Stefan G. Sarafianos Laboratory of Biochemical Pharmacology, Department of Pediatrics Emory University School of Medicine Biography Publications Institution JoVE Articles Stefan G. Sarafianos has not added a biography. If you are Stefan G. Sarafianos and would like to personalize this page please email our Author Liaison for assistance. Publications Novel HIV-1 Capsid-targeting Small Molecules of the PF74 Binding Site European Journal of Medicinal Chemistry. Oct, 2020 | Pubmed ID: 32814250 HIV-1 Replication Complexes Accumulate in Nuclear Speckles and Integrate into Speckle-associated Genomic Domains Nature Communications. 07, 2020 | Pubmed ID: 32665593 Effect of P-body Component Mov10 on HCV Virus Production and Infectivity FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Jul, 2020 | Pubmed ID: 32496609 Chemical Profiling of HIV-1 Capsid-targeting Antiviral PF74 European Journal of Medicinal Chemistry. Aug, 2020 | Pubmed ID: 32438252 Feasibility of Known RNA Polymerase Inhibitors As Anti-SARS-CoV-2 Drugs Pathogens (Basel, Switzerland). Apr, 2020 | Pubmed ID: 32357471 Toward Structurally Novel and Metabolically Stable HIV-1 Capsid-Targeting Small Molecules Viruses. 04, 2020 | Pubmed ID: 32316297 7-Deaza-7-fluoro Modification Confers on 4'-cyano-nucleosides Potent Activity Against Entecavir/adefovir-resistant HBV Variants and Favorable Safety Antiviral Research. 04, 2020 | Pubmed ID: 32084506 Cutting into the Substrate Dominance: Pharmacophore and Structure-Based Approaches Toward Inhibiting Human Immunodeficiency Virus Reverse Transcriptase-Associated Ribonuclease H Accounts of Chemical Research. 01, 2020 | Pubmed ID: 31880912 Visualization of Positive and Negative Sense Viral RNA for Probing the Mechanism of Direct-Acting Antivirals Against Hepatitis C Virus Viruses. 11, 2019 | Pubmed ID: 31717338 Determinants of Active-Site Inhibitor Interaction with HIV-1 RNase H ACS Infectious Diseases. 11, 2019 | Pubmed ID: 31577424 Conformational Changes in HIV-1 Reverse Transcriptase That Facilitate Its Maturation Structure (London, England : 1993). 10, 2019 | Pubmed ID: 31471129 Effects of Moloney Leukemia Virus 10 Protein on Hepatitis B Virus Infection and Viral Replication Viruses. 07, 2019 | Pubmed ID: 31319455 Long-Acting Anti-HIV Drugs Targeting HIV-1 Reverse Transcriptase and Integrase Pharmaceuticals (Basel, Switzerland). Apr, 2019 | Pubmed ID: 31010004 Novel Intersubunit Interaction Critical for HIV-1 Core Assembly Defines a Potentially Targetable Inhibitor Binding Pocket MBio. 03, 2019 | Pubmed ID: 30862755 Pharmacophore-based Design of Novel 3-hydroxypyrimidine-2,4-dione Subtypes As Inhibitors of HIV Reverse Transcriptase-associated RNase H: Tolerance of a Nonflexible Linker European Journal of Medicinal Chemistry. Mar, 2019 | Pubmed ID: 30739822 CMCdG, a Novel Nucleoside Analog with Favorable Safety Features, Exerts Potent Activity Against Wild-Type and Entecavir-Resistant Hepatitis B Virus Antimicrobial Agents and Chemotherapy. 04, 2019 | Pubmed ID: 30670420 Novel Hepatitis B Virus Capsid-Targeting Antiviral That Aggregates Core Particles and Inhibits Nuclear Entry of Viral Cores ACS Infectious Diseases. 05, 2019 | Pubmed ID: 30582687 Strain-specific Effect on Biphasic DNA Binding by HIV-1 Integrase AIDS (London, England). 03, 2019 | Pubmed ID: 30475264 Small Molecule Inhibitor That Stabilizes the Autoinhibited Conformation of the Oncogenic Tyrosine Phosphatase SHP2 Journal of Medicinal Chemistry. 02, 2019 | Pubmed ID: 30457860 Identification of a Structural Element in HIV-1 Gag Required for Virus Particle Assembly and Maturation MBio. 10, 2018 | Pubmed ID: 30327442 The High Genetic Barrier of EFdA/MK-8591 Stems from Strong Interactions with the Active Site of Drug-Resistant HIV-1 Reverse Transcriptase Cell Chemical Biology. 10, 2018 | Pubmed ID: 30174310 Structural Implications of Genotypic Variations in HIV-1 Integrase From Diverse Subtypes Frontiers in Microbiology. 2018 | Pubmed ID: 30116231 Antiretroviral Potency of 4'-ethnyl-2'-fluoro-2'-deoxyadenosine, Tenofovir Alafenamide and Second-generation NNRTIs Across Diverse HIV-1 Subtypes The Journal of Antimicrobial Chemotherapy. 10, 2018 | Pubmed ID: 30053052 6-Biphenylmethyl-3-hydroxypyrimidine-2,4-diones Potently and Selectively Inhibited HIV Reverse Transcriptase-associated RNase H European Journal of Medicinal Chemistry. Aug, 2018 | Pubmed ID: 30031978 6-Arylthio-3-hydroxypyrimidine-2,4-diones Potently Inhibited HIV Reverse Transcriptase-associated RNase H with Antiviral Activity European Journal of Medicinal Chemistry. Aug, 2018 | Pubmed ID: 30031976 Effect of TRNA on the Maturation of HIV-1 Reverse Transcriptase Journal of Molecular Biology. 06, 2018 | Pubmed ID: 29751015 4'-Ethynyl-2-fluoro-2'-deoxyadenosine, MK-8591: a Novel HIV-1 Reverse Transcriptase Translocation Inhibitor Current Opinion in HIV and AIDS. 07, 2018 | Pubmed ID: 29697468 Multiplex Single-cell Visualization of Nucleic Acids and Protein During HIV Infection Nature Communications. 12, 2017 | Pubmed ID: 29192235 Viral Nükleik Asitleri ve Proteinleri Görselleştirmek ve HIV, HTLV, HBV, HCV, Zika Virüsü ve İnfluenza Enfeksiyonunu İzlemek için Tek Hücreli Çoklanmış Floresan Görüntüleme Raven Shah*1, Shuiyun Lan*1, Maritza N. Puray-Chavez2, Dandan Liu2, Philip R. Tedbury1, Stefan G. Sarafianos1 1Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, 2Department of Molecular Microbiology & Immunology, University of Missouri School of Medicine JoVE 61843 Biology
Viral Nükleik Asitleri ve Proteinleri Görselleştirmek ve HIV, HTLV, HBV, HCV, Zika Virüsü ve İnfluenza Enfeksiyonunu İzlemek için Tek Hücreli Çoklanmış Floresan Görüntüleme Raven Shah*1, Shuiyun Lan*1, Maritza N. Puray-Chavez2, Dandan Liu2, Philip R. Tedbury1, Stefan G. Sarafianos1 1Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, 2Department of Molecular Microbiology & Immunology, University of Missouri School of Medicine JoVE 61843 Biology