Webster K. Cavenee Ludwig Institute for Cancer Research Biography Publications Institution JoVE Articles Webster K. Cavenee has not added a biography. If you are Webster K. Cavenee and would like to personalize this page please email our Author Liaison for assistance. Publications Adaptive Global Innovative Learning Environment for Glioblastoma: GBM AGILE Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Feb, 2018 | Pubmed ID: 28814435 Interleukin-13 Receptor Alpha 2 Cooperates with EGFRvIII Signaling to Promote Glioblastoma Multiforme Nature Communications. Dec, 2017 | Pubmed ID: 29203859 Going Viral? Linking the Etiology of Human Prostate Cancer to the Long Noncoding RNA and Oncogenic Viruses EMBO Molecular Medicine. Oct, 2017 | Pubmed ID: 28751581 Glioblastoma Cellular Cross-talk Converges on NF-κB to Attenuate EGFR Inhibitor Sensitivity Genes & Development. Jul, 2017 | Pubmed ID: 28724615 Selective Replication of Oncolytic Virus M1 Results in a Bystander Killing Effect That is Potentiated by Smac Mimetics Proceedings of the National Academy of Sciences of the United States of America. Jun, 2017 | Pubmed ID: 28607091 PTEN Regulates Glioblastoma Oncogenesis Through Chromatin-associated Complexes of DAXX and Histone H3.3 Nature Communications. May, 2017 | Pubmed ID: 28497778 Extrachromosomal Oncogene Amplification Drives Tumour Evolution and Genetic Heterogeneity Nature. 03, 2017 | Pubmed ID: 28178237 Inhibition of Radiation-induced Glioblastoma Invasion by Genetic and Pharmacological Targeting of MDA-9/Syntenin Proceedings of the National Academy of Sciences of the United States of America. 01, 2017 | Pubmed ID: 28011764 Simultaneous Blockade of Interacting CK2 and EGFR Pathways by Tumor-targeting Nanobioconjugates Increases Therapeutic Efficacy Against Glioblastoma Multiforme Journal of Controlled Release : Official Journal of the Controlled Release Society. Dec, 2016 | Pubmed ID: 27825958 An LXR-Cholesterol Axis Creates a Metabolic Co-Dependency for Brain Cancers Cancer Cell. Nov, 2016 | Pubmed ID: 27746144 MTORC2 Activity in Brain Cancer: Extracellular Nutrients Are Required to Maintain Oncogenic Signaling BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology. 09, 2016 | Pubmed ID: 27427440 Cancer Metabolism As a Central Driving Force of Glioma Pathogenesis Brain Tumor Pathology. Jul, 2016 | Pubmed ID: 27295313 The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a Summary Acta Neuropathologica. Jun, 2016 | Pubmed ID: 27157931 Single-Cell Phosphoproteomics Resolves Adaptive Signaling Dynamics and Informs Targeted Combination Therapy in Glioblastoma Cancer Cell. Apr, 2016 | Pubmed ID: 27070703 MTORC2 and Metabolic Reprogramming in GBM: at the Interface of Genetics and Environment Brain Pathology (Zurich, Switzerland). Nov, 2015 | Pubmed ID: 26526943 EGFR Mutation Promotes Glioblastoma Through Epigenome and Transcription Factor Network Remodeling Molecular Cell. Oct, 2015 | Pubmed ID: 26455392 Glucose-dependent Acetylation of Rictor Promotes Targeted Cancer Therapy Resistance Proceedings of the National Academy of Sciences of the United States of America. Jul, 2015 | Pubmed ID: 26170313 PRUNE2 is a Human Prostate Cancer Suppressor Regulated by the Intronic Long Noncoding RNA PCA3 Proceedings of the National Academy of Sciences of the United States of America. Jul, 2015 | Pubmed ID: 26080435 Orthogonal Targeting of EGFRvIII Expressing Glioblastomas Through Simultaneous EGFR and PLK1 Inhibition Oncotarget. May, 2015 | Pubmed ID: 26059434 Heterogeneity of Epidermal Growth Factor Receptor Signalling Networks in Glioblastoma Nature Reviews. Cancer. May, 2015 | Pubmed ID: 25855404 Mutational Landscape of Gastric Adenocarcinoma in Chinese: Implications for Prognosis and Therapy Proceedings of the National Academy of Sciences of the United States of America. Jan, 2015 | Pubmed ID: 25583476 A Urokinase Receptor-Bim Signaling Axis Emerges During EGFR Inhibitor Resistance in Mutant EGFR Glioblastoma Cancer Research. Jan, 2015 | Pubmed ID: 25432173 Efficient Synthesis of Chloro-derivatives of Sialosyllactosylceramide, and Their Enhanced Inhibitory Effect on Epidermal Growth Factor Receptor Activation Oncology Letters. Apr, 2014 | Pubmed ID: 24944646 MTORC2 in the Center of Cancer Metabolic Reprogramming Trends in Endocrinology and Metabolism: TEM. Jul, 2014 | Pubmed ID: 24856037 MTORC2 Dictates Warburg Effect and Drug Resistance Cell Cycle (Georgetown, Tex.). 2014 | Pubmed ID: 24583874 Suppression of MicroRNA-9 by Mutant EGFR Signaling Upregulates FOXP1 to Enhance Glioblastoma Tumorigenicity Cancer Research. Mar, 2014 | Pubmed ID: 24436148 Targeted Therapy Resistance Mediated by Dynamic Regulation of Extrachromosomal Mutant EGFR DNA Science (New York, N.Y.). Jan, 2014 | Pubmed ID: 24310612 Therapeutic Resistance in Cancer: MicroRNA Regulation of EGFR Signaling Networks Cancer Biology & Medicine. Dec, 2013 | Pubmed ID: 24349829 MTOR Complex 2 Controls Glycolytic Metabolism in Glioblastoma Through FoxO Acetylation and Upregulation of C-Myc Cell Metabolism. Nov, 2013 | Pubmed ID: 24140020 The MTOR Kinase Inhibitors, CC214-1 and CC214-2, Preferentially Block the Growth of EGFRvIII-activated Glioblastomas Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Oct, 2013 | Pubmed ID: 24030701 EGFR Mutation-Induced Alternative Splicing of Max Contributes to Growth of Glycolytic Tumors in Brain Cancer Cell Metabolism. May, 2013 | Pubmed ID: 23707073 De-repression of PDGFRβ Transcription Promotes Acquired Resistance to EGFR Tyrosine Kinase Inhibitors in Glioblastoma Patients Cancer Discovery. May, 2013 | Pubmed ID: 23533263 A Tale of Two Approaches: Complementary Mechanisms of Cytotoxic and Targeted Therapy Resistance May Inform Next-generation Cancer Treatments Carcinogenesis. Apr, 2013 | Pubmed ID: 23455378 Genetic Driver Events in Premalignancy: LOH Validated for Marking the Risk of Oral Cancer Cancer Prevention Research (Philadelphia, Pa.). Sep, 2012 | Pubmed ID: 22911109 Resistance to EGF Receptor Inhibitors in Glioblastoma Mediated by Phosphorylation of the PTEN Tumor Suppressor at Tyrosine 240 Proceedings of the National Academy of Sciences of the United States of America. Aug, 2012 | Pubmed ID: 22891331 Activation of Src Induces Mitochondrial Localisation of De2-7EGFR (EGFRvIII) in Glioma Cells: Implications for Glucose Metabolism Journal of Cell Science. Sep, 2011 | Pubmed ID: 21878501 Therapeutic Targeting of Epidermal Growth Factor Receptor in Human Cancer: Successes and Limitations Chinese Journal of Cancer. Jan, 2011 | Pubmed ID: 21192840 KLF6 Gene and Early Melanoma Development in a Collagen I-rich Extracellular Environment Journal of the National Cancer Institute. Aug, 2010 | Pubmed ID: 20660366 Targeting EGFR Induced Oxidative Stress by PARP1 Inhibition in Glioblastoma Therapy PloS One. May, 2010 | Pubmed ID: 20532243 Escape from Targeted Inhibition: the Dark Side of Kinase Inhibitor Therapy Cell Cycle (Georgetown, Tex.). May, 2010 | Pubmed ID: 20404502 Mutant EGFR is Required for Maintenance of Glioma Growth in Vivo, and Its Ablation Leads to Escape from Receptor Dependence Proceedings of the National Academy of Sciences of the United States of America. Feb, 2010 | Pubmed ID: 20133782 Guilt by Association: PAX3-FOXO1 Regulates Gene Expression Through Selective Destabilization of the EGR1 Transcription Factor Cell Cycle (Georgetown, Tex.). Apr, 2008 | Pubmed ID: 18414034 Genome-wide Mapping and Analysis of Active Promoters in Mouse Embryonic Stem Cells and Adult Organs Genome Research. Jan, 2008 | Pubmed ID: 18042645 PAX3-FOXO1 Controls Expression of the P57Kip2 Cell-cycle Regulator Through Degradation of EGR1 Proceedings of the National Academy of Sciences of the United States of America. Nov, 2007 | Pubmed ID: 17986608 Malignant Astrocytic Glioma: Genetics, Biology, and Paths to Treatment Genes & Development. Nov, 2007 | Pubmed ID: 17974913 The Efficacy of Epidermal Growth Factor Receptor-specific Antibodies Against Glioma Xenografts is Influenced by Receptor Levels, Activation Status, and Heterodimerization Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Mar, 2007 | Pubmed ID: 17363548 PCAF Modulates PTEN Activity The Journal of Biological Chemistry. Sep, 2006 | Pubmed ID: 16829519 Treatment of Human Tumor Xenografts with Monoclonal Antibody 806 in Combination with a Prototypical Epidermal Growth Factor Receptor-specific Antibody Generates Enhanced Antitumor Activity Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Sep, 2005 | Pubmed ID: 16144944 PTEN: a Novel Anti-oncogenic Function Independent of Phosphatase Activity Cell Cycle (Georgetown, Tex.). Apr, 2005 | Pubmed ID: 15753657 Cellular Transformation by the MSP58 Oncogene is Inhibited by Its Physical Interaction with the PTEN Tumor Suppressor Proceedings of the National Academy of Sciences of the United States of America. Feb, 2005 | Pubmed ID: 15659546 Alix/AIP1 Antagonizes Epidermal Growth Factor Receptor Downregulation by the Cbl-SETA/CIN85 Complex Molecular and Cellular Biology. Oct, 2004 | Pubmed ID: 15456872 Disruption of Forkhead Transcription Factor (FOXO) Family Members in Mice Reveals Their Functional Diversification Proceedings of the National Academy of Sciences of the United States of America. Mar, 2004 | Pubmed ID: 14978268 The Recessive Nature of Dominance Genes, Chromosomes & Cancer. Dec, 2003 | Pubmed ID: 14566850 A Global Transcriptional Regulatory Role for C-Myc in Burkitt's Lymphoma Cells Proceedings of the National Academy of Sciences of the United States of America. Jul, 2003 | Pubmed ID: 12808131 Preparing for Serendipity Cancer Biology & Therapy. Mar-Apr, 2003 | Pubmed ID: 12750567 A Monoclonal Antibody Recognizing Human Cancers with Amplification/overexpression of the Human Epidermal Growth Factor Receptor Proceedings of the National Academy of Sciences of the United States of America. Jan, 2003 | Pubmed ID: 12515857 Mutant Epidermal Growth Factor Receptor Signaling Down-regulates P27 Through Activation of the Phosphatidylinositol 3-kinase/Akt Pathway in Glioblastomas Cancer Research. Nov, 2002 | Pubmed ID: 12438278 A Novel Seven Transmembrane Receptor Induced During the Early Steps of Astrocyte Differentiation Identified by Differential Expression Journal of Neurochemistry. May, 2002 | Pubmed ID: 12065666 Genetics and New Approaches to Cancer Therapy Carcinogenesis. May, 2002 | Pubmed ID: 12016138 Novel Monoclonal Antibody Specific for the De2-7 Epidermal Growth Factor Receptor (EGFR) That Also Recognizes the EGFR Expressed in Cells Containing Amplification of the EGFR Gene International Journal of Cancer. Journal International Du Cancer. Mar, 2002 | Pubmed ID: 11920591 Embryonic Expression of the Tumor-associated PAX3-FKHR Fusion Protein Interferes with the Developmental Functions of Pax3 Proceedings of the National Academy of Sciences of the United States of America. Feb, 2001 | Pubmed ID: 11171995 A Peptide Derived from the Non-receptor-binding Region of Urokinase Plasminogen Activator Inhibits Glioblastoma Growth and Angiogenesis in Vivo in Combination with Cisplatin Proceedings of the National Academy of Sciences of the United States of America. Jul, 2000 | Pubmed ID: 10890917 Causes of Drug Resistance and Novel Therapeutic Opportunities for the Treatment of Glioblastoma Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy. Feb, 1999 | Pubmed ID: 11504467 Protein Kinase B/Akt-mediated Phosphorylation Promotes Nuclear Exclusion of the Winged Helix Transcription Factor FKHR1 Proceedings of the National Academy of Sciences of the United States of America. Jun, 1999 | Pubmed ID: 10377430 In Vitro Loss of Heterozygosity Targets the PTEN/MMAC1 Gene in Melanoma Proceedings of the National Academy of Sciences of the United States of America. Aug, 1998 | Pubmed ID: 9689095 Drug Resistance of Human Glioblastoma Cells Conferred by a Tumor-specific Mutant Epidermal Growth Factor Receptor Through Modulation of Bcl-XL and Caspase-3-like Proteases Proceedings of the National Academy of Sciences of the United States of America. May, 1998 | Pubmed ID: 9576951 Growth Suppression of Glioma Cells by PTEN Requires a Functional Phosphatase Catalytic Domain Proceedings of the National Academy of Sciences of the United States of America. Nov, 1997 | Pubmed ID: 9356475 Intracerebral Tumor-associated Hemorrhage Caused by Overexpression of the Vascular Endothelial Growth Factor Isoforms VEGF121 and VEGF165 but Not VEGF189 Proceedings of the National Academy of Sciences of the United States of America. Oct, 1997 | Pubmed ID: 9342366 Fluorescens molekylære tomografi for In Vivo billeddannelse af glioblastom Xenografts Jorge A. Benitez*1, Ciro Zanca*1, Jianhui Ma1, Webster K. Cavenee1,2,3, Frank B. Furnari1,2,4 1Ludwig Institute for Cancer Research, 2Moores Cancer Center, School of Medicine, University of California, San Diego, 3Department of Pathology, School of Medicine, University of California, San Diego, 4Department of Medicine, School of Medicine, University of California, San Diego JoVE 57448 Cancer Research
Fluorescens molekylære tomografi for In Vivo billeddannelse af glioblastom Xenografts Jorge A. Benitez*1, Ciro Zanca*1, Jianhui Ma1, Webster K. Cavenee1,2,3, Frank B. Furnari1,2,4 1Ludwig Institute for Cancer Research, 2Moores Cancer Center, School of Medicine, University of California, San Diego, 3Department of Pathology, School of Medicine, University of California, San Diego, 4Department of Medicine, School of Medicine, University of California, San Diego JoVE 57448 Cancer Research