William C. Mobley Department of Neurosciences University of California, San Diego Biography Publications Institution JoVE Articles William C. Mobley has not added a biography. If you are William C. Mobley and would like to personalize this page please email our Author Liaison for assistance. Publications Soluble γ-Secretase Modulators Selectively Inhibit the Production of the 42-Amino Acid Amyloid β Peptide Variant and Augment the Production of Multiple Carboxy-Truncated Amyloid β Species Biochemistry. Feb, 2014 | Pubmed ID: 24401146 Human Chromosome 21 Orthologous Region on Mouse Chromosome 17 is a Major Determinant of Down Syndrome-related Developmental Cognitive Deficits Human Molecular Genetics. Feb, 2014 | Pubmed ID: 24041763 The Challenge of Connecting the Dots in the B.R.a.I.N Neuron. Oct, 2013 | Pubmed ID: 24139032 Aging and Intellectual Disability: Insights from Mouse Models of Down Syndrome Developmental Disabilities Research Reviews. Aug, 2013 | Pubmed ID: 23949828 Illicium Sesquiterpenes: Divergent Synthetic Strategy and Neurotrophic Activity Studies Chemistry (Weinheim an Der Bergstrasse, Germany). May, 2013 | Pubmed ID: 23526661 Loss of Sorting Nexin 27 Contributes to Excitatory Synaptic Dysfunction by Modulating Glutamate Receptor Recycling in Down's Syndrome Nature Medicine. Apr, 2013 | Pubmed ID: 23524343 Potential Use of γ-secretase Modulators in the Treatment of Alzheimer Disease Archives of Neurology. Oct, 2012 | Pubmed ID: 22801784 Deficits in Cognition and Synaptic Plasticity in a Mouse Model of Down Syndrome Ameliorated by GABAB Receptor Antagonists The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jul, 2012 | Pubmed ID: 22764230 Cognitive and Pharmacological Insights from the Ts65Dn Mouse Model of Down Syndrome Current Opinion in Neurobiology. Oct, 2012 | Pubmed ID: 22658745 Genetic Analysis of Down Syndrome Facilitated by Mouse Chromosome Engineering Bioengineered Bugs. Jan, 2012 | Pubmed ID: 22126738 Increased Efficiency of the GABAA and GABAB Receptor-mediated Neurotransmission in the Ts65Dn Mouse Model of Down Syndrome Neurobiology of Disease. Feb, 2012 | Pubmed ID: 22062771 Mouse Models for Down Syndrome-associated Developmental Cognitive Disabilities Developmental Neuroscience. 2011 | Pubmed ID: 21865664 Enantioselective Synthesis of (-)-jiadifenin, a Potent Neurotrophic Modulator Organic Letters. Sep, 2011 | Pubmed ID: 21812392 Comprehensive Behavioral Phenotyping of Ts65Dn Mouse Model of Down Syndrome: Activation of β1-adrenergic Receptor by Xamoterol As a Potential Cognitive Enhancer Neurobiology of Disease. Aug, 2011 | Pubmed ID: 21527343 Implications for Treatment: GABAA Receptors in Aging, Down Syndrome and Alzheimer's Disease Journal of Neurochemistry. May, 2011 | Pubmed ID: 21388375 Effects of Individual Segmental Trisomies of Human Chromosome 21 Syntenic Regions on Hippocampal Long-term Potentiation and Cognitive Behaviors in Mice Brain Research. Dec, 2010 | Pubmed ID: 20932954 Modulation of Gamma-secretase Reduces Beta-amyloid Deposition in a Transgenic Mouse Model of Alzheimer's Disease Neuron. Sep, 2010 | Pubmed ID: 20826309 Deficiencies in the Region Syntenic to Human 21q22.3 Cause Cognitive Deficits in Mice Mammalian Genome : Official Journal of the International Mammalian Genome Society. Jun, 2010 | Pubmed ID: 20512340 The 50th Anniversary of the Discovery of Trisomy 21: the Past, Present, and Future of Research and Treatment of Down Syndrome Genetics in Medicine : Official Journal of the American College of Medical Genetics. Sep, 2009 | Pubmed ID: 19636252 The "Down Syndrome Critical Region" is Sufficient in the Mouse Model to Confer Behavioral, Neurophysiological, and Synaptic Phenotypes Characteristic of Down Syndrome The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. May, 2009 | Pubmed ID: 19420260 Widespread Changes in Dendritic and Axonal Morphology in Mecp2-mutant Mouse Models of Rett Syndrome: Evidence for Disruption of Neuronal Networks The Journal of Comparative Neurology. May, 2009 | Pubmed ID: 19296534 Evidence for Both Neuronal Cell Autonomous and Nonautonomous Effects of Methyl-CpG-binding Protein 2 in the Cerebral Cortex of Female Mice with Mecp2 Mutation Neurobiology of Disease. Apr, 2009 | Pubmed ID: 19167498 Excitatory-inhibitory Relationship in the Fascia Dentata in the Ts65Dn Mouse Model of Down Syndrome The Journal of Comparative Neurology. Feb, 2009 | Pubmed ID: 19034952 The Coming of Age of Axonal Neurotrophin Signaling Endosomes Journal of Proteomics. Feb, 2009 | Pubmed ID: 19028611 Endophilin B1 As a Novel Regulator of Nerve Growth Factor/ TrkA Trafficking and Neurite Outgrowth The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Sep, 2008 | Pubmed ID: 18768694 Review of the Toxicology of Chlorpyrifos with an Emphasis on Human Exposure and Neurodevelopment Critical Reviews in Toxicology. 2008 | Pubmed ID: 18726789 Comparative Study of Brain Morphology in Mecp2 Mutant Mouse Models of Rett Syndrome The Journal of Comparative Neurology. May, 2008 | Pubmed ID: 18306326 Sleep and EEG Features in Genetic Models of Down Syndrome Neurobiology of Disease. Apr, 2008 | Pubmed ID: 18282758 Membrane Targeting by APPL1 and APPL2: Dynamic Scaffolds That Oligomerize and Bind Phosphoinositides Traffic (Copenhagen, Denmark). Feb, 2008 | Pubmed ID: 18034774 Using Mouse Models to Explore Genotype-phenotype Relationship in Down Syndrome Mental Retardation and Developmental Disabilities Research Reviews. 2007 | Pubmed ID: 17910089 A Functional Dynein-microtubule Network is Required for NGF Signaling Through the Rap1/MAPK Pathway Traffic (Copenhagen, Denmark). Nov, 2007 | Pubmed ID: 17822405 One at a Time, Live Tracking of NGF Axonal Transport Using Quantum Dots Proceedings of the National Academy of Sciences of the United States of America. Aug, 2007 | Pubmed ID: 17698956 Synaptic and Cognitive Abnormalities in Mouse Models of Down Syndrome: Exploring Genotype-phenotype Relationships The Journal of Comparative Neurology. Oct, 2007 | Pubmed ID: 17663443 Retrolinkin, a Membrane Protein, Plays an Important Role in Retrograde Axonal Transport Proceedings of the National Academy of Sciences of the United States of America. Feb, 2007 | Pubmed ID: 17287360 Increased App Expression in a Mouse Model of Down's Syndrome Disrupts NGF Transport and Causes Cholinergic Neuron Degeneration Neuron. Jul, 2006 | Pubmed ID: 16815330 TrkB Binds and Tyrosine-phosphorylates Tiam1, Leading to Activation of Rac1 and Induction of Changes in Cellular Morphology Proceedings of the National Academy of Sciences of the United States of America. Jul, 2006 | Pubmed ID: 16801538 Identification and Characterization of a New Down Syndrome Model, Ts[Rb(12.1716)]2Cje, Resulting from a Spontaneous Robertsonian Fusion Between T(171)65Dn and Mouse Chromosome 12 Mammalian Genome : Official Journal of the International Mammalian Genome Society. Feb, 2005 | Pubmed ID: 15859352 Long-distance Retrograde Neurotrophic Signaling Current Opinion in Neurobiology. Feb, 2005 | Pubmed ID: 15721743 Synaptic Structural Abnormalities in the Ts65Dn Mouse Model of Down Syndrome The Journal of Comparative Neurology. Dec, 2004 | Pubmed ID: 15515178 An AUPN/ANA Survey of Department Leader Opinions on the Health of US Academic Neurology Neurology. Oct, 2004 | Pubmed ID: 15505148 Late Onset Neurodegeneration in the Cln3-/- Mouse Model of Juvenile Neuronal Ceroid Lipofuscinosis is Preceded by Low Level Glial Activation Brain Research. Oct, 2004 | Pubmed ID: 15374749 Hippocampal Long-term Potentiation Suppressed by Increased Inhibition in the Ts65Dn Mouse, a Genetic Model of Down Syndrome The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Sep, 2004 | Pubmed ID: 15371516 Going the Distance, or Not, with Neurotrophin Signals Cell. Jul, 2004 | Pubmed ID: 15260984 Signaling Endosome Hypothesis: A Cellular Mechanism for Long Distance Communication Journal of Neurobiology. Feb, 2004 | Pubmed ID: 14704953 Trafficking the NGF Signal: Implications for Normal and Degenerating Neurons Progress in Brain Research. 2004 | Pubmed ID: 14699953 NGF Signaling in Sensory Neurons: Evidence That Early Endosomes Carry NGF Retrograde Signals Neuron. Jul, 2003 | Pubmed ID: 12848933 Traffic at the Intersection of Neurotrophic Factor Signaling and Neurodegeneration Trends in Neurosciences. Feb, 2003 | Pubmed ID: 12536130 التصوير في الوقت الحقيقي من محور عصبي نقل الكم دوت المسمى عامل التغذية العصبية في الخلايا العصبية الابتدائية Xiaobei Zhao1, Yue Zhou2, April M. Weissmiller1, Matthew L. Pearn3,4, William C. Mobley1, Chengbiao Wu1 1Department of Neurosciences, University of California, San Diego, 2School of Biomedical Engineering and Med-X Research Institute, Shanghai Jiao Tong University, 3Department of Anesthesiology, University of California, San Diego, 4VA San Diego Healthcare System JoVE 51899 Neuroscience إعداد الخلايا العصبية الأولية للتصور neurites التي في دولة مجمدة رطب عن طريق التصوير المقطعي البرد الإلكترون Sarah H. Shahmoradian1, Mauricio R. Galiano2, Chengbiao Wu3, Shurui Chen4, Matthew N. Rasband2, William C. Mobley3, Wah Chiu4 1Department of Molecular Physiology and Biophysics, Baylor College of Medicine, 2Department of Neuroscience, Baylor College of Medicine, 3Department of Neuroscience, University of California at San Diego, 4National Center for Macromolecular Imaging, Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine JoVE 50783 Neuroscience
التصوير في الوقت الحقيقي من محور عصبي نقل الكم دوت المسمى عامل التغذية العصبية في الخلايا العصبية الابتدائية Xiaobei Zhao1, Yue Zhou2, April M. Weissmiller1, Matthew L. Pearn3,4, William C. Mobley1, Chengbiao Wu1 1Department of Neurosciences, University of California, San Diego, 2School of Biomedical Engineering and Med-X Research Institute, Shanghai Jiao Tong University, 3Department of Anesthesiology, University of California, San Diego, 4VA San Diego Healthcare System JoVE 51899 Neuroscience
إعداد الخلايا العصبية الأولية للتصور neurites التي في دولة مجمدة رطب عن طريق التصوير المقطعي البرد الإلكترون Sarah H. Shahmoradian1, Mauricio R. Galiano2, Chengbiao Wu3, Shurui Chen4, Matthew N. Rasband2, William C. Mobley3, Wah Chiu4 1Department of Molecular Physiology and Biophysics, Baylor College of Medicine, 2Department of Neuroscience, Baylor College of Medicine, 3Department of Neuroscience, University of California at San Diego, 4National Center for Macromolecular Imaging, Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine JoVE 50783 Neuroscience
