Valentina Gandin Lady Davis Institute and Department of Oncology McGill University Biography Publications Institution JoVE Articles Valentina Gandin has not added a biography. If you are Valentina Gandin and would like to personalize this page please email our Author Liaison for assistance. Publications Monofunctional Platinum(II) Complexes with Potent Tumor Cell Growth Inhibitory Activity: The Effect of a Hydrogen-Bond Donor/Acceptor N-Heterocyclic Ligand ChemMedChem. May, 2014 | Pubmed ID: 24799414 In Vitro and in Vivo Anticancer Activity of Copper(I) Complexes with Homoscorpionate Tridentate Tris(pyrazolyl)borate and Auxilliary Monodentate Phosphine Ligands Journal of Medicinal Chemistry. May, 2014 | Pubmed ID: 24793739 Role of Zinc Trafficking in Male Fertility: from Germ to Sperm Human Reproduction (Oxford, England). Jun, 2014 | Pubmed ID: 24771000 Trans,cis,cis-Bis(benzoato)dichlorido(cyclohexane-1R,2R-diamine)platinum(IV): a Prodrug Candidate for the Treatment of Oxaliplatin-Refractory Colorectal Cancer ChemMedChem. Apr, 2014 | Pubmed ID: 24715720 Largen: a Molecular Regulator of Mammalian Cell Size Control Molecular Cell. Mar, 2014 | Pubmed ID: 24656129 Oxygen Sufficiency Controls TOP MRNA Translation Via the TSC-Rheb-mTOR Pathway in a 4E-BP-independent Manner Journal of Molecular Cell Biology. Mar, 2014 | Pubmed ID: 24627160 Inactive C-terminal Telomerase Reverse Transcriptase Insertion Splicing Variants Are Dominant-negative Inhibitors of Telomerase Biochimie. Jun, 2014 | Pubmed ID: 24412622 Selenium Induces a Multi-targeted Cell Death Process in Addition to ROS Formation Journal of Cellular and Molecular Medicine. Apr, 2014 | Pubmed ID: 24400844 Advances in Copper Complexes As Anticancer Agents Chemical Reviews. Jan, 2014 | Pubmed ID: 24102434 RACK1 Function in Cell Motility and Protein Synthesis Genes & Cancer. Sep, 2013 | Pubmed ID: 24349634 MTORC1 Controls Mitochondrial Activity and Biogenesis Through 4E-BP-dependent Translational Regulation Cell Metabolism. Nov, 2013 | Pubmed ID: 24206664 Synthesis and in Vitro Antitumor Activity of Water Soluble Sulfonate- and Ester-functionalized Silver(I) N-heterocyclic Carbene Complexes Journal of Inorganic Biochemistry. Dec, 2013 | Pubmed ID: 24121303 Novel Mixed-ligand Copper(I) Complexes: Role of Diimine Ligands on Cytotoxicity and Genotoxicity Journal of Medicinal Chemistry. Sep, 2013 | Pubmed ID: 23964823 Cell Biology. Trans-HSF1 Express Science (New York, N.Y.). Jul, 2013 | Pubmed ID: 23869008 Distinct Translational Control in CD4+ T Cell Subsets PLoS Genetics. May, 2013 | Pubmed ID: 23658533 Novel Imino Thioether Complexes of Platinum(II): Synthesis, Structural Investigation, and Biological Activity Inorganic Chemistry. May, 2013 | Pubmed ID: 23647564 Degradation of Newly Synthesized Polypeptides by Ribosome-associated RACK1/c-Jun N-terminal Kinase/eukaryotic Elongation Factor 1A2 Complex Molecular and Cellular Biology. Jul, 2013 | Pubmed ID: 23608534 (99m)Tc(N)-DBODC(5), a Potential Radiolabeled Probe for SPECT of Multidrug Resistance: in Vitro Study Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry. Jun, 2013 | Pubmed ID: 23543234 Neutral and Charged Phosphine/scorpionate Copper(I) Complexes: Effects of Ligand Assembly on Their Antiproliferative Activity European Journal of Medicinal Chemistry. Jan, 2013 | Pubmed ID: 23229057 Methylselenol Formed by Spontaneous Methylation of Selenide is a Superior Selenium Substrate to the Thioredoxin and Glutaredoxin Systems PloS One. 2012 | Pubmed ID: 23226364 EIF4E/4E-BP Ratio Predicts the Efficacy of MTOR Targeted Therapies Cancer Research. Dec, 2012 | Pubmed ID: 23100465 Synthesis and Biological Activity of Ester- and Amide-functionalized Imidazolium Salts and Related Water-soluble Coinage Metal N-heterocyclic Carbene Complexes Inorganic Chemistry. Sep, 2012 | Pubmed ID: 22946642 Eukaryotic Initiation Factor 4E-3 is Essential for Meiotic Chromosome Segregation, Cytokinesis and Male Fertility in Drosophila Development (Cambridge, England). Sep, 2012 | Pubmed ID: 22833128 Revisiting [PtCl₂(cis-1,4-DACH)]: an Underestimated Antitumor Drug with Potential Application to the Treatment of Oxaliplatin-refractory Colorectal Cancer Journal of Medicinal Chemistry. Aug, 2012 | Pubmed ID: 22788918 Synthesis and Characterization of Azolate Gold(I) Phosphane Complexes As Thioredoxin Reductase Inhibiting Antitumor Agents Dalton Transactions (Cambridge, England : 2003). May, 2012 | Pubmed ID: 22391922 Nanocrystalline Carbonate-apatites: Role of Ca/P Ratio on the Upload and Release of Anticancer Platinum Bisphosphonates Nanoscale. Jan, 2012 | Pubmed ID: 22075933 Effects of Redox Modulation by Inhibition of Thioredoxin Reductase on Radiosensitivity and Gene Expression Journal of Cellular and Molecular Medicine. Jul, 2012 | Pubmed ID: 22003958 A Novel Copper Complex Induces Paraptosis in Colon Cancer Cells Via the Activation of ER Stress Signalling Journal of Cellular and Molecular Medicine. Jan, 2012 | Pubmed ID: 21388518 Photoreactivity of 5-fluorouracil Under UVB Light: Photolysis and Cytotoxicity Studies Chemical Research in Toxicology. Aug, 2011 | Pubmed ID: 21728355 Nitroimidazole and Glucosamine Conjugated Heteroscorpionate Ligands and Related Copper(II) Complexes. Syntheses, Biological Activity and XAS Studies Dalton Transactions (Cambridge, England : 2003). Oct, 2011 | Pubmed ID: 21709917 Chemistry and Biological Activity of Platinum Amidine Complexes ChemMedChem. Jul, 2011 | Pubmed ID: 21630470 Synthesis, Characterization and Cytotoxic Properties of Platinum(II) Complexes Containing the Nucleosides Adenosine and Cytidine Journal of Inorganic Biochemistry. Jun, 2011 | Pubmed ID: 21514543 Psoralenquinones As a Novel Class of Proteasome Inhibitors: Design, Synthesis and Biological Evaluation ChemMedChem. Jun, 2011 | Pubmed ID: 21472862 Interaction of Selenite and Tellurite with Thiol-dependent Redox Enzymes: Kinetics and Mitochondrial Implications Free Radical Biology & Medicine. Jun, 2011 | Pubmed ID: 21397686 In Vitro Antitumour Activity of Water Soluble Cu(I), Ag(I) and Au(I) Complexes Supported by Hydrophilic Alkyl Phosphine Ligands Journal of Inorganic Biochemistry. Feb, 2011 | Pubmed ID: 21194623 Cytotoxicity in Human Cancer Cells and Mitochondrial Dysfunction Induced by a Series of New Copper(I) Complexes Containing Tris(2-cyanoethyl)phosphines Investigational New Drugs. Dec, 2011 | Pubmed ID: 20567997 A New Class of Antitumor Trans-amine-amidine-Pt(II) Cationic Complexes: Influence of Chemical Structure and Solvent on in Vitro and in Vivo Tumor Cell Proliferation Journal of Medicinal Chemistry. Aug, 2010 | Pubmed ID: 20681543 S6K1 Plays a Critical Role in Early Adipocyte Differentiation Developmental Cell. May, 2010 | Pubmed ID: 20493810 The Relationship Between the Electrospray Ionization Behaviour and Biological Activity of Some Phosphino Cu(I) Complexes Rapid Communications in Mass Spectrometry : RCM. Jun, 2010 | Pubmed ID: 20486256 JNK Inhibition Arrests Cotranslational Degradation Biochimica Et Biophysica Acta. Jul, 2010 | Pubmed ID: 20359507 Cancer Cell Death Induced by Phosphine Gold(I) Compounds Targeting Thioredoxin Reductase Biochemical Pharmacology. Jan, 2010 | Pubmed ID: 19665452 Synthesis, Characterization, and Cytotoxicity of Dinuclear Platinum-bisphosphonate Complexes to Be Used As Prodrugs in the Local Treatment of Bone Tumours Dalton Transactions (Cambridge, England : 2003). Dec, 2009 | Pubmed ID: 20023921 Synthesis and Structural Characterization of Copper(I) Complexes Bearing N-methyl-1,3,5-triaza-7-phosphaadamantane (mPTA): Cytotoxic Activity Evaluation of a Series of Water Soluble Cu(I) Derivatives Containing PTA, PTAH and MPTA Ligands Journal of Inorganic Biochemistry. Dec, 2009 | Pubmed ID: 19822369 Cytotoxicity of Cis-platinum(II) Cycloaliphatic Amidine Complexes: Ring Size and Solvent Effects on the Biological Activity Journal of Inorganic Biochemistry. Aug, 2009 | Pubmed ID: 19560209 Treatment of Human Cancer Cells with Selenite or Tellurite in Combination with Auranofin Enhances Cell Death Due to Redox Shift Free Radical Biology & Medicine. Sep, 2009 | Pubmed ID: 19486940 DNA Binding Ellipticine Analogues: Synthesis, Biological Evaluation, and Structure-activity Relationships ChemMedChem. Mar, 2009 | Pubmed ID: 19197924 Effects of the Antioxidant Pycnogenol on Cellular Redox Systems in U1285 Human Lung Carcinoma Cells The FEBS Journal. Jan, 2009 | Pubmed ID: 19077163 Eukaryotic Initiation Factor 6 is Rate-limiting in Translation, Growth and Transformation Nature. Oct, 2008 | Pubmed ID: 18784653 In Vitro Antitumor Activity of the Water Soluble Copper(I) Complexes Bearing the Tris(hydroxymethyl)phosphine Ligand Journal of Medicinal Chemistry. Feb, 2008 | Pubmed ID: 18251492 Cisplatinum and Transplatinum Complexes with Benzyliminoether Ligands; Synthesis, Characterization, Structure-activity Relationships, and in Vitro and in Vivo Antitumor Efficacy Journal of Medicinal Chemistry. Sep, 2007 | Pubmed ID: 17713897 Inhibition of Thioredoxin Reductase by Auranofin Induces Apoptosis in Cisplatin-resistant Human Ovarian Cancer Cells Free Radical Biology & Medicine. Mar, 2007 | Pubmed ID: 17320769 Synthesis, Characterization, and in Vitro Antitumor Properties of Tris(hydroxymethyl)phosphine Copper(I) Complexes Containing the New Bis(1,2,4-triazol-1-yl)acetate Ligand Journal of Medicinal Chemistry. Dec, 2006 | Pubmed ID: 17149861 GABP Complex Regulates Transcription of EIF6 (p27BBP), an Essential Trans-acting Factor in Ribosome Biogenesis FEBS Letters. Apr, 2006 | Pubmed ID: 16530192 Fibronectin Controls Cap-dependent Translation Through Beta1 Integrin and Eukaryotic Initiation Factors 4 and 2 Coordinated Pathways Proceedings of the National Academy of Sciences of the United States of America. Jun, 2005 | Pubmed ID: 15961545 Polysome fraksjonering og analyse av pattedyr Translatomes på en Genome-wide Scale Valentina Gandin1, Kristina Sikström2, Tommy Alain3, Masahiro Morita3, Shannon McLaughlan1, Ola Larsson2, Ivan Topisirovic1 1Lady Davis Institute and Department of Oncology, McGill University, 2Department of Oncology-Pathology, Karolinska Institutet, 3Goodman Cancer Centre and Department of Biochemistry, McGill University JoVE 51455 Biology
Polysome fraksjonering og analyse av pattedyr Translatomes på en Genome-wide Scale Valentina Gandin1, Kristina Sikström2, Tommy Alain3, Masahiro Morita3, Shannon McLaughlan1, Ola Larsson2, Ivan Topisirovic1 1Lady Davis Institute and Department of Oncology, McGill University, 2Department of Oncology-Pathology, Karolinska Institutet, 3Goodman Cancer Centre and Department of Biochemistry, McGill University JoVE 51455 Biology