Thomas Fleming Department of Internal Medicine Heidelberg University Biography Publications Institution JoVE Articles Thomas Fleming has not added a biography. If you are Thomas Fleming and would like to personalize this page please email our Author Liaison for assistance. Publications Dietary Stearic Acid Regulates Mitochondria in Vivo in Humans Nature Communications. Aug, 2018 | Pubmed ID: 30087348 Impairment of the Akt Pathway in Transplanted Type 1 Diabetic Hearts is Associated with Post-transplant Graft Injury Interactive Cardiovascular and Thoracic Surgery. Jun, 2018 | Pubmed ID: 29912386 Carnosine Catalyzes the Formation of the Oligo/Polymeric Products of Methylglyoxal Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 2018 | Pubmed ID: 29621776 Elevated Levels of the Reactive Metabolite Methylglyoxal Recapitulate Progression of Type 2 Diabetes Cell Metabolism. Apr, 2018 | Pubmed ID: 29551588 Cell Cycle Arrest and Cell Death Correlate with the Extent of Ischaemia and Reperfusion Injury in Patients Following Kidney Transplantation - Results of an Observational Pilot Study Transplant International : Official Journal of the European Society for Organ Transplantation. 07, 2018 | Pubmed ID: 29505681 Impact of Carbonylation on Glutathione Peroxidase-1 Activity in Human Hyperglycemic Endothelial Cells Redox Biology. 06, 2018 | Pubmed ID: 29499564 Risk Factors for Incident Diabetic Polyneuropathy in a Cohort With Screen-Detected Type 2 Diabetes Followed for 13 Years: ADDITION-Denmark Diabetes Care. 05, 2018 | Pubmed ID: 29487078 Effects of the Reactive Metabolite Methylglyoxal on Cellular Signalling, Insulin Action and Metabolism - What We Know in Mammals and What We Can Learn From Yeast Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association. Feb, 2018 | Pubmed ID: 29421830 High-glucose Toxicity is Mediated by AICAR-transformylase/IMP Cyclohydrolase and Mitigated by AMP-activated Protein Kinase in The Journal of Biological Chemistry. Mar, 2018 | Pubmed ID: 29414769 TRPC Proteins Contribute to Development of Diabetic Retinopathy and Regulate Glyoxalase 1 Activity and Methylglyoxal Accumulation Molecular Metabolism. Mar, 2018 | Pubmed ID: 29373286 The NADPH Organizers NoxO1 and P47phox Are Both Mediators of Diabetes-induced Vascular Dysfunction in Mice Redox Biology. 05, 2018 | Pubmed ID: 29195137 Modulation of Glutathione Peroxidase Activity by Age-dependent Carbonylation in Glomeruli of Diabetic Mice Journal of Diabetes and Its Complications. Nov, 2017 | Pubmed ID: 29223856 Homeostatic Nuclear RAGE-ATM Interaction is Essential for Efficient DNA Repair Nucleic Acids Research. Oct, 2017 | Pubmed ID: 28977635 Hormesis Enables Cells to Handle Accumulating Toxic Metabolites During Increased Energy Flux Redox Biology. 10, 2017 | Pubmed ID: 28826004 A Hepatic GAbp-AMPK Axis Links Inflammatory Signaling to Systemic Vascular Damage Cell Reports. Aug, 2017 | Pubmed ID: 28793265 Reply to Richarme: Evidence Against a Role of DJ-1 in Methylglyoxal Detoxification The Journal of Biological Chemistry. Aug, 2017 | Pubmed ID: 28778882 Dietary Sugars, Not Lipids, Drive Hypothalamic Inflammation Molecular Metabolism. Aug, 2017 | Pubmed ID: 28752053 Electrical Muscle Stimulation Induces an Increase of VEGFR2 on Circulating Hematopoietic Stem Cells in Patients With Diabetes Clinical Therapeutics. Jun, 2017 | Pubmed ID: 28554530 Dicarbonyls and Advanced Glycation End-Products in the Development of Diabetic Complications and Targets for Intervention International Journal of Molecular Sciences. May, 2017 | Pubmed ID: 28475116 STZ Causes Depletion of Immune Cells in Sciatic Nerve and Dorsal Root Ganglion in Experimental Diabetes Journal of Neuroimmunology. May, 2017 | Pubmed ID: 28385191 The Glyoxalase System and Methylglyoxal-Derived Carbonyl Stress in Sepsis: Glycotoxic Aspects of Sepsis Pathophysiology International Journal of Molecular Sciences. Mar, 2017 | Pubmed ID: 28304355 Evidence Against a Role for the Parkinsonism-associated Protein DJ-1 in Methylglyoxal Detoxification The Journal of Biological Chemistry. Jan, 2017 | Pubmed ID: 27903648 Reduction in Ins-7 Gene Expression in Non-neuronal Cells of High Glucose Exposed Caenorhabditis Elegans Protects from Reactive Metabolites, Preserves Neuronal Structure and Head Motility, and Prolongs Lifespan Journal of Diabetes and Its Complications. Feb, 2017 | Pubmed ID: 27776915 Soluble TREM-1 As a Diagnostic and Prognostic Biomarker in Patients with Septic Shock: an Observational Clinical Study Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals. Feb, 2017 | Pubmed ID: 27319606 Impaired Glyoxalase Activity is Associated with Reduced Expression of Neurotrophic Factors and Pro-inflammatory Processes in Diabetic Skin Cells Experimental Dermatology. 01, 2017 | Pubmed ID: 27306297 Control of Diabetic Hyperglycaemia and Insulin Resistance Through TSC22D4 Nature Communications. 11, 2016 | Pubmed ID: 27827363 Characterization of Aggregate Load and Pattern in Living Yeast Cells by Flow Cytometry BioTechniques. 2016 | Pubmed ID: 27625208 RAGE-mediated Inflammation in Patients with Septic Shock The Journal of Surgical Research. 05, 2016 | Pubmed ID: 27229106 Receptor for Advanced Glycation End Products (RAGE) Knockout Reduces Fetal Dysmorphogenesis in Murine Diabetic Pregnancy Reproductive Toxicology (Elmsford, N.Y.). Jul, 2016 | Pubmed ID: 27109771 Role of the RAGE Axis During the Immune Response After Severe Trauma: A Prospective Pilot Study Mediators of Inflammation. 2015 | Pubmed ID: 26880860 Impaired Aldehyde Dehydrogenase 1 Subfamily Member 2A-dependent Retinoic Acid Signaling is Related with a Mesenchymal-like Phenotype and an Unfavorable Prognosis of Head and Neck Squamous Cell Carcinoma Molecular Cancer. Dec, 2015 | Pubmed ID: 26634247 High Tissue Glucose Alters Intersomitic Blood Vessels in Zebrafish Via Methylglyoxal Targeting the VEGF Receptor Signaling Cascade Diabetes. Jan, 2015 | Pubmed ID: 25092676 Methylglyoxal As a New Biomarker in Patients with Septic Shock: an Observational Clinical Study Critical Care (London, England). Dec, 2014 | Pubmed ID: 25498125 Reactive Metabolites As a Cause of Late Diabetic Complications Biochemical Society Transactions. Apr, 2014 | Pubmed ID: 24646257 Plate-baserte stor skala dyrking av Caenorhabditis elegans: Sample forberedelse for studiet av metabolske forandringer i Diabetes Katharina Kohl1, Thomas Fleming2,3, Kübra Acunman1, Hans-Peter Hammes1,4, Michael Morcos*1, Andrea Schlotterer*1 15th Medical Department, Medical Faculty Mannheim, Heidelberg University, 2Department of Internal Medicine, Heidelberg University, 3German Center for Diabetes Research (DZD), 4European Center for Angioscience, Medical Faculty Mannheim, Heidelberg University JoVE 58117 Biochemistry Analyse av immunceller i enkelt Sciatic nerver og Dorsal Root Ganglion fra en enkelt mus med flowcytometri Asa S. Hidmark1, Peter P. Nawroth1,2,3, Thomas Fleming1,3 1Department of Medicine I and Clinical Chemistry, University Hospital of Heidelberg, 2Institute for Diabetes and Cancer IDC Helmholtz Center Munich, Germany & Joint Heidelberg-IDC Translational Diabetes Program, 3German Center for Diabetes Research (DZD) JoVE 56538 Neuroscience
Plate-baserte stor skala dyrking av Caenorhabditis elegans: Sample forberedelse for studiet av metabolske forandringer i Diabetes Katharina Kohl1, Thomas Fleming2,3, Kübra Acunman1, Hans-Peter Hammes1,4, Michael Morcos*1, Andrea Schlotterer*1 15th Medical Department, Medical Faculty Mannheim, Heidelberg University, 2Department of Internal Medicine, Heidelberg University, 3German Center for Diabetes Research (DZD), 4European Center for Angioscience, Medical Faculty Mannheim, Heidelberg University JoVE 58117 Biochemistry
Analyse av immunceller i enkelt Sciatic nerver og Dorsal Root Ganglion fra en enkelt mus med flowcytometri Asa S. Hidmark1, Peter P. Nawroth1,2,3, Thomas Fleming1,3 1Department of Medicine I and Clinical Chemistry, University Hospital of Heidelberg, 2Institute for Diabetes and Cancer IDC Helmholtz Center Munich, Germany & Joint Heidelberg-IDC Translational Diabetes Program, 3German Center for Diabetes Research (DZD) JoVE 56538 Neuroscience
