In JoVE (1)
Other Publications (1)
Articles by Sivan Yuran in JoVE
Formazione di strutture biomolecolari ordinate dalla Self-assemblaggio di piccoli peptidi Sivan Yuran1, Meital Reches1 1Institute of Chemistry and The Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem Questo documento descrive la formazione di strutture a base di peptidi altamente ordinati dal processo spontaneo di auto-assemblaggio. Il metodo utilizza peptidi disponibili sul mercato e le apparecchiature di laboratorio comune. Questa tecnica può essere applicata a una grande varietà di peptidi e può portare alla scoperta di nuovi assemblaggi a base di peptidi.
Other articles by Sivan Yuran on PubMed
Coassembly of Aromatic Dipeptides into Biomolecular Necklaces ACS Nano. Nov, 2012 | Pubmed ID: 23061818 This paper describes the formation of complex peptide-based structures by the coassembly of two simple peptides, the diphenylalanine peptide and its tert-butyl dicarbonate (Boc) protected analogue. Each of these peptides can self-assemble into a distinct architecture: the diphenylalanine peptide into tubular structures and its analogue into spheres. Integrated together, these peptides coassemble into a construction of beaded strings, where spherical assemblies are connected by elongated elements. Electron and scanning force microscopy demonstrated the morphology of these structures, which we termed "biomolecular necklaces". Additional experiments indicated the reversibility of the coassembly process and the stability of the structures. Furthermore, we suggest a possible mechanism of formation for the biomolecular necklaces. Our suggestion is based on the necklace model for polyelectrolyte chains, which proposes that a necklace structure appears as a result of counterion condensation on the backbone of a polyelectrolyte. Overall, the approach of coassembly, demonstrated using aromatic peptides, can be adapted to any peptides and may lead to the development and discovery of new self-assembled architectures formed by peptides and other biomolecules.