Samuel H. Wilson Genome Integrity and Structural Biology Laboratory National Institute of Environmental Health Sciences, National Institutes of Health Biography Publications Institution JoVE Articles Samuel H. Wilson has not added a biography. If you are Samuel H. Wilson and would like to personalize this page please email our Author Liaison for assistance. Publications Watching Right and Wrong Nucleotide Insertion Captures Hidden Polymerase Fidelity Checkpoints Nature Communications. 06, 2022 | Pubmed ID: 35680862 Structural Basis for Proficient Oxidized Ribonucleotide Insertion in Double Strand Break Repair Nature Communications. 08, 2021 | Pubmed ID: 34417448 Perspectives on Formaldehyde Dysregulation: Mitochondrial DNA Damage and Repair in Mammalian Cells DNA Repair. 09, 2021 | Pubmed ID: 34116475 Watching a Double Strand Break Repair Polymerase Insert a Pro-mutagenic Oxidized Nucleotide Nature Communications. 04, 2021 | Pubmed ID: 33824325 Lysines in the Lyase Active Site of DNA Polymerase β Destabilize Nonspecific DNA Binding, Facilitating Searching and DNA Gap Recognition The Journal of Biological Chemistry. 08, 2020 | Pubmed ID: 32647014 Preferential DNA Polymerase β Reverse Reaction with Imidodiphosphate ACS Omega. Jun, 2020 | Pubmed ID: 32637805 Structure of a DNA Polymerase Abortive Complex with the 8OG:dA Base Pair at the Primer Terminus Communications Biology. 07, 2020 | Pubmed ID: 32620932 Requirements for PARP-1 Covalent Crosslinking to DNA (PARP-1 DPC) DNA Repair. 06, 2020 | Pubmed ID: 32438305 Mitochondrial Dysfunction and DNA Damage Accompany Enhanced Levels of Formaldehyde in Cultured Primary Human Fibroblasts Scientific Reports. 03, 2020 | Pubmed ID: 32221313 WITHDRAWN: Requirements for PARP-1 Covalent Crosslinking to DNA (PARP-1 DPC) DNA Repair. 05, 2020 | Pubmed ID: 32151818 Revealing an Internal Stabilization Deficiency in the DNA Polymerase β K289M Cancer Variant Through the Combined Use of Chemical Biology and X-ray Crystallography Biochemistry. 03, 2020 | Pubmed ID: 31999437 Oxidative DNA Damage Modulates DNA Methylation Pattern in Human Breast Cancer 1 (BRCA1) Gene Via the Crosstalk Between DNA Polymerase β and a DNA Methyltransferase Cells. 01, 2020 | Pubmed ID: 31963223 Oxidative DNA-protein Crosslinks Formed in Mammalian Cells by Abasic Site Lyases Involved in DNA Repair DNA Repair. 03, 2020 | Pubmed ID: 31945542 DNA Polymerase β Nucleotide-stabilized Template Misalignment Fidelity Depends on Local Sequence Context The Journal of Biological Chemistry. 01, 2020 | Pubmed ID: 31801827 Shining Light on the Response to Repair Intermediates in DNA of Living Cells DNA Repair. 01, 2020 | Pubmed ID: 31790865 DNA Polymerase Beta and Other Gap-filling Enzymes in Mammalian Base Excision Repair The Enzymes. 2019 | Pubmed ID: 31627875 The Pol β Variant Containing Exon α is Deficient in DNA Polymerase but Has Full DRP Lyase Activity Scientific Reports. 07, 2019 | Pubmed ID: 31289286 Eukaryotic Base Excision Repair: New Approaches Shine Light on Mechanism Annual Review of Biochemistry. 06, 2019 | Pubmed ID: 31220977 Molecular Basis for the Faithful Replication of 5-methylcytosine and Its Oxidized Forms by DNA Polymerase β The Journal of Biological Chemistry. 05, 2019 | Pubmed ID: 30885943 A Transition-State Perspective on Y-Family DNA Polymerase η Fidelity in Comparison with X-Family DNA Polymerases λ and β Biochemistry. 04, 2019 | Pubmed ID: 30839203 Repair Pathway for PARP-1 DNA-protein Crosslinks DNA Repair. 01, 2019 | Pubmed ID: 30466837 Pol μ DGTP Mismatch Insertion Opposite T Coupled with Ligation Reveals Promutagenic DNA Repair Intermediate Nature Communications. 10, 2018 | Pubmed ID: 30310068 DNA Scanning by Base Excision Repair Enzymes and Implications for Pathway Coordination DNA Repair. 11, 2018 | Pubmed ID: 30181039 Transitions in DNA Polymerase β μs-ms Dynamics Related to Substrate Binding and Catalysis Nucleic Acids Research. 08, 2018 | Pubmed ID: 29917149 Probing DNA Base-Dependent Leaving Group Kinetic Effects on the DNA Polymerase Transition State Biochemistry. 07, 2018 | Pubmed ID: 29889506 Mapping Functional Substrate-Enzyme Interactions in the Pol β Active Site Through Chemical Biology: Structural Responses to Acidity Modification of Incoming DNTPs Biochemistry. 07, 2018 | Pubmed ID: 29874056 Transcriptional Mutagenesis Mediated by 8-oxoG Induces Translational Errors in Mammalian Cells Proceedings of the National Academy of Sciences of the United States of America. 04, 2018 | Pubmed ID: 29610342 XRCC1 Phosphorylation Affects Aprataxin Recruitment and DNA Deadenylation Activity DNA Repair. 04, 2018 | Pubmed ID: 29477978 DNA Polymerase β: A Missing Link of the Base Excision Repair Machinery in Mammalian Mitochondria DNA Repair. 12, 2017 | Pubmed ID: 29100041 Role of DNA Polymerase β Oxidized Nucleotide Insertion in DNA Ligation Failure Journal of Radiation Research. Sep, 2017 | Pubmed ID: 28992331 Complementation of Aprataxin Deficiency by Base Excision Repair Enzymes in Mitochondrial Extracts Nucleic Acids Research. Sep, 2017 | Pubmed ID: 28973450 Assay to Measure DNA Polymerase β Nucleotide Insertion Coupled with the DNA Ligation Reaction During Base Excision Repair Bio-protocol. Jun, 2017 | Pubmed ID: 28835905 Time-lapse Crystallography Snapshots of a Double-strand Break Repair Polymerase in Action Nature Communications. 08, 2017 | Pubmed ID: 28811466 DNA Polymerase β Uses Its Lyase Domain in a Processive Search for DNA Damage Nucleic Acids Research. 04, 2017 | Pubmed ID: 28119421 Revealing the Role of the Product Metal in DNA Polymerase β Catalysis Nucleic Acids Research. 03, 2017 | Pubmed ID: 28108654 Oxidized Nucleotide Insertion by Pol β Confounds Ligation During Base Excision Repair Nature Communications. 01, 2017 | Pubmed ID: 28067232 Hiding in Plain Sight: The Bimetallic Magnesium Covalent Bond in Enzyme Active Sites Inorganic Chemistry. Jan, 2017 | Pubmed ID: 27976880 DNA Polymerase β Contains a Functional Nuclear Localization Signal at Its N-terminus Nucleic Acids Research. Feb, 2017 | Pubmed ID: 27956495 Impact of Ribonucleotide Backbone on Translesion Synthesis and Repair of 7,8-Dihydro-8-oxoguanine The Journal of Biological Chemistry. Nov, 2016 | Pubmed ID: 27660390 Structures of DNA Polymerase Mispaired DNA Termini Transitioning to Pre-catalytic Complexes Support an Induced-Fit Fidelity Mechanism Structure (London, England : 1993). 11, 2016 | Pubmed ID: 27642161 Combined Effects of High-Dose Bisphenol A and Oxidizing Agent (KBrO3) on Cellular Microenvironment, Gene Expression, and Chromatin Structure of Ku70-deficient Mouse Embryonic Fibroblasts Environmental Health Perspectives. Aug, 2016 | Pubmed ID: 27082013 Insertion of Oxidized Nucleotide Triggers Rapid DNA Polymerase Opening Nucleic Acids Research. 05, 2016 | Pubmed ID: 27034465 Oxidized DNTPs and the OGG1 and MUTYH DNA Glycosylases Combine to Induce CAG/CTG Repeat Instability Nucleic Acids Research. 06, 2016 | Pubmed ID: 26980281 Enzymatic Activity Assays for Base Excision Repair Enzymes in Cell Extracts from Vertebrate Cells Bio-protocol. 2015 | Pubmed ID: 27390764 Capturing Snapshots of APE1 Processing DNA Damage Nature Structural & Molecular Biology. Nov, 2015 | Pubmed ID: 26458045 Requirement for Transient Metal Ions Revealed Through Computational Analysis for DNA Polymerase Going in Reverse Proceedings of the National Academy of Sciences of the United States of America. Sep, 2015 | Pubmed ID: 26351676 Intrinsic Mutagenic Properties of 5-chlorocytosine: A Mechanistic Connection Between Chronic Inflammation and Cancer Proceedings of the National Academy of Sciences of the United States of America. Aug, 2015 | Pubmed ID: 26243878 New Structural Snapshots Provide Molecular Insights into the Mechanism of High Fidelity DNA Synthesis DNA Repair. Aug, 2015 | Pubmed ID: 26002198 Two Scaffolds from Two Flips: (α,β)/(β,γ) CH2/NH "Met-Im" Analogues of DTTP Organic Letters. Jun, 2015 | Pubmed ID: 25970636 Structures of Human DNA Polymerases ν and θ Expose Their End Game Nature Structural & Molecular Biology. Apr, 2015 | Pubmed ID: 25837870 Uncovering the Polymerase-induced Cytotoxicity of an Oxidized Nucleotide Nature. Jan, 2015 | Pubmed ID: 25409153 Phylogenetic Analysis and Evolutionary Origins of DNA Polymerase X-family Members DNA Repair. Oct, 2014 | Pubmed ID: 25112931 The Dark Side of DNA Repair ELife. May, 2014 | Pubmed ID: 24844708 Role of Polymerase β in Complementing Aprataxin Deficiency During Abasic-site Base Excision Repair Nature Structural & Molecular Biology. May, 2014 | Pubmed ID: 24777061 Structure and Mechanism of DNA Polymerase β Biochemistry. May, 2014 | Pubmed ID: 24717170 Understanding the Loss-of-function in a Triple Missense Mutant of DNA Polymerase β Found in Prostate Cancer International Journal of Oncology. Oct, 2013 | Pubmed ID: 23877444 Preventing Oxidation of Cellular XRCC1 Affects PARP-mediated DNA Damage Responses DNA Repair. Sep, 2013 | Pubmed ID: 23871146 Observing a DNA Polymerase Choose Right from Wrong Cell. Jul, 2013 | Pubmed ID: 23827680 Interaction Between DNA Polymerase β and BRCA1 PloS One. 2013 | Pubmed ID: 23826138 Insights into the Conformation of Aminofluorene-deoxyguanine Adduct in a DNA Polymerase Active Site The Journal of Biological Chemistry. Aug, 2013 | Pubmed ID: 23798703 Amino Acid Substitution in the Active Site of DNA Polymerase β Explains the Energy Barrier of the Nucleotidyl Transfer Reaction Journal of the American Chemical Society. May, 2013 | Pubmed ID: 23647366 DNA Polymerase Minor Groove Interactions Modulate Mutagenic Bypass of a Templating 8-oxoguanine Lesion Nucleic Acids Research. Feb, 2013 | Pubmed ID: 23267011 Predicting Enhanced Cell Killing Through PARP Inhibition Molecular Cancer Research : MCR. Jan, 2013 | Pubmed ID: 23193155 Identification of One of the Apurinic/apyrimidinic Lyase Active Sites of Topoisomerase V by Structural and Functional Studies Nucleic Acids Research. Jan, 2013 | Pubmed ID: 23125368 Perspective: Pre-chemistry Conformational Changes in DNA Polymerase Mechanisms Theoretical Chemistry Accounts. Nov, 2012 | Pubmed ID: 23459563 Hyperactivation of PARP Triggers Nonhomologous End-joining in Repair-deficient Mouse Fibroblasts PloS One. 2012 | Pubmed ID: 23145148 Evidence for Abasic Site Sugar Phosphate-mediated Cytotoxicity in Alkylating Agent Treated Saccharomyces Cerevisiae PloS One. 2012 | Pubmed ID: 23144716 DNA Polymerase β Gap-filling Translesion DNA Synthesis Chemical Research in Toxicology. Dec, 2012 | Pubmed ID: 23121263 Effect of β,γ-CHF- and β,γ-CHCl-dGTP Halogen Atom Stereochemistry on the Transition State of DNA Polymerase β Biochemistry. Oct, 2012 | Pubmed ID: 23043620 Pol β Associated Complex and Base Excision Repair Factors in Mouse Fibroblasts Nucleic Acids Research. Dec, 2012 | Pubmed ID: 23042675 DNA Sequence Context Effects on the Glycosylase Activity of Human 8-oxoguanine DNA Glycosylase The Journal of Biological Chemistry. Oct, 2012 | Pubmed ID: 22989888 Structures of DNTP Intermediate States During DNA Polymerase Active Site Assembly Structure (London, England : 1993). Nov, 2012 | Pubmed ID: 22959623 HMGN1 Protein Regulates Poly(ADP-ribose) Polymerase-1 (PARP-1) Self-PARylation in Mouse Fibroblasts The Journal of Biological Chemistry. Aug, 2012 | Pubmed ID: 22736760 β,γ-CHF- and β,γ-CHCl-dGTP Diastereomers: Synthesis, Discrete 31P NMR Signatures, and Absolute Configurations of New Stereochemical Probes for DNA Polymerases Journal of the American Chemical Society. May, 2012 | Pubmed ID: 22397499 Stereospecific Formation of a Ternary Complex of (S)-α,β-fluoromethylene-dATP with DNA Pol β Chembiochem : a European Journal of Chemical Biology. Mar, 2012 | Pubmed ID: 22315190 DNA Base Excision Repair: a Mechanism of Trinucleotide Repeat Expansion Trends in Biochemical Sciences. Apr, 2012 | Pubmed ID: 22285516 Increased PARP-1 Association with DNA in Alkylation Damaged, PARP-inhibited Mouse Fibroblasts Molecular Cancer Research : MCR. Mar, 2012 | Pubmed ID: 22246237 Binary Complex Crystal Structure of DNA Polymerase β Reveals Multiple Conformations of the Templating 8-oxoguanine Lesion Proceedings of the National Academy of Sciences of the United States of America. Jan, 2012 | Pubmed ID: 22178760 Metal-induced DNA Translocation Leads to DNA Polymerase Conformational Activation Nucleic Acids Research. Apr, 2012 | Pubmed ID: 22169953 Single-nucleotide Base Excision Repair DNA Polymerase Activity in C. Elegans in the Absence of DNA Polymerase β Nucleic Acids Research. Jan, 2012 | Pubmed ID: 21917855 Lucanthone and Its Derivative Hycanthone Inhibit Apurinic Endonuclease-1 (APE1) by Direct Protein Binding PloS One. 2011 | Pubmed ID: 21935361 Molecular Insights into DNA Polymerase Deterrents for Ribonucleotide Insertion The Journal of Biological Chemistry. Sep, 2011 | Pubmed ID: 21733843 Requirement for NBS1 in the S Phase Checkpoint Response to DNA Methylation Combined with PARP Inhibition DNA Repair. Feb, 2011 | Pubmed ID: 21130714 Substrate Channeling in Mammalian Base Excision Repair Pathways: Passing the Baton The Journal of Biological Chemistry. Dec, 2010 | Pubmed ID: 20952393 Base Excision Repair and Design of Small Molecule Inhibitors of Human DNA Polymerase β Cellular and Molecular Life Sciences : CMLS. Nov, 2010 | Pubmed ID: 20844920 Mutagenesis Dependent Upon the Combination of Activation-induced Deaminase Expression and a Double-strand Break Molecular Immunology. Nov-Dec, 2010 | Pubmed ID: 20828826 DNA Polymerases Beta and Lambda Mediate Overlapping and Independent Roles in Base Excision Repair in Mouse Embryonic Fibroblasts PloS One. 2010 | Pubmed ID: 20805875 Synthesis and Biological Evaluation of Fluorinated Deoxynucleotide Analogs Based on Bis-(difluoromethylene)triphosphoric Acid Proceedings of the National Academy of Sciences of the United States of America. Sep, 2010 | Pubmed ID: 20724659 DNA Polymerase Structure-based Insight on the Mutagenic Properties of 8-oxoguanine Mutation Research. Nov, 2010 | Pubmed ID: 20696268 Alkylation DNA Damage in Combination with PARP Inhibition Results in Formation of S-phase-dependent Double-strand Breaks DNA Repair. Aug, 2010 | Pubmed ID: 20573551 Mutagenic Conformation of 8-oxo-7,8-dihydro-2'-dGTP in the Confines of a DNA Polymerase Active Site Nature Structural & Molecular Biology. Jul, 2010 | Pubmed ID: 20526335 DNA Polymerase Beta Ribonucleotide Discrimination: Insertion, Misinsertion, Extension, and Coding The Journal of Biological Chemistry. Aug, 2010 | Pubmed ID: 20519499 Halogenated Beta,gamma-methylene- and Ethylidene-dGTP-DNA Ternary Complexes with DNA Polymerase Beta: Structural Evidence for Stereospecific Binding of the Fluoromethylene Analogues Journal of the American Chemical Society. Jun, 2010 | Pubmed ID: 20465217 FEN1 Functions in Long Patch Base Excision Repair Under Conditions of Oxidative Stress in Vertebrate Cells Molecular Cancer Research : MCR. Feb, 2010 | Pubmed ID: 20145043 HMGB1: Roles in Base Excision Repair and Related Function Biochimica Et Biophysica Acta. Jan-Feb, 2010 | Pubmed ID: 20123074 DNA Polymerase Beta-dependent Long Patch Base Excision Repair in Living Cells DNA Repair. Feb, 2010 | Pubmed ID: 20006562 DNA Polymerase Beta Substrate Specificity: Side Chain Modulation of the "A-rule" The Journal of Biological Chemistry. Nov, 2009 | Pubmed ID: 19759017 DNA Polymerase Beta and PARP Activities in Base Excision Repair in Living Cells DNA Repair. Nov, 2009 | Pubmed ID: 19748837 PARP Inhibition During Alkylation-induced Genotoxic Stress Signals a Cell Cycle Checkpoint Response Mediated by ATM DNA Repair. Nov, 2009 | Pubmed ID: 19717351 A Real-time Fluorescence Method for Enzymatic Characterization of Specialized Human DNA Polymerases Nucleic Acids Research. Oct, 2009 | Pubmed ID: 19684079 Coordination Between Polymerase Beta and FEN1 Can Modulate CAG Repeat Expansion The Journal of Biological Chemistry. Oct, 2009 | Pubmed ID: 19674974 Gastrointestinal Hyperplasia with Altered Expression of DNA Polymerase Beta PloS One. 2009 | Pubmed ID: 19654874 Characterization of DNA Polymerase Beta Splicing Variants in Gastric Cancer: the Most Frequent Exon 2-deleted Isoform is a Non-coding RNA Mutation Research. Nov, 2009 | Pubmed ID: 19635489 Alpha,beta-difluoromethylene Deoxynucleoside 5'-triphosphates: a Convenient Synthesis of Useful Probes for DNA Polymerase Beta Structure and Function Organic Letters. May, 2009 | Pubmed ID: 19351147 Human DNA Polymerase Theta Possesses 5'-dRP Lyase Activity and Functions in Single-nucleotide Base Excision Repair in Vitro Nucleic Acids Research. Apr, 2009 | Pubmed ID: 19188258 Alpha,beta-methylene-2'-deoxynucleoside 5'-triphosphates As Noncleavable Substrates for DNA Polymerases: Isolation, Characterization, and Stability Studies of Novel 2'-deoxycyclonucleosides, 3,5'-cyclo-dG, and 2,5'-cyclo-dT Journal of Medicinal Chemistry. Oct, 2008 | Pubmed ID: 18811136 Interaction Between PARP-1 and ATR in Mouse Fibroblasts is Blocked by PARP Inhibition DNA Repair. Nov, 2008 | Pubmed ID: 18691676 Mutagenesis is Elevated in Male Germ Cells Obtained from DNA Polymerase-beta Heterozygous Mice Biology of Reproduction. Nov, 2008 | Pubmed ID: 18650495 Folate Deficiency Induces Neurodegeneration and Brain Dysfunction in Mice Lacking Uracil DNA Glycosylase The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jul, 2008 | Pubmed ID: 18614692 Structures of DNA Polymerase Beta with Active-site Mismatches Suggest a Transient Abasic Site Intermediate During Misincorporation Molecular Cell. May, 2008 | Pubmed ID: 18471977 Negligible Impact of Pol Iota Expression on the Alkylation Sensitivity of Pol Beta-deficient Mouse Fibroblast Cells DNA Repair. Jun, 2008 | Pubmed ID: 18434259 DNA Damage Response Protein ASCIZ Links Base Excision Repair with Immunoglobulin Gene Conversion Biochemical and Biophysical Research Communications. Jun, 2008 | Pubmed ID: 18433721 Incorrect Nucleotide Insertion at the Active Site of a G:A Mismatch Catalyzed by DNA Polymerase Beta Proceedings of the National Academy of Sciences of the United States of America. Apr, 2008 | Pubmed ID: 18391201 XRCC1 and DNA Polymerase Beta in Cellular Protection Against Cytotoxic DNA Single-strand Breaks Cell Research. Jan, 2008 | Pubmed ID: 18166976 DNA Polymerase Beta Fidelity: Halomethylene-modified Leaving Groups in Pre-steady-state Kinetic Analysis Reveal Differences at the Chemical Transition State Biochemistry. Jan, 2008 | Pubmed ID: 18161950 Exploring the Role of Large Conformational Changes in the Fidelity of DNA Polymerase Beta Proteins. Jan, 2008 | Pubmed ID: 17671961 (R)-beta,gamma-fluoromethylene-dGTP-DNA Ternary Complex with DNA Polymerase Beta Journal of the American Chemical Society. Dec, 2007 | Pubmed ID: 18031037 HMGB1 is a Cofactor in Mammalian Base Excision Repair Molecular Cell. Sep, 2007 | Pubmed ID: 17803946 Comparative Assessment of Plasmid and Oligonucleotide DNA Substrates in Measurement of in Vitro Base Excision Repair Activity Nucleic Acids Research. 2007 | Pubmed ID: 17720705 Stimulation of NEIL2-mediated Oxidized Base Excision Repair Via YB-1 Interaction During Oxidative Stress The Journal of Biological Chemistry. Sep, 2007 | Pubmed ID: 17686777 The X Family Portrait: Structural Insights into Biological Functions of X Family Polymerases DNA Repair. Dec, 2007 | Pubmed ID: 17631059 Different Structural States in Oligonucleosomes Are Required for Early Versus Late Steps of Base Excision Repair Nucleic Acids Research. 2007 | Pubmed ID: 17576692 Ochratoxin A-induced Mutagenesis in Mammalian Cells is Consistent with the Production of Oxidative Stress Chemical Research in Toxicology. Jul, 2007 | Pubmed ID: 17567156 OGG1 Initiates Age-dependent CAG Trinucleotide Expansion in Somatic Cells Nature. May, 2007 | Pubmed ID: 17450122 Interplay Between DNA Polymerases Beta and Lambda in Repair of Oxidation DNA Damage in Chicken DT40 Cells DNA Repair. Jun, 2007 | Pubmed ID: 17363341 Coordination of Steps in Single-nucleotide Base Excision Repair Mediated by Apurinic/apyrimidinic Endonuclease 1 and DNA Polymerase Beta The Journal of Biological Chemistry. May, 2007 | Pubmed ID: 17355977 Differing Conformational Pathways Before and After Chemistry for Insertion of DATP Versus DCTP Opposite 8-oxoG in DNA Polymerase Beta Biophysical Journal. May, 2007 | Pubmed ID: 17293403 ATR Signaling Mediates an S-phase Checkpoint After Inhibition of Poly(ADP-ribose) Polymerase Activity DNA Repair. Jun, 2007 | Pubmed ID: 17292679 Modifying the Beta,gamma Leaving-group Bridging Oxygen Alters Nucleotide Incorporation Efficiency, Fidelity, and the Catalytic Mechanism of DNA Polymerase Beta Biochemistry. Jan, 2007 | Pubmed ID: 17209556 Magnesium-cationic Dummy Atom Molecules Enhance Representation of DNA Polymerase Beta in Molecular Dynamics Simulations: Improved Accuracy in Studies of Structural Features and Mutational Effects Journal of Molecular Biology. Feb, 2007 | Pubmed ID: 17174326 Down-regulation of DNA Polymerase Beta Accompanies Somatic Hypermutation in Human BL2 Cell Lines DNA Repair. Feb, 2007 | Pubmed ID: 17127106 Hypersensitivity Phenotypes Associated with Genetic and Synthetic Inhibitor-induced Base Excision Repair Deficiency DNA Repair. Apr, 2007 | Pubmed ID: 17113833 Regulation of DNA Repair Fidelity by Molecular Checkpoints: "gates" in DNA Polymerase Beta's Substrate Selection Biochemistry. Dec, 2006 | Pubmed ID: 17176036 Structure of DNA Polymerase Beta with a Benzo[c]phenanthrene Diol Epoxide-adducted Template Exhibits Mutagenic Features Proceedings of the National Academy of Sciences of the United States of America. Nov, 2006 | Pubmed ID: 17079493 Vertebrate POLQ and POLbeta Cooperate in Base Excision Repair of Oxidative DNA Damage Molecular Cell. Oct, 2006 | Pubmed ID: 17018297 NEIL2-initiated, APE-independent Repair of Oxidized Bases in DNA: Evidence for a Repair Complex in Human Cells DNA Repair. Dec, 2006 | Pubmed ID: 16982218 Energy Analysis of Chemistry for Correct Insertion by DNA Polymerase Beta Proceedings of the National Academy of Sciences of the United States of America. Sep, 2006 | Pubmed ID: 16938895 Haploinsufficiency in DNA Polymerase Beta Increases Cancer Risk with Age and Alters Mortality Rate Cancer Research. Aug, 2006 | Pubmed ID: 16885342 Disease-first: a New Paradigm for Environmental Health Science Research Environmental Health Perspectives. Jul, 2006 | Pubmed ID: 16835037 Activities and Mechanism of DNA Polymerase Beta Methods in Enzymology. 2006 | Pubmed ID: 16793365 Determination of Lysine PK Values Using [5-13C]lysine: Application to the Lyase Domain of DNA Pol Beta Journal of the American Chemical Society. Jun, 2006 | Pubmed ID: 16787052 Magnesium-induced Assembly of a Complete DNA Polymerase Catalytic Complex Structure (London, England : 1993). Apr, 2006 | Pubmed ID: 16615916 Structure and Mechanism of DNA Polymerase Beta Chemical Reviews. Feb, 2006 | Pubmed ID: 16464010 The Werner Syndrome Protein Operates in Base Excision Repair and Cooperates with DNA Polymerase Beta Nucleic Acids Research. 2006 | Pubmed ID: 16449207 A Thymine Isostere in the Templating Position Disrupts Assembly of the Closed DNA Polymerase Beta Ternary Complex Biochemistry. Nov, 2005 | Pubmed ID: 16285726 Syn-full Behavior by T7 DNA Polymerase Structure (London, England : 1993). Nov, 2005 | Pubmed ID: 16271879 Framework for Environmental Exposure Research: the Disease-first Approach Molecular Interventions. Oct, 2005 | Pubmed ID: 16249520 The Need for Exposure Health Sciences Environmental Health Perspectives. Oct, 2005 | Pubmed ID: 16203220 Mismatch-induced Conformational Distortions in Polymerase Beta Support an Induced-fit Mechanism for Fidelity Biochemistry. Oct, 2005 | Pubmed ID: 16201758 Structural Insight into the DNA Polymerase Beta Deoxyribose Phosphate Lyase Mechanism DNA Repair. Dec, 2005 | Pubmed ID: 16172026 Nucleotide-induced DNA Polymerase Active Site Motions Accommodating a Mutagenic DNA Intermediate Structure (London, England : 1993). Aug, 2005 | Pubmed ID: 16084394 Strategic Planning: Establishing Need and Clarifying Motivation Environmental Health Perspectives. Aug, 2005 | Pubmed ID: 16079048 DNA Polymerase Lambda Protects Mouse Fibroblasts Against Oxidative DNA Damage and is Recruited to Sites of DNA Damage/repair The Journal of Biological Chemistry. Sep, 2005 | Pubmed ID: 16002405 Personalized Exposure Assessment: Promising Approaches for Human Environmental Health Research Environmental Health Perspectives. Jul, 2005 | Pubmed ID: 16002370 Involvement of Poly(ADP-ribose) Polymerase Activity in Regulating Chk1-dependent Apoptotic Cell Death DNA Repair. Sep, 2005 | Pubmed ID: 16002346 REV1 Mediated Mutagenesis in Base Excision Repair Deficient Mouse Fibroblast DNA Repair. Sep, 2005 | Pubmed ID: 15950550 DNA Polymerase Lambda Mediates a Back-up Base Excision Repair Activity in Extracts of Mouse Embryonic Fibroblasts The Journal of Biological Chemistry. May, 2005 | Pubmed ID: 15749700 Human Base Excision Repair Enzymes Apurinic/apyrimidinic Endonuclease1 (APE1), DNA Polymerase Beta and Poly(ADP-ribose) Polymerase 1: Interplay Between Strand-displacement DNA Synthesis and Proofreading Exonuclease Activity Nucleic Acids Research. 2005 | Pubmed ID: 15731342 Poly(ADP-ribose) Polymerase Activity Prevents Signaling Pathways for Cell Cycle Arrest After DNA Methylating Agent Exposure The Journal of Biological Chemistry. Apr, 2005 | Pubmed ID: 15701627 Base Excision Repair in Nucleosomes Lacking Histone Tails DNA Repair. Feb, 2005 | Pubmed ID: 15590328 DNA Polymerase Beta and Flap Endonuclease 1 Enzymatic Specificities Sustain DNA Synthesis for Long Patch Base Excision Repair The Journal of Biological Chemistry. Feb, 2005 | Pubmed ID: 15561706 Structural Insights into DNA Polymerase Beta Deterrents for Misincorporation Support an Induced-fit Mechanism for Fidelity Structure (London, England : 1993). Oct, 2004 | Pubmed ID: 15458631 In Situ Analysis of Repair Processes for Oxidative DNA Damage in Mammalian Cells Proceedings of the National Academy of Sciences of the United States of America. Sep, 2004 | Pubmed ID: 15365186 AP Endonuclease-independent DNA Base Excision Repair in Human Cells Molecular Cell. Jul, 2004 | Pubmed ID: 15260972 Identification of Small Molecule Synthetic Inhibitors of DNA Polymerase Beta by NMR Chemical Shift Mapping The Journal of Biological Chemistry. Sep, 2004 | Pubmed ID: 15258144 Dynamic Characterization of a DNA Repair Enzyme: NMR Studies of [methyl-13C]methionine-labeled DNA Polymerase Beta Biochemistry. Jul, 2004 | Pubmed ID: 15248749 Critical Role of Magnesium Ions in DNA Polymerase Beta's Closing and Active Site Assembly Journal of the American Chemical Society. Jul, 2004 | Pubmed ID: 15238001 The Environmental Genome Project: Phase I and Beyond Molecular Interventions. Jun, 2004 | Pubmed ID: 15210868 Increased Postischemic Brain Injury in Mice Deficient in Uracil-DNA Glycosylase The Journal of Clinical Investigation. Jun, 2004 | Pubmed ID: 15199406 Highly Organized but Pliant Active Site of DNA Polymerase Beta: Compensatory Mechanisms in Mutant Enzymes Revealed by Dynamics Simulations and Energy Analyses Biophysical Journal. Jun, 2004 | Pubmed ID: 15189842 Influence of DNA Structure on DNA Polymerase Beta Active Site Function: Extension of Mutagenic DNA Intermediates The Journal of Biological Chemistry. Jul, 2004 | Pubmed ID: 15145936 AP Endonuclease and Poly(ADP-ribose) Polymerase-1 Interact with the Same Base Excision Repair Intermediate DNA Repair. Jun, 2004 | Pubmed ID: 15135726 Shaping Science Policy in the Age of Genomics Nature Reviews. Genetics. Apr, 2004 | Pubmed ID: 15134075 Recombinogenic Phenotype of Human Activation-induced Cytosine Deaminase Journal of Immunology (Baltimore, Md. : 1950). Apr, 2004 | Pubmed ID: 15034045 High-level Expression and Purification of Untagged and Histidine-tagged HIV-1 Reverse Transcriptase Protein Expression and Purification. Mar, 2004 | Pubmed ID: 14766302 Base Excision Repair Deficiency Caused by Polymerase Beta Haploinsufficiency: Accelerated DNA Damage and Increased Mutational Response to Carcinogens Cancer Research. Sep, 2003 | Pubmed ID: 14522902 Cloning and Characterization of a Novel Member of the Human ATF/CREB Family: ATF2 Deletion, a Potential Regulator of the Human DNA Polymerase Beta Promoter Gene. Jul, 2003 | Pubmed ID: 12909347 Base Excision Repair Intermediates Induce P53-independent Cytotoxic and Genotoxic Responses The Journal of Biological Chemistry. Oct, 2003 | Pubmed ID: 12882965 Suppressed Catalytic Activity of Base Excision Repair Enzymes on Rotationally Positioned Uracil in Nucleosomes Proceedings of the National Academy of Sciences of the United States of America. Jun, 2003 | Pubmed ID: 12799467 Localization of the Deoxyribose Phosphate Lyase Active Site in Human DNA Polymerase Iota by Controlled Proteolysis The Journal of Biological Chemistry. Aug, 2003 | Pubmed ID: 12777390 Structural Insights into the Origins of DNA Polymerase Fidelity Structure (London, England : 1993). May, 2003 | Pubmed ID: 12737815 The Base Substitution Fidelity of DNA Polymerase Beta-dependent Single Nucleotide Base Excision Repair The Journal of Biological Chemistry. Jul, 2003 | Pubmed ID: 12734201 Report on the First US-Japan DNA Repair Meeting. Sendai, Japan, October 27-31, 2002 DNA Repair. May, 2003 | Pubmed ID: 12713820 Regulated Over-expression of DNA Polymerase Beta Mediates Early Onset Cataract in Mice DNA Repair. May, 2003 | Pubmed ID: 12713817 DNA Polymerase Beta Gene Expression: the Promoter Activator CREB-1 is Upregulated in Chinese Hamster Ovary Cells by DNA Alkylating Agent-induced Stress Biological Chemistry. Jan, 2003 | Pubmed ID: 12674496 The Werner Syndrome Protein Stimulates DNA Polymerase Beta Strand Displacement Synthesis Via Its Helicase Activity The Journal of Biological Chemistry. Jun, 2003 | Pubmed ID: 12665521 Structure of DNA Polymerase Beta with the Mutagenic DNA Lesion 8-oxodeoxyguanine Reveals Structural Insights into Its Coding Potential Structure (London, England : 1993). Jan, 2003 | Pubmed ID: 12517346 Hypersensitivity of DNA Polymerase Beta Null Mouse Fibroblasts Reflects Accumulation of Cytotoxic Repair Intermediates from Site-specific Alkyl DNA Lesions DNA Repair. Jan, 2003 | Pubmed ID: 12509266 Rapid Segmental and Subdomain Motions of DNA Polymerase Beta The Journal of Biological Chemistry. Feb, 2003 | Pubmed ID: 12458221 Involvement of DNA Polymerase Beta in Protection Against the Cytotoxicity of Oxidative DNA Damage DNA Repair. Apr, 2002 | Pubmed ID: 12509250 Mapping of the Interaction Interface of DNA Polymerase Beta with XRCC1 Structure (London, England : 1993). Dec, 2002 | Pubmed ID: 12467578 Efficiency of Correct Nucleotide Insertion Governs DNA Polymerase Fidelity The Journal of Biological Chemistry. Dec, 2002 | Pubmed ID: 12370169 Binary System for Selective Photoaffinity Labeling of Base Excision Repair DNA Polymerases Nucleic Acids Research. Jul, 2002 | Pubmed ID: 12136121 Direct Interaction Between Mammalian DNA Polymerase Beta and Proliferating Cell Nuclear Antigen The Journal of Biological Chemistry. Aug, 2002 | Pubmed ID: 12063248 Mutations Associated with Base Excision Repair Deficiency and Methylation-induced Genotoxic Stress Proceedings of the National Academy of Sciences of the United States of America. May, 2002 | Pubmed ID: 11983862 Polymerase Beta Simulations Suggest That Arg258 Rotation is a Slow Step Rather Than Large Subdomain Motions Per Se Journal of Molecular Biology. Apr, 2002 | Pubmed ID: 11955015 1H, 13C and 15N Resonance Assignments for the Perdeuterated 22 KD Palm-thumb Domain of DNA Polymerase Beta Journal of Biomolecular NMR. Feb, 2002 | Pubmed ID: 11883786 DNA Polymerase Beta The International Journal of Biochemistry & Cell Biology. Apr, 2002 | Pubmed ID: 11854030 Loss of DNA Polymerase Beta Stacking Interactions with Templating Purines, but Not Pyrimidines, Alters Catalytic Efficiency and Fidelity The Journal of Biological Chemistry. Mar, 2002 | Pubmed ID: 11756435 The Domain Organization and Properties of Individual Domains of DNA Topoisomerase V, a Type 1B Topoisomerase with DNA Repair Activities The Journal of Biological Chemistry. Feb, 2002 | Pubmed ID: 11733530 क्रायो-इलेक्ट्रॉन माइक्रोस्कोपी संरचनात्मक निर्धारण के लिए डीएनए मरम्मत कारकों के साथ जटिल न्यूक्लियोसोम कोर कणों की तैयारी Yesenia Rodriguez1, Kevin John Butay*1, Kedar Sharma*1, Elizabeth Viverette*1, Samuel H. Wilson1 1Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health JoVE 64061 Biochemistry डीएनए Glycosylase गतिविधि के लिए स्थिर राज्य, पूर्व स्थिर राज्य, और एकल कारोबार काइनेटिक मापन Akira Sassa1, William A. Beard1, David D. Shock1, Samuel H. Wilson1 1Laboratory of Structural Biology, NIEHS, National Institutes of Health JoVE 50695 Chemistry
क्रायो-इलेक्ट्रॉन माइक्रोस्कोपी संरचनात्मक निर्धारण के लिए डीएनए मरम्मत कारकों के साथ जटिल न्यूक्लियोसोम कोर कणों की तैयारी Yesenia Rodriguez1, Kevin John Butay*1, Kedar Sharma*1, Elizabeth Viverette*1, Samuel H. Wilson1 1Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health JoVE 64061 Biochemistry
डीएनए Glycosylase गतिविधि के लिए स्थिर राज्य, पूर्व स्थिर राज्य, और एकल कारोबार काइनेटिक मापन Akira Sassa1, William A. Beard1, David D. Shock1, Samuel H. Wilson1 1Laboratory of Structural Biology, NIEHS, National Institutes of Health JoVE 50695 Chemistry
