William J. Janssen

Publications

• Disulfide Disruption Reverses Mucus Dysfunction in Allergic Airway Disease
  Nature Communications. 01, 2021  |   Pubmed ID: 33431872
• Human and Mouse Transcriptome Profiling Identifies Cross-Species Homology in Pulmonary and Lymph Node Mononuclear Phagocytes
  Cell Reports. Nov, 2020  |   Pubmed ID: 33147458
• Airspace Macrophages and Monocytes Exist in Transcriptionally Distinct Subsets in Healthy Adults
  American Journal of Respiratory and Critical Care Medicine. Oct, 2020  |   Pubmed ID: 33079572
• Cholesterol 25-hydroxylase Promotes Efferocytosis and Resolution of Lung Inflammation
  JCI Insight. 06, 2020  |   Pubmed ID: 32343675
• Localization of Macrophages in the Human Lung Via Design-based Stereology
  American Journal of Respiratory and Critical Care Medicine. 05, 2020  |   Pubmed ID: 32197050
• NF-κB Mediates Lipopolysaccharide-induced Alternative Pre-mRNA Splicing of in Mouse Macrophages
  The Journal of Biological Chemistry. 05, 2020  |   Pubmed ID: 32179652
• Inflammation-Induced Alternative Pre-mRNA Splicing in Mouse Alveolar Macrophages
  G3 (Bethesda, Md.). 02, 2020  |   Pubmed ID: 31810980
• Interstitial Macrophage-derived Thrombospondin-1 Contributes to Hypoxia-induced Pulmonary Hypertension
  Cardiovascular Research. Oct, 2020  |   Pubmed ID: 31710666
• Inflammation Via Myeloid Differentiation Primary Response Gene 88 Signaling Mediates the Fibrotic Response to Implantable Synthetic Poly(ethylene Glycol) Hydrogels
  Acta Biomaterialia. 12, 2019  |   Pubmed ID: 31568879
• Redistribution of EC-SOD Resolves Bleomycin-induced Inflammation Increased Apoptosis of Recruited Alveolar Macrophages
  FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. 12, 2019  |   Pubmed ID: 31560857
• Single Cell RNA Sequencing Identifies Unique Inflammatory Airspace Macrophage Subsets
  JCI Insight. 03, 2019  |   Pubmed ID: 30721157
• Cholestenoic Acid is a Prognostic Biomarker in Acute Respiratory Distress Syndrome
  The Journal of Allergy and Clinical Immunology. 01, 2019  |   Pubmed ID: 30296525
• Mucociliary Defense: Emerging Cellular, Molecular, and Animal Models
  Annals of the American Thoracic Society. 11, 2018  |   Pubmed ID: 30431350
• Mouse Models of Viral Infection
  Methods in Molecular Biology (Clifton, N.J.). 2018  |   Pubmed ID: 29987803
• Modulation of Myeloid Cell Function Using Conditional and Inducible Transgenic Approaches
  Methods in Molecular Biology (Clifton, N.J.). 2018  |   Pubmed ID: 29987790
• Recombinant IFN-β for Postseptic Acute Lung Injury-What's the Mechanism?
  American Journal of Respiratory Cell and Molecular Biology. 07, 2018  |   Pubmed ID: 29957050
• Rapid Clearance of Heavy Chain-modified Hyaluronan During Resolving Acute Lung Injury
  Respiratory Research. 05, 2018  |   Pubmed ID: 29855321
• Correction To: Dual RNA-seq Reveals Viral Infections in Asthmatic Children Without Respiratory Illness Which Are Associated with Changes in the Airway Transcriptome
  Genome Biology. 04, 2018  |   Pubmed ID: 29636099
• Phagocytosis of Microparticles by Alveolar Macrophages During Acute Lung Injury Requires MerTK
  American Journal of Physiology. Lung Cellular and Molecular Physiology. 01, 2018  |   Pubmed ID: 28935638
• Deletion of C-FLIP from CD11b Macrophages Prevents Development of Bleomycin-induced Lung Fibrosis
  American Journal of Respiratory Cell and Molecular Biology. 01, 2018  |   Pubmed ID: 28850249
• Promoter Specificity and Efficacy in Conditional and Inducible Transgenic Targeting of Lung Macrophages
  Frontiers in Immunology. 2017  |   Pubmed ID: 29225599
• Neutrophil Transfer of to Lung Epithelial Cells Dampens Acute Lung Injury in Mice
  Science Translational Medicine. Sep, 2017  |   Pubmed ID: 28931657
• TGF-β Activation by Bone Marrow-derived Thrombospondin-1 Causes Schistosoma- and Hypoxia-induced Pulmonary Hypertension
  Nature Communications. 05, 2017  |   Pubmed ID: 28555642
• A Time- and Compartment-Specific Activation of Lung Macrophages in Hypoxic Pulmonary Hypertension
  Journal of Immunology (Baltimore, Md. : 1950). 06, 2017  |   Pubmed ID: 28500078
• High Resolution Computed Tomography Pattern of Usual Interstitial Pneumonia in Rheumatoid Arthritis-associated Interstitial Lung Disease: Relationship to Survival
  Respiratory Medicine. 05, 2017  |   Pubmed ID: 28427540
• Cell Origin Dictates Programming of Resident Versus Recruited Macrophages During Acute Lung Injury
  American Journal of Respiratory Cell and Molecular Biology. 09, 2017  |   Pubmed ID: 28421818
• Three Unique Interstitial Macrophages in the Murine Lung at Steady State
  American Journal of Respiratory Cell and Molecular Biology. 07, 2017  |   Pubmed ID: 28257233
• Power of Place: Intravascular Superoxide Dismutase for Prevention of Acute Respiratory Distress Syndrome
  American Journal of Respiratory Cell and Molecular Biology. 02, 2017  |   Pubmed ID: 28145771
• Dual RNA-seq Reveals Viral Infections in Asthmatic Children Without Respiratory Illness Which Are Associated with Changes in the Airway Transcriptome
  Genome Biology. 01, 2017  |   Pubmed ID: 28103897
• CD73 Regulates Anti-inflammatory Signaling Between Apoptotic Cells and Endotoxin-conditioned Tissue Macrophages
  Cell Death and Differentiation. 03, 2017  |   Pubmed ID: 28060378
• Scratching Below the Surface
  The New England Journal of Medicine. 12, 2016  |   Pubmed ID: 27959764
• Myeloid Cell Turnover and Clearance
  Microbiology Spectrum. 11, 2016  |   Pubmed ID: 27837740
• Control of Lung Defence by Mucins and Macrophages: Ancient Defence Mechanisms with Modern Functions
  The European Respiratory Journal. 10, 2016  |   Pubmed ID: 27587549
• Selective and Inducible Targeting of CD11b+ Mononuclear Phagocytes in the Murine Lung with HCD68-rtTA Transgenic Systems
  American Journal of Physiology. Lung Cellular and Molecular Physiology. 07, 2016  |   Pubmed ID: 27190063
• Mucins and Their Sugars. Critical Mediators of Hyperreactivity and Inflammation
  Annals of the American Thoracic Society. Mar, 2016  |   Pubmed ID: 27027967
• MicroRNA-34a Negatively Regulates Efferocytosis by Tissue Macrophages in Part Via SIRT1
  Journal of Immunology (Baltimore, Md. : 1950). Feb, 2016  |   Pubmed ID: 26718338
• Flow Cytometric Analysis of Mononuclear Phagocytes in Nondiseased Human Lung and Lung-Draining Lymph Nodes
  American Journal of Respiratory and Critical Care Medicine. Mar, 2016  |   Pubmed ID: 26551758
• The Causal Role of IL-4 and IL-13 in Schistosoma Mansoni Pulmonary Hypertension
  American Journal of Respiratory and Critical Care Medicine. Oct, 2015  |   Pubmed ID: 26192556
• Tracheal Dysplasia Precedes Bronchial Dysplasia in Mouse Model of N-nitroso Trischloroethylurea Induced Squamous Cell Lung Cancer
  PloS One. 2015  |   Pubmed ID: 25860262
• Conceptual Approaches to Lung Injury and Repair
  Annals of the American Thoracic Society. Mar, 2015  |   Pubmed ID: 25830855
• The Polymeric Mucin Muc5ac is Required for Allergic Airway Hyperreactivity
  Nature Communications. Feb, 2015  |   Pubmed ID: 25687754
• Endogenous Airway Mucins Carry Glycans That Bind Siglec-F and Induce Eosinophil Apoptosis
  The Journal of Allergy and Clinical Immunology. May, 2015  |   Pubmed ID: 25497369
• General Parity Between Trio and Pairwise Breeding of Laboratory Mice in Static Caging
  Journal of Immunology (Baltimore, Md. : 1950). Nov, 2014  |   Pubmed ID: 25381356
• Kinetics of the Angiogenic Response in Lung Endothelium Following Acute Inflammatory Injury with Bleomycin
  Experimental Lung Research. Oct, 2014  |   Pubmed ID: 25153689
• Dendritic Cell Subsets Require Cis-activation for Cytotoxic CD8 T-cell Induction
  Nature Communications. Aug, 2014  |   Pubmed ID: 25135627
• Fas Ligand-expressing Lymphocytes Enhance Alveolar Macrophage Apoptosis in the Resolution of Acute Pulmonary Inflammation
  American Journal of Physiology. Lung Cellular and Molecular Physiology. Jul, 2014  |   Pubmed ID: 24838751
• Protein Tyrosine Phosphatase α Mediates Profibrotic Signaling in Lung Fibroblasts Through TGF-β Responsiveness
  The American Journal of Pathology. May, 2014  |   Pubmed ID: 24650563
• Muc5b is Required for Airway Defence
  Nature. Jan, 2014  |   Pubmed ID: 24317696
• Circulating Hematopoietic Progenitor Cells Are Decreased in COPD
  COPD. Jun, 2014  |   Pubmed ID: 24182349
• The Fibroproliferative Response in Acute Respiratory Distress Syndrome: Mechanisms and Clinical Significance
  The European Respiratory Journal. Jan, 2014  |   Pubmed ID: 23520315
• Alveolar Macrophage Dysfunction and Chronic Alcohol Use. Time to Think About Zinc
  American Journal of Respiratory and Critical Care Medicine. Sep, 2013  |   Pubmed ID: 24032380
• Chest CT Features Are Associated with Poorer Quality of Life in Acute Lung Injury Survivors
  Critical Care Medicine. Feb, 2013  |   Pubmed ID: 23263616
• Defective Efferocytosis by Alveolar Macrophages in IPF Patients
  Respiratory Medicine. Dec, 2012  |   Pubmed ID: 22999220
• Apoptotic Cell Clearance and Fibrotic Lung Disease
  The European Respiratory Journal. Aug, 2012  |   Pubmed ID: 22855466
• The Pulmonary Endothelial Glycocalyx Regulates Neutrophil Adhesion and Lung Injury During Experimental Sepsis
  Nature Medicine. Jul, 2012  |   Pubmed ID: 22820644
• Increased Lymphatic Vessel Length is Associated with the Fibroblast Reticulum and Disease Severity in Usual Interstitial Pneumonia and Nonspecific Interstitial Pneumonia
  Chest. Dec, 2012  |   Pubmed ID: 22797508
• Nrf2 Protects Human Alveolar Epithelial Cells Against Injury Induced by Influenza A Virus
  Respiratory Research. Jun, 2012  |   Pubmed ID: 22672594
• Vascular Endothelial Growth Factor Enhances Macrophage Clearance of Apoptotic Cells
  American Journal of Physiology. Lung Cellular and Molecular Physiology. Apr, 2012  |   Pubmed ID: 22307908
• Macrophages Mediate Lung Inflammation in a Mouse Model of Ischemic Acute Kidney Injury
  American Journal of Physiology. Renal Physiology. Feb, 2012  |   Pubmed ID: 22114207
• Cellular Regulation of the Inflammatory Response
  Toxicologic Pathology. 2012  |   Pubmed ID: 22089838
• Fas Determines Differential Fates of Resident and Recruited Macrophages During Resolution of Acute Lung Injury
  American Journal of Respiratory and Critical Care Medicine. Sep, 2011  |   Pubmed ID: 21471090
• Impaired Phagocytosis of Apoptotic Cells by Macrophages in Chronic Granulomatous Disease is Reversed by IFN-γ in a Nitric Oxide-dependent Manner
  Journal of Immunology (Baltimore, Md. : 1950). Oct, 2010  |   Pubmed ID: 20805415
• Development and Characterization of a Lung-protective Method of Bone Marrow Transplantation in the Mouse
  Journal of Immunological Methods. May, 2010  |   Pubmed ID: 20347833
• TNFalpha Inhibits Apoptotic Cell Clearance in the Lung, Exacerbating Acute Inflammation
  American Journal of Physiology. Lung Cellular and Molecular Physiology. Oct, 2009  |   Pubmed ID: 19648283
• Cigarette Smoke Impairs Clearance of Apoptotic Cells Through Oxidant-dependent Activation of RhoA
  American Journal of Respiratory and Critical Care Medicine. Jun, 2009  |   Pubmed ID: 19264974
• CD38 Plays a Dual Role in Allergen-induced Airway Hyperresponsiveness
  American Journal of Respiratory Cell and Molecular Biology. Apr, 2009  |   Pubmed ID: 18931329
• Dyspnea, Chest Pain, and Altered Mental Status in a 33-year-old Carpenter
  Chest. Nov, 2008  |   Pubmed ID: 18988783