Rudolf Jaenisch Whitehead Institute for Biomedical Research Biography Publications Institution JoVE Articles Rudolf Jaenisch has not added a biography. If you are Rudolf Jaenisch and would like to personalize this page please email our Author Liaison for assistance. Publications Reprogramming Factor Stoichiometry Influences the Epigenetic State and Biological Properties of Induced Pluripotent Stem Cells Cell Stem Cell. Dec, 2011 | Pubmed ID: 22136932 Surface-engineered Substrates for Improved Human Pluripotent Stem Cell Culture Under Fully Defined Conditions Proceedings of the National Academy of Sciences of the United States of America. Nov, 2011 | Pubmed ID: 22065768 Functional Integration of Dopaminergic Neurons Directly Converted from Mouse Fibroblasts Cell Stem Cell. Nov, 2011 | Pubmed ID: 22019014 Deletion of the De Novo DNA Methyltransferase Dnmt3a Promotes Lung Tumor Progression Proceedings of the National Academy of Sciences of the United States of America. Nov, 2011 | Pubmed ID: 22011581 Blimp1 Expression Predicts Embryonic Stem Cell Development In vitro Current Biology : CB. Oct, 2011 | Pubmed ID: 22000107 Transgene Excision Has No Impact on in Vivo Integration of Human IPS Derived Neural Precursors PloS One. 2011 | Pubmed ID: 21961042 Mir-290-295 Deficiency in Mice Results in Partially Penetrant Embryonic Lethality and Germ Cell Defects Proceedings of the National Academy of Sciences of the United States of America. Aug, 2011 | Pubmed ID: 21844366 Tet1 is Dispensable for Maintaining Pluripotency and Its Loss is Compatible with Embryonic and Postnatal Development Cell Stem Cell. Aug, 2011 | Pubmed ID: 21816367 Generation of Isogenic Pluripotent Stem Cells Differing Exclusively at Two Early Onset Parkinson Point Mutations Cell. Jul, 2011 | Pubmed ID: 21757228 Genetic Engineering of Human Pluripotent Cells Using TALE Nucleases Nature Biotechnology. Aug, 2011 | Pubmed ID: 21738127 De Novo DNA Methylation by Dnmt3a and Dnmt3b is Dispensable for Nuclear Reprogramming of Somatic Cells to a Pluripotent State Genes & Development. May, 2011 | Pubmed ID: 21576263 A Latent Pro-survival Function for the Mir-290-295 Cluster in Mouse Embryonic Stem Cells PLoS Genetics. May, 2011 | Pubmed ID: 21573140 Reprogramming of Postnatal Neurons into Induced Pluripotent Stem Cells by Defined Factors Stem Cells (Dayton, Ohio). Jun, 2011 | Pubmed ID: 21563275 Pan-Src Family Kinase Inhibitors Replace Sox2 During the Direct Reprogramming of Somatic Cells Angewandte Chemie (International Ed. in English). Jun, 2011 | Pubmed ID: 21547985 Genes Methylated by DNA Methyltransferase 3b Are Similar in Mouse Intestine and Human Colon Cancer The Journal of Clinical Investigation. May, 2011 | Pubmed ID: 21490393 Histone H3K27ac Separates Active from Poised Enhancers and Predicts Developmental State Proceedings of the National Academy of Sciences of the United States of America. Dec, 2010 | Pubmed ID: 21106759 Pluripotency and Cellular Reprogramming: Facts, Hypotheses, Unresolved Issues Cell. Nov, 2010 | Pubmed ID: 21074044 T-cell Receptor-driven Lymphomagenesis in Mice Derived from a Reprogrammed T Cell Proceedings of the National Academy of Sciences of the United States of America. Nov, 2010 | Pubmed ID: 20956329 Differentiated Parkinson Patient-derived Induced Pluripotent Stem Cells Grow in the Adult Rodent Brain and Reduce Motor Asymmetry in Parkinsonian Rats Proceedings of the National Academy of Sciences of the United States of America. Sep, 2010 | Pubmed ID: 20798034 Combinatorial Development of Biomaterials for Clonal Growth of Human Pluripotent Stem Cells Nature Materials. Sep, 2010 | Pubmed ID: 20729850 Position-dependent Silencing of Germline Vß Segments on TCRß Alleles Containing Preassembled VßDJßCß1 Genes Journal of Immunology (Baltimore, Md. : 1950). Sep, 2010 | Pubmed ID: 20709953 Chromatin Structure and Gene Expression Programs of Human Embryonic and Induced Pluripotent Stem Cells Cell Stem Cell. Aug, 2010 | Pubmed ID: 20682450 Reprogramming of Human Peripheral Blood Cells to Induced Pluripotent Stem Cells Cell Stem Cell. Jul, 2010 | Pubmed ID: 20621045 Musashi-2 Regulates Normal Hematopoiesis and Promotes Aggressive Myeloid Leukemia Nature Medicine. Aug, 2010 | Pubmed ID: 20616797 Functional Genomics, Proteomics, and Regulatory DNA Analysis in Isogenic Settings Using Zinc Finger Nuclease-driven Transgenesis into a Safe Harbor Locus in the Human Genome Genome Research. Aug, 2010 | Pubmed ID: 20508142 Derivation of Pre-X Inactivation Human Embryonic Stem Cells Under Physiological Oxygen Concentrations Cell. May, 2010 | Pubmed ID: 20471072 Human Embryonic Stem Cells with Biological and Epigenetic Characteristics Similar to Those of Mouse ESCs Proceedings of the National Academy of Sciences of the United States of America. May, 2010 | Pubmed ID: 20442331 Beta 2-microglobulin Deficient Mice Lack CD4-8+ Cytolytic T Cells. 1990 Journal of Immunology (Baltimore, Md. : 1950). May, 2010 | Pubmed ID: 20410495 Two-step Imprinted X Inactivation: Repeat Versus Genic Silencing in the Mouse Molecular and Cellular Biology. Jul, 2010 | Pubmed ID: 20404085 Transnuclear Mice with Predefined T Cell Receptor Specificities Against Toxoplasma Gondii Obtained Via SCNT Science (New York, N.Y.). Apr, 2010 | Pubmed ID: 20378817 Generation of IPSCs from Cultured Human Malignant Cells Blood. May, 2010 | Pubmed ID: 20233975 Pluripotent Stem Cells Are Highly Susceptible Targets for Syngeneic, Allogeneic, and Xenogeneic Natural Killer Cells FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Jul, 2010 | Pubmed ID: 20145206 TCR Beta Feedback Signals Inhibit the Coupling of Recombinationally Accessible V Beta 14 Segments with DJ Beta Complexes Journal of Immunology (Baltimore, Md. : 1950). Feb, 2010 | Pubmed ID: 20042591 Single-gene Transgenic Mouse Strains for Reprogramming Adult Somatic Cells Nature Methods. Jan, 2010 | Pubmed ID: 20010831 Technical Challenges in Using Human Induced Pluripotent Stem Cells to Model Disease Cell Stem Cell. Dec, 2009 | Pubmed ID: 19951687 Direct Cell Reprogramming is a Stochastic Process Amenable to Acceleration Nature. Dec, 2009 | Pubmed ID: 19898493 DNA Methylation Protects Hematopoietic Stem Cell Multipotency from Myeloerythroid Restriction Nature Genetics. Nov, 2009 | Pubmed ID: 19801979 Functional Characterization of Cardiomyocytes Derived from Murine Induced Pluripotent Stem Cells in Vitro FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Dec, 2009 | Pubmed ID: 19703934 Efficient Targeting of Expressed and Silent Genes in Human ESCs and IPSCs Using Zinc-finger Nucleases Nature Biotechnology. Sep, 2009 | Pubmed ID: 19680244 Loss of Cardiac MicroRNA-mediated Regulation Leads to Dilated Cardiomyopathy and Heart Failure Circulation Research. Sep, 2009 | Pubmed ID: 19679836 Cardiac Myocytes Derived from Murine Reprogrammed Fibroblasts: Intact Hormonal Regulation, Cardiac Ion Channel Expression and Development of Contractility Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 2009 | Pubmed ID: 19590195 DNMT3B Expression Might Contribute to CpG Island Methylator Phenotype in Colorectal Cancer Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jun, 2009 | Pubmed ID: 19470733 Reprogramming of Murine Fibroblasts to Induced Pluripotent Stem Cells with Chemical Complementation of Klf4 Proceedings of the National Academy of Sciences of the United States of America. Jun, 2009 | Pubmed ID: 19447925 Metastable Pluripotent States in NOD-mouse-derived ESCs Cell Stem Cell. Jun, 2009 | Pubmed ID: 19427283 HDAC2 Negatively Regulates Memory Formation and Synaptic Plasticity Nature. May, 2009 | Pubmed ID: 19424149 Epigenetic Hierarchy Governing Nestin Expression Stem Cells (Dayton, Ohio). May, 2009 | Pubmed ID: 19415779 Parkinson's Disease Patient-derived Induced Pluripotent Stem Cells Free of Viral Reprogramming Factors Cell. Mar, 2009 | Pubmed ID: 19269371 Broader Implications of Defining Standards for the Pluripotency of IPSCs Cell Stem Cell. Mar, 2009 | Pubmed ID: 19265657 Phosphorylation of MeCP2 at Serine 80 Regulates Its Chromatin Association and Neurological Function Proceedings of the National Academy of Sciences of the United States of America. Mar, 2009 | Pubmed ID: 19225110 Partial Reversal of Rett Syndrome-like Symptoms in MeCP2 Mutant Mice Proceedings of the National Academy of Sciences of the United States of America. Feb, 2009 | Pubmed ID: 19208815 Chromatin Signature Reveals over a Thousand Highly Conserved Large Non-coding RNAs in Mammals Nature. Mar, 2009 | Pubmed ID: 19182780 Transgenic Mice with Defined Combinations of Drug-inducible Reprogramming Factors Nature Biotechnology. Feb, 2009 | Pubmed ID: 19151700 Microfluidic Control of Cell Pairing and Fusion Nature Methods. Feb, 2009 | Pubmed ID: 19122668 Reprogramming of Murine and Human Somatic Cells Using a Single Polycistronic Vector Proceedings of the National Academy of Sciences of the United States of America. Jan, 2009 | Pubmed ID: 19109433 Derivation and Manipulation of Murine Embryonic Stem Cells Methods in Molecular Biology (Clifton, N.J.). 2009 | Pubmed ID: 19089346 Analysis of Histone 2B-GFP Retention Reveals Slowly Cycling Hematopoietic Stem Cells Nature Biotechnology. Jan, 2009 | Pubmed ID: 19060879 Folate Deficiency Induces Genomic Uracil Misincorporation and Hypomethylation but Does Not Increase DNA Point Mutations Gastroenterology. Jan, 2009 | Pubmed ID: 18992744 Celebrating 10 Years of HESC Lines: an Interview with Rudolf Jaenisch Stem Cells (Dayton, Ohio). Dec, 2008 | Pubmed ID: 19112652 H2AZ is Enriched at Polycomb Complex Target Genes in ES Cells and is Necessary for Lineage Commitment Cell. Nov, 2008 | Pubmed ID: 18992931 A Drug-inducible System for Direct Reprogramming of Human Somatic Cells to Pluripotency Cell Stem Cell. Sep, 2008 | Pubmed ID: 18786421 Nanoparticles for Gene Transfer to Human Embryonic Stem Cell Colonies Nano Letters. Oct, 2008 | Pubmed ID: 18754690 Interview with Rudolf Jaenisch, M.D Rejuvenation Research. Aug, 2008 | Pubmed ID: 18729819 Analysis of the Mouse Embryonic Stem Cell Regulatory Networks Obtained by ChIP-chip and ChIP-PET Genome Biology. 2008 | Pubmed ID: 18700969 Connecting MicroRNA Genes to the Core Transcriptional Regulatory Circuitry of Embryonic Stem Cells Cell. Aug, 2008 | Pubmed ID: 18692474 Wnt Signaling Promotes Reprogramming of Somatic Cells to Pluripotency Cell Stem Cell. Aug, 2008 | Pubmed ID: 18682236 Reprogramming of Neural Progenitor Cells into Induced Pluripotent Stem Cells in the Absence of Exogenous Sox2 Expression Stem Cells (Dayton, Ohio). Oct, 2008 | Pubmed ID: 18635867 Folate Deficiency Induces Neurodegeneration and Brain Dysfunction in Mice Lacking Uracil DNA Glycosylase The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jul, 2008 | Pubmed ID: 18614692 Genome-scale DNA Methylation Maps of Pluripotent and Differentiated Cells Nature. Aug, 2008 | Pubmed ID: 18600261 A Drug-inducible Transgenic System for Direct Reprogramming of Multiple Somatic Cell Types Nature Biotechnology. Aug, 2008 | Pubmed ID: 18594521 Somatic Cell Nuclear Transfer and Derivation of Embryonic Stem Cells in the Mouse Methods (San Diego, Calif.). Jun, 2008 | Pubmed ID: 18593608 Maternal and Zygotic Dnmt1 Are Necessary and Sufficient for the Maintenance of DNA Methylation Imprints During Preimplantation Development Genes & Development. Jun, 2008 | Pubmed ID: 18559477 Dissecting Direct Reprogramming Through Integrative Genomic Analysis Nature. Jul, 2008 | Pubmed ID: 18509334 Direct Reprogramming of Terminally Differentiated Mature B Lymphocytes to Pluripotency Cell. Apr, 2008 | Pubmed ID: 18423197 Neurons Derived from Reprogrammed Fibroblasts Functionally Integrate into the Fetal Brain and Improve Symptoms of Rats with Parkinson's Disease Proceedings of the National Academy of Sciences of the United States of America. Apr, 2008 | Pubmed ID: 18391196 Promoter CpG Methylation Contributes to ES Cell Gene Regulation in Parallel with Oct4/Nanog, PcG Complex, and Histone H3 K4/K27 Trimethylation Cell Stem Cell. Feb, 2008 | Pubmed ID: 18371437 Sequential Expression of Pluripotency Markers During Direct Reprogramming of Mouse Somatic Cells Cell Stem Cell. Feb, 2008 | Pubmed ID: 18371436 C-Myc is Dispensable for Direct Reprogramming of Mouse Fibroblasts Cell Stem Cell. Jan, 2008 | Pubmed ID: 18371415 Targeted Deletion Reveals Essential and Overlapping Functions of the MiR-17 Through 92 Family of MiRNA Clusters Cell. Mar, 2008 | Pubmed ID: 18329372 Stem Cells, the Molecular Circuitry of Pluripotency and Nuclear Reprogramming Cell. Feb, 2008 | Pubmed ID: 18295576 The Pluripotency Regulator Oct4: a Role in Somatic Stem Cells? Cell Cycle (Georgetown, Tex.). Mar, 2008 | Pubmed ID: 18239456 New Advances in IPS Cell Research Do Not Obviate the Need for Human Embryonic Stem Cells Cell Stem Cell. Oct, 2007 | Pubmed ID: 18371375 Recombination Signatures Distinguish Embryonic Stem Cells Derived by Parthenogenesis and Somatic Cell Nuclear Transfer Cell Stem Cell. Sep, 2007 | Pubmed ID: 18371368 Directly Reprogrammed Fibroblasts Show Global Epigenetic Remodeling and Widespread Tissue Contribution Cell Stem Cell. Jun, 2007 | Pubmed ID: 18371336 Oct4 Expression is Not Required for Mouse Somatic Stem Cell Self-renewal Cell Stem Cell. Oct, 2007 | Pubmed ID: 18159219 Treatment of Sickle Cell Anemia Mouse Model with IPS Cells Generated from Autologous Skin Science (New York, N.Y.). Dec, 2007 | Pubmed ID: 18063756 Dnmt3b Promotes Tumorigenesis in Vivo by Gene-specific De Novo Methylation and Transcriptional Silencing Genes & Development. Dec, 2007 | Pubmed ID: 18056424 YAP1 Increases Organ Size and Expands Undifferentiated Progenitor Cells Current Biology : CB. Dec, 2007 | Pubmed ID: 17980593 DNA Methylation in the Human Cerebral Cortex is Dynamically Regulated Throughout the Life Span and Involves Differentiated Neurons PloS One. 2007 | Pubmed ID: 17878930 Direct Reprogramming of Genetically Unmodified Fibroblasts into Pluripotent Stem Cells Nature Biotechnology. Oct, 2007 | Pubmed ID: 17724450 A Chromatin Landmark and Transcription Initiation at Most Promoters in Human Cells Cell. Jul, 2007 | Pubmed ID: 17632057 Early TCR Expression and Aberrant T Cell Development in Mice with Endogenous Prerearranged T Cell Receptor Genes Journal of Immunology (Baltimore, Md. : 1950). Jul, 2007 | Pubmed ID: 17617584 Genome-wide Maps of Chromatin State in Pluripotent and Lineage-committed Cells Nature. Aug, 2007 | Pubmed ID: 17603471 In Vitro Reprogramming of Fibroblasts into a Pluripotent ES-cell-like State Nature. Jul, 2007 | Pubmed ID: 17554336 Ablation of De Novo DNA Methyltransferase Dnmt3a in the Nervous System Leads to Neuromuscular Defects and Shortened Lifespan Developmental Dynamics : an Official Publication of the American Association of Anatomists. Jun, 2007 | Pubmed ID: 17477386 Sprouty-2 Regulates Oncogenic K-ras in Lung Development and Tumorigenesis Genes & Development. Mar, 2007 | Pubmed ID: 17369402 Commentary: Isolated Stem Cells--patentable As Cultural Artifacts? Stem Cells (Dayton, Ohio). Jun, 2007 | Pubmed ID: 17347494 Expression of Oncogenic K-ras from Its Endogenous Promoter Leads to a Partial Block of Erythroid Differentiation and Hyperactivation of Cytokine-dependent Signaling Pathways Blood. Jun, 2007 | Pubmed ID: 17317860 Partial Rescue of MeCP2 Deficiency by Postnatal Activation of MeCP2 Proceedings of the National Academy of Sciences of the United States of America. Feb, 2007 | Pubmed ID: 17267601 On the Cloning of Animals from Terminally Differentiated Cells Nature Genetics. Feb, 2007 | Pubmed ID: 17262020 DGCR8 is Essential for MicroRNA Biogenesis and Silencing of Embryonic Stem Cell Self-renewal Nature Genetics. Mar, 2007 | Pubmed ID: 17259983 Hematopoietic Precursor Cells Transiently Reestablish Permissiveness for X Inactivation Molecular and Cellular Biology. Oct, 2006 | Pubmed ID: 16980619 Molecular Control of Pluripotency Current Opinion in Genetics & Development. Oct, 2006 | Pubmed ID: 16920351 Mammalian Nuclear Transfer Developmental Dynamics : an Official Publication of the American Association of Anatomists. Sep, 2006 | Pubmed ID: 16881069 Nuclear Reprogramming and Pluripotency Nature. Jun, 2006 | Pubmed ID: 16810240 Reprogramming Efficiency Following Somatic Cell Nuclear Transfer is Influenced by the Differentiation and Methylation State of the Donor Nucleus Stem Cells (Dayton, Ohio). Sep, 2006 | Pubmed ID: 16709876 NT-3 Facilitates Hippocampal Plasticity and Learning and Memory by Regulating Neurogenesis Learning & Memory (Cold Spring Harbor, N.Y.). May-Jun, 2006 | Pubmed ID: 16705139 A Bivalent Chromatin Structure Marks Key Developmental Genes in Embryonic Stem Cells Cell. Apr, 2006 | Pubmed ID: 16630819 Control of Developmental Regulators by Polycomb in Human Embryonic Stem Cells Cell. Apr, 2006 | Pubmed ID: 16630818 Polycomb Complexes Repress Developmental Regulators in Murine Embryonic Stem Cells Nature. May, 2006 | Pubmed ID: 16625203 Suppression of Intestinal Neoplasia by Deletion of Dnmt3b Molecular and Cellular Biology. Apr, 2006 | Pubmed ID: 16581773 Politically Correct Human Embryonic Stem Cells? The New England Journal of Medicine. Mar, 2006 | Pubmed ID: 16540629 The Disease Progression of Mecp2 Mutant Mice is Affected by the Level of BDNF Expression Neuron. Feb, 2006 | Pubmed ID: 16446138 ES Cells Derived from Cloned and Fertilized Blastocysts Are Transcriptionally and Functionally Indistinguishable Proceedings of the National Academy of Sciences of the United States of America. Jan, 2006 | Pubmed ID: 16418286 Severe Deficits in 5-HT2A -mediated Neurotransmission in BDNF Conditional Mutant Mice Journal of Neurobiology. Mar, 2006 | Pubmed ID: 16408297 Efficient Method to Generate Single-copy Transgenic Mice by Site-specific Integration in Embryonic Stem Cells Genesis (New York, N.Y. : 2000). Jan, 2006 | Pubmed ID: 16400644 Generation of Nuclear Transfer-derived Pluripotent ES Cells from Cloned Cdx2-deficient Blastocysts Nature. Jan, 2006 | Pubmed ID: 16227971 Postnatal Loss of Methyl-CpG Binding Protein 2 in the Forebrain is Sufficient to Mediate Behavioral Aspects of Rett Syndrome in Mice Biological Psychiatry. Mar, 2006 | Pubmed ID: 16199017 Global Loss of Imprinting Leads to Widespread Tumorigenesis in Adult Mice Cancer Cell. Oct, 2005 | Pubmed ID: 16226703 Reduced Representation Bisulfite Sequencing for Comparative High-resolution DNA Methylation Analysis Nucleic Acids Research. 2005 | Pubmed ID: 16224102 Opposing Effects of DNA Hypomethylation on Intestinal and Liver Carcinogenesis Proceedings of the National Academy of Sciences of the United States of America. Sep, 2005 | Pubmed ID: 16174748 Core Transcriptional Regulatory Circuitry in Human Embryonic Stem Cells Cell. Sep, 2005 | Pubmed ID: 16153702 Reduced Cortical Activity Due to a Shift in the Balance Between Excitation and Inhibition in a Mouse Model of Rett Syndrome Proceedings of the National Academy of Sciences of the United States of America. Aug, 2005 | Pubmed ID: 16116096 Nuclear Cloning, Epigenetic Reprogramming and Cellular Differentiation Novartis Foundation Symposium. 2005 | Pubmed ID: 16050253 Characterization of a Highly Variable Eutherian MicroRNA Gene RNA (New York, N.Y.). Aug, 2005 | Pubmed ID: 15987809 Ectopic Expression of Oct-4 Blocks Progenitor-cell Differentiation and Causes Dysplasia in Epithelial Tissues Cell. May, 2005 | Pubmed ID: 15882627 Normal Eye-specific Patterning of Retinal Inputs to Murine Subcortical Visual Nuclei in the Absence of Brain-derived Neurotrophic Factor Visual Neuroscience. Jan-Feb, 2005 | Pubmed ID: 15842738 DNA CpG Hypomethylation Induces Heterochromatin Reorganization Involving the Histone Variant MacroH2A Journal of Cell Science. Apr, 2005 | Pubmed ID: 15784683 Direct in Vivo VH to JH Rearrangement Violating the 12/23 Rule The Journal of Experimental Medicine. Feb, 2005 | Pubmed ID: 15699070 X Chromosome Choice Occurs Independently of Asynchronous Replication Timing The Journal of Cell Biology. Jan, 2005 | Pubmed ID: 15668296 Human Cloning - the Science and Ethics of Nuclear Transplantation The New England Journal of Medicine. Dec, 2004 | Pubmed ID: 15625328 Developmentally Regulated Alterations in Polycomb Repressive Complex 1 Proteins on the Inactive X Chromosome The Journal of Cell Biology. Dec, 2004 | Pubmed ID: 15596546 Sixteenth Annual Pezcoller Symposium: Stem Cells and Epigenesis in Cancer Cancer Research. Nov, 2004 | Pubmed ID: 15548721 At Most Three ES Cells Contribute to the Somatic Lineages of Chimeric Mice and of Mice Produced by ES-tetraploid Complementation Developmental Biology. Nov, 2004 | Pubmed ID: 15464582 Uracil DNA Glycosylase Activity is Dispensable for Immunoglobulin Class Switch Science (New York, N.Y.). Aug, 2004 | Pubmed ID: 15326357 Nuclear Cloning of Embryonal Carcinoma Cells Proceedings of the National Academy of Sciences of the United States of America. Sep, 2004 | Pubmed ID: 15306687 Reprogramming of a Melanoma Genome by Nuclear Transplantation Genes & Development. Aug, 2004 | Pubmed ID: 15289459 Cre-lox-regulated Conditional RNA Interference from Transgenes Proceedings of the National Academy of Sciences of the United States of America. Jul, 2004 | Pubmed ID: 15240889 Increased Postischemic Brain Injury in Mice Deficient in Uracil-DNA Glycosylase The Journal of Clinical Investigation. Jun, 2004 | Pubmed ID: 15199406 Nuclear Transplantation, Embryonic Stem Cells and the Potential for Cell Therapy The Hematology Journal : the Official Journal of the European Haematology Association / EHA. 2004 | Pubmed ID: 15190291 Expression of MeCP2 in Postmitotic Neurons Rescues Rett Syndrome in Mice Proceedings of the National Academy of Sciences of the United States of America. Apr, 2004 | Pubmed ID: 15069197 Wt1 Functions in the Development of Germ Cells in Addition to Somatic Cell Lineages of the Testis Developmental Biology. Apr, 2004 | Pubmed ID: 15063178 Mice Cloned from Olfactory Sensory Neurons Nature. Mar, 2004 | Pubmed ID: 14990966 Micromanipulating Dosage Compensation: Understanding X-chromosome Inactivation Through Nuclear Transplantation Seminars in Cell & Developmental Biology. Dec, 2003 | Pubmed ID: 15015742 Differentiation of F1 Embryonic Stem Cells into Viable Male and Female Mice by Tetraploid Embryo Complementation Methods in Enzymology. 2003 | Pubmed ID: 14696335 Derepression of BDNF Transcription Involves Calcium-dependent Phosphorylation of MeCP2 Science (New York, N.Y.). Oct, 2003 | Pubmed ID: 14593183 Nuclear Transplantation, Embryonic Stem Cells, and the Potential for Cell Therapy The New England Journal of Medicine. Jul, 2003 | Pubmed ID: 12867612 Hybrid Embryonic Stem Cell-derived Tetraploid Mice Show Apparently Normal Morphological, Physiological, and Neurological Characteristics Molecular and Cellular Biology. Jun, 2003 | Pubmed ID: 12748299 Stem Cells. Setting Standards for Human Embryonic Stem Cells Science (New York, N.Y.). May, 2003 | Pubmed ID: 12738841 Induction of Tumors in Mice by Genomic Hypomethylation Science (New York, N.Y.). Apr, 2003 | Pubmed ID: 12702876 Chromosomal Instability and Tumors Promoted by DNA Hypomethylation Science (New York, N.Y.). Apr, 2003 | Pubmed ID: 12702868 Asynchronous Replication Timing of Imprinted Loci is Independent of DNA Methylation, but Consistent with Differential Subnuclear Localization Genes & Development. Mar, 2003 | Pubmed ID: 12651894 HIF-1alpha is Essential for Myeloid Cell-mediated Inflammation Cell. Mar, 2003 | Pubmed ID: 12628185 Incomplete Reactivation of Oct4-related Genes in Mouse Embryos Cloned from Somatic Nuclei Development (Cambridge, England). Apr, 2003 | Pubmed ID: 12620990 Epigenetic Regulation of Gene Expression: How the Genome Integrates Intrinsic and Environmental Signals Nature Genetics. Mar, 2003 | Pubmed ID: 12610534 Rapid Generation of Inducible Mouse Mutants Nucleic Acids Research. Feb, 2003 | Pubmed ID: 12582257 Stroke Damage in Mice After Knocking the Neutrophin-4 Gene into the Brain-derived Neurotrophic Factor Locus Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. Feb, 2003 | Pubmed ID: 12571446 Nuclear Cloning, Embryonic Stem Cells, and Transplantation Therapy Harvey Lectures. -2003, 2002 | Pubmed ID: 16033160 Nuclear Transplantation: Lessons from Frogs and Mice Current Opinion in Cell Biology. Dec, 2002 | Pubmed ID: 12473349 X-chromosome Inactivation During Spermatogenesis is Regulated by an Xist/Tsix-independent Mechanism in the Mouse Genesis (New York, N.Y. : 2000). Dec, 2002 | Pubmed ID: 12434336 Transcriptional Profiling of a Mouse Model for Rett Syndrome Reveals Subtle Transcriptional Changes in the Brain Proceedings of the National Academy of Sciences of the United States of America. Nov, 2002 | Pubmed ID: 12432090 Meiotic Sex Chromosome Inactivation in Male Mice with Targeted Disruptions of Xist Journal of Cell Science. Nov, 2002 | Pubmed ID: 12356914 Abnormal Gene Expression in Cloned Mice Derived from Embryonic Stem Cell and Cumulus Cell Nuclei Proceedings of the National Academy of Sciences of the United States of America. Oct, 2002 | Pubmed ID: 12235366 Brain-derived Neurotrophic Factor is Essential for Opiate-induced Plasticity of Noradrenergic Neurons The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. May, 2002 | Pubmed ID: 12019333 Male and Female Mice Derived from the Same Embryonic Stem Cell Clone by Tetraploid Embryo Complementation Nature Biotechnology. May, 2002 | Pubmed ID: 11981557 Correction of a Genetic Defect by Nuclear Transplantation and Combined Cell and Gene Therapy Cell. Apr, 2002 | Pubmed ID: 11955443 Dnmt1 Overexpression Causes Genomic Hypermethylation, Loss of Imprinting, and Embryonic Lethality Molecular and Cellular Biology. Apr, 2002 | Pubmed ID: 11884600 Monoclonal Mice Generated by Nuclear Transfer from Mature B and T Donor Cells Nature. Feb, 2002 | Pubmed ID: 11875572 Flp Recombinase Regulated LacZ Expression at the ROSA26 Locus Genesis (New York, N.Y. : 2000). Feb, 2002 | Pubmed ID: 11857816 Neurotrophin-3 Promotes Cell Death Induced in Cerebral Ischemia, Oxygen-glucose Deprivation, and Oxidative Stress: Possible Involvement of Oxygen Free Radicals Neurobiology of Disease. Feb, 2002 | Pubmed ID: 11848682 Chromosomal Silencing and Localization Are Mediated by Different Domains of Xist RNA Nature Genetics. Feb, 2002 | Pubmed ID: 11780141 Transnuclear Мыши с Предустановленные Т Особенности клеточного рецептора Против Toxoplasma гондий, Полученные через SCNT Oktay Kirak1, Eva-Maria Frickel1, Gijsbert M. Grotenbreg1,2, Heikyung Suh1, Rudolf Jaenisch1,3, Hidde L. Ploegh1,3 1Whitehead Institute for Biomedical Research, 2Departments of Microbiology and Biological Sciences, National University of Singapore, 3Department of Biology, Massachusetts Institute of Technology JoVE 2168 Immunology and Infection Создание плюрипотентных Клетки MEFS через принудительный Выражение Sox-2, Oct-4, с-Myc, и Klf4 G. Grant Welstead1, Tobias Brambrink1, Rudolf Jaenisch1 1Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology JoVE 734 Biology
Transnuclear Мыши с Предустановленные Т Особенности клеточного рецептора Против Toxoplasma гондий, Полученные через SCNT Oktay Kirak1, Eva-Maria Frickel1, Gijsbert M. Grotenbreg1,2, Heikyung Suh1, Rudolf Jaenisch1,3, Hidde L. Ploegh1,3 1Whitehead Institute for Biomedical Research, 2Departments of Microbiology and Biological Sciences, National University of Singapore, 3Department of Biology, Massachusetts Institute of Technology JoVE 2168 Immunology and Infection
Создание плюрипотентных Клетки MEFS через принудительный Выражение Sox-2, Oct-4, с-Myc, и Klf4 G. Grant Welstead1, Tobias Brambrink1, Rudolf Jaenisch1 1Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology JoVE 734 Biology
