Tobias Moser InnerEarLab, Department of Otolaryngology University Medical Center Goettingen Biography Publications Institution JoVE Articles Tobias Moser has not added a biography. If you are Tobias Moser and would like to personalize this page please email our Author Liaison for assistance. Publications Uniquantal Release Through a Dynamic Fusion Pore Is a Candidate Mechanism of Hair Cell Exocytosis Neuron. Sep, 2014 | Pubmed ID: 25199706 A New Probe for Super-resolution Imaging of Membranes Elucidates Trafficking Pathways The Journal of Cell Biology. May, 2014 | Pubmed ID: 24862576 ATP Hydrolysis is Critically Required for Function of CaV1.3 Channels in Cochlear Inner Hair Cells Via Fueling Ca2+ Clearance The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. May, 2014 | Pubmed ID: 24828638 Optogenetic Stimulation of the Auditory Pathway The Journal of Clinical Investigation. Mar, 2014 | Pubmed ID: 24509078 Bassoon-disruption Slows Vesicle Replenishment and Induces Homeostatic Plasticity at a CNS Synapse The EMBO Journal. Mar, 2014 | Pubmed ID: 24442636 Developmental Refinement of Hair Cell Synapses Tightens the Coupling of Ca2+ Influx to Exocytosis The EMBO Journal. Feb, 2014 | Pubmed ID: 24442635 Modes and Regulation of Endocytic Membrane Retrieval in Mouse Auditory Hair Cells The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jan, 2014 | Pubmed ID: 24431429 Concurrent Maturation of Inner Hair Cell Synaptic Ca2+ Influx and Auditory Nerve Spontaneous Activity Around Hearing Onset in Mice The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jun, 2013 | Pubmed ID: 23804089 Review of Hair Cell Synapse Defects in Sensorineural Hearing Impairment Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology. Aug, 2013 | Pubmed ID: 23628789 Harmonin Enhances Voltage-dependent Facilitation of Cav1.3 Channels and Synchronous Exocytosis in Mouse Inner Hair Cells The Journal of Physiology. Jul, 2013 | Pubmed ID: 23613530 Disruption of the Presynaptic Cytomatrix Protein Bassoon Degrades Ribbon Anchorage, Multiquantal Release, and Sound Encoding at the Hair Cell Afferent Synapse The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Mar, 2013 | Pubmed ID: 23467361 Ephrin-A5/EphA4 Signalling Controls Specific Afferent Targeting to Cochlear Hair Cells Nature Communications. 2013 | Pubmed ID: 23385583 A Critical Role for the Cholesterol-associated Proteolipids PLP and M6B in Myelination of the Central Nervous System Glia. Apr, 2013 | Pubmed ID: 23322581 A Mutation in PNPT1, Encoding Mitochondrial-RNA-Import Protein PNPase, Causes Hereditary Hearing Loss American Journal of Human Genetics. Nov, 2012 | Pubmed ID: 23084290 A Mutation in CABP2, Expressed in Cochlear Hair Cells, Causes Autosomal-recessive Hearing Impairment American Journal of Human Genetics. Oct, 2012 | Pubmed ID: 22981119 Otoferlin: a Multi-C2 Domain Protein Essential for Hearing Trends in Neurosciences. Nov, 2012 | Pubmed ID: 22959777 Deletion of the Presynaptic Scaffold CAST Reduces Active Zone Size in Rod Photoreceptors and Impairs Visual Processing The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Aug, 2012 | Pubmed ID: 22933801 The Mechanosensory Structure of the Hair Cell Requires Clarin-1, a Protein Encoded by Usher Syndrome III Causative Gene The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jul, 2012 | Pubmed ID: 22787034 Spike Encoding of Neurotransmitter Release Timing by Spiral Ganglion Neurons of the Cochlea The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Apr, 2012 | Pubmed ID: 22492033 Harmonin Inhibits Presynaptic Cav1.3 Ca²⁺ Channels in Mouse Inner Hair Cells Nature Neuroscience. Sep, 2011 | Pubmed ID: 21822269 Connexin32 Can Restore Hearing in Connexin26 Deficient Mice European Journal of Cell Biology. Oct, 2011 | Pubmed ID: 21813206 A Synthetic Prestin Reveals Protein Domains and Molecular Operation of Outer Hair Cell Piezoelectricity The EMBO Journal. Jul, 2011 | Pubmed ID: 21701557 Probing the Functional Equivalence of Otoferlin and Synaptotagmin 1 in Exocytosis The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Mar, 2011 | Pubmed ID: 21451027 Exocytosis at the Hair Cell Ribbon Synapse Apparently Operates Without Neuronal SNARE Proteins Nature Neuroscience. Apr, 2011 | Pubmed ID: 21378973 Neuroligin-4 is Localized to Glycinergic Postsynapses and Regulates Inhibition in the Retina Proceedings of the National Academy of Sciences of the United States of America. Feb, 2011 | Pubmed ID: 21282647 The Crystal Structure of the C₂A Domain of Otoferlin Reveals an Unconventional Top Loop Region Journal of Molecular Biology. Feb, 2011 | Pubmed ID: 21216247 The Connexin26 S17F Mouse Mutant Represents a Model for the Human Hereditary Keratitis-ichthyosis-deafness Syndrome Human Molecular Genetics. Jan, 2011 | Pubmed ID: 20926451 Bassoon and the Synaptic Ribbon Organize Ca²+ Channels and Vesicles to Add Release Sites and Promote Refilling Neuron. Nov, 2010 | Pubmed ID: 21092861 Structure and Function of Cochlear Afferent Innervation Current Opinion in Otolaryngology & Head and Neck Surgery. Oct, 2010 | Pubmed ID: 20802334 A Missense Mutation in a Highly Conserved Alternate Exon of Dynamin-1 Causes Epilepsy in Fitful Mice PLoS Genetics. Aug, 2010 | Pubmed ID: 20700442 Hearing Requires Otoferlin-dependent Efficient Replenishment of Synaptic Vesicles in Hair Cells Nature Neuroscience. Jul, 2010 | Pubmed ID: 20562868 Onset Coding is Degraded in Auditory Nerve Fibers from Mutant Mice Lacking Synaptic Ribbons The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jun, 2010 | Pubmed ID: 20519533 Functional Properties of Synaptic Transmission in Primary Sense Organs The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Oct, 2009 | Pubmed ID: 19828792 The Ca2+ Channel Subunit Beta2 Regulates Ca2+ Channel Abundance and Function in Inner Hair Cells and is Required for Hearing The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Aug, 2009 | Pubmed ID: 19710324 Neuroligin 2 Controls the Maturation of GABAergic Synapses and Information Processing in the Retina The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jun, 2009 | Pubmed ID: 19553444 Complexin-I is Required for High-fidelity Transmission at the Endbulb of Held Auditory Synapse The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jun, 2009 | Pubmed ID: 19553439 Does a Single Session of Theta-burst Transcranial Magnetic Stimulation of Inferior Temporal Cortex Affect Tinnitus Perception? BMC Neuroscience. 2009 | Pubmed ID: 19480651 Tuning of Synapse Number, Structure and Function in the Cochlea Nature Neuroscience. Apr, 2009 | Pubmed ID: 19270686 Mechanisms Contributing to Synaptic Ca2+ Signals and Their Heterogeneity in Hair Cells Proceedings of the National Academy of Sciences of the United States of America. Mar, 2009 | Pubmed ID: 19246382 Impairment of SLC17A8 Encoding Vesicular Glutamate Transporter-3, VGLUT3, Underlies Nonsyndromic Deafness DFNA25 and Inner Hair Cell Dysfunction in Null Mice American Journal of Human Genetics. Aug, 2008 | Pubmed ID: 18674745 Probing the Mechanism of Exocytosis at the Hair Cell Ribbon Synapse The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Nov, 2007 | Pubmed ID: 18032667 Ca2+-binding Proteins Tune Ca2+-feedback to Cav1.3 Channels in Mouse Auditory Hair Cells The Journal of Physiology. Dec, 2007 | Pubmed ID: 17947313 Maturation of Ribbon Synapses in Hair Cells is Driven by Thyroid Hormone The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Mar, 2007 | Pubmed ID: 17376978 Measurements of Membrane Patch Capacitance Using a Software-based Lock-in System Pflügers Archiv : European Journal of Physiology. May, 2007 | Pubmed ID: 17206448 Intracavity Generation of Radially Polarized CO2 Laser Beams Based on a Simple Binary Dielectric Diffraction Grating Applied Optics. Nov, 2006 | Pubmed ID: 17086263 Otoferlin, Defective in a Human Deafness Form, is Essential for Exocytosis at the Auditory Ribbon Synapse Cell. Oct, 2006 | Pubmed ID: 17055430 [Hearing Loss -- Can Heat Shock Protein 70 Be Cited As Prognostic Marker?] Laryngo- Rhino- Otologie. Oct, 2006 | Pubmed ID: 17031759 Hair Cell Ribbon Synapses Cell and Tissue Research. Nov, 2006 | Pubmed ID: 16944206 Mechanisms Underlying the Temporal Precision of Sound Coding at the Inner Hair Cell Ribbon Synapse The Journal of Physiology. Oct, 2006 | Pubmed ID: 16901948 CSPalpha-deficiency Causes Massive and Rapid Photoreceptor Degeneration Proceedings of the National Academy of Sciences of the United States of America. Feb, 2006 | Pubmed ID: 16477021 Mice with Altered KCNQ4 K+ Channels Implicate Sensory Outer Hair Cells in Human Progressive Deafness The EMBO Journal. Feb, 2006 | Pubmed ID: 16437162 Expression Pattern and Functional Characterization of Connexin29 in Transgenic Mice Glia. Apr, 2006 | Pubmed ID: 16435366 Few CaV1.3 Channels Regulate the Exocytosis of a Synaptic Vesicle at the Hair Cell Ribbon Synapse The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Dec, 2005 | Pubmed ID: 16354915 Hair Cell Synaptic Ribbons Are Essential for Synchronous Auditory Signalling Nature. Apr, 2005 | Pubmed ID: 15829963 BetaIVSigma1 Spectrin Stabilizes the Nodes of Ranvier and Axon Initial Segments The Journal of Cell Biology. Sep, 2004 | Pubmed ID: 15381686 CaV1.3 Channels Are Essential for Development and Presynaptic Activity of Cochlear Inner Hair Cells The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Nov, 2003 | Pubmed ID: 14645476 The Afferent Synapse of Cochlear Hair Cells Current Opinion in Neurobiology. Aug, 2003 | Pubmed ID: 12965293 Calcium Regulates Exocytosis at the Level of Single Vesicles Nature Neuroscience. Aug, 2003 | Pubmed ID: 12845327 LIMP-2/LGP85 Deficiency Causes Ureteric Pelvic Junction Obstruction, Deafness and Peripheral Neuropathy in Mice Human Molecular Genetics. Mar, 2003 | Pubmed ID: 12620969 تحفيز Optogenetic من العصب السمعي Victor H. Hernandez1,2,5, Anna Gehrt1,3, Zhizi Jing3, Gerhard Hoch1, Marcus Jeschke1, Nicola Strenzke3, Tobias Moser1,2,4 1InnerEarLab, Department of Otolaryngology, University Medical Center Goettingen, 2Bernstein Focus for Neurotechnology, University of Goettingen, 3Auditory Systems Physiology Group, Department of Otolaryngology, University Medical Center Goettingen, 4Center for Nanoscale Microscopy and Molecular Physiology of the Brain, University of Goettingen, 5Department of Chemical, Electronic, and Biomedical Engineering, University of Guanajuato JoVE 52069 Neuroscience
تحفيز Optogenetic من العصب السمعي Victor H. Hernandez1,2,5, Anna Gehrt1,3, Zhizi Jing3, Gerhard Hoch1, Marcus Jeschke1, Nicola Strenzke3, Tobias Moser1,2,4 1InnerEarLab, Department of Otolaryngology, University Medical Center Goettingen, 2Bernstein Focus for Neurotechnology, University of Goettingen, 3Auditory Systems Physiology Group, Department of Otolaryngology, University Medical Center Goettingen, 4Center for Nanoscale Microscopy and Molecular Physiology of the Brain, University of Goettingen, 5Department of Chemical, Electronic, and Biomedical Engineering, University of Guanajuato JoVE 52069 Neuroscience
