Samuel Weiss Hotchkiss Brain Institute, Department of Cell Biology and Anatomy, Cumming School of Medicine University of Calgary Biography Publications Institution JoVE Articles Samuel Weiss has not added a biography. If you are Samuel Weiss and would like to personalize this page please email our Author Liaison for assistance. Publications The JAK2/STAT3 Inhibitor Pacritinib Effectively Inhibits Patient-derived GBM Brain Tumor Initiating Cells in Vitro and when Used in Combination with Temozolomide Increases Survival in an Orthotopic Xenograft Model PloS One. 2017 | Pubmed ID: 29253028 Clonal Expansion and Epigenetic Reprogramming Following Deletion or Amplification of Mutant Proceedings of the National Academy of Sciences of the United States of America. 10, 2017 | Pubmed ID: 28916733 Control of Glioblastoma Tumorigenesis by Feed-forward Cytokine Signaling Nature Neuroscience. Jun, 2016 | Pubmed ID: 27110918 Disulfiram when Combined with Copper Enhances the Therapeutic Effects of Temozolomide for the Treatment of Glioblastoma Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Aug, 2016 | Pubmed ID: 27006494 Brain Tumour Cells Interconnect to a Functional and Resistant Network Nature. Dec, 2015 | Pubmed ID: 26536111 Precursor States of Brain Tumor Initiating Cell Lines Are Predictive of Survival in Xenografts and Associated with Glioblastoma Subtypes Stem Cell Reports. Jul, 2015 | Pubmed ID: 26095605 IDH1 Mutation Induces Reprogramming of Pyruvate Metabolism Cancer Research. Aug, 2015 | Pubmed ID: 26045167 Prolactin in Combination with Interferon-β Reduces Disease Severity in an Animal Model of Multiple Sclerosis Journal of Neuroinflammation. Mar, 2015 | Pubmed ID: 25889599 Dual MTORC1/2 Blockade Inhibits Glioblastoma Brain Tumor Initiating Cells in Vitro and in Vivo and Synergizes with Temozolomide to Increase Orthotopic Xenograft Survival Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Nov, 2014 | Pubmed ID: 25316808 Novel MSH6 Mutations in Treatment-naïve Glioblastoma and Anaplastic Oligodendroglioma Contribute to Temozolomide Resistance Independently of MGMT Promoter Methylation Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Sep, 2014 | Pubmed ID: 25078279 Therapeutic Activation of Macrophages and Microglia to Suppress Brain Tumor-initiating Cells Nature Neuroscience. Jan, 2014 | Pubmed ID: 24316889 Therapeutic Activation of Macrophages and Microglia to Suppress Brain Tumor-initiating Cells Annals of Neurosciences. Oct, 2013 | Pubmed ID: 25206040 Potent Targeting of the STAT3 Protein in Brain Cancer Stem Cells: A Promising Route for Treating Glioblastoma ACS Medicinal Chemistry Letters. Nov, 2013 | Pubmed ID: 24900612 Transcription Factors FOXG1 and Groucho/TLE Promote Glioblastoma Growth Nature Communications. 2013 | Pubmed ID: 24356439 Culturing Fetal Precursor Cells Using Free Floating Serum-free Conditions Methods in Molecular Biology (Clifton, N.J.). 2013 | Pubmed ID: 23934829 Spontaneous Loss of Heterozygosity Leading to Homozygous R132H in a Patient-derived IDH1 Mutant Cell Line Neuro-oncology. Aug, 2013 | Pubmed ID: 23757293 Bi-parental Care Contributes to Sexually Dimorphic Neural Cell Genesis in the Adult Mammalian Brain PloS One. 2013 | Pubmed ID: 23650527 Treating Brain Tumor-initiating Cells Using a Combination of Myxoma Virus and Rapamycin Neuro-oncology. Jul, 2013 | Pubmed ID: 23585629 On-target JAK2/STAT3 Inhibition Slows Disease Progression in Orthotopic Xenografts of Human Glioblastoma Brain Tumor Stem Cells Neuro-oncology. Feb, 2013 | Pubmed ID: 23262510 Prolactin in Multiple Sclerosis Multiple Sclerosis (Houndmills, Basingstoke, England). Jan, 2013 | Pubmed ID: 22933621 DNA Hypermethylation and 1p Loss Silence NHE-1 in Oligodendroglioma Annals of Neurology. Jun, 2012 | Pubmed ID: 22718548 Adult Periventricular Neural Stem Cells: Outstanding Progress and Outstanding Issues Developmental Neurobiology. Jul, 2012 | Pubmed ID: 22539410 Transformation by the (R)-enantiomer of 2-hydroxyglutarate Linked to EGLN Activation Nature. Mar, 2012 | Pubmed ID: 22343896 An in Vivo Patient-derived Model of Endogenous IDH1-mutant Glioma Neuro-oncology. Feb, 2012 | Pubmed ID: 22166263 Gleichzeitige CIC-Mutationen, IDH-Mutationen Und 1 P/19q, Nicht Distale Verlust Unterscheiden Oligodendrogliome Von Anderen Krebsarten The Journal of Pathology. Jan, 2012 | Pubmed ID: 22072542 PDGFRα Expression Distinguishes GFAP-expressing Neural Stem Cells from PDGF-responsive Neural Precursors in the Adult Periventricular Area The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jun, 2011 | Pubmed ID: 21715615 Paternal Recognition of Adult Offspring Mediated by Newly Generated CNS Neurons Nature Neuroscience. Jun, 2010 | Pubmed ID: 20453850 Sensitivity to Temozolomide in Brain Tumor Initiating Cells Neuro-oncology. Jul, 2010 | Pubmed ID: 20388697 Oligodendroglioma Cell Lines Containing T(1;19)(q10;p10) Neuro-oncology. Jul, 2010 | Pubmed ID: 20388696 Pigment Epithelium-derived Growth Factor: Modulating Adult Neural Stem Cell Self-renewal Nature Neuroscience. Dec, 2009 | Pubmed ID: 19935725 Promoting Oligodendrogenesis and Myelin Repair Using the Multiple Sclerosis Medication Glatiramer Acetate Proceedings of the National Academy of Sciences of the United States of America. Oct, 2009 | Pubmed ID: 19815532 Proliferation of Human Glioblastoma Stem Cells Occurs Independently of Exogenous Mitogens Stem Cells (Dayton, Ohio). Aug, 2009 | Pubmed ID: 19544433 Identity Crisis for Adult Periventricular Neural Stem Cells: Subventricular Zone Astrocytes, Ependymal Cells or Both? Nature Reviews. Neuroscience. Feb, 2009 | Pubmed ID: 19153578 Gamma-secretase Represents a Therapeutic Target for the Treatment of Invasive Glioma Mediated by the P75 Neurotrophin Receptor PLoS Biology. Nov, 2008 | Pubmed ID: 19067488 Distinctions Between Fetal and Adult Human Platelet-derived Growth Factor-responsive Neural Precursors Annals of Neurology. Aug, 2008 | Pubmed ID: 18756507 Production of Neurons, Astrocytes and Oligodendrocytes from Mammalian CNS Stem Cells Nature Protocols. 2008 | Pubmed ID: 18536641 Männliche Pheromon-stimuliert Neurogenese Im Erwachsenen Weiblichen Gehirn: Mögliche Rolle Bei Der Paarung Verhalten Nature Neuroscience. Aug, 2007 | Pubmed ID: 17603480 STAT5A/B-Aktivität Ist in Der Entwicklung Von Stirnhirn Und Rückenmark Erforderlich Molecular and Cellular Neurosciences. Jun, 2007 | Pubmed ID: 17462911 Weißen Substanz Plastizität Und Verbesserte Remyelination Im Mütterlichen ZNS The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Feb, 2007 | Pubmed ID: 17314279 Hypophyse Adenylate Cyclase-Aktivierung Polypeptid Regelt Stirnhirn Neurale Stammzellen Und Neurogenese in Vitro Und in Vivo Journal of Neuroscience Research. Nov, 2006 | Pubmed ID: 16941483 CNTF/LIF/gp130 Rezeptor-Komplex Pflegt Eine Signalisierung VZ Vorläufer Differenzierung Gradient Im Sich Entwickelnden Ventralen Vorderhirn Development (Cambridge, England). Feb, 2005 | Pubmed ID: 15634701 Isolation of a Novel Platelet-derived Growth Factor-responsive Precursor from the Embryonic Ventral Forebrain The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Dec, 2004 | Pubmed ID: 15574739 Alterung Führt Zu Einer Verringerten Epidermalen Wachstumsfaktor-Rezeptor-Signalisierung, Verminderter Geruchssinn Neurogenese, Und Defizite in Der Feinen Geruchssinn Diskriminierung The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Sep, 2004 | Pubmed ID: 15385618 Generation Funktioneller Radialen Gliazellen Von Embryonalen Und Adulten Neuralen Stammzellen Vorderhirn The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Dec, 2003 | Pubmed ID: 14684861 Glykoprotein 130 Signalweg Reguliert Notch1 Expression Und Aktivierung in Der Selbsterneuerung Von Säugetieren Vorderhirn Neuralen Stammzellen The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Mar, 2003 | Pubmed ID: 12629177 Neurogenese Im Erwachsenen Weiblichen Vorderhirn Durch Prolaktin Vermittelte Schwangerschaft-stimulierte Science (New York, N.Y.). Jan, 2003 | Pubmed ID: 12511652 Radialen Gliazellen Als Neuronale Vorläufer: Die Nächste Generation? Journal of Neuroscience Research. Sep, 2002 | Pubmed ID: 12205663 Live Cell Imaging-Assays Studie Glioblastom Gehirn Tumor Stammzellen Migration und Invasion Ian Restall1, Danielle Anne Bozek1, Charles Chesnelong1,2, Samuel Weiss1, H. Artee Luchman1 1Hotchkiss Brain Institute, Department of Cell Biology and Anatomy, Cumming School of Medicine, University of Calgary, 2Department of Developmental and Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children JoVE 58152 Cancer Research
Live Cell Imaging-Assays Studie Glioblastom Gehirn Tumor Stammzellen Migration und Invasion Ian Restall1, Danielle Anne Bozek1, Charles Chesnelong1,2, Samuel Weiss1, H. Artee Luchman1 1Hotchkiss Brain Institute, Department of Cell Biology and Anatomy, Cumming School of Medicine, University of Calgary, 2Department of Developmental and Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children JoVE 58152 Cancer Research
