Torben Heick Jensen Department of Molecular Biology and Genetics Aarhus University Biography Publications Institution JoVE Articles Torben Heick Jensen has not added a biography. If you are Torben Heick Jensen and would like to personalize this page please email our Author Liaison for assistance. Publications A Two-Layered Targeting Mechanism Underlies Nuclear RNA Sorting by the Human Exosome Cell Reports. Feb, 2020 | Pubmed ID: 32075771 The Human ZC3H3 and RBM26/27 Proteins Are Critical for PAXT-mediated Nuclear RNA Decay Nucleic Acids Research. 03, 2020 | Pubmed ID: 31950173 Global Identification of Human Exosome Substrates Using RNA Interference and RNA Sequencing Methods in Molecular Biology (Clifton, N.J.). 2020 | Pubmed ID: 31768975 Nuclear Sorting of RNA Wiley Interdisciplinary Reviews. RNA. Mar, 2020 | Pubmed ID: 31713323 The Nuclear RNA Exosome and Its Cofactors Advances in Experimental Medicine and Biology. 2019 | Pubmed ID: 31811632 A Functional Link Between Nuclear RNA Decay and Transcriptional Control Mediated by the Polycomb Repressive Complex 2 Cell Reports. Nov, 2019 | Pubmed ID: 31722198 The Long Noncoding RNA is Seemingly Dispensable for Normal Tissue Homeostasis and Cancer Cell Growth RNA (New York, N.Y.). 12, 2019 | Pubmed ID: 31551298 The MTR4 Helicase Recruits Nuclear Adaptors of the Human RNA Exosome Using Distinct Arch-interacting Motifs Nature Communications. 07, 2019 | Pubmed ID: 31358741 Preparation of RNA 3' End Sequencing Libraries of Total and 4-thiouracil Labeled RNA for Simultaneous Measurement of Transcription, RNA Synthesis and Decay in Bio-protocol. Mar, 2019 | Pubmed ID: 30931349 Escaping Nuclear Decay: the Significance of MRNA Export for Gene Expression Current Genetics. Apr, 2019 | Pubmed ID: 30515529 The Multitasking PolyA Tail: Nuclear RNA Maturation, Degradation and Export Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 11, 2018 | Pubmed ID: 30397105 Box C/D SnoRNP Autoregulation by a Cis-Acting SnoRNA in the NOP56 Pre-mRNA Molecular Cell. 10, 2018 | Pubmed ID: 30220559 The RNA Exosome Contributes to Gene Expression Regulation During Stem Cell Differentiation Nucleic Acids Research. 11, 2018 | Pubmed ID: 30212902 Simultaneous Measurement of Transcriptional and Post-transcriptional Parameters by 3' End RNA-Seq Cell Reports. 08, 2018 | Pubmed ID: 30157438 A Nuclear Export Block Triggers the Decay of Newly Synthesized Polyadenylated RNA Cell Reports. Aug, 2018 | Pubmed ID: 30157437 Diminished Nuclear RNA Decay Upon Infection Upregulates Antibacterial Noncoding RNAs The EMBO Journal. 07, 2018 | Pubmed ID: 29880601 The RNA Exosome Adaptor ZFC3H1 Functionally Competes with Nuclear Export Activity to Retain Target Transcripts Cell Reports. 05, 2018 | Pubmed ID: 29768216 Controlling Nuclear RNA Levels Nature Reviews. Genetics. 08, 2018 | Pubmed ID: 29748575 Transcription Start Site Analysis Reveals Widespread Divergent Transcription in D. Melanogaster and Core Promoter-encoded Enhancer Activities Nucleic Acids Research. 06, 2018 | Pubmed ID: 29659982 Characterizing ZC3H18, a Multi-domain Protein at the Interface of RNA Production and Destruction Decisions Cell Reports. 01, 2018 | Pubmed ID: 29298432 Characterising -regulatory Variation in the Transcriptome of Histologically Normal and Tumour-derived Pancreatic Tissues Gut. 03, 2018 | Pubmed ID: 28634199 ARS2 is a General Suppressor of Pervasive Transcription Nucleic Acids Research. Sep, 2017 | Pubmed ID: 28973446 Polo-like Kinase 2 Modulates α-synuclein Protein Levels by Regulating Its MRNA Production Neurobiology of Disease. Oct, 2017 | Pubmed ID: 28648742 Targeting the Nuclear RNA Exosome: Poly(A) Binding Proteins Enter the Stage RNA Biology. 07, 2017 | Pubmed ID: 28421898 Mutually Exclusive CBC-Containing Complexes Contribute to RNA Fate Cell Reports. 03, 2017 | Pubmed ID: 28297668 Nuclear Decay Factors Crack Up MRNA Molecular Cell. Mar, 2017 | Pubmed ID: 28257696 Lariat Capping As a Tool to Manipulate the 5' End of Individual Yeast MRNA Species in Vivo RNA (New York, N.Y.). 05, 2017 | Pubmed ID: 28159804 Structure of the RBM7-ZCCHC8 Core of the NEXT Complex Reveals Connections to Splicing Factors Nature Communications. Dec, 2016 | Pubmed ID: 27905398 Identification of a Nuclear Exosome Decay Pathway for Processed Transcripts Molecular Cell. Nov, 2016 | Pubmed ID: 27871484 A Conserved Virus-induced Cytoplasmic TRAMP-like Complex Recruits the Exosome to Target Viral RNA for Degradation Genes & Development. 07, 2016 | Pubmed ID: 27474443 Principles for RNA Metabolism and Alternative Transcription Initiation Within Closely Spaced Promoters Nature Genetics. 09, 2016 | Pubmed ID: 27455346 Purification and Analysis of Endogenous Human RNA Exosome Complexes RNA (New York, N.Y.). Sep, 2016 | Pubmed ID: 27402899 Relationships Between PROMPT and Gene Expression RNA Biology. 2016 | Pubmed ID: 26574648 Human Gene Promoters Are Intrinsically Bidirectional Molecular Cell. Nov, 2015 | Pubmed ID: 26545074 Nonsense-mediated MRNA Decay: an Intricate Machinery That Shapes Transcriptomes Nature Reviews. Molecular Cell Biology. Nov, 2015 | Pubmed ID: 26397022 The Nuclear PolyA-Binding Protein Nab2p Is Essential for MRNA Production Cell Reports. Jul, 2015 | Pubmed ID: 26119729 Rapid, Optimized Interactomic Screening Nature Methods. Jun, 2015 | Pubmed ID: 25938370 The Human Nuclear Exosome Targeting Complex is Loaded Onto Newly Synthesized RNA to Direct Early Ribonucleolysis Cell Reports. Jan, 2015 | Pubmed ID: 25578728 Human Nonsense-mediated RNA Decay Initiates Widely by Endonucleolysis and Targets SnoRNA Host Genes Genes & Development. Nov, 2014 | Pubmed ID: 25403180 SnapShot: Nuclear RNAPII Transcript Modification Cell. May, 2014 | Pubmed ID: 24855955 Rat1p Maintains RNA Polymerase II CTD Phosphorylation Balance RNA (New York, N.Y.). Apr, 2014 | Pubmed ID: 24501251 The Human Cap-binding Complex is Functionally Connected to the Nuclear RNA Exosome Nature Structural & Molecular Biology. Dec, 2013 | Pubmed ID: 24270879 Dealing with Pervasive Transcription Molecular Cell. Nov, 2013 | Pubmed ID: 24267449 Mutational Analysis of the Yeast RNA Helicase Sub2p Reveals Conserved Domains Required for Growth, MRNA Export, and Genomic Stability RNA (New York, N.Y.). Oct, 2013 | Pubmed ID: 23962665 Polyadenylation Site-induced Decay of Upstream Transcripts Enforces Promoter Directionality Nature Structural & Molecular Biology. Aug, 2013 | Pubmed ID: 23851456 Exonuclease HDIS3L2 Specifies an Exosome-independent 3'-5' Degradation Pathway of Human Cytoplasmic MRNA The EMBO Journal. Jul, 2013 | Pubmed ID: 23756462 Making Ends Meet: Coordination Between RNA 3'-end Processing and Transcription Initiation Wiley Interdisciplinary Reviews. RNA. May-Jun, 2013 | Pubmed ID: 23450686 Transcription-associated Quality Control of MRNP Biochimica Et Biophysica Acta. Jan, 2013 | Pubmed ID: 22982197 Biochemistry and Function of RNA Exosomes The Enzymes. 2012 | Pubmed ID: 27166438 MRN1 Implicates Chromatin Remodeling Complexes and Architectural Factors in MRNA Maturation PloS One. 2012 | Pubmed ID: 23028530 Promoter-proximal Polyadenylation Sites Reduce Transcription Activity Genes & Development. Oct, 2012 | Pubmed ID: 23028143 Nuclear Retention Prevents Premature Cytoplasmic Appearance of MRNA Molecular Cell. Oct, 2012 | Pubmed ID: 22921936 Rrp6p Controls MRNA Poly(A) Tail Length and Its Decoration with Poly(A) Binding Proteins Molecular Cell. Jul, 2012 | Pubmed ID: 22683267 Improved Methodology for the Affinity Isolation of Human Protein Complexes Expressed at Near Endogenous Levels BioTechniques. May, 2012 | Pubmed ID: 22668517 Saccharomyces Cerevisiae Ngl3p is an Active 3'-5' Exonuclease with a Specificity Towards Poly-A RNA Reminiscent of Cellular Deadenylases Nucleic Acids Research. Jan, 2012 | Pubmed ID: 21965533 Implication of Ccr4-Not Complex Function in MRNA Quality Control in Saccharomyces Cerevisiae RNA (New York, N.Y.). Oct, 2011 | Pubmed ID: 21862638 Interaction Profiling Identifies the Human Nuclear Exosome Targeting Complex Molecular Cell. Aug, 2011 | Pubmed ID: 21855801 PROMoter UPstream Transcripts Share Characteristics with MRNAs and Are Produced Upstream of All Three Major Types of Mammalian Promoters Nucleic Acids Research. Sep, 2011 | Pubmed ID: 21596787 T-body Formation Precedes Virus-like Particle Maturation in S. Cerevisiae RNA Biology. Mar-Apr, 2011 | Pubmed ID: 21358276 The Eukaryotic RNA Exosome: Same Scaffold but Variable Catalytic Subunits RNA Biology. Jan-Feb, 2011 | Pubmed ID: 21289487 Nuclear Quality Control of RNA Polymerase II Transcripts Wiley Interdisciplinary Reviews. RNA. Nov-Dec, 2010 | Pubmed ID: 21956943 RNA Exosome. Preface Advances in Experimental Medicine and Biology. 2010 | Pubmed ID: 21618869 A Pause to Splice Molecular Cell. Nov, 2010 | Pubmed ID: 21095579 Translation by Remote Control Cell. Nov, 2010 | Pubmed ID: 21074041 Crosstalk Between MRNA 3' End Processing and Transcription Initiation Molecular Cell. Nov, 2010 | Pubmed ID: 21070967 The Human Core Exosome Interacts with Differentially Localized Processive RNases: HDIS3 and HDIS3L The EMBO Journal. Jul, 2010 | Pubmed ID: 20531386 The Yeast 5'-3' Exonuclease Rat1p Functions During Transcription Elongation by RNA Polymerase II Molecular Cell. Feb, 2010 | Pubmed ID: 20188675 Assembly of an Export-competent MRNP is Needed for Efficient Release of the 3'-end Processing Complex After Polyadenylation Molecular and Cellular Biology. Oct, 2009 | Pubmed ID: 19635808 Assembly of Export-competent MRNP: It's All About Being Connected Molecular Cell. Jan, 2009 | Pubmed ID: 19187754 RNA Exosome Depletion Reveals Transcription Upstream of Active Human Promoters Science (New York, N.Y.). Dec, 2008 | Pubmed ID: 19056938 Exonucleolysis is Required for Nuclear MRNA Quality Control in Yeast THO Mutants RNA (New York, N.Y.). Nov, 2008 | Pubmed ID: 18824516 The T Body, a New Cytoplasmic RNA Granule in Saccharomyces Cerevisiae Molecular and Cellular Biology. Oct, 2008 | Pubmed ID: 18678648 Nuclear MRNA Surveillance in THO/sub2 Mutants is Triggered by Inefficient Polyadenylation Molecular Cell. Jul, 2008 | Pubmed ID: 18614048 Dissecting Mechanisms of Nuclear MRNA Surveillance in THO/sub2 Complex Mutants The EMBO Journal. May, 2007 | Pubmed ID: 17410208 A Novel Plasmid-based Microarray Screen Identifies Suppressors of Rrp6Delta in Saccharomyces Cerevisiae Molecular and Cellular Biology. Feb, 2007 | Pubmed ID: 17101774 The Role of the Brr5/Ysh1 C-terminal Domain and Its Homolog Syc1 in MRNA 3'-end Processing in Saccharomyces Cerevisiae RNA (New York, N.Y.). Mar, 2006 | Pubmed ID: 16431986 Dramatically Improved RNA in Situ Hybridization Signals Using LNA-modified Probes RNA (New York, N.Y.). Nov, 2005 | Pubmed ID: 16177135 Modulation of Transcription Affects MRNP Quality Molecular Cell. Oct, 2004 | Pubmed ID: 15494310 Localization of Nuclear Retained MRNAs in Saccharomyces Cerevisiae RNA (New York, N.Y.). Sep, 2003 | Pubmed ID: 12923254 Early Formation of MRNP: License for Export or Quality Control? Molecular Cell. May, 2003 | Pubmed ID: 12769839 Interactions Between MRNA Export Commitment, 3'-end Quality Control, and Nuclear Degradation Molecular and Cellular Biology. Dec, 2002 | Pubmed ID: 12417728 Monitoraggio delle dinamiche di interazione proteina-RNA in vivo ad alta risoluzione temporale utilizzando χCRAC Stuart W. McKellar1, Ivayla Ivanova1, Robert W. van Nues2, Ross A. Cordiner3, Mehak Chauhan1, Niki Christopoulou1, Will Worboys4, Andrew Langford4, Torben Heick Jensen3, Sander Granneman1 1Centre for Engineering Biology, University of Edinburgh, 2Institute of Cell Biology, University of Edinburgh, 3Department of Molecular Biology and Genetics, Aarhus University, 4UVO3 Ltd. JoVE 61027 Biochemistry
Monitoraggio delle dinamiche di interazione proteina-RNA in vivo ad alta risoluzione temporale utilizzando χCRAC Stuart W. McKellar1, Ivayla Ivanova1, Robert W. van Nues2, Ross A. Cordiner3, Mehak Chauhan1, Niki Christopoulou1, Will Worboys4, Andrew Langford4, Torben Heick Jensen3, Sander Granneman1 1Centre for Engineering Biology, University of Edinburgh, 2Institute of Cell Biology, University of Edinburgh, 3Department of Molecular Biology and Genetics, Aarhus University, 4UVO3 Ltd. JoVE 61027 Biochemistry