Thomas Powles St Bartholomew's Cancer Institute, Experimental Cancer Medicine Centre Queen Mary University of London Biography Publications Institution JoVE Articles Thomas Powles has not added a biography. If you are Thomas Powles and would like to personalize this page please email our Author Liaison for assistance. Publications The Conundrum of Clinical Trials in Adult Germ-cell Tumours The Lancet Oncology. Jan, 2013 | Pubmed ID: 23276363 Probability of Downsizing Primary Tumors of Renal Cell Carcinoma by Targeted Therapies is Related to Size at Presentation Urology. Jan, 2013 | Pubmed ID: 23153934 Gemcitabine, Cisplatin, and Sunitinib for Metastatic Urothelial Carcinoma and As Preoperative Therapy for Muscle-Invasive Bladder Cancer Clinical Genitourinary Cancer. Dec, 2012 | Pubmed ID: 23228446 The Hazards of Cross Comparing the Drug Toxicity Results from Different Trials in Metastatic Renal Cancer: In Response to a Letter from Dr. Catalá-López European Journal of Cancer (Oxford, England : 1990). Nov, 2012 | Pubmed ID: 23138000 Carboplatin AUC 10 for IGCCCG Good Prognosis Metastatic Seminoma Acta Oncologica (Stockholm, Sweden). Sep, 2012 | Pubmed ID: 22943385 Management of Favorable-risk Patients with Metastatic Renal Cell Carcinoma: when to Start and when to Stop Targeted Therapy Clinical Genitourinary Cancer. Dec, 2012 | Pubmed ID: 22939100 Contrasting Effects of Sunitinib Within in Vivo Models of Metastasis Angiogenesis. Dec, 2012 | Pubmed ID: 22843200 An Indirect Comparison of the Toxicity of Sunitinib and Pazopanib in Metastatic Clear Cell Renal Cancer European Journal of Cancer (Oxford, England : 1990). Nov, 2012 | Pubmed ID: 22766517 Neoadjuvant and Adjuvant Treatment of Renal Cell Carcinoma Expert Review of Anticancer Therapy. Jun, 2012 | Pubmed ID: 22716493 A Systematic Review of Neoadjuvant and Adjuvant Chemotherapy for Muscle-invasive Bladder Cancer European Urology. Sep, 2012 | Pubmed ID: 22677572 Treatment of Relapsed/refractory Germ Cell Tumours: an Equipoise Between Conventional and High Dose Therapy Current Treatment Options in Oncology. Jun, 2012 | Pubmed ID: 22623055 Accelerated Methotrexate, Vinblastine, Doxorubicin, and Cisplatin (AMVAC) As Neoadjuvant Chemotherapy for Patients with Muscle-invasive Transitional Cell Carcinoma of the Bladder Cancer. Aug, 2012 | Pubmed ID: 22614698 Performing Cytoreductive Nephrectomy Following Targeted Sunitinib Therapy for Metastatic Renal Cell Carcinoma: a Surgical Perspective Urologia Internationalis. 2012 | Pubmed ID: 22614181 Second-line Therapy After VEGF Targeted Therapy in Metastatic Renal Cancer: a Law of Diminishing Returns Clinical Genitourinary Cancer. Jun, 2012 | Pubmed ID: 22608779 Whole Blood Stem Cell Re-infusion and Escalated Dose Melphalan in Castration-resistant Prostate Cancer: a Phase 1 Study Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Mar, 2012 | Pubmed ID: 22392912 Sequential Therapy in Metastatic Renal Cell Carcinoma: What Comes Next? Medical Oncology (Northwood, London, England). Sep, 2012 | Pubmed ID: 21964814 Is High Dose Therapy Superior to Conventional Dose Therapy As Initial Treatment for Relapsed Germ Cell Tumors? The TIGER Trial Journal of Cancer. 2011 | Pubmed ID: 21750688 Sequential FDG-PET/CT As a Biomarker of Response to Sunitinib in Metastatic Clear Cell Renal Cancer Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Sep, 2011 | Pubmed ID: 21742806 The Outcome of Patients Treated with Sunitinib Prior to Planned Nephrectomy in Metastatic Clear Cell Renal Cancer European Urology. Sep, 2011 | Pubmed ID: 21612860 Stage I Nonseminomatous Germ Cell Tumor of the Testis: More Questions Than Answers? Hematology/oncology Clinics of North America. Jun, 2011 | Pubmed ID: 21570606 What Can Molecular Pathology Contribute to the Management of Renal Cell Carcinoma? Nature Reviews. Urology. May, 2011 | Pubmed ID: 21487387 Conventional-dose Versus High-dose Chemotherapy As First Salvage Treatment in Male Patients with Metastatic Germ Cell Tumors: Evidence from a Large International Database Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Jun, 2011 | Pubmed ID: 21444870 Efficacy and Toxicity of Sunitinib in Patients with Metastatic Renal Cell Carcinoma with Severe Renal Impairment or on Haemodialysis BJU International. Oct, 2011 | Pubmed ID: 21244613 The Effect of Sunitinib on Immune Subsets in Metastatic Clear Cell Renal Cancer Urologia Internationalis. 2011 | Pubmed ID: 20975250 Castration Refractory Prostate Cancer: Cinderella Finally Comes to the Ball Onkologie. 2010 | Pubmed ID: 21124035 Prognostic Factors in Patients with Metastatic Germ Cell Tumors Who Experienced Treatment Failure with Cisplatin-based First-line Chemotherapy Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Nov, 2010 | Pubmed ID: 20956623 A Synergistic Interaction Between Lapatinib and Chemotherapy Agents in a Panel of Cell Lines is Due to the Inhibition of the Efflux Pump BCRP Molecular Cancer Therapeutics. Dec, 2010 | Pubmed ID: 20889729 Integrating Surgery with Targeted Therapies for Renal Cell Carcinoma: Current Evidence and Ongoing Trials European Urology. Dec, 2010 | Pubmed ID: 20828919 Elevated LDH Predicts Poor Outcome of Recurrent Germ Cell Tumours Treated with Dose Dense Chemotherapy European Journal of Cancer (Oxford, England : 1990). Nov, 2010 | Pubmed ID: 20709529 The Application of the National Institute of Clinical Excellence Guidelines for Treatment of Metastatic Renal Cell Carcinoma in the United Kingdom: Friend or Foe? BJU International. Aug, 2010 | Pubmed ID: 20576026 A Validated Prognostic Index Predicting Response to Dexamethasone and Diethylstilbestrol in Castrate-resistant Prostate Cancer Cancer. Aug, 2010 | Pubmed ID: 20564115 The Association of CCND1 Overexpression and Cisplatin Resistance in Testicular Germ Cell Tumors and Other Cancers The American Journal of Pathology. Jun, 2010 | Pubmed ID: 20395447 Amplification of Epidermal Growth Factor Receptor Gene in Renal Cell Carcinoma European Journal of Cancer (Oxford, England : 1990). Mar, 2010 | Pubmed ID: 20167476 The Relative Activity of Cisplatin, Oxaliplatin and Satraplatin in Testicular Germ Cell Tumour Sensitive and Resistant Cell Lines Cancer Chemotherapy and Pharmacology. Oct, 2009 | Pubmed ID: 19263053 Highly Active Antiretroviral Therapy and the Incidence of Non-AIDS-defining Cancers in People with HIV Infection Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Feb, 2009 | Pubmed ID: 19114688 The Efficacy and Safety of Weekly Vinorelbine in Relapsed Malignant Pleural Mesothelioma Lung Cancer (Amsterdam, Netherlands). Jan, 2009 | Pubmed ID: 18486273 The Efficacy and Safety of Irinotecan Cisplatin and Mitomycin Chemotherapy in Sunitinib Pre-treated Metastatic Clear Cell Renal Cancer OncoTargets and Therapy. 2008 | Pubmed ID: 21127750 Smoke and Mirrors: HIV-related Lung Cancer Current Opinion in Oncology. Sep, 2008 | Pubmed ID: 19106655 Human Immunodeficiency Virus--associated Renal Cell Carcinoma: a Transatlantic Case Series Clinical Genitourinary Cancer. Sep, 2008 | Pubmed ID: 18824430 Enhancing the in Vitro Cytotoxic Activity of Delta9-tetrahydrocannabinol in Leukemic Cells Through a Combinatorial Approach Leukemia & Lymphoma. Sep, 2008 | Pubmed ID: 18608861 Hepatocellular Carcinoma, Human Immunodeficiency Virus and Viral Hepatitis in the HAART Era World Journal of Gastroenterology : WJG. Mar, 2008 | Pubmed ID: 18350596 Novel Agents for Muscle-invasive and Advanced Urothelial Cancer BJU International. Apr, 2008 | Pubmed ID: 18005203 Malignant Germ Cell Tumours in the Elderly: a Histopathological Review of 50 Cases in Men Aged 60 Years or Over Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc. Jan, 2008 | Pubmed ID: 17975539 Prostate Cancer in HIV-positive Individuals: What We Know and What We Don't Journal of HIV Therapy. Sep, 2007 | Pubmed ID: 17962795 HIV-associated Castleman's Disease: from Case Reports to Evidence Journal of HIV Therapy. Sep, 2007 | Pubmed ID: 17962792 Germ-cell Tumors The New England Journal of Medicine. Oct, 2007 | Pubmed ID: 17960020 Neoadjuvant Therapy Followed by Prostatectomy for Clinically Localized Prostate Cancer Cancer. Dec, 2007 | Pubmed ID: 17941029 A Comparison of the Platinum Analogues in Bladder Cancer Cell Lines Urologia Internationalis. 2007 | Pubmed ID: 17627172 Does PET Imaging Have a Role in Renal Cancers After All? The Lancet Oncology. Apr, 2007 | Pubmed ID: 17395099 Non-AIDS-defining Cancers in People with HIV Infection: a Sleeping Giant? Journal of HIV Therapy. Sep, 2006 | Pubmed ID: 17580500 Hepatocellular Cancer in HIV-infected Individuals: Tomorrow's Problem? Expert Review of Anticancer Therapy. Nov, 2006 | Pubmed ID: 17134360 The Changing Presentation of Germ Cell Tumours of the Testis Between 1983 and 2002 BJU International. Jun, 2005 | Pubmed ID: 15892800 Antiapoptotic Effect of Growth Factors in Leukemia Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Jan, 2005 | Pubmed ID: 15659515 Cannabis-induced Cytotoxicity in Leukemic Cell Lines: the Role of the Cannabinoid Receptors and the MAPK Pathway Blood. Feb, 2005 | Pubmed ID: 15454482 HIV and the Risk of Lung Cancer Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Apr, 2004 | Pubmed ID: 15051794 Erythropoietin to Treat Anaemia in Patients with Head and Neck Cancer Lancet. Jan, 2004 | Pubmed ID: 14724015 Effect of Haemopoietic Growth Factors on Cancer Cell Lines and Their Role in Chemosensitivity Oncogene. Jan, 2004 | Pubmed ID: 14647427 Bireysel Renal Hücreli Kanserlerde içinde Protein Ekspresyonu Varyasyon kaynakları için Ters Faz Protein Diziler (RPPA) ve Kullanımı Fiach C. O'Mahony1, Jyoti Nanda1, Alexander Laird1, Peter Mullen2, Helen Caldwell3, Ian M. Overton4, Lel Eory4, Marie O'Donnell1,5, Dana Faratian6, Thomas Powles7, David J. Harrison1,2, Grant D. Stewart1 1Edinburgh Urological Cancer Group, University of Edinburgh, 2School of Medicine, University of St Andrews, 3Division of Pathology, University of Edinburgh, 4MRC Human Genetics Unit, MRC IGMM, University of Edinburgh, 5Department of Pathology, Western General Hospital, 6Breakthrough Breast Cancer Research Unit, University of Edinburgh, 7St Bartholomew's Cancer Institute, Experimental Cancer Medicine Centre, Queen Mary University of London JoVE 50221 Medicine
Bireysel Renal Hücreli Kanserlerde içinde Protein Ekspresyonu Varyasyon kaynakları için Ters Faz Protein Diziler (RPPA) ve Kullanımı Fiach C. O'Mahony1, Jyoti Nanda1, Alexander Laird1, Peter Mullen2, Helen Caldwell3, Ian M. Overton4, Lel Eory4, Marie O'Donnell1,5, Dana Faratian6, Thomas Powles7, David J. Harrison1,2, Grant D. Stewart1 1Edinburgh Urological Cancer Group, University of Edinburgh, 2School of Medicine, University of St Andrews, 3Division of Pathology, University of Edinburgh, 4MRC Human Genetics Unit, MRC IGMM, University of Edinburgh, 5Department of Pathology, Western General Hospital, 6Breakthrough Breast Cancer Research Unit, University of Edinburgh, 7St Bartholomew's Cancer Institute, Experimental Cancer Medicine Centre, Queen Mary University of London JoVE 50221 Medicine