Sakthivel Sadayappan Department of Cell and Molecular Physiology Loyola University Chicago Biography Publications Institution JoVE Articles Sakthivel Sadayappan has not added a biography. If you are Sakthivel Sadayappan and would like to personalize this page please email our Author Liaison for assistance. Publications Increase in Cardiac Myosin Binding Protein-C Plasma Levels is a Sensitive and Cardiac-specific Biomarker of Myocardial Infarction American Journal of Cardiovascular Disease. 2013 | Pubmed ID: 23785583 Agonist Activated PKCβII Translocation and Modulation of Cardiac Myocyte Contractile Function Scientific Reports. 2013 | Pubmed ID: 23756828 Myofilament Ca2+ Desensitization Mediates Positive Lusitropic Effect of Neuronal Nitric Oxide Synthase in Left Ventricular Myocytes from Murine Hypertensive Heart Journal of Molecular and Cellular Cardiology. Jul, 2013 | Pubmed ID: 23624088 Perturbed Length-dependent Activation in Human Hypertrophic Cardiomyopathy with Missense Sarcomeric Gene Mutations Circulation Research. May, 2013 | Pubmed ID: 23508784 GSK3β Phosphorylates Newly Identified Site in the Proline-alanine-rich Region of Cardiac Myosin-binding Protein C and Alters Cross-bridge Cycling Kinetics in Human: Short Communication Circulation Research. Feb, 2013 | Pubmed ID: 23277198 In Vivo and in Vitro Cardiac Responses to Beta-adrenergic Stimulation in Volume-overload Heart Failure Journal of Molecular and Cellular Cardiology. Apr, 2013 | Pubmed ID: 23220155 Cardiac Myosin Binding Protein-C: Redefining Its Structure and Function Biophysical Reviews. Jun, 2012 | Pubmed ID: 22707987 Interleukin-10 Treatment Attenuates Pressure Overload-induced Hypertrophic Remodeling and Improves Heart Function Via Signal Transducers and Activators of Transcription 3-dependent Inhibition of Nuclear Factor-κB Circulation. Jul, 2012 | Pubmed ID: 22705886 Protein Kinase D Increases Maximal Ca2+-activated Tension of Cardiomyocyte Contraction by Phosphorylation of CMyBP-C-Ser315 American Journal of Physiology. Heart and Circulatory Physiology. Aug, 2012 | Pubmed ID: 22636676 Protein Kinase C Depresses Cardiac Myocyte Power Output and Attenuates Myofilament Responses Induced by Protein Kinase A Journal of Muscle Research and Cell Motility. Dec, 2012 | Pubmed ID: 22527640 Pathogenic Properties of the N-terminal Region of Cardiac Myosin Binding Protein-C in Vitro Journal of Muscle Research and Cell Motility. May, 2012 | Pubmed ID: 22527638 Cardiac Myosin Binding Protein-C: a Potential Early-stage, Cardiac-specific Biomarker of Ischemia-reperfusion Injury Biomarkers in Medicine. Feb, 2012 | Pubmed ID: 22296197 Structural Insight into Unique Cardiac Myosin-binding Protein-C Motif: a Partially Folded Domain The Journal of Biological Chemistry. Mar, 2012 | Pubmed ID: 22235120 Contractile Dysfunction Irrespective of the Mutant Protein in Human Hypertrophic Cardiomyopathy with Normal Systolic Function Circulation. Heart Failure. Jan, 2012 | Pubmed ID: 22178992 Unique Single Molecule Binding of Cardiac Myosin Binding Protein-C to Actin and Phosphorylation-dependent Inhibition of Actomyosin Motility Requires 17 Amino Acids of the Motif Domain Journal of Molecular and Cellular Cardiology. Jan, 2012 | Pubmed ID: 21978630 Cardiac Myosin Binding Protein-C is a Potential Diagnostic Biomarker for Myocardial Infarction Journal of Molecular and Cellular Cardiology. Jan, 2012 | Pubmed ID: 21971072 Roles for Cardiac MyBP-C in Maintaining Myofilament Lattice Rigidity and Prolonging Myosin Cross-bridge Lifetime Biophysical Journal. Oct, 2011 | Pubmed ID: 21961592 A Critical Function for Ser-282 in Cardiac Myosin Binding Protein-C Phosphorylation and Cardiac Function Circulation Research. Jul, 2011 | Pubmed ID: 21597010 Novel Role for P90 Ribosomal S6 Kinase in the Regulation of Cardiac Myofilament Phosphorylation The Journal of Biological Chemistry. Feb, 2011 | Pubmed ID: 21148481 Analysis of Cardiac Myosin Binding Protein-C Phosphorylation in Human Heart Muscle Journal of Molecular and Cellular Cardiology. Dec, 2010 | Pubmed ID: 20850451 Targeted Genome-wide Enrichment of Functional Regions PloS One. 2010 | Pubmed ID: 20585402 Distinct Sarcomeric Substrates Are Responsible for Protein Kinase D-mediated Regulation of Cardiac Myofilament Ca2+ Sensitivity and Cross-bridge Cycling The Journal of Biological Chemistry. Feb, 2010 | Pubmed ID: 20018870 Phosphorylation and Function of Cardiac Myosin Binding Protein-C in Health and Disease Journal of Molecular and Cellular Cardiology. May, 2010 | Pubmed ID: 19962384 Inducible Expression of Active Protein Phosphatase-1 Inhibitor-1 Enhances Basal Cardiac Function and Protects Against Ischemia/reperfusion Injury Circulation Research. Apr, 2009 | Pubmed ID: 19299645 Cardiac Myosin Binding Protein-C Phosphorylation in a {beta}-myosin Heavy Chain Background Circulation. Mar, 2009 | Pubmed ID: 19237661 A Common MYBPC3 (cardiac Myosin Binding Protein C) Variant Associated with Cardiomyopathies in South Asia Nature Genetics. Feb, 2009 | Pubmed ID: 19151713 The Death of Transcriptional Chauvinism in the Control and Regulation of Cardiac Contractility Annals of the New York Academy of Sciences. Mar, 2008 | Pubmed ID: 18375572 Role of the Acidic N' Region of Cardiac Troponin I in Regulating Myocardial Function FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Apr, 2008 | Pubmed ID: 17984178 Control of in Vivo Left Ventricular [correction] Contraction/relaxation Kinetics by Myosin Binding Protein C: Protein Kinase A Phosphorylation Dependent and Independent Regulation Circulation. Nov, 2007 | Pubmed ID: 17984378 Cardiac Transgenic and Gene Transfer Strategies Converge to Support an Important Role for Troponin I in Regulating Relaxation in Cardiac Myocytes Circulation Research. Aug, 2007 | Pubmed ID: 17615373 Distribution and Structure-function Relationship of Myosin Heavy Chain Isoforms in the Adult Mouse Heart The Journal of Biological Chemistry. Aug, 2007 | Pubmed ID: 17575272 Novel Mitochondrial DNA Mutations Implicated in Noonan Syndrome International Journal of Cardiology. Aug, 2007 | Pubmed ID: 17092585 Cardiac Myosin Binding Protein C Phosphorylation is Cardioprotective Proceedings of the National Academy of Sciences of the United States of America. Nov, 2006 | Pubmed ID: 17075052 PKC-betaII Sensitizes Cardiac Myofilaments to Ca2+ by Phosphorylating Troponin I on Threonine-144 Journal of Molecular and Cellular Cardiology. Nov, 2006 | Pubmed ID: 17010989 Cardiac Isoform of Alpha-2 Macroglobulin--a New Biomarker for Myocardial Infarcted Diabetic Patients Atherosclerosis. May, 2006 | Pubmed ID: 16102773 Cardiac Myosin-binding Protein-C Phosphorylation and Cardiac Function Circulation Research. Nov, 2005 | Pubmed ID: 16224063 Transgenic Rabbit Model for Human Troponin I-based Hypertrophic Cardiomyopathy Circulation. May, 2005 | Pubmed ID: 15867176 In Vivo and in Vitro Analysis of Cardiac Troponin I Phosphorylation The Journal of Biological Chemistry. Jan, 2005 | Pubmed ID: 15507454 Novel Deletions in MYH7 and MYBPC3 Identified in Indian Families with Familial Hypertrophic Cardiomyopathy Journal of Molecular and Cellular Cardiology. Jun, 2003 | Pubmed ID: 12788380 שיטת Quantitation רגישה וספציפית לקביעת חלבון-C שרירן לב סרום הכבילה ידי Immunoassay Electrochemiluminescence Diederik W.D. Kuster1, David Barefield1, Suresh Govindan1, Sakthivel Sadayappan1 1Department of Cell and Molecular Physiology, Loyola University Chicago JoVE 50786 Biology
שיטת Quantitation רגישה וספציפית לקביעת חלבון-C שרירן לב סרום הכבילה ידי Immunoassay Electrochemiluminescence Diederik W.D. Kuster1, David Barefield1, Suresh Govindan1, Sakthivel Sadayappan1 1Department of Cell and Molecular Physiology, Loyola University Chicago JoVE 50786 Biology