Sharon A. Tooze

Publications

• Autophagosome Membrane Expansion is Mediated by the N-terminus and -membrane Association of Human ATG8s
  ELife. Jun, 2023  |   Pubmed ID: 37288820
• Membrane Association of the ATG8 Conjugation Machinery Emerges As a Key Regulatory Feature for Autophagosome Biogenesis
  FEBS Letters. Jun, 2023  |   Pubmed ID: 37259601
• Loss of NDR1/2 Kinases Impairs Endomembrane Trafficking and Autophagy Leading to Neurodegeneration
  Life Science Alliance. Feb, 2023  |   Pubmed ID: 36446521
• ATG9A and ATG2A Form a Heteromeric Complex Essential for Autophagosome Formation
  Molecular Cell. Nov, 2022  |   Pubmed ID: 36347259
• Unraveling Membrane Properties at the Organelle-level with LipidDyn
  Computational and Structural Biotechnology Journal. 2022  |   Pubmed ID: 35860415
• Autophagy Coordinates Chondrocyte Development and Early Joint Formation in Zebrafish
  FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Nov, 2021  |   Pubmed ID: 34708458
• Homozygous Missense Variants Cause a Congenital Disorder of Autophagy with Neurodevelopmental Impairments of Variable Clinical Severity and Disease Course
  Brain Communications. 2021  |   Pubmed ID: 34557665
• The Ingenious ULKs: Expanding the Repertoire of the ULK Complex with Phosphoproteomics
  Autophagy. Dec, 2021  |   Pubmed ID: 34520329
• Autophagy in Major Human Diseases
  The EMBO Journal. Oct, 2021  |   Pubmed ID: 34459017
• SAMM50 is a Receptor for Basal Piecemeal Mitophagy and Acts with SQSTM1/p62 in OXPHOS-induced Mitophagy
  Autophagy. Sep, 2021  |   Pubmed ID: 34275433
• ATG9A Protects the Plasma Membrane from Programmed and Incidental Permeabilization
  Nature Cell Biology. Aug, 2021  |   Pubmed ID: 34257406
• Phosphoproteomic Identification of ULK Substrates Reveals VPS15-dependent ULK/VPS34 Interplay in the Regulation of Autophagy
  The EMBO Journal. Jul, 2021  |   Pubmed ID: 34121209
• Corrigendum to Phosphorylation of the LIR Domain of SCOC Modulates ATG8 Binding Affinity and Specificity
  Journal of Molecular Biology. Jul, 2021  |   Pubmed ID: 34052024
• SAMM50 Acts with P62 in Piecemeal Basal- and OXPHOS-induced Mitophagy of SAM and MICOS Components
  The Journal of Cell Biology. Aug, 2021  |   Pubmed ID: 34037656
• ATG4: More Than a Protease?
  Trends in Cell Biology. Jul, 2021  |   Pubmed ID: 33972154
• Membrane Supply and Remodeling During Autophagosome Biogenesis
  Current Opinion in Cell Biology. Aug, 2021  |   Pubmed ID: 33930785
• Phosphorylation of the LIR Domain of SCOC Modulates ATG8 Binding Affinity and Specificity
  Journal of Molecular Biology. Jun, 2021  |   Pubmed ID: 33845085
• Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy (4th Edition)
  Autophagy. Feb, 2021  |   Pubmed ID: 33634751
• The Phosphatidylinositol 3-phosphate-binding Protein SNX4 Controls ATG9A Recycling and Autophagy
  Journal of Cell Science. Feb, 2021  |   Pubmed ID: 33468622
• Path to Autophagy Therapeutics with Beth Levine
  Nature Reviews. Molecular Cell Biology. Oct, 2020  |   Pubmed ID: 32770126
• Emerging Roles of ATG Proteins and Membrane Lipids in Autophagosome Formation
  Cell Discovery. 2020  |   Pubmed ID: 32509328
• The Golgi As an Assembly Line to the Autophagosome
  Trends in Biochemical Sciences. Jun, 2020  |   Pubmed ID: 32307224
• Twenty Years of Traffic
  Traffic (Copenhagen, Denmark). Jan, 2020  |   Pubmed ID: 31854088
• Axonal Autophagosome Maturation Defect Through Failure of ATG9A Sorting Underpins Pathology in AP-4 Deficiency Syndrome
  Autophagy. Mar, 2020  |   Pubmed ID: 31142229
• Expression of WIPI2B Counteracts Age-related Decline in Autophagosome Biogenesis in Neurons
  ELife. Jul, 2019  |   Pubmed ID: 31309927
• Autophagy, Inflammation, and Metabolism (AIM) Center in Its Second Year
  Autophagy. Oct, 2019  |   Pubmed ID: 31234750
• ATG9A Supplies PtdIns4P to the Autophagosome Initiation Site
  Autophagy. Sep, 2019  |   Pubmed ID: 31204568
• Molecular Determinants Regulating Selective Binding of Autophagy Adapters and Receptors to ATG8 Proteins
  Nature Communications. May, 2019  |   Pubmed ID: 31053714
• A Mutation in the Major Autophagy Gene, WIPI2, Associated with Global Developmental Abnormalities
  Brain : a Journal of Neurology. May, 2019  |   Pubmed ID: 30968111
• ATG9A Shapes the Forming Autophagosome Through Arfaptin 2 and Phosphatidylinositol 4-kinase IIIβ
  The Journal of Cell Biology. May, 2019  |   Pubmed ID: 30917996
• Suppression of Autophagy During Mitosis Via CUL4-RING Ubiquitin Ligases-mediated WIPI2 Polyubiquitination and Proteasomal Degradation
  Autophagy. Nov, 2019  |   Pubmed ID: 30898011
• Members of the Autophagy Class III Phosphatidylinositol 3-kinase Complex I Interact with GABARAP and GABARAPL1 Via LIR Motifs
  Autophagy. Aug, 2019  |   Pubmed ID: 30767700
• MDH1 and MPP7 Regulate Autophagy in Pancreatic Ductal Adenocarcinoma
  Cancer Research. Apr, 2019  |   Pubmed ID: 30765601
• Autophagy Pathway Mapping to Elucidate the Function of Novel Autophagy Regulators Identified by High-Throughput Screening
  Methods in Molecular Biology (Clifton, N.J.). 2019  |   Pubmed ID: 30610711
• Identification and Validation of Novel Autophagy Regulators Using an Endogenous Readout SiGENOME Screen
  Methods in Molecular Biology (Clifton, N.J.). 2019  |   Pubmed ID: 30610710
• MTOR Independent Alteration in ULK1 Ser758 Phosphorylation Following Chronic LRRK2 Kinase Inhibition
  Bioscience Reports. Apr, 2018  |   Pubmed ID: 29563162
• SNAREing an ARP Requires a LIR
  The Journal of Cell Biology. Mar, 2018  |   Pubmed ID: 29449316
• A Molecular Perspective of Mammalian Autophagosome Biogenesis
  The Journal of Biological Chemistry. Apr, 2018  |   Pubmed ID: 29371398
• Control of GABARAP-mediated Autophagy by the Golgi Complex, Centrosome and Centriolar Satellites
  Biology of the Cell. Jan, 2018  |   Pubmed ID: 28990689
• Autophagy Pathway: Cellular and Molecular Mechanisms
  Autophagy. 2018  |   Pubmed ID: 28933638
• Vps34 PI 3-kinase Inactivation Enhances Insulin Sensitivity Through Reprogramming of Mitochondrial Metabolism
  Nature Communications. Nov, 2017  |   Pubmed ID: 29180704
• Centrosome to Autophagosome Signaling: Specific GABARAP Regulation by Centriolar Satellites
  Autophagy. 2017  |   Pubmed ID: 29099272
• Membrane Dynamics and Organelle Biogenesis-lipid Pipelines and Vesicular Carriers
  BMC Biology. 10, 2017  |   Pubmed ID: 29089042
• Centriolar Satellites Control GABARAP Ubiquitination and GABARAP-Mediated Autophagy
  Current Biology : CB. Jul, 2017  |   Pubmed ID: 28712572
• Molecular Definitions of Autophagy and Related Processes
  The EMBO Journal. Jul, 2017  |   Pubmed ID: 28596378
• Editorial Overview: Celebrating the Advances in Cell Biology from China
  Traffic (Copenhagen, Denmark). Jun, 2017  |   Pubmed ID: 28513089
• Molecular Pathways Controlling Autophagy in Pancreatic Cancer
  Frontiers in Oncology. 2017  |   Pubmed ID: 28316954
• ATG4B Contains a C-terminal LIR Motif Important for Binding and Efficient Cleavage of Mammalian Orthologs of Yeast Atg8
  Autophagy. May, 2017  |   Pubmed ID: 28287329
• Quantifying Autophagic Structures in Mammalian Cells Using Confocal Microscopy
  Methods in Enzymology. 2017  |   Pubmed ID: 28253957
• A Switch from Canonical to Noncanonical Autophagy Shapes B Cell Responses
  Science (New York, N.Y.). Feb, 2017  |   Pubmed ID: 28183981
• Fundamental Mechanisms Deliver the Nobel Prize to Ohsumi
  Traffic (Copenhagen, Denmark). Feb, 2017  |   Pubmed ID: 28097732
• Molecular Mechanisms of Autophagy-Part B
  Journal of Molecular Biology. Feb, 2017  |   Pubmed ID: 28087262
• So Long Tom!
  Traffic (Copenhagen, Denmark). Jan, 2017  |   Pubmed ID: 28008716
• Autophagy Captures the Nobel Prize
  Cell. Dec, 2016  |   Pubmed ID: 27912049
• Rabs and GAPs in Starvation-induced Autophagy
  Small GTPases. Oct, 2016  |   Pubmed ID: 27669114
• An SiRNA Screen for ATG Protein Depletion Reveals the Extent of the Unconventional Functions of the Autophagy Proteome in Virus Replication
  The Journal of Cell Biology. Aug, 2016  |   Pubmed ID: 27573464
• TBC1D14 Sets the TRAPP for ATG9
  Autophagy. Jul, 2016  |   Pubmed ID: 27171758
• TBC1D14 and TRAPP - Regulating Autophagy Through ATG9
  Cell Cycle (Georgetown, Tex.). Jul, 2016  |   Pubmed ID: 27105289
• Digesting the Expanding Mechanisms of Autophagy
  Trends in Cell Biology. Aug, 2016  |   Pubmed ID: 27050762
• Clec16a is Critical for Autolysosome Function and Purkinje Cell Survival
  Scientific Reports. 2016  |   Pubmed ID: 26987296
• GABARAP Activates ULK1 and Traffics from the Centrosome Dependent on Golgi Partners WAC and GOLGA2/GM130
  Autophagy. May, 2016  |   Pubmed ID: 26986052
• Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy (3rd Edition)
  Autophagy. Jan, 2016  |   Pubmed ID: 26799652
• TBC1D14 Regulates Autophagy Via the TRAPP Complex and ATG9 Traffic
  The EMBO Journal. Feb, 2016  |   Pubmed ID: 26711178
• Activation of ULK Kinase and Autophagy by GABARAP Trafficking from the Centrosome Is Regulated by WAC and GM130
  Molecular Cell. Dec, 2015  |   Pubmed ID: 26687599