Sally A. Cowley

Publications

• Tissue-resident Macrophages Regulate Lymphatic Vessel Growth and Patterning in the Developing Heart
  Development (Cambridge, England). Feb, 2021   |   Pubmed ID: 33462113
• Honing the Double-Edged Sword: Improving Human IPSC-Microglia Models
  Frontiers in Immunology. Month, 2020   |   Pubmed ID: 33363548
• TREM2 Alzheimer's Variant R47H Causes Similar Transcriptional Dysregulation to Knockout, Yet Only Subtle Functional Phenotypes in Human IPSC-derived Macrophages
  Alzheimer's Research & Therapy. 11, 2020   |   Pubmed ID: 33198789
• ADAM17-triggered TNF Signalling Protects the Ageing Drosophila Retina from Lipid Droplet-mediated Degeneration
  The EMBO Journal. Sep, 2020   |   Pubmed ID: 32715522
• Large-Scale Production of Human IPSC-Derived Macrophages for Drug Screening
  International Journal of Molecular Sciences. Jul, 2020   |   Pubmed ID: 32645954
• Profiling of Naïve and Primed Human Pluripotent Stem Cells Reveals State-associated MiRNAs
  Scientific Reports. 06, 2020   |   Pubmed ID: 32601281
• Rates of Homology Directed Repair of CRISPR-Cas9 Induced Double Strand Breaks Are Lower in Naïve Compared to Primed Human Pluripotent Stem Cells
  Stem Cell Research. 07, 2020   |   Pubmed ID: 32521498
• Correction of Amyotrophic Lateral Sclerosis Related Phenotypes in Induced Pluripotent Stem Cell-derived Motor Neurons Carrying a Hexanucleotide Expansion Mutation in C9orf72 by CRISPR/Cas9 Genome Editing Using Homology-directed Repair
  Human Molecular Genetics. Aug, 2020   |   Pubmed ID: 32504093
• Generation of Twenty Four Induced Pluripotent Stem Cell Lines from Twenty Four Members of the Lothian Birth Cohort 1936
  Stem Cell Research. 07, 2020   |   Pubmed ID: 32450543
• Patient Fibroblast Circadian Rhythms Predict Lithium Sensitivity in Bipolar Disorder
  Molecular Psychiatry. May, 2020   |   Pubmed ID: 32404948
• LRRK2 Is Recruited to Phagosomes and Co-recruits RAB8 and RAB10 in Human Pluripotent Stem Cell-Derived Macrophages
  Stem Cell Reports. 05, 2020   |   Pubmed ID: 32359446
• Impairment of Mitochondrial Calcium Buffering Links Mutations in C9ORF72 and TARDBP in IPS-Derived Motor Neurons from Patients with ALS/FTD
  Stem Cell Reports. 05, 2020   |   Pubmed ID: 32330447
• A Causal Role for TRESK Loss of Function in Migraine Mechanisms
  Brain : a Journal of Neurology. 12, 2019   |   Pubmed ID: 31742594
• Application of CRISPR/Cas9 Editing and Digital Droplet PCR in Human IPSCs to Generate Novel Knock-in Reporter Lines to Visualize Dopaminergic Neurons
  Stem Cell Research. 12, 2019   |   Pubmed ID: 31733438
• RNA Sequencing Reveals MMP2 and TGFB1 Downregulation in LRRK2 G2019S Parkinson's IPSC-derived Astrocytes
  Neurobiology of Disease. 09, 2019   |   Pubmed ID: 31085228
• An Integrated Transcriptomics and Proteomics Analysis Reveals Functional Endocytic Dysregulation Caused by Mutations in LRRK2
  Neurobiology of Disease. 07, 2019   |   Pubmed ID: 30954703
• Proteolytic Shedding of the Prion Protein Via Activation of Metallopeptidase ADAM10 Reduces Cellular Binding and Toxicity of Amyloid-β Oligomers
  The Journal of Biological Chemistry. 04, 2019   |   Pubmed ID: 30872401
• Cellular α-synuclein Pathology is Associated with Bioenergetic Dysfunction in Parkinson's IPSC-derived Dopamine Neurons
  Human Molecular Genetics. 06, 2019   |   Pubmed ID: 30753527
• Microglial Inflammation and Phagocytosis in Alzheimer's Disease: Potential Therapeutic Targets
  British Journal of Pharmacology. 09, 2019   |   Pubmed ID: 30740661
• Single-Cell Sequencing of IPSC-Dopamine Neurons Reconstructs Disease Progression and Identifies HDAC4 As a Regulator of Parkinson Cell Phenotypes
  Cell Stem Cell. 01, 2019   |   Pubmed ID: 30503143
• Lentiviral Gene Therapy Vector with UCOE Stably Restores Function in IPSC-derived Neutrophils of a CDG Patient
  Matters. Month, 2018   |   Pubmed ID: 31008103
• RIPK1 is a Critical Modulator of Both Tonic and TLR-responsive Inflammatory and Cell Death Pathways in Human Macrophage Differentiation
  Cell Death & Disease. 09, 2018   |   Pubmed ID: 30250197
• Neurodegeneration in SCA14 is Associated with Increased PKCγ Kinase Activity, Mislocalization and Aggregation
  Acta Neuropathologica Communications. 09, 2018   |   Pubmed ID: 30249303
• Genome Editing in Induced Pluripotent Stem Cells Rescues TAF1 Levels in X-linked Dystonia-parkinsonism
  Movement Disorders : Official Journal of the Movement Disorder Society. 07, 2018   |   Pubmed ID: 30153385
• FRMD8 Promotes Inflammatory and Growth Factor Signalling by Stabilising the IRhom/ADAM17 Sheddase Complex
  ELife. 06, 2018   |   Pubmed ID: 29897336
• LRRK2 is a Negative Regulator of Phagosome Maturation in Macrophages
  The EMBO Journal. Jun, 2018   |   Pubmed ID: 29789389
• Stem Cell Modeling of Mitochondrial Parkinsonism Reveals Key Functions of OPA1
  Annals of Neurology. 05, 2018   |   Pubmed ID: 29604226
• A Simplified Method for Generating Purkinje Cells from Human-Induced Pluripotent Stem Cells
  Cerebellum (London, England). Aug, 2018   |   Pubmed ID: 29397531
• Alpha-synuclein Induces the Unfolded Protein Response in Parkinson's Disease SNCA Triplication IPSC-derived Neurons
  Human Molecular Genetics. 11, 2017   |   Pubmed ID: 28973645
• Excess α-synuclein Compromises Phagocytosis in IPSC-derived Macrophages
  Scientific Reports. 08, 2017   |   Pubmed ID: 28827786
• MAPT Genetic Variation and Neuronal Maturity Alter Isoform Expression Affecting Axonal Transport in IPSC-Derived Dopamine Neurons
  Stem Cell Reports. 08, 2017   |   Pubmed ID: 28689993
• A Highly Efficient Human Pluripotent Stem Cell Microglia Model Displays a Neuronal-Co-culture-Specific Expression Profile and Inflammatory Response
  Stem Cell Reports. 06, 2017   |   Pubmed ID: 28591653
• LRRK2 in Peripheral and Central Nervous System Innate Immunity: Its Link to Parkinson's Disease
  Biochemical Society Transactions. Feb, 2017   |   Pubmed ID: 28202666
• Multiplex High-Throughput Targeted Proteomic Assay To Identify Induced Pluripotent Stem Cells
  Analytical Chemistry. 02, 2017   |   Pubmed ID: 28192931
• Transcriptomic Profiling of Purified Patient-derived Dopamine Neurons Identifies Convergent Perturbations and Therapeutics for Parkinson's Disease
  Human Molecular Genetics. 02, 2017   |   Pubmed ID: 28096185
• Variant U1 SnRNAs Are Implicated in Human Pluripotent Stem Cell Maintenance and Neuromuscular Disease
  Nucleic Acids Research. 12, 2016   |   Pubmed ID: 27536002
• C9orf72 Hexanucleotide Expansions Are Associated with Altered Endoplasmic Reticulum Calcium Homeostasis and Stress Granule Formation in Induced Pluripotent Stem Cell-Derived Neurons from Patients with Amyotrophic Lateral Sclerosis and Frontotemporal Dementia
  Stem Cells (Dayton, Ohio). 08, 2016   |   Pubmed ID: 27097283
• ER Stress and Autophagic Perturbations Lead to Elevated Extracellular α-Synuclein in GBA-N370S Parkinson's IPSC-Derived Dopamine Neurons
  Stem Cell Reports. Mar, 2016   |   Pubmed ID: 26905200
• The Current State of Naïve Human Pluripotency
  Stem Cells (Dayton, Ohio). Nov, 2015   |   Pubmed ID: 26119873
• CRISPR-mediated Genotypic and Phenotypic Correction of a Chronic Granulomatous Disease Mutation in Human IPS Cells
  Experimental Hematology. Oct, 2015   |   Pubmed ID: 26101162
• Physiological Characterisation of Human IPS-derived Dopaminergic Neurons
  PloS One. Month, 2014   |   Pubmed ID: 24586273
• The Productive Entry Pathway of HIV-1 in Macrophages is Dependent on Endocytosis Through Lipid Rafts Containing CD4
  PloS One. Month, 2014   |   Pubmed ID: 24465876
• Efficient, Long Term Production of Monocyte-derived Macrophages from Human Pluripotent Stem Cells Under Partly-defined and Fully-defined Conditions
  PloS One. Month, 2013   |   Pubmed ID: 23951090
• Differentially Expressed, Variant U1 SnRNAs Regulate Gene Expression in Human Cells
  Genome Research. Feb, 2013   |   Pubmed ID: 23070852
• Cellular Reprogramming: a New Approach to Modelling Parkinson's Disease
  Biochemical Society Transactions. Oct, 2012   |   Pubmed ID: 22988881
• Transportin 3 Promotes a Nuclear Maturation Step Required for Efficient HIV-1 Integration
  PLoS Pathogens. Aug, 2011   |   Pubmed ID: 21901095
• Episomal Transgene Expression in Pluripotent Stem Cells
  Methods in Molecular Biology (Clifton, N.J.). Month, 2011   |   Pubmed ID: 21822889
• Protein Kinase C and NF-κB-dependent CD4 Downregulation in Macrophages Induced by T Cell-derived Soluble Factors: Consequences for HIV-1 Infection
  Journal of Immunology (Baltimore, Md. : 1950). Jul, 2011   |   Pubmed ID: 21666058
• Derivation and Characterisation of the Human Embryonic Stem Cell Line, OxF1
  In Vitro Cellular & Developmental Biology. Animal. Apr, 2010   |   Pubmed ID: 20333479