Susan Lindquist Whitehead Institute for Biomedical Research Biography Publications Institution JoVE Articles Susan Lindquist has not added a biography. If you are Susan Lindquist and would like to personalize this page please email our Author Liaison for assistance. Publications Prions Are a Common Mechanism for Phenotypic Inheritance in Wild Yeasts Nature. Feb, 2012 | Pubmed ID: 22337056 SIRT1 Protects Against α-synuclein Aggregation by Activating Molecular Chaperones The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jan, 2012 | Pubmed ID: 22219275 Different 8-Hydroxyquinolines Protect Models of TDP-43 Protein, α-Synuclein, and Polyglutamine Proteotoxicity Through Distinct Mechanisms The Journal of Biological Chemistry. Feb, 2012 | Pubmed ID: 22147697 QnAs with Susan L. Lindquist. Interviewed by Prashant Nair Proceedings of the National Academy of Sciences of the United States of America. Dec, 2011 | Pubmed ID: 22123945 STITCHER: Dynamic Assembly of Likely Amyloid and Prion β-structures from Secondary Structure Predictions Proteins. Sep, 2011 | Pubmed ID: 22095906 Using the Heat-Shock Response To Discover Anticancer Compounds That Target Protein Homeostasis ACS Chemical Biology. Nov, 2011 | Pubmed ID: 22050377 High Levels of Nuclear Heat-shock Factor 1 (HSF1) Are Associated with Poor Prognosis in Breast Cancer Proceedings of the National Academy of Sciences of the United States of America. Nov, 2011 | Pubmed ID: 22042860 Functional Links Between Aβ Toxicity, Endocytic Trafficking, and Alzheimer's Disease Risk Factors in Yeast Science (New York, N.Y.). Dec, 2011 | Pubmed ID: 22033521 Chemical and Biological Approaches for Adapting Proteostasis to Ameliorate Protein Misfolding and Aggregation Diseases: Progress and Prognosis Cold Spring Harbor Perspectives in Biology. Dec, 2011 | Pubmed ID: 21900404 TorsinA and the TorsinA-interacting Protein Printor Have No Impact on Endoplasmic Reticulum Stress or Protein Trafficking in Yeast PloS One. 2011 | Pubmed ID: 21818381 Piperazinyl Quinolines As Chemosensitizers to Increase Fluconazole Susceptibility of Candida Albicans Clinical Isolates Bioorganic & Medicinal Chemistry Letters. Sep, 2011 | Pubmed ID: 21802942 Physical Properties of Polymorphic Yeast Prion Amyloid Fibers Biophysical Journal. Jul, 2011 | Pubmed ID: 21767497 Generation of Isogenic Pluripotent Stem Cells Differing Exclusively at Two Early Onset Parkinson Point Mutations Cell. Jul, 2011 | Pubmed ID: 21757228 Opposing Effects of Glutamine and Asparagine Govern Prion Formation by Intrinsically Disordered Proteins Molecular Cell. Jul, 2011 | Pubmed ID: 21726811 A Method for Probing the Mutational Landscape of Amyloid Structure Bioinformatics (Oxford, England). Jul, 2011 | Pubmed ID: 21685090 Prion Formation and Polyglutamine Aggregation Are Controlled by Two Classes of Genes PLoS Genetics. May, 2011 | Pubmed ID: 21625618 A Flurry of Folding Problems: an Interview with Susan Lindquist by Jane Gitschier PLoS Genetics. May, 2011 | Pubmed ID: 21589898 ResponseNet: Revealing Signaling and Regulatory Networks Linking Genetic and Transcriptomic Screening Data Nucleic Acids Research. Jul, 2011 | Pubmed ID: 21576238 A Yeast Model of FUS/TLS-dependent Cytotoxicity PLoS Biology. Apr, 2011 | Pubmed ID: 21541368 The Cellular Prion Protein Mediates Neurotoxic Signalling of β-sheet-rich Conformers Independent of Prion Replication The EMBO Journal. May, 2011 | Pubmed ID: 21441896 Protein-only Mechanism Induces Self-perpetuating Changes in the Activity of Neuronal Aplysia Cytoplasmic Polyadenylation Element Binding Protein (CPEB) Proceedings of the National Academy of Sciences of the United States of America. Feb, 2011 | Pubmed ID: 21270333 Cyclin-G-associated Kinase Modifies α-synuclein Expression Levels and Toxicity in Parkinson's Disease: Results from the GenePD Study Human Molecular Genetics. Apr, 2011 | Pubmed ID: 21258085 Hsp90 and Environmental Stress Transform the Adaptive Value of Natural Genetic Variation Science (New York, N.Y.). Dec, 2010 | Pubmed ID: 21205668 Optical Trapping with High Forces Reveals Unexpected Behaviors of Prion Fibrils Nature Structural & Molecular Biology. Dec, 2010 | Pubmed ID: 21113168 Three Quite Different Things That Matter to Me Molecular Biology of the Cell. Nov, 2010 | Pubmed ID: 21079020 Protein Homeostasis and the Phenotypic Manifestation of Genetic Diversity: Principles and Mechanisms Annual Review of Genetics. 2010 | Pubmed ID: 21047258 Epigenetics in the Extreme: Prions and the Inheritance of Environmentally Acquired Traits Science (New York, N.Y.). Oct, 2010 | Pubmed ID: 21030648 Biochemical, Cell Biological, and Genetic Assays to Analyze Amyloid and Prion Aggregation in Yeast Methods in Enzymology. 2010 | Pubmed ID: 20946833 Polyamine Pathway Contributes to the Pathogenesis of Parkinson Disease Proceedings of the National Academy of Sciences of the United States of America. Sep, 2010 | Pubmed ID: 20837543 HSP90 at the Hub of Protein Homeostasis: Emerging Mechanistic Insights Nature Reviews. Molecular Cell Biology. Jul, 2010 | Pubmed ID: 20531426 α-Synuclein: Membrane Interactions and Toxicity in Parkinson's Disease Annual Review of Cell and Developmental Biology. Nov, 2010 | Pubmed ID: 20500090 Conversion of a Yeast Prion Protein to an Infectious Form in Bacteria Proceedings of the National Academy of Sciences of the United States of America. Jun, 2010 | Pubmed ID: 20484678 Modelling Neurodegeneration in Saccharomyces Cerevisiae: Why Cook with Baker's Yeast? Nature Reviews. Neuroscience. Jun, 2010 | Pubmed ID: 20424620 Prion Induction Involves an Ancient System for the Sequestration of Aggregated Proteins and Heritable Changes in Prion Fragmentation Proceedings of the National Academy of Sciences of the United States of America. May, 2010 | Pubmed ID: 20421488 Prions, Protein Homeostasis, and Phenotypic Diversity Trends in Cell Biology. Mar, 2010 | Pubmed ID: 20071174 Compounds from an Unbiased Chemical Screen Reverse Both ER-to-Golgi Trafficking Defects and Mitochondrial Dysfunction in Parkinson's Disease Models Disease Models & Mechanisms. Mar-Apr, 2010 | Pubmed ID: 20038714 Context-dependent Perturbation of Neural Systems in Transgenic Mice Expressing a Cytosolic Prion Protein NeuroImage. Feb, 2010 | Pubmed ID: 19835963 Context Dependent Neuroprotective Properties of Prion Protein (PrP) Prion. Oct-Dec, 2009 | Pubmed ID: 19901559 A Heritable Switch in Carbon Source Utilization Driven by an Unusual Yeast Prion Genes & Development. Oct, 2009 | Pubmed ID: 19797769 The Schizosaccharomyces Pombe Hsp104 Disaggregase is Unable to Propagate the [PSI] Prion PloS One. 2009 | Pubmed ID: 19759825 Spontaneous Generation of Prion Infectivity in Fatal Familial Insomnia Knockin Mice Neuron. Aug, 2009 | Pubmed ID: 19709627 Loss of Hsp70 Exacerbates Pathogenesis but Not Levels of Fibrillar Aggregates in a Mouse Model of Huntington's Disease The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jul, 2009 | Pubmed ID: 19605647 Rapid Selection of Cyclic Peptides That Reduce Alpha-synuclein Toxicity in Yeast and Animal Models Nature Chemical Biology. Sep, 2009 | Pubmed ID: 19597508 Unraveling Infectious Structures, Strain Variants and Species Barriers for the Yeast Prion [PSI+] Nature Structural & Molecular Biology. Jun, 2009 | Pubmed ID: 19491937 Amyloid Deposits: Protection Against Toxic Protein Species? Cell Cycle (Georgetown, Tex.). Jun, 2009 | Pubmed ID: 19411847 Motor Mechanism for Protein Threading Through Hsp104 Molecular Cell. Apr, 2009 | Pubmed ID: 19362537 A Nucleolar Protein Allows Viability in the Absence of the Essential ER-residing Molecular Chaperone Calnexin Journal of Cell Science. May, 2009 | Pubmed ID: 19351719 A Systematic Survey Identifies Prions and Illuminates Sequence Features of Prionogenic Proteins Cell. Apr, 2009 | Pubmed ID: 19345193 Inhibiting the Transcription Factor HSF1 As an Anticancer Strategy Expert Opinion on Therapeutic Targets. Apr, 2009 | Pubmed ID: 19335068 BETASCAN: Probable Beta-amyloids Identified by Pairwise Probabilistic Analysis PLoS Computational Biology. Mar, 2009 | Pubmed ID: 19325876 Bridging High-throughput Genetic and Transcriptional Data Reveals Cellular Responses to Alpha-synuclein Toxicity Nature Genetics. Mar, 2009 | Pubmed ID: 19234470 Harnessing Hsp90 Function As a Powerful, Broadly Effective Therapeutic Strategy for Fungal Infectious Disease Proceedings of the National Academy of Sciences of the United States of America. Feb, 2009 | Pubmed ID: 19196973 Alpha-synuclein is Part of a Diverse and Highly Conserved Interaction Network That Includes PARK9 and Manganese Toxicity Nature Genetics. Mar, 2009 | Pubmed ID: 19182805 Evidence That Alpha-synuclein Does Not Inhibit Phospholipase D Biochemistry. Feb, 2009 | Pubmed ID: 19146388 Lymphotoxin-dependent Prion Replication in Inflammatory Stromal Cells of Granulomas Immunity. Dec, 2008 | Pubmed ID: 19100703 Prion Switching in Response to Environmental Stress PLoS Biology. Nov, 2008 | Pubmed ID: 19067491 Using Yeast to Understand Protein Folding Diseases: an Interview with Susan Lindquist by Kristin Kain Disease Models & Mechanisms. Jul-Aug, 2008 | Pubmed ID: 19048046 Impaired ERAD and ER Stress Are Early and Specific Events in Polyglutamine Toxicity Genes & Development. Dec, 2008 | Pubmed ID: 19015277 Hsp104, Hsp70 and Hsp40 Interplay Regulates Formation, Growth and Elimination of Sup35 Prions The EMBO Journal. Oct, 2008 | Pubmed ID: 18833196 The Role of Calorie Restriction and SIRT1 in Prion-mediated Neurodegeneration Experimental Gerontology. Dec, 2008 | Pubmed ID: 18799131 Heat Shock Factor 1 Regulates Lifespan As Distinct from Disease Onset in Prion Disease Proceedings of the National Academy of Sciences of the United States of America. Sep, 2008 | Pubmed ID: 18757733 Hsp104 Antagonizes Alpha-synuclein Aggregation and Reduces Dopaminergic Degeneration in a Rat Model of Parkinson Disease The Journal of Clinical Investigation. Sep, 2008 | Pubmed ID: 18704197 Direct and Selective Elimination of Specific Prions and Amyloids by 4,5-dianilinophthalimide and Analogs Proceedings of the National Academy of Sciences of the United States of America. May, 2008 | Pubmed ID: 18480256 Chaperone-dependent Amyloid Assembly Protects Cells from Prion Toxicity Proceedings of the National Academy of Sciences of the United States of America. May, 2008 | Pubmed ID: 18480252 A Yeast TDP-43 Proteinopathy Model: Exploring the Molecular Determinants of TDP-43 Aggregation and Cellular Toxicity Proceedings of the National Academy of Sciences of the United States of America. Apr, 2008 | Pubmed ID: 18434538 Detection of Compounds That Rescue Rab1-synuclein Toxicity Methods in Enzymology. 2008 | Pubmed ID: 18374176 Hsp110 Chaperones Regulate Prion Formation and Propagation in S. Cerevisiae by Two Discrete Activities PloS One. 2008 | Pubmed ID: 18335038 HSP90 Affects the Expression of Genetic Variation and Developmental Stability in Quantitative Traits Proceedings of the National Academy of Sciences of the United States of America. Feb, 2008 | Pubmed ID: 18287065 HSP90-buffered Genetic Variation is Common in Arabidopsis Thaliana Proceedings of the National Academy of Sciences of the United States of America. Feb, 2008 | Pubmed ID: 18287064 The Parkinson's Disease Protein Alpha-synuclein Disrupts Cellular Rab Homeostasis Proceedings of the National Academy of Sciences of the United States of America. Jan, 2008 | Pubmed ID: 18162536 Prion Pathogenesis is Independent of Caspase-12 Prion. Oct-Dec, 2007 | Pubmed ID: 19164919 The Prion Protein Knockout Mouse: a Phenotype Under Challenge Prion. Apr-Jun, 2007 | Pubmed ID: 19164918 Atypical AAA+ Subunit Packing Creates an Expanded Cavity for Disaggregation by the Protein-remodeling Factor Hsp104 Cell. Dec, 2007 | Pubmed ID: 18160044 Illuminating Aggregate Heterogeneity in Neurodegenerative Disease Nature Methods. Dec, 2007 | Pubmed ID: 18049468 Diminishing Apoptosis by Deletion of Bax or Overexpression of Bcl-2 Does Not Protect Against Infectious Prion Toxicity in Vivo The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Nov, 2007 | Pubmed ID: 18032675 Alternative Assembly Pathways of the Amyloidogenic Yeast Prion Determinant Sup35-NM EMBO Reports. Dec, 2007 | Pubmed ID: 17975557 Probing the Role of PrP Repeats in Conformational Conversion and Amyloid Assembly of Chimeric Yeast Prions The Journal of Biological Chemistry. Nov, 2007 | Pubmed ID: 17893150 Heat Shock Factor 1 is a Powerful Multifaceted Modifier of Carcinogenesis Cell. Sep, 2007 | Pubmed ID: 17889646 Phenotypic Diversity and Altered Environmental Plasticity in Arabidopsis Thaliana with Reduced Hsp90 Levels PloS One. 2007 | Pubmed ID: 17653275 A Suite of Gateway Cloning Vectors for High-throughput Genetic Analysis in Saccharomyces Cerevisiae Yeast (Chichester, England). Oct, 2007 | Pubmed ID: 17583893 Prion Recognition Elements Govern Nucleation, Strain Specificity and Species Barriers Nature. May, 2007 | Pubmed ID: 17495929 A Natively Unfolded Yeast Prion Monomer Adopts an Ensemble of Collapsed and Rapidly Fluctuating Structures Proceedings of the National Academy of Sciences of the United States of America. Feb, 2007 | Pubmed ID: 17299036 The Power of Automated High-resolution Behavior Analysis Revealed by Its Application to Mouse Models of Huntington's and Prion Diseases Proceedings of the National Academy of Sciences of the United States of America. Feb, 2007 | Pubmed ID: 17261803 Asymmetric Deceleration of ClpB or Hsp104 ATPase Activity Unleashes Protein-remodeling Activity Nature Structural & Molecular Biology. Feb, 2007 | Pubmed ID: 17259993 Genetic Architecture of Hsp90-dependent Drug Resistance Eukaryotic Cell. Dec, 2006 | Pubmed ID: 17056742 Green Tea (-)-epigallocatechin-gallate Modulates Early Events in Huntingtin Misfolding and Reduces Toxicity in Huntington's Disease Models Human Molecular Genetics. Sep, 2006 | Pubmed ID: 16893904 Destruction or Potentiation of Different Prions Catalyzed by Similar Hsp104 Remodeling Activities Molecular Cell. Aug, 2006 | Pubmed ID: 16885031 Flanking Sequences Profoundly Alter Polyglutamine Toxicity in Yeast Proceedings of the National Academy of Sciences of the United States of America. Jul, 2006 | Pubmed ID: 16832050 A Network of Protein Interactions Determines Polyglutamine Toxicity Proceedings of the National Academy of Sciences of the United States of America. Jul, 2006 | Pubmed ID: 16832049 Alpha-synuclein Blocks ER-Golgi Traffic and Rab1 Rescues Neuron Loss in Parkinson's Models Science (New York, N.Y.). Jul, 2006 | Pubmed ID: 16794039 Prion Protein (PrPc) Positively Regulates Neural Precursor Proliferation During Developmental and Adult Mammalian Neurogenesis Proceedings of the National Academy of Sciences of the United States of America. Feb, 2006 | Pubmed ID: 16492732 Prion Protein is Expressed on Long-term Repopulating Hematopoietic Stem Cells and is Important for Their Self-renewal Proceedings of the National Academy of Sciences of the United States of America. Feb, 2006 | Pubmed ID: 16467153 Harnessing Natural Diversity to Probe Metabolic Pathways PLoS Genetics. Dec, 2005 | Pubmed ID: 16429164 Increase in Activity During Calorie Restriction Requires Sirt1 Science (New York, N.Y.). Dec, 2005 | Pubmed ID: 16339438 Hsp90 Potentiates the Rapid Evolution of New Traits: Drug Resistance in Diverse Fungi Science (New York, N.Y.). Sep, 2005 | Pubmed ID: 16195452 HSP90 and the Chaperoning of Cancer Nature Reviews. Cancer. Oct, 2005 | Pubmed ID: 16175177 Structural Insights into a Yeast Prion Illuminate Nucleation and Strain Diversity Nature. Jun, 2005 | Pubmed ID: 15944694 Prions As Adaptive Conduits of Memory and Inheritance Nature Reviews. Genetics. Jun, 2005 | Pubmed ID: 15931169 A Chaperone Pathway in Protein Disaggregation. Hsp26 Alters the Nature of Protein Aggregates to Facilitate Reactivation by Hsp104 The Journal of Biological Chemistry. Jun, 2005 | Pubmed ID: 15845535 Navigating the ClpB Channel to Solution Nature Structural & Molecular Biology. Jan, 2005 | Pubmed ID: 15689967 Potent Inhibition of Huntingtin Aggregation and Cytotoxicity by a Disulfide Bond-free Single-domain Intracellular Antibody Proceedings of the National Academy of Sciences of the United States of America. Dec, 2004 | Pubmed ID: 15598740 Effects of Q/N-rich, PolyQ, and Non-polyQ Amyloids on the De Novo Formation of the [PSI+] Prion in Yeast and Aggregation of Sup35 in Vitro Proceedings of the National Academy of Sciences of the United States of America. Aug, 2004 | Pubmed ID: 15326312 Epigenetic Regulation of Translation Reveals Hidden Genetic Variation to Produce Complex Traits Nature. Sep, 2004 | Pubmed ID: 15311209 Hsp104 Catalyzes Formation and Elimination of Self-replicating Sup35 Prion Conformers Science (New York, N.Y.). Jun, 2004 | Pubmed ID: 15155912 Interactions Among Alpha-synuclein, Dopamine, and Biomembranes: Some Clues for Understanding Neurodegeneration in Parkinson's Disease Journal of Molecular Neuroscience : MN. 2004 | Pubmed ID: 15126689 Under Cover: Causes, Effects and Implications of Hsp90-mediated Genetic Capacitance BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology. Apr, 2004 | Pubmed ID: 15057933 The Elongation of Yeast Prion Fibers Involves Separable Steps of Association and Conversion Proceedings of the National Academy of Sciences of the United States of America. Feb, 2004 | Pubmed ID: 14983002 Dominant Gain-of-function Mutations in Hsp104p Reveal Crucial Roles for the Middle Region Molecular Biology of the Cell. May, 2004 | Pubmed ID: 14978213 A Neuronal Isoform of the Aplysia CPEB Has Prion-like Properties Cell. Dec, 2003 | Pubmed ID: 14697205 Yeast Cells Provide Insight into Alpha-synuclein Biology and Pathobiology Science (New York, N.Y.). Dec, 2003 | Pubmed ID: 14657500 Yeast Genes That Enhance the Toxicity of a Mutant Huntingtin Fragment or Alpha-synuclein Science (New York, N.Y.). Dec, 2003 | Pubmed ID: 14657499 Prion Protein Gene Polymorphisms in Saccharomyces Cerevisiae Molecular Microbiology. Aug, 2003 | Pubmed ID: 12890024 Hsp90 and Chromatin: Where is the Link? Cell Cycle (Georgetown, Tex.). May-Jun, 2003 | Pubmed ID: 12734413 Conducting Nanowires Built by Controlled Self-assembly of Amyloid Fibers and Selective Metal Deposition Proceedings of the National Academy of Sciences of the United States of America. Apr, 2003 | Pubmed ID: 12672964 Prion Proteins: One Surprise After Another Harvey Lectures. -2003, 2002 | Pubmed ID: 16033161 Self-perpetuating Structural States in Biology, Disease, and Genetics Proceedings of the National Academy of Sciences of the United States of America. Dec, 2002 | Pubmed ID: 12475994 Changes in the Middle Region of Sup35 Profoundly Alter the Nature of Epigenetic Inheritance for the Yeast Prion [PSI+] Proceedings of the National Academy of Sciences of the United States of America. Dec, 2002 | Pubmed ID: 12461168 Neurotoxicity and Neurodegeneration when PrP Accumulates in the Cytosol Science (New York, N.Y.). Nov, 2002 | Pubmed ID: 12386337 Conversion of PrP to a Self-perpetuating PrPSc-like Conformation in the Cytosol Science (New York, N.Y.). Nov, 2002 | Pubmed ID: 12386336 Prions As Protein-based Genetic Elements Annual Review of Microbiology. 2002 | Pubmed ID: 12142498 Analysis of Prion Factors in Yeast Methods in Enzymology. 2002 | Pubmed ID: 12073366 Hsp90 As a Capacitor of Phenotypic Variation Nature. Jun, 2002 | Pubmed ID: 12050657 Defining a Pathway of Communication from the C-terminal Peptide Binding Domain to the N-terminal ATPase Domain in a AAA Protein Molecular Cell. Apr, 2002 | Pubmed ID: 11983167 Analysis of the AAA Sensor-2 Motif in the C-terminal ATPase Domain of Hsp104 with a Site-specific Fluorescent Probe of Nucleotide Binding Proceedings of the National Academy of Sciences of the United States of America. Mar, 2002 | Pubmed ID: 11867765 Susan L. Lindquist Trends in Cell Biology. Mar, 2002 | Pubmed ID: 11859028 Cooperative Kinetics of Both Hsp104 ATPase Domains and Interdomain Communication Revealed by AAA Sensor-1 Mutants The EMBO Journal. Jan, 2002 | Pubmed ID: 11782421 Screening för Amyloid aggregation av Semi-Denaturering Tvättmedel-agarosgelelektrofores Randal Halfmann1,2,3, Susan Lindquist1,2,3 1Whitehead Institute for Biomedical Research, 2Department of Biology, MIT - Massachusetts Institute of Technology, 3Howard Hughes Medical Institute JoVE 838 Biology Intervju: Protein Folding och studier av neurodegenerativa sjukdomar Susan Lindquist1 1Whitehead Institute for Biomedical Research, MIT - Massachusetts Institute of Technology JoVE 786 Biology
Screening för Amyloid aggregation av Semi-Denaturering Tvättmedel-agarosgelelektrofores Randal Halfmann1,2,3, Susan Lindquist1,2,3 1Whitehead Institute for Biomedical Research, 2Department of Biology, MIT - Massachusetts Institute of Technology, 3Howard Hughes Medical Institute JoVE 838 Biology
Intervju: Protein Folding och studier av neurodegenerativa sjukdomar Susan Lindquist1 1Whitehead Institute for Biomedical Research, MIT - Massachusetts Institute of Technology JoVE 786 Biology
