Sergii Afonin Karlsruhe Institute of Technology Biography Publications Institution JoVE Articles Sergii Afonin has not added a biography. If you are Sergii Afonin and would like to personalize this page please email our Author Liaison for assistance. Publications Structural Dissection of Epsin-1 N-Terminal Helical Peptide: The Role of Hydrophobic Residues in Modulating Membrane Curvature Chemistry (Weinheim an Der Bergstrasse, Germany). May, 2023 | Pubmed ID: 36878866 Length Matters: Functional Flip of the Short TatA Transmembrane Helix Biophysical Journal. Jun, 2023 | Pubmed ID: 36523158 Highly Fluorinated Peptide Probes with Enhanced In Vivo Stability for F-MRI Small (Weinheim an Der Bergstrasse, Germany). Oct, 2022 | Pubmed ID: 36074982 Towards in Vivo Photomediated Delivery of Anticancer Peptides: Insights from Pharmacokinetic and -dynamic Data Journal of Photochemistry and Photobiology. B, Biology. Aug, 2022 | Pubmed ID: 35660309 Probing and Manipulating the Lateral Pressure Profile in Lipid Bilayers Using Membrane-Active Peptides-A Solid-State F NMR Study International Journal of Molecular Sciences. Apr, 2022 | Pubmed ID: 35562938 Diarylethene-Based Photoswitchable Inhibitors of Serine Proteases Angewandte Chemie (International Ed. in English). Sep, 2021 | Pubmed ID: 34268844 Behavior of the Antibacterial Peptide Cyclo[RRRWFW], Explored Using a 3-Hydroxychromone-Derived Fluorescent Amino Acid Frontiers in Chemistry. 2021 | Pubmed ID: 34262894 TAT-RasGAP Kills Cells by Targeting Inner-leaflet-enriched Phospholipids Proceedings of the National Academy of Sciences of the United States of America. Dec, 2020 | Pubmed ID: 33257567 Structural and Functional Characterization of the Pore-forming Domain of Pinholin S68 Proceedings of the National Academy of Sciences of the United States of America. Nov, 2020 | Pubmed ID: 33154156 Diarylethene Moiety As an Enthalpy-entropy Switch: Photoisomerizable Stapled Peptides for Modulating P53/MDM2 Interaction Organic & Biomolecular Chemistry. Jul, 2020 | Pubmed ID: 32390036 Enhancing the Activity of Membrane Remodeling Epsin-peptide by Trimerization Bioorganic & Medicinal Chemistry Letters. Jun, 2020 | Pubmed ID: 32317210 Nanomolar Synthesis in Droplet Microarrays with UV-Triggered On-Chip Cell Screening Small (Weinheim an Der Bergstrasse, Germany). Mar, 2020 | Pubmed ID: 31985878 Light-controllable Dithienylethene-modified Cyclic Peptides: Photoswitching the in Vivo Toxicity in Zebrafish Embryos Beilstein Journal of Organic Chemistry. 2020 | Pubmed ID: 31976015 Supreme Activity of Gramicidin S Against Resistant, Persistent and Biofilm Cells of Staphylococci and Enterococci Scientific Reports. Nov, 2019 | Pubmed ID: 31784584 Inhibition of Pseudomonas Aeruginosa Biofilm Formation and Expression of Virulence Genes by Selective Epimerization in the Peptide Esculentin-1a(1-21)NH The FEBS Journal. Oct, 2019 | Pubmed ID: 31144441 Structure-Activity Relationships of Photoswitchable Diarylethene-Based β-Hairpin Peptides As Membranolytic Antimicrobial and Anticancer Agents Journal of Medicinal Chemistry. Dec, 2018 | Pubmed ID: 30452249 Efficiently Photocontrollable or Not? Biological Activity of Photoisomerizable Diarylethenes Chemistry (Weinheim an Der Bergstrasse, Germany). Aug, 2018 | Pubmed ID: 29633378 Orthogonal F-Labeling for Solid-State NMR Spectroscopy Reveals the Conformation and Orientation of Short Peptaibols in Membranes Chemistry (Weinheim an Der Bergstrasse, Germany). Mar, 2018 | Pubmed ID: 29323432 Flexibility Vs Rigidity of Amphipathic Peptide Conjugates when Interacting with Lipid Bilayers Biochimica Et Biophysica Acta. Biomembranes. Dec, 2017 | Pubmed ID: 28958778 Lactam-Stapled Cell-Penetrating Peptides: Cell Uptake and Membrane Binding Properties Journal of Medicinal Chemistry. Oct, 2017 | Pubmed ID: 28921993 Structural Behavior of the Peptaibol Harzianin HK VI in a DMPC Bilayer: Insights from MD Simulations Biophysical Journal. Jun, 2017 | Pubmed ID: 28636916 Conformational Plasticity of the Cell-Penetrating Peptide SAP As Revealed by Solid-State F-NMR and Circular Dichroism Spectroscopies The Journal of Physical Chemistry. B. Jul, 2017 | Pubmed ID: 28608690 Loosening of Lipid Packing Promotes Oligoarginine Entry into Cells Angewandte Chemie (International Ed. in English). Jun, 2017 | Pubmed ID: 28597524 Diphytanoyl Lipids As Model Systems for Studying Membrane-active Peptides Biochimica Et Biophysica Acta. Biomembranes. Oct, 2017 | Pubmed ID: 28587828 Antimicrobial Peptide Gramicidin S is Accumulated in Granules of Producer Cells for Storage of Bacterial Phosphagens Scientific Reports. Mar, 2017 | Pubmed ID: 28295017 Orientation and Location of the Cyclotide Kalata B1 in Lipid Bilayers Revealed by Solid-State NMR Biophysical Journal. Feb, 2017 | Pubmed ID: 28256223 Coding and Decoding Libraries of Sequence-defined Functional Copolymers Synthesized Via Photoligation Nature Communications. Nov, 2016 | Pubmed ID: 27901024 Delivering Structural Information on the Polar Face of Membrane-Active Peptides: F-NMR Labels with a Cationic Side Chain Angewandte Chemie (International Ed. in English). Nov, 2016 | Pubmed ID: 27761988 Design, Synthesis, and Application of an Optimized Monofluorinated Aliphatic Label for Peptide Studies by Solid-State F NMR Spectroscopy Angewandte Chemie (International Ed. in English). Nov, 2016 | Pubmed ID: 27706889 Therapeutic Potential of Gramicidin S in the Treatment of Root Canal Infections Pharmaceuticals (Basel, Switzerland). Sep, 2016 | Pubmed ID: 27618065 Membrane Thinning and Thickening Induced by Membrane-Active Amphipathic Peptides Frontiers in Cell and Developmental Biology. 2016 | Pubmed ID: 27595096 Does a Methionine-to-norleucine Substitution in PGLa Influence Peptide-membrane Interactions? Biochimica Et Biophysica Acta. Sep, 2016 | Pubmed ID: 27267703 Direct Photocontrol of Peptidomimetics: An Alternative to Oxygen-Dependent Photodynamic Cancer Therapy Angewandte Chemie (International Ed. in English). Apr, 2016 | Pubmed ID: 27028784 Fermentation and Cost-Effective 13C/15N Labeling of the Nonribosomal Peptide Gramicidin S for Nuclear Magnetic Resonance Structure Analysis Applied and Environmental Microbiology. Jun, 2015 | Pubmed ID: 25795666 γ-(S)-Trifluoromethyl Proline: Evaluation As a Structural Substitute of Proline for Solid State (19)F-NMR Peptide Studies Organic & Biomolecular Chemistry. Mar, 2015 | Pubmed ID: 25703116 Action of the Multifunctional Peptide BP100 on Native Biomembranes Examined by Solid-state NMR Journal of Biomolecular NMR. Apr, 2015 | Pubmed ID: 25616492 Control and Role of PH in Peptide-lipid Interactions in Oriented Membrane Samples Biochimica Et Biophysica Acta. Mar, 2015 | Pubmed ID: 25511586 Structure Analysis and Conformational Transitions of the Cell Penetrating Peptide Transportan 10 in the Membrane-bound State PloS One. 2014 | Pubmed ID: 24937132 (19)F NMR Screening of Unrelated Antimicrobial Peptides Shows That Membrane Interactions Are Largely Governed by Lipids Biochimica Et Biophysica Acta. Sep, 2014 | Pubmed ID: 24699372 Controlling Biological Activity with Light: Diarylethene-containing Cyclic Peptidomimetics Angewandte Chemie (International Ed. in English). Mar, 2014 | Pubmed ID: 24554486 Stereochemical Effects on the Aggregation and Biological Properties of the Fibril-forming Peptide [KIGAKI]3 in Membranes Physical Chemistry Chemical Physics : PCCP. Jun, 2013 | Pubmed ID: 23652359 Incorporation of Cis- and Trans-4,5-difluoromethanoprolines into Polypeptides Organic Letters. Oct, 2012 | Pubmed ID: 23020292 Structure Analysis of the Membrane-bound PhoD Signal Peptide of the Tat Translocase Shows an N-terminal Amphiphilic Helix Biochimica Et Biophysica Acta. Dec, 2012 | Pubmed ID: 22960285 Antimicrobial Peptides Can Enhance the Risk of Persistent Infections Frontiers in Immunology. 2012 | Pubmed ID: 22870073 Hydrophobic Matching Controls the Tilt and Stability of the Dimeric Platelet-derived Growth Factor Receptor (PDGFR) β Transmembrane Segment The Journal of Biological Chemistry. Jul, 2012 | Pubmed ID: 22619173 Alignment of Druglike Compounds in Lipid Bilayers Analyzed by Solid-state (19)F-NMR and Molecular Dynamics, Based on Dipolar Couplings of Adjacent CF3 Groups The Journal of Physical Chemistry. B. Apr, 2012 | Pubmed ID: 22439912 Solid-state (19)F-NMR of Peptides in Native Membranes Topics in Current Chemistry. 2012 | Pubmed ID: 21598096 Special Issue on Membrane-active Peptides European Biophysics Journal : EBJ. Apr, 2011 | Pubmed ID: 21286705 Structural Role of the Conserved Cysteines in the Dimerization of the Viral Transmembrane Oncoprotein E5 Biophysical Journal. Sep, 2010 | Pubmed ID: 20858420 19F NMR Analysis of the Antimicrobial Peptide PGLa Bound to Native Cell Membranes from Bacterial Protoplasts and Human Erythrocytes Journal of the American Chemical Society. Jul, 2010 | Pubmed ID: 20550126 Dynamic Transitions of Membrane-active Peptides Methods in Molecular Biology (Clifton, N.J.). 2010 | Pubmed ID: 20094866 Chemical Labeling Strategy with (R)- and (S)-trifluoromethylalanine for Solid State 19F NMR Analysis of Peptaibols in Membranes Journal of the American Chemical Society. Nov, 2009 | Pubmed ID: 19827760 Solid State NMR Structure Analysis of the Antimicrobial Peptide Gramicidin S in Lipid Membranes: Concentration-Dependent Re-alignment and Self-Assembly As A β-Barrel Topics in Current Chemistry. 2008 | Pubmed ID: 23605461 Using a Sterically Restrictive Amino Acid As a 19F NMR Label to Monitor and to Control Peptide Aggregation in Membranes Journal of the American Chemical Society. Dec, 2008 | Pubmed ID: 19554688 Temperature-dependent Transmembrane Insertion of the Amphiphilic Peptide PGLa in Lipid Bilayers Observed by Solid State 19F NMR Spectroscopy Journal of the American Chemical Society. Dec, 2008 | Pubmed ID: 19049452 Conformation and Membrane Orientation of Amphiphilic Helical Peptides by Oriented Circular Dichroism Biophysical Journal. Oct, 2008 | Pubmed ID: 18621832 Synthesis of Trifluoromethyl-substituted Proline Analogues As 19F NMR Labels for Peptides in the Polyproline II Conformation Angewandte Chemie (International Ed. in English). 2008 | Pubmed ID: 18576439 In-vitro - und In-vivo-Evaluierung photokontrollierter biologisch aktiver Substanzen - potenzielle Wirkstoffkandidaten für die Krebspharmakologie Kateryna Horbatok*1,2, Tetyana Makhnii*2, Viktoriia Kosach2, Volodymyr Danko1, Andrey Kovalenko1, Stanislav Fatiushchenkov1, Petro Borysko2, Iryna Pishel2, Oleg Babii3,4, Anne S. Ulrich3, Tim Schober4, Sergii Afonin3, Igor V. Komarov1,2,4 1Taras Shevchenko National University of Kyiv, 2Bienta/Enamine, 3Karlsruhe Institute of Technology, 4Lumobiotics JoVE 64902 Chemistry
In-vitro - und In-vivo-Evaluierung photokontrollierter biologisch aktiver Substanzen - potenzielle Wirkstoffkandidaten für die Krebspharmakologie Kateryna Horbatok*1,2, Tetyana Makhnii*2, Viktoriia Kosach2, Volodymyr Danko1, Andrey Kovalenko1, Stanislav Fatiushchenkov1, Petro Borysko2, Iryna Pishel2, Oleg Babii3,4, Anne S. Ulrich3, Tim Schober4, Sergii Afonin3, Igor V. Komarov1,2,4 1Taras Shevchenko National University of Kyiv, 2Bienta/Enamine, 3Karlsruhe Institute of Technology, 4Lumobiotics JoVE 64902 Chemistry
