Sean Chia Centre for Misfolding Diseases, Department of Chemistry University of Cambridge Biography Publications Institution JoVE Articles Sean Chia has not added a biography. If you are Sean Chia and would like to personalize this page please email our Author Liaison for assistance. Publications Trodusquemine Enhances Aβ Aggregation but Suppresses Its Toxicity by Displacing Oligomers from Cell Membranes Nature Communications. 01, 2019 | Pubmed ID: 30644384 Chemical and Mechanistic Analysis of Photodynamic Inhibition of Alzheimer's β-amyloid Aggregation Chemical Communications (Cambridge, England). Jan, 2019 | Pubmed ID: 30632567 SAR by Kinetics for Drug Discovery in Protein Misfolding Diseases Proceedings of the National Academy of Sciences of the United States of America. 10, 2018 | Pubmed ID: 30257937 Microfluidic Deposition for Resolving Single-molecule Protein Architecture and Heterogeneity Nature Communications. Sep, 2018 | Pubmed ID: 30250131 Stabilization and Characterization of Cytotoxic Aβ Oligomers Isolated from an Aggregation Reaction in the Presence of Zinc Ions ACS Chemical Neuroscience. Aug, 2018 | Pubmed ID: 29986583 Cholesterol Catalyses Aβ42 Aggregation Through a Heterogeneous Nucleation Pathway in the Presence of Lipid Membranes Nature Chemistry. Jun, 2018 | Pubmed ID: 29736006 Chemical Kinetics for Bridging Molecular Mechanisms and Macroscopic Measurements of Amyloid Fibril Formation Annual Review of Physical Chemistry. 04, 2018 | Pubmed ID: 29490200 Monomeric and Fibrillar α-synuclein Exert Opposite Effects on the Catalytic Cycle That Promotes the Proliferation of Aβ42 Aggregates Proceedings of the National Academy of Sciences of the United States of America. 07, 2017 | Pubmed ID: 28698377 Systematic Development of Small Molecules to Inhibit Specific Microscopic Steps of Aβ42 Aggregation in Alzheimer's Disease Proceedings of the National Academy of Sciences of the United States of America. 01, 2017 | Pubmed ID: 28011763 An Anticancer Drug Suppresses the Primary Nucleation Reaction That Initiates the Production of the Toxic Aβ42 Aggregates Linked with Alzheimer's Disease Science Advances. Feb, 2016 | Pubmed ID: 26933687 A Fragment-Based Method of Creating Small-Molecule Libraries to Target the Aggregation of Intrinsically Disordered Proteins ACS Combinatorial Science. Mar, 2016 | Pubmed ID: 26923286 Characterizing Individual Protein Aggregates by Infrared Nanospectroscopy and Atomic Force Microscopy Francesco Simone Ruggeri1, Tomas Šneideris1,2, Sean Chia1, Michele Vendruscolo1, Tuomas P. J. Knowles1,3 1Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, 2Institute of Biotechnology, Life Sciences Center, Vilnius University, 3Cavendish Laboratory, Department of Physics, University of Cambridge JoVE 60108 Biochemistry
Characterizing Individual Protein Aggregates by Infrared Nanospectroscopy and Atomic Force Microscopy Francesco Simone Ruggeri1, Tomas Šneideris1,2, Sean Chia1, Michele Vendruscolo1, Tuomas P. J. Knowles1,3 1Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, 2Institute of Biotechnology, Life Sciences Center, Vilnius University, 3Cavendish Laboratory, Department of Physics, University of Cambridge JoVE 60108 Biochemistry
