In JoVE (1)
Other Publications (1)
Articles by Thomas F. Schuessler in JoVE
Evaluation of Respiratory System Mechanics in Mice using the Forced Oscillation Technique Toby K. McGovern*1, Annette Robichaud*2, Liah Fereydoonzad2, Thomas F. Schuessler2, James G. Martin1 1Meakins-Christie Laboratories, Department of Medicine, McGill University, 2SCIREQ Scientific Respiratory Equipment Inc. The present protocol provides a detailed step-by-step description of the procedures required to execute measurements of respiratory system mechanics as well as the assessment of airway responsiveness to inhaled methacholine in mice using the forced oscillation technique (flexiVent; SCIREQ Inc, Montreal, Qc, Canada).
Other articles by Thomas F. Schuessler on PubMed
Combined Forced Oscillation and Forced Expiration Measurements in Mice for the Assessment of Airway Hyperresponsiveness Respiratory Research. 2010 | Pubmed ID: 20565957 Pulmonary function has been reported in mice using negative pressure-driven forced expiratory manoeuvres (NPFE) and the forced oscillation technique (FOT). However, both techniques have always been studied using separate cohorts of animals or systems. The objective of this study was to obtain NPFE and FOT measurements at baseline and following bronchoconstriction from a single cohort of mice using a combined system in order to assess both techniques through a refined approach.