Tobias Madl

Publications

• P53 Transactivation Domain Mediates Binding and Phase Separation with Poly-PR/GR
  International Journal of Molecular Sciences. Oct, 2021  |   Pubmed ID: 34768862
• XIAP Restrains TNF-driven Intestinal Inflammation and Dysbiosis by Promoting Innate Immune Responses of Paneth and Dendritic Cells
  Science Immunology. 11, 2021  |   Pubmed ID: 34739338
• Phosphorylation Regulates CIRBP Arginine Methylation, Transportin-1 Binding and Liquid-Liquid Phase Separation
  Frontiers in Molecular Biosciences. 2021  |   Pubmed ID: 34738012
• Intracellular Drug Binding Affinities by NMR
  Acta Crystallographica. Section D, Structural Biology. Oct, 2021  |   Pubmed ID: 34605425
• Branched-Chain Amino Acids Can Predict Mortality in ICU Sepsis Patients
  Nutrients. Sep, 2021  |   Pubmed ID: 34578983
• Reduced B12 Uptake and Increased Gastrointestinal Formate Are Associated with Archaeome-mediated Breath Methane Emission in Humans
  Microbiome. 09, 2021  |   Pubmed ID: 34560884
• Structural and DNA-binding Properties of the Cytoplasmic Domain of Vibrio Cholerae Transcription Factor ToxR
  The Journal of Biological Chemistry. 10, 2021  |   Pubmed ID: 34487759
• Metabolic Profiling Links Cardiovascular Risk and Vascular End Organ Damage
  Atherosclerosis. 08, 2021  |   Pubmed ID: 34344526
• Multiple Regulatory Intrinsically Disordered Motifs Control FOXO4 Transcription Factor Binding and Function
  Cell Reports. Jul, 2021  |   Pubmed ID: 34320339
• Wide-Range, Rapid, and Specific Identification of Pathogenic Bacteria by Surface-Enhanced Raman Spectroscopy
  ACS Sensors. 08, 2021  |   Pubmed ID: 34282892
• ATP Regulates RNA-driven Cold Inducible RNA Binding Protein Phase Separation
  Protein Science : a Publication of the Protein Society. 07, 2021  |   Pubmed ID: 33991007
• Growing Human Hepatocellular Tumors Undergo a Global Metabolic Reprogramming
  Cancers. Apr, 2021  |   Pubmed ID: 33924061
• Potassium Ions Promote Hexokinase-II Dependent Glycolysis
  IScience. Apr, 2021  |   Pubmed ID: 33870140
• NLRP3 As a Sensor of Metabolism Gone Awry
  Current Opinion in Biotechnology. 04, 2021  |   Pubmed ID: 33862489
• Dietary Spermidine Improves Cognitive Function
  Cell Reports. 04, 2021  |   Pubmed ID: 33852843
• Lysophosphatidic Acid Induces Aerobic Glycolysis, Lipogenesis, and Increased Amino Acid Uptake in BV-2 Microglia
  International Journal of Molecular Sciences. Feb, 2021  |   Pubmed ID: 33671212
• Metabolic, Phenotypic, and Neuropathological Characterization of the Tg4-42 Mouse Model for Alzheimer's Disease
  Journal of Alzheimer's Disease : JAD. 2021  |   Pubmed ID: 33646155
• Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy (4th Edition)
  Autophagy. Feb, 2021  |   Pubmed ID: 33634751
• Tissue-Specific Landscape of Metabolic Dysregulation During Ageing
  Biomolecules. 02, 2021  |   Pubmed ID: 33562384
• Endothelial Lipase Modulates Paraoxonase 1 Content and Arylesterase Activity of HDL
  International Journal of Molecular Sciences. Jan, 2021  |   Pubmed ID: 33450841
• Imbalances in the Eye Lens Proteome Are Linked to Cataract Formation
  Nature Structural & Molecular Biology. 02, 2021  |   Pubmed ID: 33432246
• β-catenin Regulates FOXP2 Transcriptional Activity Via Multiple Binding Sites
  The FEBS Journal. 05, 2021  |   Pubmed ID: 33284517
• Nuclear Import Receptors Directly Bind to Arginine-Rich Dipeptide Repeat Proteins and Suppress Their Pathological Interactions
  Cell Reports. 12, 2020  |   Pubmed ID: 33357437
• Metabolic Reprogramming of Donor T Cells Enhances Graft-versus-leukemia Effects in Mice and Humans
  Science Translational Medicine. 10, 2020  |   Pubmed ID: 33115954
• Dipeptidyl Peptidase 3 Modulates the Renin-angiotensin System in Mice
  The Journal of Biological Chemistry. 10, 2020  |   Pubmed ID: 32546481
• Human Milk Oligosaccharides Modulate the Risk for Preterm Birth in a Microbiome-Dependent and -Independent Manner
  MSystems. Jun, 2020  |   Pubmed ID: 32518196
• Transgene Integration Causes RARB Downregulation in Homozygous Tg4-42 Mice
  Scientific Reports. 04, 2020  |   Pubmed ID: 32286473
• Nonclassical Nuclear Localization Signals Mediate Nuclear Import of CIRBP
  Proceedings of the National Academy of Sciences of the United States of America. 04, 2020  |   Pubmed ID: 32234784
• Probing Surfaces in Dynamic Protein Interactions
  Journal of Molecular Biology. 04, 2020  |   Pubmed ID: 32135192
• Structure of an RNA Aptamer in Complex with the Fluorophore Tetramethylrhodamine
  Nucleic Acids Research. 01, 2020  |   Pubmed ID: 31754719
• A Small Molecule Chaperone Rescues the Stability and Activity of a Cancer-associated Variant of NAD(P)H:quinone Oxidoreductase 1 In vitro
  FEBS Letters. 02, 2020  |   Pubmed ID: 31605637
• Cysteine Oxidation Triggers Amyloid Fibril Formation of the Tumor Suppressor P16
  Redox Biology. 01, 2020  |   Pubmed ID: 31539802
• Low Cardiac Lipolysis Reduces Mitochondrial Fission and Prevents Lipotoxic Heart Dysfunction in Perilipin 5 Mutant Mice
  Cardiovascular Research. 02, 2020  |   Pubmed ID: 31166588
• Presenilin-1 Established ER-Ca Leak: a Follow Up on Its Importance for the Initial Insulin Secretion in Pancreatic Islets and β-Cells Upon Elevated Glucose
  Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 2019  |   Pubmed ID: 31529929
• Alternate Day Fasting Improves Physiological and Molecular Markers of Aging in Healthy, Non-obese Humans
  Cell Metabolism. 09, 2019  |   Pubmed ID: 31471173
• NMR Characterization of Solvent Accessibility and Transient Structure in Intrinsically Disordered Proteins
  Journal of Biomolecular NMR. Jul, 2019  |   Pubmed ID: 31297688
• Endothelial Lipase Increases Antioxidative Capacity of High-density Lipoprotein
  Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids. 10, 2019  |   Pubmed ID: 31220617
• Acetyl-CoA Carboxylase 1-dependent Lipogenesis Promotes Autophagy Downstream of AMPK
  The Journal of Biological Chemistry. 08, 2019  |   Pubmed ID: 31209110
• Serum Concentrations of Citrate, Tyrosine, 2- and 3- Hydroxybutyrate Are Associated with Increased 3-Month Mortality in Acute Heart Failure Patients
  Scientific Reports. 05, 2019  |   Pubmed ID: 31043697
• Increased Aggregation Tendency of Alpha-Synuclein in a Fully Disordered Protein Complex
  Journal of Molecular Biology. 06, 2019  |   Pubmed ID: 31034892
• Impaired Retinal Vessel Dilation Predicts Mortality in End-Stage Renal Disease
  Circulation Research. Apr, 2019  |   Pubmed ID: 30929571
• The Co-chaperone Cns1 and the Recruiter Protein Hgh1 Link Hsp90 to Translation Elongation Via Chaperoning Elongation Factor 2
  Molecular Cell. 04, 2019  |   Pubmed ID: 30876805
• PH-Lemon, a Fluorescent Protein-Based PH Reporter for Acidic Compartments
  ACS Sensors. 04, 2019  |   Pubmed ID: 30864782
• Glycogen Synthase Kinase 3 Beta Controls Presenilin-1-Mediated Endoplasmic Reticulum Ca²⁺ Leak Directed to Mitochondria in Pancreatic Islets and β-Cells
  Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 2019  |   Pubmed ID: 30790505
• A Single Alcohol Binge Impacts on Neutrophil Function Without Changes in Gut Barrier Function and Gut Microbiome Composition in Healthy Volunteers
  PloS One. 2019  |   Pubmed ID: 30707717
• N-acetylaspartate Pathway is Nutrient Responsive and Coordinates Lipid and Energy Metabolism in Brown Adipocytes
  Biochimica Et Biophysica Acta. Molecular Cell Research. 03, 2019  |   Pubmed ID: 30595160
• Enhanced Inter-compartmental Ca Flux Modulates Mitochondrial Metabolism and Apoptotic Threshold During Aging
  Redox Biology. 01, 2019  |   Pubmed ID: 30458321
• Oxidative Stress-induced Structural Changes in the Microtubule-associated Flavoenzyme Irc15p from Saccharomyces Cerevisiae
  Protein Science : a Publication of the Protein Society. 01, 2019  |   Pubmed ID: 30267443
• Saxagliptin but Not Sitagliptin Inhibits CaMKII and PKC Via DPP9 Inhibition in Cardiomyocytes
  Frontiers in Physiology. 2018  |   Pubmed ID: 30487758
• NMR Spectroscopy Enables Simultaneous Quantification of Carbohydrates for Diagnosis of Intestinal and Gastric Permeability
  Scientific Reports. 10, 2018  |   Pubmed ID: 30279548
• Cytosolic Aspartate Availability Determines Cell Survival When Glutamine Is Limiting
  Cell Metabolism. 11, 2018  |   Pubmed ID: 30122555
• The Neuronal S100B Protein is a Calcium-tuned Suppressor of Amyloid-β Aggregation
  Science Advances. 06, 2018  |   Pubmed ID: 29963623
• Acetate-free, Citrate-acidified Bicarbonate Dialysis Improves Serum Calcification Propensity-a Preliminary Study
  Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association. 11, 2018  |   Pubmed ID: 29860419
• Lysyl Oxidase-like Protein 2 (LOXL2) Modulates Barrier Function in Cholangiocytes in Cholestasis
  Journal of Hepatology. 08, 2018  |   Pubmed ID: 29709678
• Regulation of Cellular Senescence Via the FOXO4-p53 Axis
  FEBS Letters. 06, 2018  |   Pubmed ID: 29683489
• Phase Separation of FUS Is Suppressed by Its Nuclear Import Receptor and Arginine Methylation
  Cell. 04, 2018  |   Pubmed ID: 29677514
• A Switch Point in the Molecular Chaperone Hsp90 Responding to Client Interaction
  Nature Communications. 04, 2018  |   Pubmed ID: 29662162
• Novel Genetically Encoded Fluorescent Probes Enable Real-time Detection of Potassium in Vitro and in Vivo
  Nature Communications. 11, 2017  |   Pubmed ID: 29127288
• Integrative Metabolomics As Emerging Tool to Study Autophagy Regulation
  Microbial Cell (Graz, Austria). Jul, 2017  |   Pubmed ID: 28845422
• Patchy Proteins Form a Perfect Lens
  Science (New York, N.Y.). 08, 2017  |   Pubmed ID: 28798115
• Characterization of Protein-Protein Interfaces in Large Complexes by Solid-State NMR Solvent Paramagnetic Relaxation Enhancements
  Journal of the American Chemical Society. 09, 2017  |   Pubmed ID: 28780861
• RNA Structure Refinement Using NMR Solvent Accessibility Data
  Scientific Reports. 07, 2017  |   Pubmed ID: 28710477
• Flexible IgE Epitope-containing Domains of Phl P 5 Cause High Allergenic Activity
  The Journal of Allergy and Clinical Immunology. 10, 2017  |   Pubmed ID: 28532654
• Transient Helicity in Intrinsically Disordered Axin-1 Studied by NMR Spectroscopy and Molecular Dynamics Simulations
  PloS One. 2017  |   Pubmed ID: 28355271
• Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging
  Cell. 03, 2017  |   Pubmed ID: 28340339
• The Redox Environment Triggers Conformational Changes and Aggregation of HIAPP in Type II Diabetes
  Scientific Reports. 03, 2017  |   Pubmed ID: 28287098
• Allosteric Modulation of Peroxisomal Membrane Protein Recognition by Farnesylation of the Peroxisomal Import Receptor PEX19
  Nature Communications. 03, 2017  |   Pubmed ID: 28281558
• Long-range Allosteric Signaling in Red Light-regulated Diguanylyl Cyclases
  Science Advances. Mar, 2017  |   Pubmed ID: 28275738
• Catalytic Competence, Structure and Stability of the Cancer-associated R139W Variant of the Human NAD(P)H:quinone Oxidoreductase 1 (NQO1)
  The FEBS Journal. 04, 2017  |   Pubmed ID: 28236663
• Increasing the Chemical-Shift Dispersion of Unstructured Proteins with a Covalent Lanthanide Shift Reagent
  Angewandte Chemie (International Ed. in English). 11, 2016  |   Pubmed ID: 27763708
• Importance of Cycle Timing for the Function of the Molecular Chaperone Hsp90
  Nature Structural & Molecular Biology. Nov, 2016  |   Pubmed ID: 27723736
• Crystal and Solution Structural Studies of Mouse Phospholipid Hydroperoxide Glutathione Peroxidase 4
  Acta Crystallographica. Section F, Structural Biology Communications. 10, 2016  |   Pubmed ID: 27710939
• PRMT1-mediated Methylation of MICU1 Determines the UCP2/3 Dependency of Mitochondrial Ca(2+) Uptake in Immortalized Cells
  Nature Communications. Sep, 2016  |   Pubmed ID: 27642082
• Prediction of Protein Structure Using Surface Accessibility Data
  Angewandte Chemie (International Ed. in English). 09, 2016  |   Pubmed ID: 27560616
• Lysosomal Acid Lipase Regulates VLDL Synthesis and Insulin Sensitivity in Mice
  Diabetologia. Aug, 2016  |   Pubmed ID: 27153842
• Axin Cancer Mutants Form Nanoaggregates to Rewire the Wnt Signaling Network
  Nature Structural & Molecular Biology. Apr, 2016  |   Pubmed ID: 26974125
• Monomethylated and Unmethylated FUS Exhibit Increased Binding to Transportin and Distinguish FTLD-FUS from ALS-FUS
  Acta Neuropathologica. Apr, 2016  |   Pubmed ID: 26895297
• Structural Basis of Nucleic-acid Recognition and Double-strand Unwinding by the Essential Neuronal Protein Pur-alpha
  ELife. Jan, 2016  |   Pubmed ID: 26744780
• The Activity of Protein Phosphatase 5 Towards Native Clients is Modulated by the Middle- and C-terminal Domains of Hsp90
  Scientific Reports. Nov, 2015  |   Pubmed ID: 26593036
• Optimization of Lipid Production with a Genome-scale Model of Yarrowia Lipolytica
  BMC Systems Biology. Oct, 2015  |   Pubmed ID: 26503450
• The Solution Structure of the Lantibiotic Immunity Protein NisI and Its Interactions with Nisin
  The Journal of Biological Chemistry. Nov, 2015  |   Pubmed ID: 26459561
• Type-II NADH:quinone Oxidoreductase from Staphylococcus Aureus Has Two Distinct Binding Sites and is Rate Limited by Quinone Reduction
  Molecular Microbiology. Oct, 2015  |   Pubmed ID: 26172206
• Hsp90 Regulates the Dynamics of Its Cochaperone Sti1 and the Transfer of Hsp70 Between Modules
  Nature Communications. Apr, 2015  |   Pubmed ID: 25851214
• Introduction of Germline Residues Improves the Stability of Anti-HIV MAb 2G12-IgM
  Biochimica Et Biophysica Acta. Oct, 2015  |   Pubmed ID: 25748881
• AAA+ Chaperones and Acyldepsipeptides Activate the ClpP Protease Via Conformational Control
  Nature Communications. Feb, 2015  |   Pubmed ID: 25695750
• A Compact Native 24-residue Supersecondary Structure Derived from the Villin Headpiece Subdomain
  Biophysical Journal. Feb, 2015  |   Pubmed ID: 25650934
• Hop/Sti1 Phosphorylation Inhibits Its Co-chaperone Function
  EMBO Reports. Feb, 2015  |   Pubmed ID: 25504578