Tsuyoshi Miyakawa Division of Systems Medical Science, Institute for Comprehensive Medical Science Fujita Health University Biography Publications Institution JoVE Articles Tsuyoshi Miyakawa has not added a biography. If you are Tsuyoshi Miyakawa and would like to personalize this page please email our Author Liaison for assistance. Publications Reply to Warren Et Al. and Shay Et Al.: Commonalities Across Species Do Exist and Are Potentially Important Proceedings of the National Academy of Sciences of the United States of America. Jan, 2015 | Pubmed ID: 25540421 Genomic Responses in Mouse Models Greatly Mimic Human Inflammatory Diseases Proceedings of the National Academy of Sciences of the United States of America. Jan, 2015 | Pubmed ID: 25092317 IL1RAPL1 Knockout Mice Show Spine Density Decrease, Learning Deficiency, Hyperactivity and Reduced Anxiety-like Behaviours Scientific Reports. 2014 | Pubmed ID: 25312502 Transient Receptor Potential Ankyrin 1 in Spinal Cord Dorsal Horn is Involved in Neuropathic Pain in Nerve Root Constriction Rats Molecular Pain. 2014 | Pubmed ID: 25192906 SIRT1 Overexpression Ameliorates a Mouse Model of SOD1-linked Amyotrophic Lateral Sclerosis Via HSF1/HSP70i Chaperone System Molecular Brain. 2014 | Pubmed ID: 25167838 [Immaturity of Brain As an Endophenotype of Neuropsychiatric Disorders] Nihon Shinkei Seishin Yakurigaku Zasshi = Japanese Journal of Psychopharmacology. Jun, 2014 | Pubmed ID: 25076776 Mechanisms for Interferon-α-induced Depression and Neural Stem Cell Dysfunction Stem Cell Reports. Jul, 2014 | Pubmed ID: 25068123 Enhanced Stability of Hippocampal Place Representation Caused by Reduced Magnesium Block of NMDA Receptors in the Dentate Gyrus Molecular Brain. 2014 | Pubmed ID: 24893573 Transcriptomic Evidence for Immaturity of the Prefrontal Cortex in Patients with Schizophrenia Molecular Brain. 2014 | Pubmed ID: 24886351 Hippocampal Neurogenesis Regulates Forgetting During Adulthood and Infancy Science (New York, N.Y.). May, 2014 | Pubmed ID: 24812394 Comprehensive Behavioral Study of MGluR3 Knockout Mice: Implication in Schizophrenia Related Endophenotypes Molecular Brain. 2014 | Pubmed ID: 24758191 Targeted Deletion of the C-terminus of the Mouse Adenomatous Polyposis Coli Tumor Suppressor Results in Neurologic Phenotypes Related to Schizophrenia Molecular Brain. 2014 | Pubmed ID: 24678719 Comprehensive Behavioral Analysis of Cluster of Differentiation 47 Knockout Mice PloS One. 2014 | Pubmed ID: 24586890 Increased Behavioral and Neuronal Responses to a Hallucinogenic Drug in PACAP Heterozygous Mutant Mice PloS One. 2014 | Pubmed ID: 24586556 Absence of BRINP1 in Mice Causes Increase of Hippocampal Neurogenesis and Behavioral Alterations Relevant to Human Psychiatric Disorders Molecular Brain. 2014 | Pubmed ID: 24528488 Microendoscopy-assisted Muscle-preserving Interlaminar Decompression for Lumbar Spinal Stenosis: Clinical Results of Consecutive 105 Cases with More Than 3-year Follow-up Spine. Mar, 2014 | Pubmed ID: 24365896 Mice Lacking Collapsin Response Mediator Protein 1 Manifest Hyperactivity, Impaired Learning and Memory, and Impaired Prepulse Inhibition Frontiers in Behavioral Neuroscience. 2013 | Pubmed ID: 24409129 PRICKLE1 Interaction with SYNAPSIN I Reveals a Role in Autism Spectrum Disorders PloS One. 2013 | Pubmed ID: 24312498 In Vivo Evaluation of Cellular Activity in αCaMKII Heterozygous Knockout Mice Using Manganese-enhanced Magnetic Resonance Imaging (MEMRI) Frontiers in Integrative Neuroscience. 2013 | Pubmed ID: 24273499 Chronic Fluoxetine Treatment Reduces Parvalbumin Expression and Perineuronal Nets in Gamma-aminobutyric Acidergic Interneurons of the Frontal Cortex in Adult Mice Molecular Brain. 2013 | Pubmed ID: 24228616 Point Mutation in Syntaxin-1A Causes Abnormal Vesicle Recycling, Behaviors, and Short Term Plasticity The Journal of Biological Chemistry. Nov, 2013 | Pubmed ID: 24136198 Orexin Receptor-1 in the Locus Coeruleus Plays an Important Role in Cue-dependent Fear Memory Consolidation The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Sep, 2013 | Pubmed ID: 24005305 Chronic Overload of SEPT4, a Parkin Substrate That Aggregates in Parkinson's Disease, Causes Behavioral Alterations but Not Neurodegeneration in Mice Molecular Brain. 2013 | Pubmed ID: 23938054 Immature Dentate Gyrus: an Endophenotype of Neuropsychiatric Disorders Neural Plasticity. 2013 | Pubmed ID: 23840971 ENU-mutagenesis Mice with a Non-synonymous Mutation in Grin1 Exhibit Abnormal Anxiety-like Behaviors, Impaired Fear Memory, and Decreased Acoustic Startle Response BMC Research Notes. 2013 | Pubmed ID: 23688147 The Immature Dentate Gyrus Represents a Shared Phenotype of Mouse Models of Epilepsy and Psychiatric Disease Bipolar Disorders. Jun, 2013 | Pubmed ID: 23560889 Synaptosomal-associated Protein 25 Mutation Induces Immaturity of the Dentate Granule Cells of Adult Mice Molecular Brain. 2013 | Pubmed ID: 23497716 Post-natal Treatment by a Blood-brain-barrier Permeable Calpain Inhibitor, SNJ1945 Rescued Defective Function in Lissencephaly Scientific Reports. 2013 | Pubmed ID: 23390575 Deficiency of Schnurri-2, an MHC Enhancer Binding Protein, Induces Mild Chronic Inflammation in the Brain and Confers Molecular, Neuronal, and Behavioral Phenotypes Related to Schizophrenia Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. Jul, 2013 | Pubmed ID: 23389689 Fluoxetine-induced Cortical Adult Neurogenesis Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. May, 2013 | Pubmed ID: 23303069 Increased Astrocytic ATP Release Results in Enhanced Excitability of the Hippocampus Glia. Feb, 2013 | Pubmed ID: 23018918 Behavioral Abnormalities Observed in Zfhx2-deficient Mice PloS One. 2012 | Pubmed ID: 23300874 Impaired Synaptic Clustering of Postsynaptic Density Proteins and Altered Signal Transmission in Hippocampal Neurons, and Disrupted Learning Behavior in PDZ1 and PDZ2 Ligand Binding-deficient PSD-95 Knockin Mice Molecular Brain. 2012 | Pubmed ID: 23268962 Comprehensive Behavioral Analysis of Pituitary Adenylate Cyclase-activating Polypeptide (PACAP) Knockout Mice Frontiers in Behavioral Neuroscience. 2012 | Pubmed ID: 23060763 α-Synuclein BAC Transgenic Mice As a Model for Parkinson's Disease Manifested Decreased Anxiety-like Behavior and Hyperlocomotion Neuroscience Research. Jun, 2012 | Pubmed ID: 22475625 M4 Muscarinic Receptor Knockout Mice Display Abnormal Social Behavior and Decreased Prepulse Inhibition Molecular Brain. 2012 | Pubmed ID: 22463818 ENU誘発性DISC1のQ31Lと-L100P変異マウスの包括的な行動分析 BMC Research Notes. Feb, 2012 | Pubmed ID: 22348257 スプリットブレインマウスにおける空間記憶の右半球優位 Hippocampus. Feb, 2012 | Pubmed ID: 21069782 大腸腺腫性ポリポーシスは、ヘテロ接合体ノックアウトマウスは自発運動の抑制と年齢に依存するワーキングメモリーの障害を表示します。 Frontiers in Behavioral Neuroscience. 2011 | Pubmed ID: 22347851 バーンズ迷路のウィッシュDIP /欠乏強化シナプス機能とパフォーマンス Molecular Brain. 2011 | Pubmed ID: 22018352 AMPA受容体サブユニットGluR1とGluR2の発現は、海馬歯状回の顆粒細胞の成熟に関係している Frontiers in Neuroscience. 2011 | Pubmed ID: 21927594 リラキシン-3欠損マウスは、不安関連行動のわずかな変更を見せた Frontiers in Behavioral Neuroscience. 2011 | Pubmed ID: 21887138 P301S変異型ヒトタウトランスジェニックマウスは、認知症と変更された感覚ゲーティングと人間のタウオパチーの初期症状、マニフェスト PloS One. 2011 | Pubmed ID: 21698260 前脳特異的構成的に活性なCaMKKαトランスジェニックマウスは海馬依存長期記憶の欠損を表示する Neurobiology of Learning and Memory. Sep, 2011 | Pubmed ID: 21558011 コンテキスト恐怖条件付けにおけるシナプスE3リガーゼSCRAPPER:SCRAPPERヘテロ接合体と過剰発現変異マウスの広範な行動表現型解析 PloS One. 2011 | Pubmed ID: 21390313 6週間以上のためのフルオキセチンの慢性治療は、成体マウスの脳室下帯における神経を下げ Molecular Brain. 2011 | Pubmed ID: 21385396 APP過剰発現マウスにおける認知機能とアミロイドβの代謝に及ぼす慢性脳低灌流の影響 PloS One. 2011 | Pubmed ID: 21305033 線維芽細胞成長因子結合タンパク質3の不活化は、不安関連行動を引き起こす Molecular and Cellular Neurosciences. Jan, 2011 | Pubmed ID: 20851768 15qの重複症候群のマウスモデルにおける探索行動の減少;セロトニンの外乱に対する影響は、シグナリング PloS One. 2010 | Pubmed ID: 21179543 成体マウス歯状回の成熟顆粒細胞におけるトリプトファン2,3 - ジオキシゲナーゼの発現 Molecular Brain. 2010 | Pubmed ID: 20815922 信号調節タンパク質αのストレス誘発チロシンリン酸化は、強制水泳試験で行動不動を調節する The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Aug, 2010 | Pubmed ID: 20685990 三C57BL / 6亜系統の行動プロファイル Frontiers in Behavioral Neuroscience. 2010 | Pubmed ID: 20676234 [精神疾患の候補Endophenotypeとして未熟な歯状回] Nihon Shinkei Seishin Yakurigaku Zasshi = Japanese Journal of Psychopharmacology. Jun, 2010 | Pubmed ID: 20666142 ケースレポート:痛みを伴う四肢移動/四肢:2症例の報告 Clinical Orthopaedics and Related Research. Dec, 2010 | Pubmed ID: 20585912 海馬萎縮と血管性痴呆の特徴を特徴づけるモデルマウス Stroke; a Journal of Cerebral Circulation. Jun, 2010 | Pubmed ID: 20448204 セロトニン作動性抗うつ薬による海馬ニューロン成熟の逆転 Proceedings of the National Academy of Sciences of the United States of America. May, 2010 | Pubmed ID: 20404165 カルシウム/カルモジュリン依存性プロテインキナーゼIVのノックアウトマウスの包括的な行動分析 PloS One. 2010 | Pubmed ID: 20209163 SDOP-DB:マウス表現型解析のための比較標準プロトコルデータベース Bioinformatics (Oxford, England). Apr, 2010 | Pubmed ID: 20194625 大脳新皮質レイヤ1前駆細胞の虚血誘発ニューロン新生 Nature Neuroscience. Feb, 2010 | Pubmed ID: 20037576 Nardilysinは、中枢および末梢神経系における軸索の成熟と髄鞘形成を調節する Nature Neuroscience. Dec, 2009 | Pubmed ID: 19935654 GSK-3α変異マウスの脳の構造と動作の異常 Molecular Brain. 2009 | Pubmed ID: 19925672 KF-1ユビキチンリガーゼ:不安サプレッサ Frontiers in Neuroscience. May, 2009 | Pubmed ID: 19753093 α-CaMKIIのヘテロノックアウトマウスではワーキングメモリの赤字を基礎と神経活動の変化 Frontiers in Behavioral Neuroscience. 2009 | Pubmed ID: 19750198 カルパインの阻害はLIS1発現を増加させると部分的滑脳症のマウスモデルにおいてインビボ表現型のレスキュー Nature Medicine. Oct, 2009 | Pubmed ID: 19734909 子宮内環境ゲノム相互作用と子どもの発達(4):精神神経疾患の研究を包括的行動テストバッテリーを用いた遺伝子改変マウスの脳行動Phenotypying The Journal of Toxicological Sciences. 2009 | Pubmed ID: 19571483 改変されたミエリンプロテオリピドタンパク質遺伝子発現の表示認知障害を持つマウスは、異常ニューロングリアの相互作用を伴い、伝導速度の減少 The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jul, 2009 | Pubmed ID: 19571127 自閉症に見られるヒト15q11-13重複のために染色体改変マウスモデルにおける異常な挙動 Cell. Jun, 2009 | Pubmed ID: 19563756 異常な社会的行動、多動、障害遠隔空間メモリ、および神経型一酸化窒素合成酵素のノックアウトマウスではD1-媒介増加ドーパミンシグナリング Molecular Brain. 2009 | Pubmed ID: 19538708 リアノジン受容体タイプ3(RyR3)ノックアウトマウスの包括的な行動の表現型解析:二社会的相互作用試験では減少社会との接触時間 Frontiers in Behavioral Neuroscience. 2009 | Pubmed ID: 19503748 [遺伝子、ビヘイビアと精神疾患] Tanpakushitsu Kakusan Koso. Protein, Nucleic Acid, Enzyme. Mar, 2008 | Pubmed ID: 21089339 正常なミトコンドリアの呼吸機能は、マウスの空間リモートメモリのために不可欠である Molecular Brain. 2008 | Pubmed ID: 19087269 マウスのプロトカドヘリンαアイソフォームのダウンレギュレーションは、コンテキスト恐怖条件付けと空間ワーキングメモリを変更します The European Journal of Neuroscience. Oct, 2008 | Pubmed ID: 18973563 KF-1遺伝子展示を欠損したマウスは不安はなく、絶望のような動作の向上 Frontiers in Behavioral Neuroscience. 2008 | Pubmed ID: 18958194 障害者の長期記憶の保持とDtnbp1の欠失を有するSDY変異マウスのワーキングメモリ、統合失調症の感受性遺伝子 Molecular Brain. 2008 | Pubmed ID: 18945333 カルパスタチンノックアウトマウスの包括的な行動表現型解析 Molecular Brain. 2008 | Pubmed ID: 18803809 α-CaMKIIの欠乏は、未熟な歯状回、精神疾患の新規候補Endophenotype原因 Molecular Brain. 2008 | Pubmed ID: 18803808 大人の前脳の構造と機能の整合性の継続的なニューロン新生の役割 Nature Neuroscience. Oct, 2008 | Pubmed ID: 18758458 統合失調症の可能性感受性遺伝子としてYWHAEコードする遺伝子14-3-3epsilonの識別 Human Molecular Genetics. Oct, 2008 | Pubmed ID: 18658164 精神刺激に統合失調症関連タンパク質FEZ1マニフェスト多動性と優れた応答性を欠損したマウス Human Molecular Genetics. Oct, 2008 | Pubmed ID: 18647754 [精神疾患の遺伝子から行動経路の調査:遺伝子改変マウスでの包括的行動テストバッテリーを用いたアプローチ] Nihon Shinkei Seishin Yakurigaku Zasshi = Japanese Journal of Psychopharmacology. Jun, 2008 | Pubmed ID: 18646600 プシン(カリクレイン関連ペプチダーゼ8)遺伝子欠損マウスで増加した不安様行動 Behavioral Neuroscience. Jun, 2008 | Pubmed ID: 18513120 小さい樹状突起スパイン、弱いシナプス伝達が、Shank1の欠損マウスで強化された空間学習 The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Feb, 2008 | Pubmed ID: 18272690 線条体中型有棘ニューロン固有のホスホジエステラーゼ10A2の欠損マウスで増加した社会的インタラクション Journal of Neurochemistry. Apr, 2008 | Pubmed ID: 18088367 マウスにおけるNMDA受容体サブユニットNR3Bの遺伝的アブレーションは、運動ニューロンとNonmotoneuronal表現型を明らかに The European Journal of Neuroscience. Sep, 2007 | Pubmed ID: 17880385 足場タンパク質Tamalinのノックアウトマウスではモルヒネやコカインに変更さ感度 Proceedings of the National Academy of Sciences of the United States of America. Sep, 2007 | Pubmed ID: 17766434 慢性脳低灌流のマウスモデルにおけるワーキングメモリの選択的障害 Stroke; a Journal of Cerebral Circulation. Oct, 2007 | Pubmed ID: 17761909 精神神経疾患の研究における遺伝子改変マウスの脳の動作Phenotypyingの影響 Neuroscience Research. Jun, 2007 | Pubmed ID: 17524507 濃縮された環境では、うつ病に関連した大人のマウスの行動とその海馬における新生細胞の生存に影響を与える Behavioural Brain Research. Jun, 2007 | Pubmed ID: 17397941 統合脳研究のためのマウスのリエゾン Neuroscience Research. Jun, 2007 | Pubmed ID: 17382419 Sept4、シナプス足場およびレビー体のコンポーネントは、α-シヌクレインの毒性の抑制が必要です Neuron. Feb, 2007 | Pubmed ID: 17296554 精神疾患における遺伝子から行動経路の調査:遺伝子改変マウスに関する包括的な行動テストバッテリーの使用 Annals of the New York Academy of Sciences. Nov, 2006 | Pubmed ID: 17185513 齧歯類モデルにおける統合失調症関連の行動テスト:ユニークな人間の疾患? Biological Psychiatry. Jun, 2006 | Pubmed ID: 16797265 21番染色体上のDSCR1とDYRK1Aの増量により、NFATの調節異常 Nature. Jun, 2006 | Pubmed ID: 16554754 [精神疾患のストレスおよび動物モデル] Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica. Sep, 2005 | Pubmed ID: 16272762 末梢有髄軸索のシュワン細胞におけるタイトジャンクション:クローディン-19欠損マウスからのレッスン The Journal of Cell Biology. May, 2005 | Pubmed ID: 15883201 代謝型グルタミン酸受容体サブタイプ2ノックアウトマウスでは強化されたコカインの応答性と協調運動障害 Proceedings of the National Academy of Sciences of the United States of America. Mar, 2005 | Pubmed ID: 15753323 The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Nov, 2004 | Pubmed ID: 15537882 聴覚経路を介して視覚的な手掛かり恐怖条件の加速 Nature Neuroscience. Sep, 2004 | Pubmed ID: 15322551 カルシニューリンガンマサブユニットをコードする8p21.3の遺伝子の遺伝的変異と統合失調症協会、PPP3CC、の証拠 Proceedings of the National Academy of Sciences of the United States of America. Jul, 2003 | Pubmed ID: 12851458 条件カルシニューリンノックアウトマウスは統合失調症に関連する複数の異常行動を示す Proceedings of the National Academy of Sciences of the United States of America. Jul, 2003 | Pubmed ID: 12851457 マウスにおけるビデオ解析システムを用いた文脈と手掛り恐怖条件付け試験 Hirotaka Shoji1,2, Keizo Takao2,3, Satoko Hattori1,2, Tsuyoshi Miyakawa1,2,3 1Division of Systems Medical Science, Institute for Comprehensive Medical Science, Fujita Health University, 2Japan Science and Technology Agency, Core Research for Evolutionary Science and Technology (CREST), 3Center for Genetic Analysis of Behavior, National Institute for Physiological Sciences, National Institutes of Natural Sciences JoVE 50871 Behavior マウスで作業していて、メモリの参照を評価するためのT-迷路強制交替と左右弁別課題 Hirotaka Shoji1,2, Hideo Hagihara1, Keizo Takao3, Satoko Hattori1,2,3, Tsuyoshi Miyakawa1,2,3 1Division of Systems Medical Science, Institute for Comprehensive Medical Science, Fujita Health University, 2Japan Science and Technology Agency, Core Research for Evolutionary Science and Technology (CREST), 3Center for Genetic Analysis of Behavior, National Institute for Physiological Sciences, National Institutes of Natural Sciences JoVE 3300 Neuroscience 成体マウスから海馬歯状回の解剖 Hideo Hagihara1,2, Keiko Toyama1,2, Nobuyuki Yamasaki1,3, Tsuyoshi Miyakawa1,2,4,5 1Japan Science and Technology Agency, Core Research for Evolutionary Science and Technology (CREST), 2Division of Systems Medical Science, Institute for Comprehensive Medical Science, Fujita Health University, 3Department of Psychiatry, Graduate School of Medicine, Kyoto University, 4Genetic Engineering and Functional Genomics Group, Horizontal Medical Research Organization, Graduate School of Medicine, Kyoto University, 5Center for Genetic Analysis of Behavior, National Institute for Physiological Sciences, National Institutes of Natural Sciences JoVE 1543 Biology マウス用高架式十字迷路 Munekazu Komada1, Keizo Takao1,2, Tsuyoshi Miyakawa2 1Genetic Engineering and Functional Genomics Unit, Frontier Technology Center, Graduate School of Medicine, Kyoto University, 2Institute for Comprehensive Medical Science Division of Systems Medicine, Fujita Health University JoVE 1088 Biology マウス用ダーク/ライト遷移テスト Keizo Takao1, Tsuyoshi Miyakawa1 1Genetic Engineering and Functional Genomics Unit, Horizontal Medical Research Organization, Graduate School of Medicine, Kyoto University JoVE 104 Biology
マウスにおけるビデオ解析システムを用いた文脈と手掛り恐怖条件付け試験 Hirotaka Shoji1,2, Keizo Takao2,3, Satoko Hattori1,2, Tsuyoshi Miyakawa1,2,3 1Division of Systems Medical Science, Institute for Comprehensive Medical Science, Fujita Health University, 2Japan Science and Technology Agency, Core Research for Evolutionary Science and Technology (CREST), 3Center for Genetic Analysis of Behavior, National Institute for Physiological Sciences, National Institutes of Natural Sciences JoVE 50871 Behavior
マウスで作業していて、メモリの参照を評価するためのT-迷路強制交替と左右弁別課題 Hirotaka Shoji1,2, Hideo Hagihara1, Keizo Takao3, Satoko Hattori1,2,3, Tsuyoshi Miyakawa1,2,3 1Division of Systems Medical Science, Institute for Comprehensive Medical Science, Fujita Health University, 2Japan Science and Technology Agency, Core Research for Evolutionary Science and Technology (CREST), 3Center for Genetic Analysis of Behavior, National Institute for Physiological Sciences, National Institutes of Natural Sciences JoVE 3300 Neuroscience
成体マウスから海馬歯状回の解剖 Hideo Hagihara1,2, Keiko Toyama1,2, Nobuyuki Yamasaki1,3, Tsuyoshi Miyakawa1,2,4,5 1Japan Science and Technology Agency, Core Research for Evolutionary Science and Technology (CREST), 2Division of Systems Medical Science, Institute for Comprehensive Medical Science, Fujita Health University, 3Department of Psychiatry, Graduate School of Medicine, Kyoto University, 4Genetic Engineering and Functional Genomics Group, Horizontal Medical Research Organization, Graduate School of Medicine, Kyoto University, 5Center for Genetic Analysis of Behavior, National Institute for Physiological Sciences, National Institutes of Natural Sciences JoVE 1543 Biology
マウス用高架式十字迷路 Munekazu Komada1, Keizo Takao1,2, Tsuyoshi Miyakawa2 1Genetic Engineering and Functional Genomics Unit, Frontier Technology Center, Graduate School of Medicine, Kyoto University, 2Institute for Comprehensive Medical Science Division of Systems Medicine, Fujita Health University JoVE 1088 Biology
マウス用ダーク/ライト遷移テスト Keizo Takao1, Tsuyoshi Miyakawa1 1Genetic Engineering and Functional Genomics Unit, Horizontal Medical Research Organization, Graduate School of Medicine, Kyoto University JoVE 104 Biology