Stephen C. Pflugfelder

Publications

• Differentially Expressed Tear Proteins in Sjögren's Syndrome Keratoconjunctivitis Sicca
  Translational Vision Science & Technology. Jun, 2023  |   Pubmed ID: 37310735
• Dry Eye Disease and Blinking Behaviors: A Narrative Review of Methodologies for Measuring Blink Dynamics and Inducing Blink Response
  The Ocular Surface. May, 2023  |   Pubmed ID: 37257694
• Comparison of Efficacy and Inflammatory Response to Thermoconjunctivoplasty Performed with Cautery or Pulsed 1460 Nm Laser
  International Journal of Molecular Sciences. Mar, 2023  |   Pubmed ID: 36982810
• Clinical Diagnosis and Management of Demodex Blepharitis: the Demodex Expert Panel on Treatment and Eyelid Health (DEPTH)
  Eye (London, England). Mar, 2023  |   Pubmed ID: 36964261
• Non-invasive and Objective Tear Film Breakup Detection on Interference Color Images Using Convolutional Neural Networks
  PloS One. 2023  |   Pubmed ID: 36913382
• Delphi Panel Consensus Regarding Current Clinical Practice Management Options for
  Clinical Ophthalmology (Auckland, N.Z.). 2023  |   Pubmed ID: 36875531
• Quantitative Assessment of Botulinum Toxin Injection on Blink Rate in Blepharospasm
  Orbit (Amsterdam, Netherlands). Dec, 2022  |   Pubmed ID: 36484152
• Imbalanced IL-37/TNF-α/CTSS Signaling Disrupts Corneal Epithelial Barrier in a Dry Eye Model in Vitro
  The Ocular Surface. Oct, 2022  |   Pubmed ID: 36208723
• Nicotinic Acetylcholine Receptor Stimulation: A New Approach for Stimulating Tear Secretion in Dry Eye Disease
  The Ocular Surface. Jul, 2022  |   Pubmed ID: 35550851
• A Multicenter Report of the Use of Plasma Rich in Growth Factors (PRGF) for the Treatment of Patients with Ocular Surface Diseases in North America
  The Ocular Surface. Jul, 2022  |   Pubmed ID: 35489588
• Author Correction: Gut-derived Butyrate Suppresses Ocular Surface Inflammation
  Scientific Reports. Apr, 2022  |   Pubmed ID: 35449441
• IL-17 Producing Lymphocytes Cause Dry Eye and Corneal Disease With Aging in RXRα Mutant Mouse
  Frontiers in Medicine. 2022  |   Pubmed ID: 35402439
• Single-cell Transcriptional Profiling of Murine Conjunctival Immune Cells Reveals Distinct Populations Expressing Homeostatic and Regulatory Genes
  Mucosal Immunology. Apr, 2022  |   Pubmed ID: 35361907
• Gut Microbiota From Sjögren Syndrome Patients Causes Decreased T Regulatory Cells in the Lymphoid Organs and Desiccation-Induced Corneal Barrier Disruption in Mice
  Frontiers in Medicine. 2022  |   Pubmed ID: 35355610
• Gut-derived Butyrate Suppresses Ocular Surface Inflammation
  Scientific Reports. Mar, 2022  |   Pubmed ID: 35296712
• Combined Therapy of Ocular Surface Disease with Plasma Rich in Growth Factors and Scleral Contact Lenses
  The Ocular Surface. Jan, 2022  |   Pubmed ID: 34537416
• IL-36α/IL-36RA/IL-38 Signaling Mediates Inflammation and Barrier Disruption in Human Corneal Epithelial Cells Under Hyperosmotic Stress
  The Ocular Surface. Oct, 2021  |   Pubmed ID: 34428579
• Differentially Expressed Gene Pathways in the Conjunctiva of Sjögren Syndrome Keratoconjunctivitis Sicca
  Frontiers in Immunology. 2021  |   Pubmed ID: 34349764
• Desiccation Induced Conjunctival Monocyte Recruitment and Activation - Implications for Keratoconjunctivitis
  Frontiers in Immunology. 2021  |   Pubmed ID: 34305940
• Dry Eye Disease Flares: A Rapid Evidence Assessment
  The Ocular Surface. Oct, 2021  |   Pubmed ID: 34303844
• Single-Cell Transcriptomics Identifies a Unique Entity and Signature Markers of Transit-Amplifying Cells in Human Corneal Limbus
  Investigative Ophthalmology & Visual Science. Jul, 2021  |   Pubmed ID: 34297801
• Video Viewing Blink Rate in Normal and Dry Eyes
  Eye & Contact Lens. Aug, 2021  |   Pubmed ID: 33900215
• Conjunctivochalasis and Tear Osmolarity Are Associated With Reduced Conjunctival Epithelial Thickness in Dry Eye
  American Journal of Ophthalmology. Jul, 2021  |   Pubmed ID: 33571473
• Retinoid Regulation of Ocular Surface Innate Inflammation
  International Journal of Molecular Sciences. Jan, 2021  |   Pubmed ID: 33499199
• Single-cell Transcriptomics Identifies Limbal Stem Cell Population and Cell Types Mapping Its Differentiation Trajectory in Limbal Basal Epithelium of Human Cornea
  The Ocular Surface. Apr, 2021  |   Pubmed ID: 33388438
• Defining Dry Eye from a Clinical Perspective
  International Journal of Molecular Sciences. Dec, 2020  |   Pubmed ID: 33291796
• Autophagy Activation Protects Ocular Surface from Inflammation in a Dry Eye Model In Vitro
  International Journal of Molecular Sciences. Nov, 2020  |   Pubmed ID: 33255884
• Rapamycin Eyedrops Increased CD4Foxp3 Cells and Prevented Goblet Cell Loss in the Aged Ocular Surface
  International Journal of Molecular Sciences. Nov, 2020  |   Pubmed ID: 33255287
• Unilateral Pediatric Neurotrophic Keratitis Due to Congenital Left Trigeminal Nerve Aplasia with PROSE (prosthetic Replacement of the Ocular Surface Ecosystem) Treatment
  American Journal of Ophthalmology Case Reports. Dec, 2020  |   Pubmed ID: 33094195
• Inflammatory Basis for Dry Eye Disease Flares
  Experimental Eye Research. Dec, 2020  |   Pubmed ID: 33039458
• The Cornea in Keratoconjunctivitis Sicca
  Experimental Eye Research. Dec, 2020  |   Pubmed ID: 33038387
• Trehalose Induces Autophagy Against Inflammation by Activating TFEB Signaling Pathway in Human Corneal Epithelial Cells Exposed to Hyperosmotic Stress
  Investigative Ophthalmology & Visual Science. Aug, 2020  |   Pubmed ID: 32785678
• Calcineurin Inhibitor Voclosporin Preserves Corneal Barrier and Conjunctival Goblet Cells in Experimental Dry Eye
  Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics. Nov, 2020  |   Pubmed ID: 32721249
• Goblet Cells Promote Tolerance Induction in the Conjunctiva
  Mucosal Immunology. Sep, 2020  |   Pubmed ID: 32616838
• Biological Functions of Tear Film
  Experimental Eye Research. Aug, 2020  |   Pubmed ID: 32561483
• IL-33/ST2/IL-9/IL-9R Signaling Disrupts Ocular Surface Barrier in Allergic Inflammation
  Mucosal Immunology. Nov, 2020  |   Pubmed ID: 32358573
• Regional Comparison of Goblet Cell Number and Area in Exposed and Covered Dry Eyes and Their Correlation with Tear MUC5AC
  Scientific Reports. Feb, 2020  |   Pubmed ID: 32076085
• Mechanisms of Disease in Sjögren Syndrome-New Developments and Directions
  International Journal of Molecular Sciences. Jan, 2020  |   Pubmed ID: 31963817
• Immune - Goblet Cell Interaction in the Conjunctiva
  The Ocular Surface. Apr, 2020  |   Pubmed ID: 31953222
• The Gut-eye-lacrimal Gland-microbiome Axis in Sjögren Syndrome
  The Ocular Surface. Apr, 2020  |   Pubmed ID: 31644955
• Topical Recombinant Human Nerve Growth Factor (Cenegermin) for Neurotrophic Keratopathy: A Multicenter Randomized Vehicle-Controlled Pivotal Trial
  Ophthalmology. Jan, 2020  |   Pubmed ID: 31585826
• Ocular Complications of Atopic Dermatitis
  Cutis. Sep, 2019  |   Pubmed ID: 31675394
• Dysbiosis Modulates Ocular Surface Inflammatory Response to Liposaccharide
  Investigative Ophthalmology & Visual Science. Oct, 2019  |   Pubmed ID: 31618426
• Topical Cyclosporine A Therapy for Dry Eye Syndrome
  The Cochrane Database of Systematic Reviews. Sep, 2019  |   Pubmed ID: 31517988
• Short Ragweed Pollen Promotes M2 Macrophage Polarization Via TSLP/TSLPR/OX40L Signaling in Allergic Inflammation
  Mucosal Immunology. 09, 2019  |   Pubmed ID: 31350466
• Age-associated Antigen-presenting Cell Alterations Promote Dry-eye Inducing Th1 Cells
  Mucosal Immunology. Jul, 2019  |   Pubmed ID: 30696983
• IL-27 Signaling Deficiency Develops Th17-enhanced Th2-dominant Inflammation in Murine Allergic Conjunctivitis Model
  Allergy. May, 2019  |   Pubmed ID: 30515838
• Reduced Corneal Innervation in the CD25 Null Model of Sjögren Syndrome
  International Journal of Molecular Sciences. Nov, 2018  |   Pubmed ID: 30513621
• Bilateral Candida Parapsilosis Infiltration of Nonhealing Indolent Epithelial Defects in a Diabetic Patient with Neurotrophic Keratopathy
  Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie. Dec, 2018  |   Pubmed ID: 30502998
• Severity of Sjögren's Syndrome Keratoconjunctivitis Sicca Increases with Increased Percentage of Conjunctival Antigen-Presenting Cells
  International Journal of Molecular Sciences. Sep, 2018  |   Pubmed ID: 30223431
• Goblet Cell-produced Retinoic Acid Suppresses CD86 Expression and IL-12 Production in Bone Marrow-derived Cells
  International Immunology. Sep, 2018  |   Pubmed ID: 30010888
• Suppression of Th1-Mediated Keratoconjunctivitis Sicca by Lifitegrast
  Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics. Sep, 2018  |   Pubmed ID: 29958030
• Protective Role of Commensal Bacteria in Sjögren Syndrome
  Journal of Autoimmunity. Sep, 2018  |   Pubmed ID: 29934134
• Near-infrared Laser Thermal Conjunctivoplasty
  Scientific Reports. Mar, 2018  |   Pubmed ID: 29497112
• Sjögren-Like Lacrimal Keratoconjunctivitis in Germ-Free Mice
  International Journal of Molecular Sciences. Feb, 2018  |   Pubmed ID: 29438346
• Assessment of the Prosthetic Replacement of Ocular Surface Ecosystem (PROSE) Scleral Lens on Visual Acuity for Corneal Irregularity and Ocular Surface Disease
  The Ocular Surface. Apr, 2018  |   Pubmed ID: 29425812
• Goblet Cell Loss Abrogates Ocular Surface Immune Tolerance
  JCI Insight. Feb, 2018  |   Pubmed ID: 29415888
• Reduced Intraepithelial Corneal Nerve Density and Sensitivity Accompany Desiccating Stress and Aging in C57BL/6 Mice
  Experimental Eye Research. Apr, 2018  |   Pubmed ID: 29407221
• The Pathophysiology of Dry Eye Disease: What We Know and Future Directions for Research
  Ophthalmology. Nov, 2017  |   Pubmed ID: 29055361
• Identification for Differential Localization of Putative Corneal Epithelial Stem Cells in Mouse and Human
  Scientific Reports. Jul, 2017  |   Pubmed ID: 28701781
• Goblet Cells Contribute to Ocular Surface Immune Tolerance-Implications for Dry Eye Disease
  International Journal of Molecular Sciences. May, 2017  |   Pubmed ID: 28475124
• Evolving Risk Factors and Antibiotic Sensitivity Patterns for Microbial Keratitis at a Large County Hospital
  The British Journal of Ophthalmology. Nov, 2017  |   Pubmed ID: 28336675
• Randomized Controlled Crossover Trial Comparing the Impact of Sham or Intranasal Tear Neurostimulation on Conjunctival Goblet Cell Degranulation
  American Journal of Ophthalmology. May, 2017  |   Pubmed ID: 28302532
• Long-term Outcomes of Ciliary Sulcus Versus Capsular Bag Fixation of Intraocular Lenses in Children: An Ultrasound Biomicroscopy Study
  PloS One. 2017  |   Pubmed ID: 28301497
• What We Have Learned From Animal Models of Dry Eye
  International Ophthalmology Clinics. 2017  |   Pubmed ID: 28282318
• Tear Volume-based Diagnostic Classification for Tear Dysfunction
  International Ophthalmology Clinics. 2017  |   Pubmed ID: 28282310
• Inhibition of NLRP3 Inflammasome Pathway by Butyrate Improves Corneal Wound Healing in Corneal Alkali Burn
  International Journal of Molecular Sciences. Mar, 2017  |   Pubmed ID: 28273882
• Mitochondrial DNA Oxidation Induces Imbalanced Activity of NLRP3/NLRP6 Inflammasomes by Activation of Caspase-8 and BRCC36 in Dry Eye
  Journal of Autoimmunity. Jun, 2017  |   Pubmed ID: 28238526
• LFA-1/ICAM-1 Interaction As a Therapeutic Target in Dry Eye Disease
  Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics. 2017  |   Pubmed ID: 27906544
• Age-related Spontaneous Lacrimal Keratoconjunctivitis is Accompanied by Dysfunctional T Regulatory Cells
  Mucosal Immunology. May, 2017  |   Pubmed ID: 27706128
• Pollen/TLR4 Innate Immunity Signaling Initiates IL-33/ST2/Th2 Pathways in Allergic Inflammation
  Scientific Reports. Oct, 2016  |   Pubmed ID: 27796360
• Interferon-gamma Deficiency Protects Against Aging-related Goblet Cell Loss
  Oncotarget. Oct, 2016  |   Pubmed ID: 27623073
• Synergistic Cysteamine Delivery Nanowafer As an Efficacious Treatment Modality for Corneal Cystinosis
  Molecular Pharmaceutics. Oct, 2016  |   Pubmed ID: 27571217
• Dexamethasone Drug Eluting Nanowafers Control Inflammation in Alkali-Burned Corneas Associated With Dry Eye
  Investigative Ophthalmology & Visual Science. Jun, 2016  |   Pubmed ID: 27327581
• Inflammatory Response to Lipopolysaccharide on the Ocular Surface in a Murine Dry Eye Model
  Investigative Ophthalmology & Visual Science. May, 2016  |   Pubmed ID: 27136463
• Altered Mucosal Microbiome Diversity and Disease Severity in Sjögren Syndrome
  Scientific Reports. Apr, 2016  |   Pubmed ID: 27087247
• Interferon-γ-Induced Unfolded Protein Response in Conjunctival Goblet Cells As a Cause of Mucin Deficiency in Sjögren Syndrome
  The American Journal of Pathology. Jun, 2016  |   Pubmed ID: 27085137
• MMP-8 Is Critical for Dexamethasone Therapy in Alkali-Burned Corneas Under Dry Eye Conditions
  Journal of Cellular Physiology. Nov, 2016  |   Pubmed ID: 26923552
• Acute and Chronic Ophthalmic Involvement in Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis - A Comprehensive Review and Guide to Therapy. II. Ophthalmic Disease
  The Ocular Surface. Apr, 2016  |   Pubmed ID: 26882981
• Lifitegrast, a Novel Integrin Antagonist for Treatment of Dry Eye Disease
  The Ocular Surface. Apr, 2016  |   Pubmed ID: 26807723
• Differential Effects of Dexamethasone and Doxycycline on Inflammation and MMP Production in Murine Alkali-Burned Corneas Associated with Dry Eye
  The Ocular Surface. Apr, 2016  |   Pubmed ID: 26772899
• Blueberry Component Pterostilbene Protects Corneal Epithelial Cells from Inflammation Via Anti-oxidative Pathway
  Scientific Reports. Jan, 2016  |   Pubmed ID: 26762881
• Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis--A Comprehensive Review and Guide to Therapy. I. Systemic Disease
  The Ocular Surface. Jan, 2016  |   Pubmed ID: 26549248
• Aqueous Tear Deficiency Increases Conjunctival Interferon-γ (IFN-γ) Expression and Goblet Cell Loss
  Investigative Ophthalmology & Visual Science. Nov, 2015  |   Pubmed ID: 26618646
• Clusterin Seals the Ocular Surface Barrier in Mouse Dry Eye
  PloS One. 2015  |   Pubmed ID: 26402857
• Improvement of Outcome Measures of Dry Eye by a Novel Integrin Antagonist in the Murine Desiccating Stress Model
  Investigative Ophthalmology & Visual Science. Sep, 2015  |   Pubmed ID: 26348638
• Protective Effects of L-Carnitine Against Oxidative Injury by Hyperosmolarity in Human Corneal Epithelial Cells
  Investigative Ophthalmology & Visual Science. Aug, 2015  |   Pubmed ID: 26284556
• Corneal Sensitivity in Tear Dysfunction and Its Correlation With Clinical Parameters and Blink Rate
  American Journal of Ophthalmology. Nov, 2015  |   Pubmed ID: 26255576
• Desiccating Stress-Induced MMP Production and Activity Worsens Wound Healing in Alkali-Burned Corneas
  Investigative Ophthalmology & Visual Science. Jul, 2015  |   Pubmed ID: 26225631
• Effects of Azithromycin on Gene Expression Profiles of Proinflammatory and Anti-inflammatory Mediators in the Eyelid Margin and Conjunctiva of Patients with Meibomian Gland Disease
  JAMA Ophthalmology. Oct, 2015  |   Pubmed ID: 26204109
• Dexamethasone Nanowafer As an Effective Therapy for Dry Eye Disease
  Journal of Controlled Release : Official Journal of the Controlled Release Society. Sep, 2015  |   Pubmed ID: 26184051
• IL-13 Stimulates Proliferation and Expression of Mucin and Immunomodulatory Genes in Cultured Conjunctival Goblet Cells
  Investigative Ophthalmology & Visual Science. Jul, 2015  |   Pubmed ID: 26132778
• A Novel Innate Response of Human Corneal Epithelium to Heat-killed Candida Albicans by Producing Peptidoglycan Recognition Proteins
  PloS One. 2015  |   Pubmed ID: 26039076
• Oxidative Stress Markers Induced by Hyperosmolarity in Primary Human Corneal Epithelial Cells
  PloS One. 2015  |   Pubmed ID: 26024535
• Altered Balance of Interleukin-13/interferon-gamma Contributes to Lacrimal Gland Destruction and Secretory Dysfunction in CD25 Knockout Model of Sjögren's Syndrome
  Arthritis Research & Therapy. Mar, 2015  |   Pubmed ID: 25889094
• Clinical Guidelines for Management of Dry Eye Associated with Sjögren Disease
  The Ocular Surface. Apr, 2015  |   Pubmed ID: 25881996
• Effects of Dry Eye Therapies on Environmentally Induced Ocular Surface Disease
  American Journal of Ophthalmology. Jul, 2015  |   Pubmed ID: 25868759
• Macrophage Phenotype in the Ocular Surface of Experimental Murine Dry Eye Disease
  Archivum Immunologiae Et Therapiae Experimentalis. Aug, 2015  |   Pubmed ID: 25772203
• Age-Related Conjunctival Disease in the C57BL/6.NOD-Aec1Aec2 Mouse Model of Sjögren Syndrome Develops Independent of Lacrimal Dysfunction
  Investigative Ophthalmology & Visual Science. Apr, 2015  |   Pubmed ID: 25758816
• Unique Expression Pattern and Functional Role of Periostin in Human Limbal Stem Cells
  PloS One. 2015  |   Pubmed ID: 25658308
• Ocular Drug Delivery Nanowafer with Enhanced Therapeutic Efficacy
  ACS Nano. Feb, 2015  |   Pubmed ID: 25585134
• Effects of L-carnitine, Erythritol and Betaine on Pro-inflammatory Markers in Primary Human Corneal Epithelial Cells Exposed to Hyperosmotic Stress
  Current Eye Research. Jul, 2015  |   Pubmed ID: 25271595
• Osmoprotectants Suppress the Production and Activity of Matrix Metalloproteinases Induced by Hyperosmolarity in Primary Human Corneal Epithelial Cells
  Molecular Vision. 2014  |   Pubmed ID: 25352733
• Desiccating Stress-induced Chemokine Expression in the Epithelium is Dependent on Upregulation of NKG2D/RAE-1 and Release of IFN-γ in Experimental Dry Eye
  Journal of Immunology (Baltimore, Md. : 1950). Nov, 2014  |   Pubmed ID: 25288568
• Treatment of Blepharitis: Recent Clinical Trials
  The Ocular Surface. Oct, 2014  |   Pubmed ID: 25284773
• Effect of Loteprednol Etabonate 0.5% on Initiation of Dry Eye Treatment with Topical Cyclosporine 0.05%
  Eye & Contact Lens. Sep, 2014  |   Pubmed ID: 25083776
• Mucosal Environmental Sensors in the Pathogenesis of Dry Eye
  Expert Review of Clinical Immunology. Sep, 2014  |   Pubmed ID: 25075545
• Complications Related to a Cosmetic Eye-whitening Procedure
  American Journal of Ophthalmology. Nov, 2014  |   Pubmed ID: 25072832
• Human Corneal Epithelial Cells Produce Antimicrobial Peptides LL-37 and β-defensins in Response to Heat-killed Candida Albicans
  Ophthalmic Research. 2014  |   Pubmed ID: 24662332
• New Testing Options for Diagnosing and Grading Dry Eye Disease
  American Journal of Ophthalmology. Jun, 2014  |   Pubmed ID: 24631478
• What Causes Dryness in Sjögren's Syndrome Patients and How Can It Be Targeted?
  Expert Review of Clinical Immunology. Apr, 2014  |   Pubmed ID: 24564508
• A Potential Link Between Bacterial Pathogens and Allergic Conjunctivitis by Dendritic Cells
  Experimental Eye Research. Mar, 2014  |   Pubmed ID: 24486456
• Effect of Desiccating Stress on Mouse Meibomian Gland Function
  The Ocular Surface. Jan, 2014  |   Pubmed ID: 24439047
• Ocular Surface Disease and Dacryoadenitis in Aging C57BL/6 Mice
  The American Journal of Pathology. Mar, 2014  |   Pubmed ID: 24389165
• Atopic Keratoconjunctivitis: A Review
  Journal of the American Academy of Dermatology. Mar, 2014  |   Pubmed ID: 24342754
• Topical Interferon-gamma Neutralization Prevents Conjunctival Goblet Cell Loss in Experimental Murine Dry Eye
  Experimental Eye Research. Jan, 2014  |   Pubmed ID: 24315969
• Tear Meniscus Dimensions in Tear Dysfunction and Their Correlation with Clinical Parameters
  American Journal of Ophthalmology. Feb, 2014  |   Pubmed ID: 24315297
• In Vivo Confocal Microscopy of the Ocular Surface: from Bench to Bedside
  Current Eye Research. Mar, 2014  |   Pubmed ID: 24215436
• Chemokine Receptors CCR6 and CXCR3 Are Necessary for CD4(+) T Cell Mediated Ocular Surface Disease in Experimental Dry Eye Disease
  PloS One. 2013  |   Pubmed ID: 24223818
• T Helper Cytokines in Dry Eye Disease
  Experimental Eye Research. Dec, 2013  |   Pubmed ID: 24012834
• Dendritic Cell-derived Thrombospondin-1 is Critical for the Generation of the Ocular Surface Th17 Response to Desiccating Stress
  Journal of Leukocyte Biology. Dec, 2013  |   Pubmed ID: 23983225
• Long-term Supplementation With N-6 and N-3 PUFAs Improves Moderate-to-Severe Keratoconjunctivitis Sicca: A Randomized Double-Blind Clinical Trial
  Cornea. Oct, 2013  |   Pubmed ID: 23884332
• A Novel Interleukin 33/ST2 Signaling Regulates Inflammatory Response in Human Corneal Epithelium
  PloS One. 2013  |   Pubmed ID: 23585867
• Factors Predicting the Ocular Surface Response to Desiccating Environmental Stress
  Investigative Ophthalmology & Visual Science. May, 2013  |   Pubmed ID: 23572103
• Patient Ocular Conditions and Clinical Outcomes Using a PROSE Scleral Device
  Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association. Aug, 2013  |   Pubmed ID: 23499361
• Toll-like Receptor Expression and Activation in Mice with Experimental Dry Eye
  Investigative Ophthalmology & Visual Science. Feb, 2013  |   Pubmed ID: 23372055
• Dry Eye As a Mucosal Autoimmune Disease
  International Reviews of Immunology. Feb, 2013  |   Pubmed ID: 23360156
• PROSE Therapy Used to Minimize Corneal Trauma in Patients with Corneal Epithelial Defects
  American Journal of Ophthalmology. Apr, 2013  |   Pubmed ID: 23218704
• Morphologic Alterations of the Palpebral Conjunctival Epithelium in a Dry Eye Model
  Cornea. Apr, 2013  |   Pubmed ID: 23146932
• Increasing Prevalence and Severity of Conjunctivochalasis with Aging Detected by Anterior Segment Optical Coherence Tomography
  American Journal of Ophthalmology. Feb, 2013  |   Pubmed ID: 23036571
• A Native-like Corneal Construct Using Donor Corneal Stroma for Tissue Engineering
  PloS One. 2012  |   Pubmed ID: 23166715
• Deletion of Interferon-γ Delays Onset and Severity of Dacryoadenitis in CD25KO Mice
  Arthritis Research & Therapy. Nov, 2012  |   Pubmed ID: 23116218
• Identification of Human Fibroblast Cell Lines As a Feeder Layer for Human Corneal Epithelial Regeneration
  PloS One. 2012  |   Pubmed ID: 22723892
• NK Cells Promote Th-17 Mediated Corneal Barrier Disruption in Dry Eye
  PloS One. 2012  |   Pubmed ID: 22590618
• Botulinum Toxin Injection for the Management of Refractory Filamentary Keratitis
  Archives of Ophthalmology (Chicago, Ill. : 1960). Apr, 2012  |   Pubmed ID: 22491914
• Autoantibodies Contribute to the Immunopathogenesis of Experimental Dry Eye Disease
  Investigative Ophthalmology & Visual Science. Apr, 2012  |   Pubmed ID: 22395876
• Resolvin E1 (RX-10001) Reduces Corneal Epithelial Barrier Disruption and Protects Against Goblet Cell Loss in a Murine Model of Dry Eye
  Cornea. Nov, 2012  |   Pubmed ID: 22257864
• Transcription Factor TCF4 Maintains the Properties of Human Corneal Epithelial Stem Cells
  Stem Cells (Dayton, Ohio). Jan, 2012  |   Pubmed ID: 22232078
• Biodegradable PLGA-Based Drug Delivery Systems for Modulating Ocular Surface Disease Under Experimental Murine Dry Eye
  Journal of Clinical & Experimental Ophthalmology. Nov, 2011  |   Pubmed ID: 23560247
• Disruption of TGF-β Signaling Improves Ocular Surface Epithelial Disease in Experimental Autoimmune Keratoconjunctivitis Sicca
  PloS One. 2011  |   Pubmed ID: 22194977
• Challenges in the Clinical Measurement of Ocular Surface Disease in Glaucoma Patients
  Clinical Ophthalmology (Auckland, N.Z.). 2011  |   Pubmed ID: 22125404
• Tear Dysfunction and the Cornea: LXVIII Edward Jackson Memorial Lecture
  American Journal of Ophthalmology. Dec, 2011  |   Pubmed ID: 22019306
• Desiccating Stress Induces CD4+ T-cell-mediated Sjögren's Syndrome-like Corneal Epithelial Apoptosis Via Activation of the Extrinsic Apoptotic Pathway by Interferon-γ
  The American Journal of Pathology. Oct, 2011  |   Pubmed ID: 21843497
• Short Ragweed Pollen Triggers Allergic Inflammation Through Toll-like Receptor 4-dependent Thymic Stromal Lymphopoietin/OX40 Ligand/OX40 Signaling Pathways
  The Journal of Allergy and Clinical Immunology. Dec, 2011  |   Pubmed ID: 21820713
• TLR-mediated Induction of Pro-allergic Cytokine IL-33 in Ocular Mucosal Epithelium
  The International Journal of Biochemistry & Cell Biology. Sep, 2011  |   Pubmed ID: 21684348
• Interferon-γ Exacerbates Dry Eye-induced Apoptosis in Conjunctiva Through Dual Apoptotic Pathways
  Investigative Ophthalmology & Visual Science. Aug, 2011  |   Pubmed ID: 21474767
• Entrapment of Conjunctival Goblet Cells by Desiccation-induced Cornification
  Investigative Ophthalmology & Visual Science. Jun, 2011  |   Pubmed ID: 21421863
• The β-catenin/Tcf4/survivin Signaling Maintains a Less Differentiated Phenotype and High Proliferative Capacity of Human Corneal Epithelial Progenitor Cells
  The International Journal of Biochemistry & Cell Biology. May, 2011  |   Pubmed ID: 21292023
• Pharmacological Cholinergic Blockade Stimulates Inflammatory Cytokine Production and Lymphocytic Infiltration in the Mouse Lacrimal Gland
  Investigative Ophthalmology & Visual Science. May, 2011  |   Pubmed ID: 21273534
• The Impact of the Boston Ocular Surface Prosthesis on Wavefront Higher-order Aberrations
  American Journal of Ophthalmology. Apr, 2011  |   Pubmed ID: 21269603
• Noninvasive Assessment of Tear Stability with the Tear Stability Analysis System in Tear Dysfunction Patients
  Investigative Ophthalmology & Visual Science. Jan, 2011  |   Pubmed ID: 20631241
• An Immunoprotective Privilege of Corneal Epithelial Stem Cells Against Th17 Inflammatory Stress by Producing Glial Cell-derived Neurotrophic Factor
  Stem Cells (Dayton, Ohio). Dec, 2010  |   Pubmed ID: 20936708
• Anterior Segment Optical Coherence Tomography: a Diagnostic Instrument for Conjunctivochalasis
  American Journal of Ophthalmology. Dec, 2010  |   Pubmed ID: 20869039
• The Successful Use of Boston Ocular Surface Prosthesis in the Treatment of Persistent Corneal Epithelial Defect After Herpes Zoster Ophthalmicus
  Cornea. Dec, 2010  |   Pubmed ID: 20847682
• Post-LASIK Tear Dysfunction and Dysesthesia
  The Ocular Surface. Jul, 2010  |   Pubmed ID: 20712970
• Spontaneous Autoimmune Dacryoadenitis in Aged CD25KO Mice
  The American Journal of Pathology. Aug, 2010  |   Pubmed ID: 20566743
• Evaluation of the Transforming Growth Factor-beta Activity in Normal and Dry Eye Human Tears by CCL-185 Cell Bioassay
  Cornea. Sep, 2010  |   Pubmed ID: 20539212
• Suppressive Effects of Azithromycin on Zymosan-induced Production of Proinflammatory Mediators by Human Corneal Epithelial Cells
  Investigative Ophthalmology & Visual Science. Nov, 2010  |   Pubmed ID: 20538995
• Altered Morphology and Function of the Lacrimal Functional Unit in Protein Kinase C{alpha} Knockout Mice
  Investigative Ophthalmology & Visual Science. Nov, 2010  |   Pubmed ID: 20505191
• Potential Localization of Putative Stem/progenitor Cells in Human Bulbar Conjunctival Epithelium
  Journal of Cellular Physiology. Oct, 2010  |   Pubmed ID: 20458737
• Molecular Signatures and Biological Pathway Profiles of Human Corneal Epithelial Progenitor Cells
  The International Journal of Biochemistry & Cell Biology. Jul, 2010  |   Pubmed ID: 20363357
• Desiccating Stress Promotion of Th17 Differentiation by Ocular Surface Tissues Through a Dendritic Cell-mediated Pathway
  Investigative Ophthalmology & Visual Science. Jun, 2010  |   Pubmed ID: 20130281
• TSLP and Downstream Molecules in Experimental Mouse Allergic Conjunctivitis
  Investigative Ophthalmology & Visual Science. Jun, 2010  |   Pubmed ID: 20107175
• Age-related T-cell Cytokine Profile Parallels Corneal Disease Severity in Sjogren's Syndrome-like Keratoconjunctivitis Sicca in CD25KO Mice
  Rheumatology (Oxford, England). Feb, 2010  |   Pubmed ID: 20007286
• Corneal Nerve Regeneration in Neurotrophic Keratopathy Following Autologous Plasma Therapy
  The British Journal of Ophthalmology. May, 2010  |   Pubmed ID: 19965821
• Expression of CXCL9, -10, -11, and CXCR3 in the Tear Film and Ocular Surface of Patients with Dry Eye Syndrome
  Investigative Ophthalmology & Visual Science. Feb, 2010  |   Pubmed ID: 19850844
• Association Between High Tear Epidermal Growth Factor Levels and Corneal Subepithelial Fibrosis in Dry Eye Conditions
  Investigative Ophthalmology & Visual Science. Feb, 2010  |   Pubmed ID: 19815739
• Toll-like Receptors Mediate Induction of Peptidoglycan Recognition Proteins in Human Corneal Epithelial Cells
  Experimental Eye Research. Jan, 2010  |   Pubmed ID: 19799901
• Induction of Th17 Differentiation by Corneal Epithelial-derived Cytokines
  Journal of Cellular Physiology. Jan, 2010  |   Pubmed ID: 19746420
• Essential Role for C-Jun N-terminal Kinase 2 in Corneal Epithelial Response to Desiccating Stress
  Archives of Ophthalmology (Chicago, Ill. : 1960). Dec, 2009  |   Pubmed ID: 20008718
• Cleavage of Functional IL-2 Receptor Alpha Chain (CD25) from Murine Corneal and Conjunctival Epithelia by MMP-9
  Journal of Inflammation (London, England). Oct, 2009  |   Pubmed ID: 19878594
• Corneal Epithelial Opacity in Dysfunctional Tear Syndrome
  American Journal of Ophthalmology. Sep, 2009  |   Pubmed ID: 19541283
• Production and Activity of Matrix Metalloproteinase-9 on the Ocular Surface Increase in Dysfunctional Tear Syndrome
  Investigative Ophthalmology & Visual Science. Jul, 2009  |   Pubmed ID: 19255163
• Human Corneal Epithelium-derived Thymic Stromal Lymphopoietin Links the Innate and Adaptive Immune Responses Via TLRs and Th2 Cytokines
  Investigative Ophthalmology & Visual Science. Jun, 2009  |   Pubmed ID: 19151401
• Tear Cytokine Profiles in Dysfunctional Tear Syndrome
  American Journal of Ophthalmology. Feb, 2009  |   Pubmed ID: 18992869
• Glial Cell-derived Neurotrophic Factor Gene Delivery Enhances Survival of Human Corneal Epithelium in Culture and the Overexpression of GDNF in Bioengineered Constructs
  Experimental Eye Research. Dec, 2008  |   Pubmed ID: 18938159
• Epithelial-immune Cell Interaction in Dry Eye
  Cornea. Sep, 2008  |   Pubmed ID: 18813079
• Effects of Contact Lens Multipurpose Solutions on Human Corneal Epithelial Survival and Barrier Function
  Eye & Contact Lens. Sep, 2008  |   Pubmed ID: 18779668
• Desiccating Stress Decreases Apical Corneal Epithelial Cell Size--modulation by the Metalloproteinase Inhibitor Doxycycline
  Cornea. Sep, 2008  |   Pubmed ID: 18724157
• Effects of Osmoprotectants on Hyperosmolar Stress in Cultured Human Corneal Epithelial Cells
  Cornea. Jun, 2008  |   Pubmed ID: 18520508
• Prevalence, Burden, and Pharmacoeconomics of Dry Eye Disease
  The American Journal of Managed Care. Apr, 2008  |   Pubmed ID: 18452369
• Effects of Sequential Artificial Tear and Cyclosporine Emulsion Therapy on Conjunctival Goblet Cell Density and Transforming Growth Factor-beta2 Production
  Cornea. Jan, 2008  |   Pubmed ID: 18245969
• Hyperosmolarity-induced Cornification of Human Corneal Epithelial Cells is Regulated by JNK MAPK
  Investigative Ophthalmology & Visual Science. Feb, 2008  |   Pubmed ID: 18234997
• Bilateral Acanthamoeba Keratitis
  American Journal of Ophthalmology. Feb, 2008  |   Pubmed ID: 18222188
• Desiccating Environmental Stress Exacerbates Autoimmune Lacrimal Keratoconjunctivitis in Non-obese Diabetic Mice
  Journal of Autoimmunity. Jun, 2008  |   Pubmed ID: 17988834
• Nerve Growth Factor and Its Receptor TrkA Serve As Potential Markers for Human Corneal Epithelial Progenitor Cells
  Experimental Eye Research. Jan, 2008  |   Pubmed ID: 17980361
• Patterned Expression of Neurotrophic Factors and Receptors in Human Limbal and Corneal Regions
  Molecular Vision. Oct, 2007  |   Pubmed ID: 17982417
• Future Directions in Therapeutic Interventions for Conjunctival Inflammatory Disorders
  Current Opinion in Allergy and Clinical Immunology. Oct, 2007  |   Pubmed ID: 17873588
• Strain-related Cytokine Profiles on the Murine Ocular Surface in Response to Desiccating Stress
  Cornea. Jun, 2007  |   Pubmed ID: 17525655
• Expression of Th-1 Chemokines and Chemokine Receptors on the Ocular Surface of C57BL/6 Mice: Effects of Desiccating Stress
  Investigative Ophthalmology & Visual Science. Jun, 2007  |   Pubmed ID: 17525185
• Dry Eye-induced Conjunctival Epithelial Squamous Metaplasia is Modulated by Interferon-gamma
  Investigative Ophthalmology & Visual Science. Jun, 2007  |   Pubmed ID: 17525184
• Hyperosmolarity-induced Apoptosis in Human Corneal Epithelial Cells is Mediated by Cytochrome C and MAPK Pathways
  Cornea. May, 2007  |   Pubmed ID: 17457195
• Prominent Corneal Nerves in a Patient with Multiple Myeloma
  Cornea. Feb, 2007  |   Pubmed ID: 17251817
• Effect of Topical Ophthalmic Epinastine and Olopatadine on Tear Volume in Mice
  Eye & Contact Lens. Dec, 2006  |   Pubmed ID: 17099387
• Integrating Restasis into the Management of Dry Eye
  International Ophthalmology Clinics. 2006  |   Pubmed ID: 17060796
• Transglutaminase Participates in UVB-induced Cell Death Pathways in Human Corneal Epithelial Cells
  Investigative Ophthalmology & Visual Science. Oct, 2006  |   Pubmed ID: 17003418
• Targeted Inhibition of P57 and P15 Blocks Transforming Growth Factor Beta-inhibited Proliferation of Primary Cultured Human Limbal Epithelial Cells
  Molecular Vision. Aug, 2006  |   Pubmed ID: 16943770
• Desiccating Stress Stimulates Expression of Matrix Metalloproteinases by the Corneal Epithelium
  Investigative Ophthalmology & Visual Science. Aug, 2006  |   Pubmed ID: 16877394
• Apical Corneal Barrier Disruption in Experimental Murine Dry Eye is Abrogated by Methylprednisolone and Doxycycline
  Investigative Ophthalmology & Visual Science. Jul, 2006  |   Pubmed ID: 16799024
• Improved Transduction of Human Corneal Epithelial Progenitor Cells with Cell-targeting Adenoviral Vectors
  Experimental Eye Research. Oct, 2006  |   Pubmed ID: 16793039
• Corticosteroid and Doxycycline Suppress MMP-9 and Inflammatory Cytokine Expression, MAPK Activation in the Corneal Epithelium in Experimental Dry Eye
  Experimental Eye Research. Sep, 2006  |   Pubmed ID: 16643899
• Expression and Regulation of Cornified Envelope Proteins in Human Corneal Epithelium
  Investigative Ophthalmology & Visual Science. May, 2006  |   Pubmed ID: 16639001
• The Incidence and Risk Factors for Developing Dry Eye After Myopic LASIK
  American Journal of Ophthalmology. Mar, 2006  |   Pubmed ID: 16490488
• Gap Junction Protein Connexin 43 Serves As a Negative Marker for a Stem Cell-containing Population of Human Limbal Epithelial Cells
  Stem Cells (Dayton, Ohio). May, 2006  |   Pubmed ID: 16424398
• JNK and ERK MAP Kinases Mediate Induction of IL-1beta, TNF-alpha and IL-8 Following Hyperosmolar Stress in Human Limbal Epithelial Cells
  Experimental Eye Research. Apr, 2006  |   Pubmed ID: 16202406
• Cell Size Correlates with Phenotype and Proliferative Capacity in Human Corneal Epithelial Cells
  Stem Cells (Dayton, Ohio). Feb, 2006  |   Pubmed ID: 16123387
• Matrix Metalloproteinases in Corneal Inflammation
  The Ocular Surface. Oct, 2005  |   Pubmed ID: 17216119
• Stress-activated Protein Kinase Signaling Pathways in Dry Eye and Ocular Surface Disease
  The Ocular Surface. Oct, 2005  |   Pubmed ID: 17216108
• Hyperosmolar Saline is a Proinflammatory Stress on the Mouse Ocular Surface
  Eye & Contact Lens. Sep, 2005  |   Pubmed ID: 16163009
• Effect of Experimental Dry Eye on Tear Sodium Concentration in the Mouse
  Eye & Contact Lens. Jul, 2005  |   Pubmed ID: 16021005
• Therapy of Progressive Rheumatoid Arthritis-associated Corneal Ulceration with Infliximab
  Cornea. Aug, 2005  |   Pubmed ID: 16015096
• Partial Enrichment of a Population of Human Limbal Epithelial Cells with Putative Stem Cell Properties Based on Collagen Type IV Adhesiveness
  Experimental Eye Research. Apr, 2005  |   Pubmed ID: 15781286
• Doxycycline Inhibits TGF-beta1-induced MMP-9 Via Smad and MAPK Pathways in Human Corneal Epithelial Cells
  Investigative Ophthalmology & Visual Science. Mar, 2005  |   Pubmed ID: 15728539
• Matrix Metalloproteinase-9 Knockout Confers Resistance to Corneal Epithelial Barrier Disruption in Experimental Dry Eye
  The American Journal of Pathology. Jan, 2005  |   Pubmed ID: 15632000
• ABCG2 Transporter Identifies a Population of Clonogenic Human Limbal Epithelial Cells
  Stem Cells (Dayton, Ohio). 2005  |   Pubmed ID: 15625123
• Topical Cyclosporine Inhibits Conjunctival Epithelial Apoptosis in Experimental Murine Keratoconjunctivitis Sicca
  Cornea. Jan, 2005  |   Pubmed ID: 15604871
• Stimulation of Matrix Metalloproteinases by Hyperosmolarity Via a JNK Pathway in Human Corneal Epithelial Cells
  Investigative Ophthalmology & Visual Science. Dec, 2004  |   Pubmed ID: 15557436
• Experimental Dry Eye Stimulates Production of Inflammatory Cytokines and MMP-9 and Activates MAPK Signaling Pathways on the Ocular Surface
  Investigative Ophthalmology & Visual Science. Dec, 2004  |   Pubmed ID: 15557435
• Phenotypic Characterization of Human Corneal Epithelial Cells Expanded Ex Vivo from Limbal Explant and Single Cell Cultures
  Experimental Eye Research. Jul, 2004  |   Pubmed ID: 15183099
• Characterization of Putative Stem Cell Phenotype in Human Limbal Epithelia
  Stem Cells (Dayton, Ohio). 2004  |   Pubmed ID: 15153612
• Management of the Late Ocular Sequelae of Stevens-Johnson Syndrome
  The Ocular Surface. Oct, 2003  |   Pubmed ID: 17075650
• The Ocular Surface Center at the Baylor College of Medicine, Houston
  The Ocular Surface. Apr, 2003  |   Pubmed ID: 17075639
• Anti-inflammatory Therapy of Dry Eye
  The Ocular Surface. Jan, 2003  |   Pubmed ID: 17075627