Stephan E. Lehnart

Publications

• Toward Panoramic in Situ Mapping of Action Potential Propagation in Transgenic Hearts to Investigate Initiation and Therapeutic Control of Arrhythmias
  Frontiers in Physiology. 2014  |   Pubmed ID: 25249982
• Transgenic Mice for Real-time Visualization of CGMP in Intact Adult Cardiomyocytes
  Circulation Research. Apr, 2014  |   Pubmed ID: 24599804
• Tuning the Electrical Properties of the Heart by Differential Trafficking of KATP Ion Channel Complexes
  Journal of Cell Science. May, 2014  |   Pubmed ID: 24569881
• Imaging T-tubules: Dynamic Membrane Structures for Deep Functions
  Cardiovascular Research. May, 2013  |   Pubmed ID: 23504549
• Superresolution Microscopy in Heart - Cardiac Nanoscopy
  Journal of Molecular and Cellular Cardiology. May, 2013  |   Pubmed ID: 23219451
• Understanding the Physiology of Heart Failure Through Cellular and in Vivo Models-towards Targeting of Complex Mechanisms
  Experimental Physiology. Mar, 2013  |   Pubmed ID: 23064508
• Stimulated Emission Depletion Live-cell Super-resolution Imaging Shows Proliferative Remodeling of T-tubule Membrane Structures After Myocardial Infarction
  Circulation Research. Aug, 2012  |   Pubmed ID: 22723297
• Ablation of Junctin or Triadin is Associated with Increased Cardiac Injury Following Ischaemia/reperfusion
  Cardiovascular Research. May, 2012  |   Pubmed ID: 22411973
• Rationale, Objectives, and Design of the EUTrigTreat Clinical Study: a Prospective Observational Study for Arrhythmia Risk Stratification and Assessment of Interrelationships Among Repolarization Markers and Genotype
  Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology. Mar, 2012  |   Pubmed ID: 22117037
• SAP97 and Dystrophin Macromolecular Complexes Determine Two Pools of Cardiac Sodium Channels Nav1.5 in Cardiomyocytes
  Circulation Research. Feb, 2011  |   Pubmed ID: 21164104
• Phosphorylation of the Ryanodine Receptor Mediates the Cardiac Fight or Flight Response in Mice
  The Journal of Clinical Investigation. Dec, 2010  |   Pubmed ID: 21099118
• Differential Cardiac Remodeling in Preload Versus Afterload
  Circulation. Sep, 2010  |   Pubmed ID: 20733099
• An Antidote for Calcium Leak: Targeting Molecular Arrhythmia Mechanisms
  Journal of Molecular and Cellular Cardiology. Feb, 2010  |   Pubmed ID: 19931542
• K201 Improves Aspects of the Contractile Performance of Human Failing Myocardium Via Reduction in Ca2+ Leak from the Sarcoplasmic Reticulum
  Basic Research in Cardiology. Mar, 2010  |   Pubmed ID: 19718543
• Abnormalities of Calcium Metabolism and Myocardial Contractility Depression in the Failing Heart
  Heart Failure Reviews. Dec, 2009  |   Pubmed ID: 19434491
• Inhibition of Extracellular Signal-regulated Kinase Signaling to Prevent Cardiomyopathy Caused by Mutation in the Gene Encoding A-type Lamins
  Human Molecular Genetics. Jan, 2009  |   Pubmed ID: 18927124
• Arrhythmogenic Right Ventricular Cardiomyopathy in Boxer Dogs is Associated with Calstabin2 Deficiency
  Journal of Veterinary Cardiology : the Official Journal of the European Society of Veterinary Cardiology. Jun, 2008  |   Pubmed ID: 18515204
• Leaky Ca2+ Release Channel/ryanodine Receptor 2 Causes Seizures and Sudden Cardiac Death in Mice
  The Journal of Clinical Investigation. Jun, 2008  |   Pubmed ID: 18483626
• Remodeling of Ryanodine Receptor Complex Causes "leaky" Channels: a Molecular Mechanism for Decreased Exercise Capacity
  Proceedings of the National Academy of Sciences of the United States of America. Feb, 2008  |   Pubmed ID: 18268335
• Inherited Arrhythmias: a National Heart, Lung, and Blood Institute and Office of Rare Diseases Workshop Consensus Report About the Diagnosis, Phenotyping, Molecular Mechanisms, and Therapeutic Approaches for Primary Cardiomyopathies of Gene Mutations Affecting Ion Channel Function
  Circulation. Nov, 2007  |   Pubmed ID: 17998470
• Modulation of the Ryanodine Receptor and Intracellular Calcium
  Annual Review of Biochemistry. 2007  |   Pubmed ID: 17506640
• Novel Targets for Treating Heart and Muscle Disease: Stabilizing Ryanodine Receptors and Preventing Intracellular Calcium Leak
  Current Opinion in Pharmacology. Apr, 2007  |   Pubmed ID: 17306622
• Phosphodiesterase 4D and Heart Failure: a Cautionary Tale
  Expert Opinion on Therapeutic Targets. Oct, 2006  |   Pubmed ID: 16981825
• Stabilization of Cardiac Ryanodine Receptor Prevents Intracellular Calcium Leak and Arrhythmias
  Proceedings of the National Academy of Sciences of the United States of America. May, 2006  |   Pubmed ID: 16672364
• Ryanodine Receptor/calcium Release Channel PKA Phosphorylation: a Critical Mediator of Heart Failure Progression
  Proceedings of the National Academy of Sciences of the United States of America. Jan, 2006  |   Pubmed ID: 16407108
• Phosphodiesterase 4D Deficiency in the Ryanodine-receptor Complex Promotes Heart Failure and Arrhythmias
  Cell. Oct, 2005  |   Pubmed ID: 16213210
• Ryanodine Receptor-targeted Anti-arrhythmic Therapy
  Annals of the New York Academy of Sciences. Jun, 2005  |   Pubmed ID: 16093511
• Defective Ryanodine Receptor Interdomain Interactions May Contribute to Intracellular Ca2+ Leak: a Novel Therapeutic Target in Heart Failure
  Circulation. Jun, 2005  |   Pubmed ID: 15983258
• Enhancing Calstabin Binding to Ryanodine Receptors Improves Cardiac and Skeletal Muscle Function in Heart Failure
  Proceedings of the National Academy of Sciences of the United States of America. Jul, 2005  |   Pubmed ID: 15972811
• Defective Cardiac Ryanodine Receptor Regulation During Atrial Fibrillation
  Circulation. Apr, 2005  |   Pubmed ID: 15851612
• Intracellular Calcium Release and Cardiac Disease
  Annual Review of Physiology. 2005  |   Pubmed ID: 15709953
• Calstabin Deficiency, Ryanodine Receptors, and Sudden Cardiac Death
  Biochemical and Biophysical Research Communications. Oct, 2004  |   Pubmed ID: 15336974
• Cardiac Ryanodine Receptor Function and Regulation in Heart Disease
  Annals of the New York Academy of Sciences. May, 2004  |   Pubmed ID: 15201156
• Sudden Death in Familial Polymorphic Ventricular Tachycardia Associated with Calcium Release Channel (ryanodine Receptor) Leak
  Circulation. Jun, 2004  |   Pubmed ID: 15197150
• Protection from Cardiac Arrhythmia Through Ryanodine Receptor-stabilizing Protein Calstabin2
  Science (New York, N.Y.). Apr, 2004  |   Pubmed ID: 15073377
• Ca2+/calmodulin-dependent Protein Kinase II Phosphorylation Regulates the Cardiac Ryanodine Receptor
  Circulation Research. Apr, 2004  |   Pubmed ID: 15016728
• Immunophilins and Coupled Gating of Ryanodine Receptors
  Current Topics in Medicinal Chemistry. 2003  |   Pubmed ID: 12871170
• FKBP12.6 Deficiency and Defective Calcium Release Channel (ryanodine Receptor) Function Linked to Exercise-induced Sudden Cardiac Death
  Cell. Jun, 2003  |   Pubmed ID: 12837242
• PKA Phosphorylation Activates the Calcium Release Channel (ryanodine Receptor) in Skeletal Muscle: Defective Regulation in Heart Failure
  The Journal of Cell Biology. Mar, 2003  |   Pubmed ID: 12629052
• Coronary Perfusion Cocktails for in Vivo Gene Transfer
  Methods in Molecular Biology (Clifton, N.J.). 2003  |   Pubmed ID: 12597011
• Intracellular Beta-blockade: Overexpression of Galpha(i2) Depresses the Beta-adrenergic Response in Intact Myocardium
  Cardiovascular Research. Aug, 2002  |   Pubmed ID: 12123769
• Potentiation of Beta-adrenergic Inotropic Response by Pyruvate in Failing Human Myocardium
  Cardiovascular Research. Jan, 2002  |   Pubmed ID: 11744019