Victor M. Darley-Usmar UAB Mitochondrial Medicine Laboratory, Center for Free Radical Biology, Department of Pathology University of Alabama at Birmingham Biography Publications Institution JoVE Articles Victor M. Darley-Usmar has not added a biography. If you are Victor M. Darley-Usmar and would like to personalize this page please email our Author Liaison for assistance. Publications A Review of the Mitochondrial and Glycolytic Metabolism in Human Platelets and Leukocytes: Implications for Their Use As Bioenergetic Biomarkers Redox Biology. 2014 | Pubmed ID: 24494194 Inhibition of Glycolysis Attenuates 4-hydroxynonenal-dependent Autophagy and Exacerbates Apoptosis in Differentiated SH-SY5Y Neuroblastoma Cells Autophagy. Dec, 2013 | Pubmed ID: 24145463 Lipid Metabolites Enhance Secretion Acting on SNARE Microdomains and Altering the Extent and Kinetics of Single Release Events in Bovine Adrenal Chromaffin Cells PloS One. 2013 | Pubmed ID: 24073281 Quercetin Prevents Left Ventricular Hypertrophy in the Apo E Knockout Mouse Redox Biology. 2013 | Pubmed ID: 24024175 Mitochondrial Genetic Background Modulates Bioenergetics and Susceptibility to Acute Cardiac Volume Overload The Biochemical Journal. Oct, 2013 | Pubmed ID: 23924350 Dysfunctional Mitochondrial Bioenergetics and Oxidative Stress in Akita(+/Ins2)-derived β-cells American Journal of Physiology. Endocrinology and Metabolism. Sep, 2013 | Pubmed ID: 23820623 Methods for Defining Distinct Bioenergetic Profiles in Platelets, Lymphocytes, Monocytes, and Neutrophils, and the Oxidative Burst from Human Blood Laboratory Investigation; a Journal of Technical Methods and Pathology. Jun, 2013 | Pubmed ID: 23528848 Utilization of Fluorescent Probes for the Quantification and Identification of Subcellular Proteomes and Biological Processes Regulated by Lipid Peroxidation Products Free Radical Biology & Medicine. Jun, 2013 | Pubmed ID: 22954622 Integration of Cellular Bioenergetics with Mitochondrial Quality Control and Autophagy Biological Chemistry. Dec, 2012 | Pubmed ID: 23092819 Distinct Effects of Rotenone, 1-methyl-4-phenylpyridinium and 6-hydroxydopamine on Cellular Bioenergetics and Cell Death PloS One. 2012 | Pubmed ID: 22970265 Cell Signalling by Reactive Lipid Species: New Concepts and Molecular Mechanisms The Biochemical Journal. Mar, 2012 | Pubmed ID: 22364280 The Electrophile Responsive Proteome: Integrating Proteomics and Lipidomics with Cellular Function Antioxidants & Redox Signaling. Dec, 2012 | Pubmed ID: 22352679 Hemin Causes Mitochondrial Dysfunction in Endothelial Cells Through Promoting Lipid Peroxidation: The Protective Role of Autophagy American Journal of Physiology. Heart and Circulatory Physiology. Jan, 2012 | Pubmed ID: 22245770 Nitric Oxide and Hypoxia Exacerbate Alcohol-induced Mitochondrial Dysfunction in Hepatocytes Biochimica Et Biophysica Acta. Dec, 2011 | Pubmed ID: 21971515 Differentiation of SH-SY5Y Cells to a Neuronal Phenotype Changes Cellular Bioenergetics and the Response to Oxidative Stress Free Radical Biology & Medicine. Dec, 2011 | Pubmed ID: 21945098 Protein O-linked β-N-acetylglucosamine: A Novel Effector of Cardiomyocyte Metabolism and Function Journal of Molecular and Cellular Cardiology. Aug, 2011 | Pubmed ID: 21878340 Assessing Bioenergetic Function in Response to Oxidative Stress by Metabolic Profiling Free Radical Biology & Medicine. Nov, 2011 | Pubmed ID: 21872656 Differential Regulation of Metabolism by Nitric Oxide and S-nitrosothiols in Endothelial Cells American Journal of Physiology. Heart and Circulatory Physiology. Sep, 2011 | Pubmed ID: 21685262 Mitochondria-targeted Ubiquinone (MitoQ) Decreases Ethanol-dependent Micro and Macro Hepatosteatosis Hepatology (Baltimore, Md.). Jul, 2011 | Pubmed ID: 21520201 American Journal of Physiology. Cell Physiology. Jul, 2011 | Pubmed ID: 21451101 Role of IPLA(2) in the Regulation of Src Trafficking and Microglia Chemotaxis Traffic (Copenhagen, Denmark). Jul, 2011 | Pubmed ID: 21438970 Bioenergetic Function in Cardiovascular Cells: the Importance of the Reserve Capacity and Its Biological Regulation Chemico-biological Interactions. May, 2011 | Pubmed ID: 21147079 Acquisition of Temozolomide Chemoresistance in Gliomas Leads to Remodeling of Mitochondrial Electron Transport Chain The Journal of Biological Chemistry. Dec, 2010 | Pubmed ID: 20870728 What Part of NO Don't You Understand? Some Answers to the Cardinal Questions in Nitric Oxide Biology The Journal of Biological Chemistry. Jun, 2010 | Pubmed ID: 20410298 Role of Cellular Bioenergetics in Smooth Muscle Cell Proliferation Induced by Platelet-derived Growth Factor The Biochemical Journal. Jun, 2010 | Pubmed ID: 20331438 Mitochondrial Reserve Capacity in Endothelial Cells: The Impact of Nitric Oxide and Reactive Oxygen Species Free Radical Biology & Medicine. Apr, 2010 | Pubmed ID: 20093177 Regulation of Vascular Smooth Muscle Cell Bioenergetic Function by Protein Glutathiolation Biochimica Et Biophysica Acta. Feb, 2010 | Pubmed ID: 19925774 Mitochondrial Targeting of the Electrophilic Lipid 15-deoxy-Delta12,14-prostaglandin J2 Increases Apoptotic Efficacy Via Redox Cell Signalling Mechanisms The Biochemical Journal. Feb, 2010 | Pubmed ID: 19916962 Importance of the Bioenergetic Reserve Capacity in Response to Cardiomyocyte Stress Induced by 4-hydroxynonenal The Biochemical Journal. Nov, 2009 | Pubmed ID: 19740075 Methods for Imaging and Detecting Modification of Proteins by Reactive Lipid Species Free Radical Biology & Medicine. Aug, 2009 | Pubmed ID: 19446632 High Fat Diet Induces Dysregulation of Hepatic Oxygen Gradients and Mitochondrial Function in Vivo The Biochemical Journal. Jan, 2009 | Pubmed ID: 18752470 S-nitrosation and Thiol Switching in the Mitochondrion: a New Paradigm for Cardioprotection in Ischaemic Preconditioning The Biochemical Journal. Jun, 2008 | Pubmed ID: 18466111 Oxidative Stress Induces Vascular Calcification Through Modulation of the Osteogenic Transcription Factor Runx2 by AKT Signaling The Journal of Biological Chemistry. May, 2008 | Pubmed ID: 18378684 Proteomic Approaches to Identify and Characterize Alterations to the Mitochondrial Proteome in Alcoholic Liver Disease Methods in Molecular Biology (Clifton, N.J.). 2008 | Pubmed ID: 18369930 Hydrogen Sulfide Mediates the Vasoactivity of Garlic Proceedings of the National Academy of Sciences of the United States of America. Nov, 2007 | Pubmed ID: 17951430 Evidence for Oxygen As the Master Regulator of the Responsiveness of Soluble Guanylate Cyclase and Cytochrome C Oxidase to Nitric Oxide The Biochemical Journal. Jul, 2007 | Pubmed ID: 17590153 Mechanism by Which Alcohol and Wine Polyphenols Affect Coronary Heart Disease Risk Annals of Epidemiology. May, 2007 | Pubmed ID: 17478321 Is the Soluble Guanylate Cyclase Pathway the Only One Available for Nitric Oxide (NO) Signaling? IUBMB Life. Feb, 2007 | Pubmed ID: 17454303 Methods for Measuring the Regulation of Respiration by Nitric Oxide Methods in Cell Biology. 2007 | Pubmed ID: 17445706 Deoxymyoglobin is a Nitrite Reductase That Generates Nitric Oxide and Regulates Mitochondrial Respiration Circulation Research. Mar, 2007 | Pubmed ID: 17293481 Hydrogen Sulfide Mediates Vasoactivity in an O2-dependent Manner American Journal of Physiology. Heart and Circulatory Physiology. Apr, 2007 | Pubmed ID: 17237242 Free Radicals, Mitochondria, and Oxidized Lipids: the Emerging Role in Signal Transduction in Vascular Cells Circulation Research. Oct, 2006 | Pubmed ID: 17068300 Activation of Mitogen-activated Protein Kinases by Lysophosphatidylcholine-induced Mitochondrial Reactive Oxygen Species Generation in Endothelial Cells The American Journal of Pathology. May, 2006 | Pubmed ID: 16651638 A Sensitive Method for the Quantitative Measurement of Protein Thiol Modification in Response to Oxidative Stress Free Radical Biology & Medicine. Feb, 2006 | Pubmed ID: 16443161 Interaction of Electrophilic Lipid Oxidation Products with Mitochondria in Endothelial Cells and Formation of Reactive Oxygen Species American Journal of Physiology. Heart and Circulatory Physiology. May, 2006 | Pubmed ID: 16387790 Induction of the Permeability Transition and Cytochrome C Release by 15-deoxy-Delta12,14-prostaglandin J2 in Mitochondria The Biochemical Journal. Feb, 2006 | Pubmed ID: 16268779 Hypoxia, Red Blood Cells, and Nitrite Regulate NO-dependent Hypoxic Vasodilation Blood. Jan, 2006 | Pubmed ID: 16195332 Metabolism of Phytoestrogen Conjugates Methods in Enzymology. 2005 | Pubmed ID: 16399358 Polarographic Measurement of Hydrogen Sulfide Production and Consumption by Mammalian Tissues Analytical Biochemistry. Jun, 2005 | Pubmed ID: 15866526 Nitric Oxide Signaling Gone Awry: Nitration of Glutamine Synthetase and Hyperammonemia in Sepsis Hepatology (Baltimore, Md.). May, 2005 | Pubmed ID: 15841446 Oxidized LDL Induces Mitochondrially Associated Reactive Oxygen/nitrogen Species Formation in Endothelial Cells American Journal of Physiology. Heart and Circulatory Physiology. Aug, 2005 | Pubmed ID: 15805232 Nitroxia: the Pathological Consequence of Dysfunction in the Nitric Oxide-cytochrome C Oxidase Signaling Pathway Free Radical Biology & Medicine. Feb, 2005 | Pubmed ID: 15629859 Redox Signalling: from Nitric Oxide to Oxidized Lipids Biochemical Society Symposium. 2004 | Pubmed ID: 15777016 Human Glutamate Cysteine Ligase Gene Regulation Through the Electrophile Response Element Free Radical Biology & Medicine. Oct, 2004 | Pubmed ID: 15451055 The Role of INOS in Alcohol-dependent Hepatotoxicity and Mitochondrial Dysfunction in Mice Hepatology (Baltimore, Md.). Sep, 2004 | Pubmed ID: 15349894 Weight Loss and Race Modulate Nitric Oxide Metabolism in Overweight Women Free Radical Biology & Medicine. Sep, 2004 | Pubmed ID: 15288126 L-Arginine Inhibits Xanthine Oxidase-dependent Endothelial Dysfunction in Hypercholesterolemia FEBS Letters. Mar, 2004 | Pubmed ID: 15013757 Mechanisms of the Interaction of Nitroxyl with Mitochondria The Biochemical Journal. Apr, 2004 | Pubmed ID: 14723605 Chronic Exposure to Nitric Oxide Alters the Free Iron Pool in Endothelial Cells: Role of Mitochondrial Respiratory Complexes and Heat Shock Proteins Proceedings of the National Academy of Sciences of the United States of America. Jan, 2004 | Pubmed ID: 14691259 Cellular Mechanisms of Redox Cell Signalling: Role of Cysteine Modification in Controlling Antioxidant Defences in Response to Electrophilic Lipid Oxidation Products The Biochemical Journal. Mar, 2004 | Pubmed ID: 14616092 Role of Calcium and Superoxide Dismutase in Sensitizing Mitochondria to Peroxynitrite-induced Permeability Transition American Journal of Physiology. Heart and Circulatory Physiology. Jan, 2004 | Pubmed ID: 12933349 Control of the Nitric Oxide-cytochrome C Oxidase Signaling Pathway Under Pathological and Physiological Conditions IUBMB Life. Oct-Nov, 2003 | Pubmed ID: 14711003 Neutrophil Myeloperoxidase Chlorinates and Nitrates Soy Isoflavones and Enhances Their Antioxidant Properties Free Radical Biology & Medicine. Dec, 2003 | Pubmed ID: 14642389 Mass Spectrometric Methods for the Analysis of Chlorinated and Nitrated Isoflavonoids: a Novel Class of Biological Metabolites Journal of Mass Spectrometry : JMS. Jul, 2003 | Pubmed ID: 12898656 Oxidized Low-density Lipoprotein and 15-deoxy-delta 12,14-PGJ2 Increase Mitochondrial Complex I Activity in Endothelial Cells American Journal of Physiology. Heart and Circulatory Physiology. Dec, 2003 | Pubmed ID: 12881207 Chronic Alcohol Consumption Increases the Sensitivity of Rat Liver Mitochondrial Respiration to Inhibition by Nitric Oxide Hepatology (Baltimore, Md.). Jul, 2003 | Pubmed ID: 12829996 Cytoprotection Against Oxidative Stress and the Regulation of Glutathione Synthesis Biological Chemistry. Apr, 2003 | Pubmed ID: 12751783 Reversible Inhibition of Cytochrome C Oxidase by Peroxynitrite Proceeds Through Ascorbate-dependent Generation of Nitric Oxide The Journal of Biological Chemistry. Jul, 2003 | Pubmed ID: 12743113 S-nitrosothiols Inhibit Uterine Smooth Muscle Cell Proliferation Independent of Metabolism to NO and CGMP Formation American Journal of Physiology. Cell Physiology. Jun, 2003 | Pubmed ID: 12584112 Measurement of Mitochondrial Respiratory Thresholds and the Control of Respiration by Nitric Oxide Methods in Enzymology. 2002 | Pubmed ID: 12481582 Nanotransducers in Cellular Redox Signaling: Modification of Thiols by Reactive Oxygen and Nitrogen Species Trends in Biochemical Sciences. Oct, 2002 | Pubmed ID: 12368076 Obesity, Aerobic Exercise, and Vascular Disease: the Role of Oxidant Stress Obesity Research. Sep, 2002 | Pubmed ID: 12226146 Mitochondria: Regulators of Signal Transduction by Reactive Oxygen and Nitrogen Species Free Radical Biology & Medicine. Sep, 2002 | Pubmed ID: 12208364 High Throughput Two-dimensional Blue-native Electrophoresis: a Tool for Functional Proteomics of Mitochondria and Signaling Complexes Proteomics. Aug, 2002 | Pubmed ID: 12203892 Activation of C-Jun N-terminal Kinase and Apoptosis in Endothelial Cells Mediated by Endogenous Generation of Hydrogen Peroxide Biological Chemistry. Mar-Apr, 2002 | Pubmed ID: 12033458 Hypothesis: the Mitochondrial NO(*) Signaling Pathway, and the Transduction of Nitrosative to Oxidative Cell Signals: an Alternative Function for Cytochrome C Oxidase Free Radical Biology & Medicine. Feb, 2002 | Pubmed ID: 11841927 Induction of Glutathione Synthesis by Oxidized Low-density Lipoprotein and 1-palmitoyl-2-arachidonyl Phosphatidylcholine: Protection Against Quinone-mediated Oxidative Stress The Biochemical Journal. Feb, 2002 | Pubmed ID: 11829739 الطاقة الحيوية والأكسدة انفجار: بروتوكولات لعزل وتقييم الكريات البيضاء والصفائح الدموية البشرية Philip A. Kramer*1, Balu K. Chacko*1, Saranya Ravi1, Michelle S. Johnson1, Tanecia Mitchell1, Victor M. Darley-Usmar*1 1UAB Mitochondrial Medicine Laboratory, Center for Free Radical Biology, Department of Pathology, University of Alabama at Birmingham JoVE 51301 Immunology and Infection الطاقة البيولوجية التجربة الملف باستخدام الخلايا Myoblast C2C12 David G. Nicholls1, Victor M. Darley-Usmar2, Min Wu3, Per Bo Jensen3, George W. Rogers3, David A. Ferrick3 1Buck Institute for Age Research, Novato, CA, 2Department of Pathology, Center for Free Radical Biology, University of Alabama at Birmingham - UAB, 3Seahorse Bioscience, North Billerica, MA JoVE 2511 Biology
الطاقة الحيوية والأكسدة انفجار: بروتوكولات لعزل وتقييم الكريات البيضاء والصفائح الدموية البشرية Philip A. Kramer*1, Balu K. Chacko*1, Saranya Ravi1, Michelle S. Johnson1, Tanecia Mitchell1, Victor M. Darley-Usmar*1 1UAB Mitochondrial Medicine Laboratory, Center for Free Radical Biology, Department of Pathology, University of Alabama at Birmingham JoVE 51301 Immunology and Infection
الطاقة البيولوجية التجربة الملف باستخدام الخلايا Myoblast C2C12 David G. Nicholls1, Victor M. Darley-Usmar2, Min Wu3, Per Bo Jensen3, George W. Rogers3, David A. Ferrick3 1Buck Institute for Age Research, Novato, CA, 2Department of Pathology, Center for Free Radical Biology, University of Alabama at Birmingham - UAB, 3Seahorse Bioscience, North Billerica, MA JoVE 2511 Biology