Sidney Strickland Patricia and John Rosenwald Laboratory of Neurobiology and Genetics Rockefeller University Biography Publications Institution JoVE Articles Sidney Strickland has not added a biography. If you are Sidney Strickland and would like to personalize this page please email our Author Liaison for assistance. Publications A Novel Detection Method of Cleaved Plasma High-molecular-weight Kininogen Reveals Its Correlation with Alzheimer's Pathology and Cognitive Impairment Alzheimer's & Dementia (Amsterdam, Netherlands). 2018 | Pubmed ID: 30310850 Blood-derived Plasminogen Drives Brain Inflammation and Plaque Deposition in a Mouse Model of Alzheimer's Disease Proceedings of the National Academy of Sciences of the United States of America. 10, 2018 | Pubmed ID: 30254165 Abnormal Clotting of the Intrinsic/contact Pathway in Alzheimer Disease Patients is Related to Cognitive Ability Blood Advances. May, 2018 | Pubmed ID: 29700007 Aminopyrimidine Class Aggregation Inhibitor Effectively Blocks Aβ-Fibrinogen Interaction and Aβ-Induced Contact System Activation Biochemistry. 02, 2018 | Pubmed ID: 29394041 Fibrinogen in the Nervous System: Glia Beware Neuron. Dec, 2017 | Pubmed ID: 29216454 Interactions of β-amyloid Peptide with Fibrinogen and Coagulation Factor XII May Contribute to Alzheimer's Disease Current Opinion in Hematology. Sep, 2017 | Pubmed ID: 28661939 Depletion of Coagulation Factor XII Ameliorates Brain Pathology and Cognitive Impairment in Alzheimer Disease Mice Blood. 05, 2017 | Pubmed ID: 28242605 Biochemical and Structural Analysis of the Interaction Between β-amyloid and Fibrinogen Blood. 08, 2016 | Pubmed ID: 27389717 A Possible New Role for Aβ in Vascular and Inflammatory Dysfunction in Alzheimer's Disease Thrombosis Research. May, 2016 | Pubmed ID: 27207427 Laminin Regulates PDGFRβ(+) Cell Stemness and Muscle Development Nature Communications. May, 2016 | Pubmed ID: 27138650 Hyperhomocysteinemia Exacerbates Alzheimer's Disease Pathology by Way of the β-amyloid Fibrinogen Interaction Journal of Thrombosis and Haemostasis : JTH. 07, 2016 | Pubmed ID: 27090576 The Alzheimer's Disease Peptide β-amyloid Promotes Thrombin Generation Through Activation of Coagulation Factor XII Journal of Thrombosis and Haemostasis : JTH. 05, 2016 | Pubmed ID: 26613657 Chronic Hypertension Leads to Neurodegeneration in the TgSwDI Mouse Model of Alzheimer's Disease Hypertension (Dallas, Tex. : 1979). Jul, 2015 | Pubmed ID: 25941345 Activation of the Factor XII-driven Contact System in Alzheimer's Disease Patient and Mouse Model Plasma Proceedings of the National Academy of Sciences of the United States of America. Mar, 2015 | Pubmed ID: 25775543 Fibrin Deposited in the Alzheimer's Disease Brain Promotes Neuronal Degeneration Neurobiology of Aging. Feb, 2015 | Pubmed ID: 25475538 The Cellular Origin of Laminin Determines Its Role in Blood Pressure Regulation Cellular and Molecular Life Sciences : CMLS. Mar, 2015 | Pubmed ID: 25216704 A Novel Aβ-fibrinogen Interaction Inhibitor Rescues Altered Thrombosis and Cognitive Decline in Alzheimer's Disease Mice The Journal of Experimental Medicine. Jun, 2014 | Pubmed ID: 24821909 Plasmin Deficiency Leads to Fibrin Accumulation and a Compromised Inflammatory Response in the Mouse Brain Journal of Thrombosis and Haemostasis : JTH. May, 2014 | Pubmed ID: 24612416 Astrocytic Laminin Regulates Pericyte Differentiation and Maintains Blood Brain Barrier Integrity Nature Communications. Mar, 2014 | Pubmed ID: 24583950 Ablation of Astrocytic Laminin Impairs Vascular Smooth Muscle Cell Function and Leads to Hemorrhagic Stroke The Journal of Cell Biology. Jul, 2013 | Pubmed ID: 23857767 The APOE ɛ4/ɛ4 Genotype Potentiates Vascular Fibrin(ogen) Deposition in Amyloid-laden Vessels in the Brains of Alzheimer's Disease Patients Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. Aug, 2013 | Pubmed ID: 23652625 The GluK4 Kainate Receptor Subunit Regulates Memory, Mood, and Excitotoxic Neurodegeneration Neuroscience. Apr, 2013 | Pubmed ID: 23357115 Fibrinogen and Altered Hemostasis in Alzheimer's Disease Journal of Alzheimer's Disease : JAD. 2012 | Pubmed ID: 22869464 Schwann Cell Myelination Requires Integration of Laminin Activities Journal of Cell Science. Oct, 2012 | Pubmed ID: 22767514 Aβ Delays Fibrin Clot Lysis by Altering Fibrin Structure and Attenuating Plasminogen Binding to Fibrin Blood. Apr, 2012 | Pubmed ID: 22238323 Renal Collecting System Growth and Function Depend Upon Embryonic γ1 Laminin Expression Development (Cambridge, England). Oct, 2011 | Pubmed ID: 21903675 Tissue Plasminogen Activator is Required for the Development of Fetal Alcohol Syndrome in Mice Proceedings of the National Academy of Sciences of the United States of America. Mar, 2011 | Pubmed ID: 21383198 Mesenchymal Stem Cells Facilitate Axon Sorting, Myelination, and Functional Recovery in Paralyzed Mice Deficient in Schwann Cell-derived Laminin Glia. Feb, 2011 | Pubmed ID: 21125647 Alzheimer's Disease Peptide Beta-amyloid Interacts with Fibrinogen and Induces Its Oligomerization Proceedings of the National Academy of Sciences of the United States of America. Dec, 2010 | Pubmed ID: 21098282 Involvement of Tissue Plasminogen Activator in Stress Responsivity During Acute Cocaine Withdrawal in Mice Stress (Amsterdam, Netherlands). Nov, 2010 | Pubmed ID: 20666641 Fibrinogen and Beta-amyloid Association Alters Thrombosis and Fibrinolysis: a Possible Contributing Factor to Alzheimer's Disease Neuron. Jun, 2010 | Pubmed ID: 20547128 Maximum-entropy Network Analysis Reveals a Role for Tumor Necrosis Factor in Peripheral Nerve Development and Function Proceedings of the National Academy of Sciences of the United States of America. Jul, 2009 | Pubmed ID: 19597151 Plasmin-mediated Degradation of Laminin Gamma-1 is Critical for Ethanol-induced Neurodegeneration Biological Psychiatry. Oct, 2009 | Pubmed ID: 19577227 Laminin is Required for Schwann Cell Morphogenesis Journal of Cell Science. Apr, 2009 | Pubmed ID: 19295124 Tissue Plasminogen Activator Modulates the Cellular and Behavioral Response to Cocaine Proceedings of the National Academy of Sciences of the United States of America. Feb, 2009 | Pubmed ID: 19181855 Cortical Deficiency of Laminin Gamma1 Impairs the AKT/GSK-3beta Signaling Pathway and Leads to Defects in Neurite Outgrowth and Neuronal Migration Developmental Biology. Mar, 2009 | Pubmed ID: 19118544 Disruption of Laminin in the Peripheral Nervous System Impedes Nonmyelinating Schwann Cell Development and Impairs Nociceptive Sensory Function Glia. Jun, 2009 | Pubmed ID: 19053061 Proteolytic Fragments of Laminin Promote Excitotoxic Neurodegeneration by Up-regulation of the KA1 Subunit of the Kainate Receptor The Journal of Cell Biology. Dec, 2008 | Pubmed ID: 19114596 Key Role of Tissue Plasminogen Activator in Neurovascular Coupling Proceedings of the National Academy of Sciences of the United States of America. Jan, 2008 | Pubmed ID: 18195371 Modulation of NR2B-regulated Contextual Fear in the Hippocampus by the Tissue Plasminogen Activator System Proceedings of the National Academy of Sciences of the United States of America. Aug, 2007 | Pubmed ID: 17673549 Fibrin Deposition Accelerates Neurovascular Damage and Neuroinflammation in Mouse Models of Alzheimer's Disease The Journal of Experimental Medicine. Aug, 2007 | Pubmed ID: 17664291 Peripheral Regeneration Annual Review of Neuroscience. 2007 | Pubmed ID: 17341159 The Plasminogen Activator System Modulates Sympathetic Nerve Function The Journal of Experimental Medicine. Sep, 2006 | Pubmed ID: 16940168 Tissue Plasminogen Activator and Plasminogen Mediate Stress-induced Decline of Neuronal and Cognitive Functions in the Mouse Hippocampus Proceedings of the National Academy of Sciences of the United States of America. Dec, 2005 | Pubmed ID: 16330749 Schwann Cell-specific Ablation of Laminin Gamma1 Causes Apoptosis and Prevents Proliferation The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. May, 2005 | Pubmed ID: 15872093 Tissue Plasminogen Activator in Central Nervous System Physiology and Pathology Thrombosis and Haemostasis. Apr, 2005 | Pubmed ID: 15841309 Ethanol-withdrawal Seizures Are Controlled by Tissue Plasminogen Activator Via Modulation of NR2B-containing NMDA Receptors Proceedings of the National Academy of Sciences of the United States of America. Jan, 2005 | Pubmed ID: 15630096 Tissue Plasminogen Activator Promotes the Effects of Corticotropin-releasing Factor on the Amygdala and Anxiety-like Behavior Proceedings of the National Academy of Sciences of the United States of America. Nov, 2004 | Pubmed ID: 15522965 フィブリン減少は炎症を減少させ、多発性硬化症の腫瘍壊死因子トランスジェニックマウスモデルにおける脱髄の発症を遅らせる Proceedings of the National Academy of Sciences of the United States of America. Apr, 2004 | Pubmed ID: 15096619 Laminin Gamma1 is Critical for Schwann Cell Differentiation, Axon Myelination, and Regeneration in the Peripheral Nerve The Journal of Cell Biology. Nov, 2003 | Pubmed ID: 14638863 The Tissue Plasminogen Activator-plasminogen Proteolytic Cascade Accelerates Amyloid-beta (Abeta) Degradation and Inhibits Abeta-induced Neurodegeneration The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Oct, 2003 | Pubmed ID: 14523088 The Possible Role of Tissue-type Plasminogen Activator (tPA) and TPA Blockers in the Pathogenesis and Treatment of Alzheimer's Disease Journal of Molecular Neuroscience : MN. 2003 | Pubmed ID: 14501010 The Hippocampal Laminin Matrix is Dynamic and Critical for Neuronal Survival Molecular Biology of the Cell. Jul, 2003 | Pubmed ID: 12857855 フィブリンは、マウスの坐骨神経損傷後のシュワン細胞遊走のレギュレータです。 Neuroscience Letters. Mar, 2003 | Pubmed ID: 12581827 Tissue Plasminogen Activator in the Amygdala is Critical for Stress-induced Anxiety-like Behavior Nature Neuroscience. Feb, 2003 | Pubmed ID: 12524546 Tissue Plasminogen Activator and Seizures: a Clot-buster's Secret Life The Journal of Clinical Investigation. Jun, 2002 | Pubmed ID: 12070298 神経系の病理:フィブリンの展望 Biological Chemistry. Jan, 2002 | Pubmed ID: 11928820 フィブリンはシュワン細胞の分化を調節することにより、末梢神経ミエリン化を阻害する Neuron. Mar, 2002 | Pubmed ID: 11906694 Localization and Regulation of the Tissue Plasminogen Activator-plasmin System in the Hippocampus The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Mar, 2002 | Pubmed ID: 11896152 Tissue Plasminogen Activator in Nervous System Function and Dysfunction Thrombosis and Haemostasis. Jul, 2001 | Pubmed ID: 11486999 Β アミロイド誘起分光と電子顕微鏡によるフィブリン血栓構造異常の解析 Pradeep K. Singh*1, Hanna E. Berk-Rauch*1, Nadine Soplop2, Kunihiro Uryu2, Sidney Strickland1, Hyung Jin Ahn1 1Patricia and John Rosenwald Laboratory of Neurobiology and Genetics, Rockefeller University, 2Electron Microscopy Resource Center, Rockefeller University JoVE 58475 Biochemistry
Β アミロイド誘起分光と電子顕微鏡によるフィブリン血栓構造異常の解析 Pradeep K. Singh*1, Hanna E. Berk-Rauch*1, Nadine Soplop2, Kunihiro Uryu2, Sidney Strickland1, Hyung Jin Ahn1 1Patricia and John Rosenwald Laboratory of Neurobiology and Genetics, Rockefeller University, 2Electron Microscopy Resource Center, Rockefeller University JoVE 58475 Biochemistry