necrosis Factor-induced Inflammatory Shock Scientific Reports. 11, 2019 | Pubmed ID: 31719598 Interferons: A Molecular Switch Between Damage and Repair in Ageing and Alzheimer's Disease Mechanisms of Ageing and Development. Oct, 2019 | Pubmed ID: 31541624 Immunogenicity and Protection Efficacy of a Naked Self-Replicating MRNA-Based Zika Virus Vaccine Vaccines. Aug, 2019 | Pubmed ID: 31450775 Choroid Plexus-derived MiR-204 Regulates the Number of Quiescent Neural Stem Cells in the Adult Brain The EMBO Journal. Sep, 2019 | Pubmed ID: 31304985 A Single-cell Atlas of Mouse Brain Macrophages Reveals Unique Transcriptional Identities Shaped by Ontogeny and Tissue Environment Nature Neuroscience. Jun, 2019 | Pubmed ID: 31061494 Choroid Plexus Tumor Necrosis Factor Receptor 1: A New Neuroinflammatory Piece of the Complex Alzheimer's Disease Puzzle Neural Regeneration Research. Jul, 2019 | Pubmed ID: 30804238 The N-terminal P.(Ser38Cys) TIMP3 Mutation Underlying Sorsby Fundus Dystrophy is a Founder Mutation Disrupting an Intramolecular Disulfide Bond Human Mutation. May, 2019 | Pubmed ID: 30668888 Overexpression of Gilz Protects Mice Against Lethal Septic Peritonitis Shock (Augusta, Ga.). Aug, 2019 | Pubmed ID: 30124596 A New Venue of TNF Targeting International Journal of Molecular Sciences. May, 2018 | Pubmed ID: 29751683 Glucocorticoid Receptor Dimers Control Intestinal STAT1 and TNF-induced Inflammation in Mice The Journal of Clinical Investigation. Aug, 2018 | Pubmed ID: 29746256 Counteracting the Effects of TNF Receptor-1 Has Therapeutic Potential in Alzheimer's Disease EMBO Molecular Medicine. Apr, 2018 | Pubmed ID: 29472246 Correction To: Current Research into Brain Barriers and the Delivery of Therapeutics for Neurological Diseases: a Report on CNS Barrier Congress London, UK, 2017 Fluids and Barriers of the CNS. 01, 2018 | Pubmed ID: 29329565 The Choroid Plexus Epithelium As a Novel Player in the Stomach-brain Axis During Helicobacter Infection Brain, Behavior, and Immunity. Mar, 2018 | Pubmed ID: 29258921 Simultaneous Inhibition of Tumor Necrosis Factor Receptor 1 and Matrix Metalloproteinase 8 Completely Protects Against Acute Inflammation and Sepsis Critical Care Medicine. Jan, 2018 | Pubmed ID: 29095202 Current Research into Brain Barriers and the Delivery of Therapeutics for Neurological Diseases: a Report on CNS Barrier Congress London, UK, 2017 Fluids and Barriers of the CNS. Nov, 2017 | Pubmed ID: 29110676 TNFR1 Inhibition with a Nanobody Protects Against EAE Development in Mice Scientific Reports. Oct, 2017 | Pubmed ID: 29057962 Treatment of Intestinal Fibrosis in Experimental Inflammatory Bowel Disease by the Pleiotropic Actions of a Local Rho Kinase Inhibitor Gastroenterology. Oct, 2017 | Pubmed ID: 28642198 A Hidden Epithelial Barrier in the Brain with a Central Role in Regulating Brain Homeostasis. Implications for Aging Annals of the American Thoracic Society. Dec, 2016 | Pubmed ID: 28005425 MMP-3 Deficiency Alleviates Endotoxin-Induced Acute Inflammation in the Posterior Eye Segment International Journal of Molecular Sciences. Nov, 2016 | Pubmed ID: 27809288 Mouse Models of Ageing and Their Relevance to Disease Mechanisms of Ageing and Development. Dec, 2016 | Pubmed ID: 27717883 Sizing Nanomaterials in Bio-fluids by CFRAP Enables Protein Aggregation Measurements and Diagnosis of Bio-barrier Permeability Nature Communications. Sep, 2016 | Pubmed ID: 27653841 Identification of a Novel Mechanism of Blood-brain Communication During Peripheral Inflammation Via Choroid Plexus-derived Extracellular Vesicles EMBO Molecular Medicine. Oct, 2016 | Pubmed ID: 27596437 With Mouse Age Comes Wisdom: A Review and Suggestions of Relevant Mouse Models for Age-related Conditions Mechanisms of Ageing and Development. Dec, 2016 | Pubmed ID: 27450180 Caloric Restriction: Beneficial Effects on Brain Aging and Alzheimer's Disease Mammalian Genome : Official Journal of the International Mammalian Genome Society. Aug, 2016 | Pubmed ID: 27240590 The Choroid Plexus-cerebrospinal Fluid Interface in Alzheimer's Disease: More Than Just a Barrier Neural Regeneration Research. Apr, 2016 | Pubmed ID: 27212900 Efficient Analysis of Mouse Genome Sequences Reveal Many Nonsense Variants Proceedings of the National Academy of Sciences of the United States of America. May, 2016 | Pubmed ID: 27147605 The Effect of Aging on Brain Barriers and the Consequences for Alzheimer's Disease Development Mammalian Genome : Official Journal of the International Mammalian Genome Society. Aug, 2016 | Pubmed ID: 27143113 Nanobodies As Therapeutics: Big Opportunities for Small Antibodies Drug Discovery Today. Jul, 2016 | Pubmed ID: 27080147 Comparing Exosome-like Vesicles with Liposomes for the Functional Cellular Delivery of Small RNAs Journal of Controlled Release : Official Journal of the Controlled Release Society. Jun, 2016 | Pubmed ID: 27072025 Into Rather Unexplored Terrain-transcellular Transport Across the Blood-brain Barrier Glia. Jul, 2016 | Pubmed ID: 26852907 Topical Imiquimod Yields Systemic Effects Due to Unintended Oral Uptake Scientific Reports. Jan, 2016 | Pubmed ID: 26818707 Development and Validation of a Small Single-domain Antibody That Effectively Inhibits Matrix Metalloproteinase 8 Molecular Therapy : the Journal of the American Society of Gene Therapy. May, 2016 | Pubmed ID: 26775809 Endothelial LRP1 Transports Amyloid-β(1-42) Across the Blood-brain Barrier The Journal of Clinical Investigation. Jan, 2016 | Pubmed ID: 26619118 Friends or Foes: Matrix Metalloproteinases and Their Multifaceted Roles in Neurodegenerative Diseases Mediators of Inflammation. 2015 | Pubmed ID: 26538832 Decreased TNF Levels and Improved Retinal Ganglion Cell Survival in MMP-2 Null Mice Suggest a Role for MMP-2 As TNF Sheddase Mediators of Inflammation. 2015 | Pubmed ID: 26451076 Amyloid β Oligomers Disrupt Blood-CSF Barrier Integrity by Activating Matrix Metalloproteinases The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Sep, 2015 | Pubmed ID: 26377465 Hematopoietic Plakophilin-3 Regulates Acute Tissue-specific and Systemic Inflammation in Mice European Journal of Immunology. Oct, 2015 | Pubmed ID: 26173741 Passenger Mutations Confound Interpretation of All Genetically Modified Congenic Mice Immunity. Jul, 2015 | Pubmed ID: 26163370 Therapeutic Implications of the Choroid Plexus-cerebrospinal Fluid Interface in Neuropsychiatric Disorders Brain, Behavior, and Immunity. Nov, 2015 | Pubmed ID: 26116435 Glucocorticoid-induced MicroRNA-511 Protects Against TNF by Down-regulating TNFR1 EMBO Molecular Medicine. Aug, 2015 | Pubmed ID: 25995337 Clinical Implications of Leukocyte Infiltration at the Choroid Plexus in (neuro)inflammatory Disorders Drug Discovery Today. Aug, 2015 | Pubmed ID: 25979470 Dual Inhibition of TNFR1 and IFNAR1 in Imiquimod-Induced Psoriasiform Skin Inflammation in Mice Journal of Immunology (Baltimore, Md. : 1950). Jun, 2015 | Pubmed ID: 25911755 Generation and Characterization of Small Single Domain Antibodies Inhibiting Human Tumor Necrosis Factor Receptor 1 The Journal of Biological Chemistry. Feb, 2015 | Pubmed ID: 25538244 An Inflammatory Triangle in Psoriasis: TNF, Type I IFNs and IL-17 Cytokine & Growth Factor Reviews. Feb, 2015 | Pubmed ID: 25434285 Is There New Hope for Therapeutic Matrix Metalloproteinase Inhibition? Nature Reviews. Drug Discovery. Dec, 2014 | Pubmed ID: 25376097 Tauroursodeoxycholic Acid Inhibits Experimental Colitis by Preventing Early Intestinal Epithelial Cell Death Laboratory Investigation; a Journal of Technical Methods and Pathology. Dec, 2014 | Pubmed ID: 25310532 Choose Your Models Wisely: How Different Murine Bone Marrow-derived Dendritic Cell Protocols Influence the Success of Nanoparticulate Vaccines in Vitro Journal of Controlled Release : Official Journal of the Controlled Release Society. Dec, 2014 | Pubmed ID: 24960224 A New Angle on Blood-CNS Interfaces: a Role for Connexins? FEBS Letters. Apr, 2014 | Pubmed ID: 24631535 An Acute Phase Protein Ready to Go Therapeutic for Sepsis EMBO Molecular Medicine. Jan, 2014 | Pubmed ID: 24408964 Antisense Oligonucleotides Against TNFR1 Prevent Toxicity of TNF/IFNγ Treatment in Mouse Tumor Models International Journal of Cancer. Aug, 2014 | Pubmed ID: 24382818 Mice Overexpressing β-1,4-Galactosyltransferase I Are Resistant to TNF-induced Inflammation and DSS-induced Colitis PloS One. 2013 | Pubmed ID: 24339869 Matrix Metalloproteinase 13 Modulates Intestinal Epithelial Barrier Integrity in Inflammatory Diseases by Activating TNF EMBO Molecular Medicine. Jul, 2013 | Pubmed ID: 23723167 Safe TNF-based Antitumor Therapy Following P55TNFR Reduction in Intestinal Epithelium The Journal of Clinical Investigation. Jun, 2013 | Pubmed ID: 23676465 Treatment of TNF Mediated Diseases by Selective Inhibition of Soluble TNF or TNFR1 Cytokine & Growth Factor Reviews. 2011 | Pubmed ID: 21962830 Matrix Metalloproteinases As Drug Targets in Ischemia/reperfusion Injury Drug Discovery Today. Sep, 2011 | Pubmed ID: 21745586 The First MMP in Sepsis EMBO Molecular Medicine. Jul, 2011 | Pubmed ID: 21591260 Matrix Metalloproteinase8 Has a Central Role in Inflammatory Disorders and Cancer Progression Cytokine & Growth Factor Reviews. Apr, 2011 | Pubmed ID: 21388856 The Use of Inhibitors to Study Endocytic Pathways of Gene Carriers: Optimization and Pitfalls Molecular Therapy : the Journal of the American Society of Gene Therapy. Mar, 2010 | Pubmed ID: 20010917 マイクロダイセクションとホールマウント走査型電子顕微鏡によるマウス脈絡叢の可視化 Elien Van Wonterghem*1,2, Lien Van Hoecke*1,2, Griet Van Imschoot1,2, Daan Verhaege1,2, Marlies Burgelman1,2, Roosmarijn E. Vandenbroucke1,2 1VIB Center for Inflammation Research, VIB, 2Department of Biomedical Molecular Biology, Ghent University JoVE 64733 Neuroscience
マイクロダイセクションとホールマウント走査型電子顕微鏡によるマウス脈絡叢の可視化 Elien Van Wonterghem*1,2, Lien Van Hoecke*1,2, Griet Van Imschoot1,2, Daan Verhaege1,2, Marlies Burgelman1,2, Roosmarijn E. Vandenbroucke1,2 1VIB Center for Inflammation Research, VIB, 2Department of Biomedical Molecular Biology, Ghent University JoVE 64733 Neuroscience