Seppo Parkkila

Publications

• Phytochemicals As Modulators of Long Non-Coding RNAs and Inhibitors of Cancer-Related Carbonic Anhydrases
  International Journal of Molecular Sciences. Jun, 2019  |   Pubmed ID: 31208095
• Catalytically Inactive Carbonic Anhydrase-related Proteins Enhance Transport of Lactate by MCT1
  FEBS Open Bio. Jul, 2019  |   Pubmed ID: 31033227
• Discovery of New Organoselenium Compounds As Antileishmanial Agents
  Bioorganic Chemistry. May, 2019  |   Pubmed ID: 30743174
• Activation Studies of the β-Carbonic Anhydrase from the Pathogenic Protozoan with Amino Acids and Amines
  Metabolites. Feb, 2019  |   Pubmed ID: 30717275
• R-Ras Regulates Vascular Permeability, but Not Overall Healing in Skin Wounds
  Experimental Dermatology. Feb, 2019  |   Pubmed ID: 30489650
• Sulfonamide Inhibition Studies of a New β-Carbonic Anhydrase from the Pathogenic Protozoan
  International Journal of Molecular Sciences. Dec, 2018  |   Pubmed ID: 30544802
• Cloning, Characterization and Anion Inhibition Studies of a β-Carbonic Anhydrase from the Pathogenic Protozoan
  Molecules (Basel, Switzerland). Nov, 2018  |   Pubmed ID: 30486513
• Carbonic Anhydrase Inhibitors As Novel Drugs Against Mycobacterial β-Carbonic Anhydrases: An Update on and Studies
  Molecules (Basel, Switzerland). Nov, 2018  |   Pubmed ID: 30413024
• Toll-like Receptors 2, 4 and 9 and Hypoxia Markers HIF-1alpha and CAIX in Pancreatic Intraepithelial Neoplasia
  APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. Nov, 2018  |   Pubmed ID: 30357962
• Carbonic Anhydrases II, IX, and XII in Barrett's Esophagus and Adenocarcinoma
  Virchows Archiv : an International Journal of Pathology. Nov, 2018  |   Pubmed ID: 30066203
• Activation Studies with Amines and Amino Acids of the α-carbonic Anhydrase from the Pathogenic Protozoan Trypanosoma Cruzi
  Bioorganic & Medicinal Chemistry. 08, 2018  |   Pubmed ID: 30007565
• Weak HIF-1alpha Expression Indicates Poor Prognosis in Resectable Pancreatic Ductal Adenocarcinoma
  World Journal of Surgical Oncology. Jul, 2018  |   Pubmed ID: 29973215
• Nitroimidazole-based Inhibitors DTP338 and DTP348 Are Safe for Zebrafish Embryos and Efficiently Inhibit the Activity of Human CA IX in Xenopus Oocytes
  Journal of Enzyme Inhibition and Medicinal Chemistry. Dec, 2018  |   Pubmed ID: 29909747
• Involvement of β-Carbonic Anhydrase Genes in Bacterial Genomic Islands and Their Horizontal Transfer to Protists
  Applied and Environmental Microbiology. 08, 2018  |   Pubmed ID: 29802189
• Carbonic Anhydrase Related Protein Expression in Astrocytomas and Oligodendroglial Tumors
  BMC Cancer. May, 2018  |   Pubmed ID: 29792187
• Activation Studies with Amines and Amino Acids of the β-carbonic Anhydrase from the Pathogenic Protozoan Leishmania Donovani Chagasi
  Bioorganic Chemistry. 08, 2018  |   Pubmed ID: 29689418
• An Update on the Metabolic Roles of Carbonic Anhydrases in the Model Alga Chlamydomonas Reinhardtii
  Metabolites. Mar, 2018  |   Pubmed ID: 29534024
• Surveillance and Diagnosis of Zoonotic Foodborne Parasites
  Food Science & Nutrition. 01, 2018  |   Pubmed ID: 29387356
• Identification and Characterization of a Novel Zebrafish (Danio Rerio) Pentraxin-carbonic Anhydrase
  PeerJ. 2017  |   Pubmed ID: 29230365
• β-CA-specific Inhibitor Dithiocarbamate Fc14-584B: a Novel Antimycobacterial Agent with Potential to Treat Drug-resistant Tuberculosis
  Journal of Enzyme Inhibition and Medicinal Chemistry. Dec, 2017  |   Pubmed ID: 28629306
• Role of Carbonic Anhydrases in Skin Wound Healing
  Experimental & Molecular Medicine. 05, 2017  |   Pubmed ID: 28524177
• Carbonic Anhydrase II: a Novel Biomarker for Pseudomyxoma Peritonei
  APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. Mar, 2017  |   Pubmed ID: 28233447
• Anti-carbonic Anhydrase Autoantibodies and Serum Beta-2 Microglobulin Correlate with the ClinESSDAI Score in Patients with Sjögren's Syndrome
  Clinical and Experimental Rheumatology. Mar-Apr, 2017  |   Pubmed ID: 28079504
• Fluorinated Benzenesulfonamide Anticancer Inhibitors of Carbonic Anhydrase IX Exhibit Lower Toxic Effects on Zebrafish Embryonic Development Than Ethoxzolamide
  Drug and Chemical Toxicology. Jul, 2017  |   Pubmed ID: 27600313
• Carbonic Anhydrase Enzymes II, VII, IX and XII in Colorectal Carcinomas
  World Journal of Gastroenterology. Sep, 2016  |   Pubmed ID: 27688658
• Identification and Inhibition of Carbonic Anhydrases from Nematodes
  Journal of Enzyme Inhibition and Medicinal Chemistry. 2016  |   Pubmed ID: 27557594
• Altered Gene Expression in the Lower Respiratory Tract of Car6 (-/-) Mice
  Transgenic Research. 10, 2016  |   Pubmed ID: 27209317
• Carbonic Anhydrase IX Deposits Are Associated with Increased Ascending Aortic Dilatation
  Scandinavian Cardiovascular Journal : SCJ. Jun, 2016  |   Pubmed ID: 27157093
• Horizontal Transfer of β-carbonic Anhydrase Genes from Prokaryotes to Protozoans, Insects, and Nematodes
  Parasites & Vectors. Mar, 2016  |   Pubmed ID: 26983858
• Innovative Molecular Diagnosis of Trichinella Species Based on β-carbonic Anhydrase Genomic Sequence
  Microbial Biotechnology. Mar, 2016  |   Pubmed ID: 26639312
• Discovery of 1,1'-Biphenyl-4-sulfonamides As a New Class of Potent and Selective Carbonic Anhydrase XIV Inhibitors
  Journal of Medicinal Chemistry. Nov, 2015  |   Pubmed ID: 26497049
• Ascaris Lumbricoides β Carbonic Anhydrase: a Potential Target Enzyme for Treatment of Ascariasis
  Parasites & Vectors. Sep, 2015  |   Pubmed ID: 26385556
• β Carbonic Anhydrase is Required for Female Fertility in Drosophila Melanogaster
  Frontiers in Zoology. 2015  |   Pubmed ID: 26300950
• Inactivation of Ca10a and Ca10b Genes Leads to Abnormal Embryonic Development and Alters Movement Pattern in Zebrafish
  PloS One. 2015  |   Pubmed ID: 26218428
• The β-carbonic Anhydrase from the Malaria Mosquito Anopheles Gambiae is Highly Inhibited by Sulfonamides
  Bioorganic & Medicinal Chemistry. May, 2015  |   Pubmed ID: 25882523
• Beta Carbonic Anhydrases: Novel Targets for Pesticides and Anti-parasitic Agents in Agriculture and Livestock Husbandry
  Parasites & Vectors. Aug, 2014  |   Pubmed ID: 25174433
• The Role of Carbonic Anhydrase VI in Bitter Taste Perception: Evidence from the Car6⁻/⁻ Mouse Model
  Journal of Biomedical Science. Aug, 2014  |   Pubmed ID: 25134447
• Sulfonamide Inhibition Studies of the β Carbonic Anhydrase from Drosophila Melanogaster
  Bioorganic & Medicinal Chemistry Letters. Jul, 2014  |   Pubmed ID: 24852120
• Expression Patterns and Subcellular Localization of Carbonic Anhydrases Are Developmentally Regulated During Tooth Formation
  PloS One. 2014  |   Pubmed ID: 24789143
• Hsp27 and Its Expression Pattern in Diffusely Infiltrating Astrocytomas
  Histology and Histopathology. Sep, 2014  |   Pubmed ID: 24599602
• Bioinformatic Analysis of Beta Carbonic Anhydrase Sequences from Protozoans and Metazoans
  Parasites & Vectors. Jan, 2014  |   Pubmed ID: 24447594
• Anion Inhibition Studies of the α-carbonic Anhydrase from the Protozoan Pathogen Trypanosoma Cruzi, the Causative Agent of Chagas Disease
  Bioorganic & Medicinal Chemistry. Aug, 2013  |   Pubmed ID: 23790722
• Cloning, Characterization, and Sulfonamide and Thiol Inhibition Studies of an α-carbonic Anhydrase from Trypanosoma Cruzi, the Causative Agent of Chagas Disease
  Journal of Medicinal Chemistry. Feb, 2013  |   Pubmed ID: 23391336
• Characterization, Bioinformatic Analysis and Dithiocarbamate Inhibition Studies of Two New α-carbonic Anhydrases, CAH1 and CAH2, from the Fruit Fly Drosophila Melanogaster
  Bioorganic & Medicinal Chemistry. Mar, 2013  |   Pubmed ID: 22989910
• Serendipitous Fragment-based Drug Discovery: Ketogenic Diet Metabolites and Statins Effectively Inhibit Several Carbonic Anhydrases
  Chemical Communications (Cambridge, England). Apr, 2012  |   Pubmed ID: 22382897
• Characterization of Non-specific Cytotoxic Cell Receptor Protein 1: a New Member of the Lectin-type Subfamily of F-box Proteins
  PloS One. 2011  |   Pubmed ID: 22087255
• Oral Colonization by Streptococcus Mutans and Caries Development is Reduced Upon Deletion of Carbonic Anhydrase VI Expression in Saliva
  Biochimica Et Biophysica Acta. Dec, 2011  |   Pubmed ID: 21945428
• Acetaldehyde-derived Modifications on Cytosolic Human Carbonic Anhydrases
  Journal of Enzyme Inhibition and Medicinal Chemistry. Dec, 2011  |   Pubmed ID: 21679053
• Novel Carbonic Anhydrase Autoantibodies and Renal Manifestations in Patients with Primary Sjogren's Syndrome
  Rheumatology (Oxford, England). Aug, 2011  |   Pubmed ID: 21427176
• Characterization of the First Beta-class Carbonic Anhydrase from an Arthropod (Drosophila Melanogaster) and Phylogenetic Analysis of Beta-class Carbonic Anhydrases in Invertebrates
  BMC Biochemistry. Jul, 2010  |   Pubmed ID: 20659325
• Global Transcriptional Response to Carbonic Anhydrase IX Deficiency in the Mouse Stomach
  BMC Genomics. Jun, 2010  |   Pubmed ID: 20573196
• Carbonic Anhydrases II and XII Are Up-regulated in Osteoclast-like Cells in Advanced Human Atherosclerotic Plaques-Tampere Vascular Study
  Annals of Medicine. Jul, 2010  |   Pubmed ID: 20509747
• Analysis of a Shortened Form of Human Carbonic Anhydrase VII Expressed in Vitro Compared to the Full-length Enzyme
  Biochimie. Aug, 2010  |   Pubmed ID: 20493921
• The Tumour-associated Carbonic Anhydrases CA II, CA IX and CA XII in a Group of Medulloblastomas and Supratentorial Primitive Neuroectodermal Tumours: an Association of CA IX with Poor Prognosis
  BMC Cancer. Apr, 2010  |   Pubmed ID: 20398423
• Phylogeny and Expression of Carbonic Anhydrase-related Proteins
  BMC Molecular Biology. Mar, 2010  |   Pubmed ID: 20356370
• Specific Expression Profile and Prognostic Significance of Peroxiredoxins in Grade II-IV Astrocytic Brain Tumors
  BMC Cancer. Mar, 2010  |   Pubmed ID: 20307276
• The Most Recently Discovered Carbonic Anhydrase, CA XV, is Expressed in the Thick Ascending Limb of Henle and in the Collecting Ducts of Mouse Kidney
  PloS One. Mar, 2010  |   Pubmed ID: 20224780
• Carbonic Anhydrase II. A Novel Biomarker for Gastrointestinal Stromal Tumors
  Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc. May, 2010  |   Pubmed ID: 20081808
• Crystal Structure of the Catalytic Domain of the Tumor-associated Human Carbonic Anhydrase IX
  Proceedings of the National Academy of Sciences of the United States of America. Sep, 2009  |   Pubmed ID: 19805286
• Global Transcriptional Response to Hfe Deficiency and Dietary Iron Overload in Mouse Liver and Duodenum
  PloS One. Sep, 2009  |   Pubmed ID: 19787063
• The Protein Tyrosine Kinase Inhibitors Imatinib and Nilotinib Strongly Inhibit Several Mammalian Alpha-carbonic Anhydrase Isoforms
  Bioorganic & Medicinal Chemistry Letters. Aug, 2009  |   Pubmed ID: 19527930
• Expression of Iron-related Genes in Human Brain and Brain Tumors
  BMC Neuroscience. Apr, 2009  |   Pubmed ID: 19386095
• Cloning, Expression, Post-translational Modifications and Inhibition Studies on the Latest Mammalian Carbonic Anhydrase Isoform, CA XV
  Journal of Medicinal Chemistry. Feb, 2009  |   Pubmed ID: 19193158
• Modification of Carbonic Anhydrase II with Acetaldehyde, the First Metabolite of Ethanol, Leads to Decreased Enzyme Activity
  BMC Biochemistry. Nov, 2008  |   Pubmed ID: 19036170
• Biochemical Characterization of CA IX, One of the Most Active Carbonic Anhydrase Isozymes
  The Journal of Biological Chemistry. Oct, 2008  |   Pubmed ID: 18703501
• Significance of PH Regulation and Carbonic Anhydrases in Tumour Progression and Implications for Diagnostic and Therapeutic Approaches
  BJU International. Jun, 2008  |   Pubmed ID: 18430117
• Identification of an Alternatively Spliced Isoform of Carbonic Anhydrase XII in Diffusely Infiltrating Astrocytic Gliomas
  Neuro-oncology. Apr, 2008  |   Pubmed ID: 18322268
• The Calcium-binding Protein S100P in Normal and Malignant Human Tissues
  BMC Clinical Pathology. Feb, 2008  |   Pubmed ID: 18282279
• Carbonic Anhydrase IX in Oligodendroglial Brain Tumors
  BMC Cancer. Jan, 2008  |   Pubmed ID: 18173856
• Effects of Iron Loading on Muscle: Genome-wide MRNA Expression Profiling in the Mouse
  BMC Genomics. Oct, 2007  |   Pubmed ID: 17949489
• Characterization and Inhibition of the Recently Discovered Carbonic Anhydrase Isoforms CA XIII, XIV and XV
  Current Topics in Medicinal Chemistry. 2007  |   Pubmed ID: 17504134
• Carbonic Anhydrase II in the Endothelium of Glial Tumors: a Potential Target for Therapy
  Neuro-oncology. Jul, 2007  |   Pubmed ID: 17435181
• A Systematic Quantification of Carbonic Anhydrase Transcripts in the Mouse Digestive System
  BMC Molecular Biology. Mar, 2007  |   Pubmed ID: 17362527
• Expression of Membrane-bound Carbonic Anhydrases IV, IX, and XIV in the Mouse Heart
  The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. Dec, 2006  |   Pubmed ID: 16924128
• Carbonic Anhydrase Activators: Activation of Isozyme XIII with Amino Acids and Amines
  Bioorganic & Medicinal Chemistry Letters. Aug, 2006  |   Pubmed ID: 16730978
• Expression of Carbonic Anhydrases IX and XII During Mouse Embryonic Development
  BMC Developmental Biology. May, 2006  |   Pubmed ID: 16719910
• Expression of Carbonic Anhydrase IX in Astrocytic Tumors Predicts Poor Prognosis
  Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jan, 2006  |   Pubmed ID: 16428489
• Carbonic Anhydrase Gene Expression in CA II-deficient (Car2-/-) and CA IX-deficient (Car9-/-) Mice
  The Journal of Physiology. Mar, 2006  |   Pubmed ID: 16396925
• Expression of Carbonic Anhydrases II, IV, VII, VIII and XII in Rat Brain After Kainic Acid Induced Status Epilepticus
  Neurochemistry International. Jan, 2006  |   Pubmed ID: 16271802
• Carbonic Anhydrase Isozyme-II-deficient Mice Lack the Duodenal Bicarbonate Secretory Response to Prostaglandin E2
  Proceedings of the National Academy of Sciences of the United States of America. Oct, 2005  |   Pubmed ID: 16217040
• Characterization of CA XV, a New GPI-anchored Form of Carbonic Anhydrase
  The Biochemical Journal. Nov, 2005  |   Pubmed ID: 16083424
• Expression of Von Hippel-Lindau Tumor Suppressor and Tumor-associated Carbonic Anhydrases IX and XII in Normal and Neoplastic Colorectal Mucosa
  World Journal of Gastroenterology. May, 2005  |   Pubmed ID: 15849821
• Expression of a Novel Carbonic Anhydrase, CA XIII, in Normal and Neoplastic Colorectal Mucosa
  BMC Cancer. Apr, 2005  |   Pubmed ID: 15836783
• Carbonic Anhydrases in Normal Gastrointestinal Tract and Gastrointestinal Tumours
  World Journal of Gastroenterology. Jan, 2005  |   Pubmed ID: 15633208
• Hepatic and Extrahepatic Expression of the New Iron Regulatory Protein Hemojuvelin
  Haematologica. Dec, 2004  |   Pubmed ID: 15590393
• Transmembrane Carbonic Anhydrase Isozymes IX and XII in the Female Mouse Reproductive Organs
  Reproductive Biology and Endocrinology : RB&E. Oct, 2004  |   Pubmed ID: 15488153
• Carbonic Anhydrase Inhibitors. Inhibition of Cytosolic Isozyme XIII with Aromatic and Heterocyclic Sulfonamides: a Novel Target for the Drug Design
  Bioorganic & Medicinal Chemistry Letters. Jul, 2004  |   Pubmed ID: 15203157
• Expression of Hypoxia-inducible, Membrane-bound Carbonic Anhydrase Isozyme XII in Mouse Tissues
  The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology. Mar, 2004  |   Pubmed ID: 14983512
• Carbonic Anhydrase Isozymes IX and XII in Gastric Tumors
  World Journal of Gastroenterology. Jul, 2003  |   Pubmed ID: 12854129
• The Plasma Membrane Carbonic Anhydrase in Murine Hepatocytes Identified As Isozyme XIV
  BMC Gastroenterology. May, 2002  |   Pubmed ID: 12033992