Stuart G. Campbell

Publications

• Functional and Structural Differences Between Skinned and Intact Muscle Preparations
  The Journal of General Physiology. Feb, 2022  |   Pubmed ID: 35045156
• Myofilament Glycation in Diabetes Reduces Contractility by Inhibiting Tropomyosin Movement, is Rescued by CMyBPC Domains
  Journal of Molecular and Cellular Cardiology. Jan, 2022  |   Pubmed ID: 34487755
• MicroRNA Function Can Be Reversed by Altering Target Gene Expression Levels
  IScience. Oct, 2021  |   Pubmed ID: 34755085
• Loss of Crossbridge Inhibition Drives Pathological Cardiac Hypertrophy in Patients Harboring the TPM1 E192K Mutation
  The Journal of General Physiology. 09, 2021  |   Pubmed ID: 34319370
• Danicamtiv Enhances Systolic Function and Frank-Starling Behavior at Minimal Diastolic Cost in Engineered Human Myocardium
  Journal of the American Heart Association. 06, 2021  |   Pubmed ID: 34096321
• Evidence for Synergy Between Sarcomeres and Fibroblasts in an in Vitro Model of Myocardial Reverse Remodeling
  Journal of Molecular and Cellular Cardiology. 09, 2021  |   Pubmed ID: 33992697
• Potential Impacts of the Cardiac Troponin I Mobile Domain on Myofilament Activation and Relaxation
  Journal of Molecular and Cellular Cardiology. 06, 2021  |   Pubmed ID: 33647310
• Mavacamten Preserves Length-dependent Contractility and Improves Diastolic Function in Human Engineered Heart Tissue
  American Journal of Physiology. Heart and Circulatory Physiology. 03, 2021  |   Pubmed ID: 33449850
• Fast-relaxing Cardiomyocytes Exert a Dominant Role in the Relaxation Behavior of Heterogeneous Myocardium
  Archives of Biochemistry and Biophysics. 01, 2021  |   Pubmed ID: 33271148
• Multiscale Modeling of Cardiovascular Function Predicts That the End-Systolic Pressure Volume Relationship Can Be Targeted Via Multiple Therapeutic Strategies
  Frontiers in Physiology. 2020  |   Pubmed ID: 32973561
• Contractile Work Directly Modulates Mitochondrial Protein Levels in Human Engineered Heart Tissues
  American Journal of Physiology. Heart and Circulatory Physiology. 06, 2020  |   Pubmed ID: 32383992
• Polycystin 2 is Increased in Disease to Protect Against Stress-induced Cell Death
  Scientific Reports. 01, 2020  |   Pubmed ID: 31941974
• KBTBD13 and the Ever-expanding Sarcomeric Universe
  The Journal of Clinical Investigation. 02, 2020  |   Pubmed ID: 31904591
• Modular Design of a Tissue Engineered Pulsatile Conduit Using Human Induced Pluripotent Stem Cell-derived Cardiomyocytes
  Acta Biomaterialia. 01, 2020  |   Pubmed ID: 31634626
• Modelling Sarcomeric Cardiomyopathies with Human Cardiomyocytes Derived from Induced Pluripotent Stem Cells
  The Journal of Physiology. 07, 2020  |   Pubmed ID: 30624779
• A Microwell Cell Capture Device Reveals Variable Response to Dobutamine in Isolated Cardiomyocytes
  Biophysical Journal. 10, 2019  |   Pubmed ID: 31537313
• Cardiomyocyte D-dopachrome Tautomerase Protects Against Heart Failure
  JCI Insight. 09, 2019  |   Pubmed ID: 31484822
• Extracellular Matrix From Hypertrophic Myocardium Provokes Impaired Twitch Dynamics in Healthy Cardiomyocytes
  JACC. Basic to Translational Science. Aug, 2019  |   Pubmed ID: 31468004
• Patient Mutations Linked to Arrhythmogenic Cardiomyopathy Enhance Calpain-mediated Desmoplakin Degradation
  JCI Insight. 06, 2019  |   Pubmed ID: 31194698
• The Effect of Tropomyosin Mutations on Actin-Tropomyosin Binding: In Search of Lost Time
  Biophysical Journal. 06, 2019  |   Pubmed ID: 31130236
• Sarcomere-Directed Calcium Reporters in Cardiomyocytes
  Circulation Research. 04, 2019  |   Pubmed ID: 30973804
• A Short History of the Development of Mathematical Models of Cardiac Mechanics
  Journal of Molecular and Cellular Cardiology. 02, 2019  |   Pubmed ID: 30503754
• Diverse Relaxation Rates Exist Among Rat Cardiomyocytes Isolated from a Single Myocardial Region
  The Journal of Physiology. 02, 2019  |   Pubmed ID: 30315728
• Precise Binding of Tropomyosin on Actin Involves Sequence-Dependent Variance in Coiled-Coil Twisting
  Biophysical Journal. 09, 2018  |   Pubmed ID: 30195938
• Force-Dependent Recruitment from the Myosin Off State Contributes to Length-Dependent Activation
  Biophysical Journal. 08, 2018  |   Pubmed ID: 30054031
• Skeletal Myosin Binding Protein-C Isoforms Regulate Thin Filament Activity in a Ca-dependent Manner
  Scientific Reports. 02, 2018  |   Pubmed ID: 29422607
• A Protocol for Collecting Human Cardiac Tissue for Research
  The VAD Journal : the Journal of Mechanical Assisted Circulation and Heart Failure. 2016  |   Pubmed ID: 28042604
• Low-dose Dasatinib Rescues Cardiac Function in Noonan Syndrome
  JCI Insight. 12, 2016  |   Pubmed ID: 27942593
• Acute Optogenetic Modulation of Cardiac Twitch Dynamics Explored Through Modeling
  Journal of Biomechanical Engineering. 11, 2016  |   Pubmed ID: 27618140
• Anisotropic Engineered Heart Tissue Made from Laser-cut Decellularized Myocardium
  Scientific Reports. 08, 2016  |   Pubmed ID: 27572147
• Structural Determinants of Muscle Thin Filament Cooperativity
  Archives of Biochemistry and Biophysics. Mar, 2016  |   Pubmed ID: 26891592
• Modeling Predicts a Connection Between Sinus Vortex Effects and Aortic Compliance
  Journal of Theoretical Biology. Jan, 2016  |   Pubmed ID: 26585547
• Slowing of Contractile Kinetics by Myosin-binding Protein C Can Be Explained by Its Cooperative Binding to the Thin Filament
  Journal of Molecular and Cellular Cardiology. 07, 2016  |   Pubmed ID: 26454159
• Contributions of Ca2+-Independent Thin Filament Activation to Cardiac Muscle Function
  Biophysical Journal. Nov, 2015  |   Pubmed ID: 26588569
• Prospects for In Vitro Myofilament Maturation in Stem Cell-Derived Cardiac Myocytes
  Biomarker Insights. 2015  |   Pubmed ID: 26085788
• Mathematical Modeling of Aortic Valve Dynamics During Systole
  Journal of Theoretical Biology. Jan, 2015  |   Pubmed ID: 25451522
• Decreased Polycystin 2 Expression Alters Calcium-contraction Coupling and Changes β-adrenergic Signaling Pathways
  Proceedings of the National Academy of Sciences of the United States of America. Nov, 2014  |   Pubmed ID: 25368166
• Timing and Magnitude of Systolic Stretch Affect Myofilament Activation and Mechanical Work
  American Journal of Physiology. Heart and Circulatory Physiology. Aug, 2014  |   Pubmed ID: 24878774