Stephan A. Sieber Departmant of Chemistry, Center for Integrated Protein Science (CIPSM) Technische Universität München Biography Publications Institution JoVE Articles Stephan A. Sieber has not added a biography. If you are Stephan A. Sieber and would like to personalize this page please email our Author Liaison for assistance. Publications The Natural Product Elegaphenone Potentiates Antibiotic Effects Against Pseudomonas Aeruginosa Angewandte Chemie (International Ed. in English). Jun, 2019 | Pubmed ID: 30969469 Polyamide/PEG Blends As Biocompatible Biomaterials for the Convenient Regulation of Cell Adhesion and Growth Macromolecular Rapid Communications. Apr, 2019 | Pubmed ID: 30969001 Tailored Peptide Phenyl Esters Block ClpXP Proteolysis by an Unusual Breakdown into a Heptamer-Hexamer Assembly Angewandte Chemie (International Ed. in English). May, 2019 | Pubmed ID: 30829431 Bifunctional Duocarmycin Analogues As Inhibitors of Protein Tyrosine Kinases Journal of Natural Products. Jan, 2019 | Pubmed ID: 30620194 Chemical Cross-Linking Enables Drafting ClpXP Proximity Maps and Taking Snapshots of In Situ Interaction Networks Cell Chemical Biology. Jan, 2019 | Pubmed ID: 30415967 Mining the Cellular Inventory of Pyridoxal Phosphate-dependent Enzymes with Functionalized Cofactor Mimics Nature Chemistry. 12, 2018 | Pubmed ID: 30297752 Towards Synthetic Cells Using Peptide-based Reaction Compartments Nature Communications. 09, 2018 | Pubmed ID: 30242152 Selective Activation of Human Caseinolytic Protease P (ClpP) Angewandte Chemie (International Ed. in English). Oct, 2018 | Pubmed ID: 30129683 Design and Synthesis of Tailored Human Caseinolytic Protease P Inhibitors Chemical Communications (Cambridge, England). Aug, 2018 | Pubmed ID: 30109319 Chemical Probe To Monitor the Parkinsonism-Associated Protein DJ-1 in Live Cells ACS Chemical Biology. 08, 2018 | Pubmed ID: 30011180 Thinking Outside the Box-Novel Antibacterials To Tackle the Resistance Crisis Angewandte Chemie (International Ed. in English). Oct, 2018 | Pubmed ID: 29939462 Transcriptomic Profiling Suggests That Promysalin Alters the Metabolic Flux, Motility, and Iron Regulation in Pseudomonas Putida KT2440 ACS Infectious Diseases. Aug, 2018 | Pubmed ID: 29801413 Dual Inhibitor of Staphylococcus Aureus Virulence and Biofilm Attenuates Expression of Major Toxins and Adhesins Biochemistry. 03, 2018 | Pubmed ID: 29451388 Promysalin Elicits Species-Selective Inhibition of Pseudomonas Aeruginosa by Targeting Succinate Dehydrogenase Journal of the American Chemical Society. 02, 2018 | Pubmed ID: 29300464 An Antibacterial β-Lactone Kills Mycobacterium Tuberculosis by Disrupting Mycolic Acid Biosynthesis Angewandte Chemie (International Ed. in English). 01, 2018 | Pubmed ID: 29067779 An Amino Acid Domino Effect Orchestrates ClpP's Conformational States Current Opinion in Chemical Biology. Oct, 2017 | Pubmed ID: 28910721 A Chemical Disruptor of the ClpX Chaperone Complex Attenuates the Virulence of Multidrug-Resistant Staphylococcus Aureus Angewandte Chemie (International Ed. in English). 12, 2017 | Pubmed ID: 28906057 A Chemical Compound Inhibiting the Aha1-Hsp90 Chaperone Complex The Journal of Biological Chemistry. 10, 2017 | Pubmed ID: 28851842 Surface Topology Affects Wetting Behavior of Biofilms NPJ Biofilms and Microbiomes. 2017 | Pubmed ID: 28649412 Insights into ClpXP Proteolysis: Heterooligomerization and Partial Deactivation Enhance Chaperone Affinity and Substrate Turnover in Chemical Science. Feb, 2017 | Pubmed ID: 28451288 A Strategy for Dual Inhibition of the Proteasome and Fatty Acid Synthase with Belactosin C-orlistat Hybrids Bioorganic & Medicinal Chemistry. 06, 2017 | Pubmed ID: 28236510 Quantitative Map of β-Lactone-Induced Virulence Regulation Journal of Proteome Research. 03, 2017 | Pubmed ID: 28186774 Influence of Wing-tip Substituents and Reaction Conditions on the Structure, Properties and Cytotoxicity of Ag(i)- and Au(i)-bis(NHC) Complexes Dalton Transactions (Cambridge, England : 2003). Feb, 2017 | Pubmed ID: 28174778 A Whole Proteome Inventory of Background Photocrosslinker Binding Angewandte Chemie (International Ed. in English). 01, 2017 | Pubmed ID: 27981680 Activity-Based Protein Profiling in Bacteria Methods in Molecular Biology (Clifton, N.J.). 2017 | Pubmed ID: 27778281 Synthesis of Ramariolide Natural Products and Discovery of Their Targets in Mycobacteria Chemical Communications (Cambridge, England). 12, 2016 | Pubmed ID: 27847948 Natural-Product-Inspired Aminoepoxybenzoquinones Kill Members of the Gram-Negative Pathogen Salmonella by Attenuating Cellular Stress Response Angewandte Chemie (International Ed. in English). 11, 2016 | Pubmed ID: 27782347 Helicobacter Pylori Adhesin HopQ Engages in a Virulence-enhancing Interaction with Human CEACAMs Nature Microbiology. Oct, 2016 | Pubmed ID: 27748768 Mechanistic Analysis of Aliphatic β-lactones in Vibrio Harveyi Reveals a Quorum Sensing Independent Mode of Action Chemical Communications (Cambridge, England). Sep, 2016 | Pubmed ID: 27709214 Making a Long Journey Short: Alkyne Functionalization of Natural Product Scaffolds Chemistry (Weinheim an Der Bergstrasse, Germany). Mar, 2016 | Pubmed ID: 26752308 An Aromatic Hydroxyamide Attenuates Multiresistant Staphylococcus Aureus Toxin Expression Chemistry (Weinheim an Der Bergstrasse, Germany). Jan, 2016 | Pubmed ID: 26748534 Fimbrolide Natural Products Disrupt Bioluminescence of Vibrio By Targeting Autoinducer Biosynthesis and Luciferase Activity Angewandte Chemie (International Ed. in English). Jan, 2016 | Pubmed ID: 26609793 Barrel-shaped ClpP Proteases Display Attenuated Cleavage Specificities ACS Chemical Biology. Feb, 2016 | Pubmed ID: 26606371 Reversible Inhibitors Arrest ClpP in a Defined Conformational State That Can Be Revoked by ClpX Association Angewandte Chemie (International Ed. in English). Dec, 2015 | Pubmed ID: 26566002 Structural, Biochemical, and Computational Studies Reveal the Mechanism of Selective Aldehyde Dehydrogenase 1A1 Inhibition by Cytotoxic Duocarmycin Analogues Angewandte Chemie (International Ed. in English). Nov, 2015 | Pubmed ID: 26373694 Alkynol Natural Products Target ALDH2 in Cancer Cells by Irreversible Binding to the Active Site Chemical Communications (Cambridge, England). Nov, 2015 | Pubmed ID: 26365706 Phenyl Esters Are Potent Inhibitors of Caseinolytic Protease P and Reveal a Stereogenic Switch for Deoligomerization Journal of the American Chemical Society. Jul, 2015 | Pubmed ID: 26083639 A Mass Spectrometry Platform for a Streamlined Investigation of Proteasome Integrity, Posttranslational Modifications, and Inhibitor Binding Chemistry & Biology. Mar, 2015 | Pubmed ID: 25728267 AAA+ Chaperones and Acyldepsipeptides Activate the ClpP Protease Via Conformational Control Nature Communications. Feb, 2015 | Pubmed ID: 25695750 Structure and Mechanism of the Caseinolytic Protease ClpP1/2 Heterocomplex from Listeria Monocytogenes Angewandte Chemie (International Ed. in English). Mar, 2015 | Pubmed ID: 25630955 Subclass-specific Labeling of Protein-reactive Natural Products with Customized Nucleophilic Probes Chemistry (Weinheim an Der Bergstrasse, Germany). Feb, 2015 | Pubmed ID: 25605563 Effective GTP-replacing FtsZ Inhibitors and Antibacterial Mechanism of Action ACS Chemical Biology. Mar, 2015 | Pubmed ID: 25486266 Helicobacter Pylori γ-glutamyltranspeptidase Impairs T-lymphocyte Function by Compromising Metabolic Adaption Through Inhibition of CMyc and IRF4 Expression Cellular Microbiology. Jan, 2015 | Pubmed ID: 25087912 Target Discovery of Acivicin in Cancer Cells Elucidates Its Mechanism of Growth Inhibition†Electronic Supplementary Information (ESI) Available: Synthesis, Cloning, Protein Expression, Purification and Biochemical Assays. See DOI: 10.1039/c4sc02339k Chemical Science. Dec, 2014 | Pubmed ID: 25580214 A Small Molecule Inhibits Protein Disulfide Isomerase and Triggers the Chemosensitization of Cancer Cells Angewandte Chemie (International Ed. in English). Nov, 2014 | Pubmed ID: 25256790 Selective Inhibition of the Immunoproteasome by Ligand-induced Crosslinking of the Active Site Angewandte Chemie (International Ed. in English). Oct, 2014 | Pubmed ID: 25244435 A Subfamily of Bacterial Ribokinases Utilizes a Hemithioacetal for Pyridoxal Phosphate Salvage Journal of the American Chemical Society. Apr, 2014 | Pubmed ID: 24601602 Omuralide and Vibralactone: Differences in the Proteasome- β-lactone-γ-lactam Binding Scaffold Alter Target Preferences Angewandte Chemie (International Ed. in English). Jan, 2014 | Pubmed ID: 24285701 β-Sultams Exhibit Discrete Binding Preferences for Diverse Bacterial Enzymes with Nucleophilic Residues Chemical Communications (Cambridge, England). Jan, 2014 | Pubmed ID: 24251314 Disruption of Oligomerization and Dehydroalanine Formation As Mechanisms for ClpP Protease Inhibition Journal of the American Chemical Society. Jan, 2014 | Pubmed ID: 24106749 Copper-assisted Click Reactions for Activity-based Proteomics: Fine-tuned Ligands and Refined Conditions Extend the Scope of Application Chembiochem : a European Journal of Chemical Biology. Dec, 2013 | Pubmed ID: 24166841 Structural and Functional Insights into Caseinolytic Proteases Reveal an Unprecedented Regulation Principle of Their Catalytic Triad Proceedings of the National Academy of Sciences of the United States of America. Jul, 2013 | Pubmed ID: 23798410 The Two Faces of Potent Antitumor Duocarmycin-based Drugs: a Structural Dissection Reveals Disparate Motifs for DNA Versus Aldehyde Dehydrogenase 1 Affinity Angewandte Chemie (International Ed. in English). Jul, 2013 | Pubmed ID: 23681547 The Mechanism of Caseinolytic Protease (ClpP) Inhibition Angewandte Chemie (International Ed. in English). Mar, 2013 | Pubmed ID: 23361916 Target Profiling of 4-hydroxyderricin in S. Aureus Reveals Seryl-tRNA Synthetase Binding and Inhibition by Covalent Modification Molecular BioSystems. Mar, 2013 | Pubmed ID: 23295910 Structure, Phosphorylation and U2AF65 Binding of the N-terminal Domain of Splicing Factor 1 During 3'-splice Site Recognition Nucleic Acids Research. Nov, 2012 | Pubmed ID: 23175611 Target Analysis of α-alkylidene-γ-butyrolactones in Uropathogenic E. Coli Molecular BioSystems. Nov, 2012 | Pubmed ID: 22990910 Pretubulysin Derived Probes As Novel Tools for Monitoring the Microtubule Network Via Activity-based Protein Profiling and Fluorescence Microscopy Molecular BioSystems. Aug, 2012 | Pubmed ID: 22722320 Rugulactone and Its Analogues Exert Antibacterial Effects Through Multiple Mechanisms Including Inhibition of Thiamine Biosynthesis Chembiochem : a European Journal of Chemical Biology. Jul, 2012 | Pubmed ID: 22653914 Electrophilic Natural Products and Their Biological Targets Natural Product Reports. Jun, 2012 | Pubmed ID: 22504336 Duocarmycin Analogues Target Aldehyde Dehydrogenase 1 in Lung Cancer Cells Angewandte Chemie (International Ed. in English). Mar, 2012 | Pubmed ID: 22334487 Insights into Structural Network Responsible for Oligomerization and Activity of Bacterial Virulence Regulator Caseinolytic Protease P (ClpP) Protein The Journal of Biological Chemistry. Mar, 2012 | Pubmed ID: 22291011 ABPP Methodology: Introduction and Overview Topics in Current Chemistry. 2012 | Pubmed ID: 22160389 Development and Characterization of Improved β-lactone-based Anti-virulence Drugs Targeting ClpP Bioorganic & Medicinal Chemistry. Jan, 2012 | Pubmed ID: 21855356 Vibralactone As a Tool to Study the Activity and Structure of the ClpP1P2 Complex from Listeria Monocytogenes Angewandte Chemie (International Ed. in English). Nov, 2011 | Pubmed ID: 21954175 Unraveling the Protein Targets of Vancomycin in Living S. Aureus and E. Faecalis Cells Journal of the American Chemical Society. Aug, 2011 | Pubmed ID: 21736328 Evaluation of α-pyrones and Pyrimidones As Photoaffinity Probes for Affinity-based Protein Profiling The Journal of Organic Chemistry. Aug, 2011 | Pubmed ID: 21726094 Protein Reactivity of Natural Product-derived γ-butyrolactones Biochemistry. Feb, 2011 | Pubmed ID: 21188974 Disarming Clostridium Difficile Chemistry & Biology. Nov, 2010 | Pubmed ID: 21095563 The Biological Targets of Acivicin Inspired 3-chloro- and 3-bromodihydroisoxazole Scaffolds Chemical Communications (Cambridge, England). Nov, 2010 | Pubmed ID: 20936198 I Vesiculo-syntesen af Peptidmembranprækursorer til autonom vesikel vækst Kilian Vogele1, Thomas Frank1, Lukas Gasser1, Marisa A. Goetzfried1, Mathias W. Hackl2, Stephan A. Sieber2, Friedrich C. Simmel1,3, Tobias Pirzer1 1Physics of Synthetic Systems - E14, Physics-Department and ZNN, Technische Universität München, 2Departmant of Chemistry, Center for Integrated Protein Science (CIPSM), Technische Universität München, 3Nanosystems Initiative Munich JoVE 59831 Bioengineering
I Vesiculo-syntesen af Peptidmembranprækursorer til autonom vesikel vækst Kilian Vogele1, Thomas Frank1, Lukas Gasser1, Marisa A. Goetzfried1, Mathias W. Hackl2, Stephan A. Sieber2, Friedrich C. Simmel1,3, Tobias Pirzer1 1Physics of Synthetic Systems - E14, Physics-Department and ZNN, Technische Universität München, 2Departmant of Chemistry, Center for Integrated Protein Science (CIPSM), Technische Universität München, 3Nanosystems Initiative Munich JoVE 59831 Bioengineering
